Clinical trials: Cancer Weight Loss, active
Obesity, Malignant Neoplasm
A Study to See if an iPhone Weight Management App Can Help Promote Weight Loss in Adolescents and Young Adults After a Stem Cell Transplant
This early phase I trial studies how well a behavioral weight loss intervention consisting of a smartphone application and coaching works for the promotion of weight loss in adolescents and young adults after a stem cell…
- Trial name
- NCT04453072
- Testing
- Interview, Media Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Obesity, Solid Neoplasm
Weight Management in Obese Cancer Patients During Curative Active Treatment
This is a feasibility study intervention to fifty cancer patients with obesity and with newly diagnosed stage II-IV solid tumors undergoing curative treatment recruited at the Catalan Institute of Oncology (ICO) in L'Hospitalet…
- Conditions
- Obesity, Solid Neoplasm, Stage II-IV, Curative Treatment
- Trial name
- CANOBESE (NCT07058207)
- Testing
- Multimodal weight management program
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Renal Cell Carcinoma (RCC)
Comparing Two Weight Loss Programs for the Prevention of Kidney Cancer Progression Among Patients With Small Renal Masses on Active Surveillance
This clinical trial compares two different weight-loss programs, daily continuous calorie energy reduction (CER) versus (vs.) 5:2 intermittent fasting (IF), in preventing progression of kidney (renal) cancer among patients with…
- Trial name
- NCT07714018
- Testing
- Intermittent Fasting, Continuous Energy Restriction (CER)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Roswell Park Cancer Institute
Cachexia
Retrospective Review of Cachexia in Lung and Gastrointestinal Cancer Patients
The objective is to perform a retrospective chart review of patients with cachexia related to cancer in patients treated at UT Southwestern Medical Center and Parkland Hospital to evaluate the prognosis and practice patterns in…
- Trial name
- NCT03606317
- Volunteers
- 20,000 people
- Sponsor
- University of Texas Southwestern Medical Center
Gastric Cancer, Gastric Adenocarcinoma
MalnutritiOn Assessment With biOelectrical impedaNce Analysis in gastRic Cancer patIentS Undergoing Multimodal trEatment
The aim of this single-arm prospective, multicenter, cross-sectional study is to evaluate the nutritional status and body composition on tumor regression grade with bioelectrical impedance analysis in gastric cancer patients…
- Conditions
- Gastric Cancer, Gastric Adenocarcinoma, Malnutrition, Cachexia
- Trial name
- MOONRISE (NCT05723718)
- Testing
- Observational Survey
- Where
- Poland
- Volunteers
- 125 people
- Sponsor
- Medical University of Lublin
Acute Malnutrition in Childhood, Acute Malnutrition, Severe
Reduced Dosage and/or Visitation Protocol for the Treatment of Acute Malnutrition in Kenya
Severe acute malnutrition (SAM) places children at significant risk of mortality. Outpatient treatment programs are effective but there is a need to increase treatment coverage and reduce costs of treatment.
- Conditions
- Acute Malnutrition in Childhood, Acute Malnutrition, Severe, Acute Malnutrition, Moderate, Wasting
- Trial name
- RSWITCH (NCT07420062)
- Testing
- WHO-reduced, WHO-full, Kenya-IMAM
- Where
- Kenya
- Volunteers
- 2,274 people
- Sponsor
- International Food Policy Research Institute
Cachexia, Digestive System Cancer
Real-World Study on Nano-Crystalline Megestrol Acetate for Cachexia in TKI-Treated Advanced Digestive Tumors
This study is a prospective, observational clinical study aimed at evaluating the efficacy of Megestrol Acetate for cachexia in patients with advanced digestive system tumors receiving TKI-based therapy.
- Conditions
- Cachexia, Digestive System Cancer, Gastric Cancer, Colorectal Cancer
- Trial name
- NCT06940102
- Testing
- Nano-crystalline Megestrol Acetate Oral Suspension, TKI-Based Therapy
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Advanced Cancer, Anorexia
Effects of Mirtazapine on Appetite in Advanced Cancer Patients
Primary objective: This is a preliminary study to determine if Mirtazapine in comparison to placebo will improve appetite in advanced cancer patients with anorexia and weight loss.
- Conditions
- Advanced Cancer, Anorexia, Weight Loss, Insomnia
- Trial name
- NCT00488072
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- M.D. Anderson Cancer Center
Non Small Cell Lung Cancer
Circulating and Molecular Markers Involved in the Processes of Cachexia, Anorexia and Sarcopenia in Patients With NSCLC
The study aim to evaluate whether some substances produced by muscle or adipose tissue may play a role in the course of the disease by interfering with the effectiveness of therapies.
- Trial name
- SARCLUNG (NCT06808113)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Obesity
Anti-obesity Pharmacotherapy and Inflammation
This study evaluates the relationship between weight loss, circulating inflammatory markers and lipids from 24 patients before and after 6 months of pharmacotherapy as a standard of care for anti-obesity treatment
- Trial name
- NCT05756764
- Testing
- Semaglutide, Phentermine-Topiramate combination, Phentermine
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Weight Loss, Overweight and Obesity
Choosing Healthy Activities and Lifestyle Management Through Portal Support
The study aims to randomize 250 participants to 1 of 2 arms: a.) an Active Intervention Group (based on the Look AHEAD* ILI) or b.) a Comparison Group (based on the Look AHEAD DSE Comparison group) to test the hypothesis that a…
- Conditions
- Weight Loss, Overweight and Obesity, Behavior, Health
- Trial name
- CHAMPS (NCT05410353)
- Testing
- Active Intervention Group, Comparison Group
- Where
- United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Cancer-associated Cachexia
Visugromab in Cachexia International Trial
A study of how well and safely a new drug called visugromab works in people with certain kinds of cancer (including lung and bowel cancer) and unintended weight loss known as cachexia.
- Trial name
- VINCIT (NCT07112196)
- Testing
- Visugromab (CTL-002)
- Where
- 79 sites in United States, Bulgaria and 12 more
- Volunteers
- 518 people
- Sponsor
- CatalYm GmbH
Cachexia; Cancer
A Phase I Clinical Study to Evaluate the Efficacy and Safety of GB18 Injection in Patients With Tumor Cachexia
KXZY-GB18-101(1B) is an extension of KXZY-GB18-101, a first-in-human, dose-escalation trial in healthy adult participants to evaluate the safety, tolerability, PK, PD, and immunogenicity of GB18.
- Trial name
- NCT07519564
- Testing
- GB18
- Where
- 2 sites in China
- Volunteers
- 18 people
- Sponsor
- Kexing Biopharm Co., Ltd.
Lung Cancer Screening
A Study of Lung Cancer Screening in People With Unexplained Weight Loss
The researchers are doing this study to see if people with unexplained weight loss who have lung cancer screening are more likely to have or develop lung cancer than people without unexplained weight loss.
- Trial name
- NCT06717334
- Testing
- Low Dose CT imaging, blood draws, screening questionnaire
- Where
- 8 sites in United States
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Advanced Cancer, Cachexia
A Phase I Study on Evaluating the Safety, Tolerability, Pharmacokinetic Characteristics and Preliminary Efficacy of SXRN Plasmid DNA Technique in Patients With Advanced Solid Tumors
The purpose of this clinical trial is to evaluate the safety and tolerability of SXRN Plasmid DNA Technique in patients with advanced solid tumors.
- Trial name
- NCT06736275
- Testing
- SXRN
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Jiangsu Nutai Biologics Co., Ltd
Stage IV Non-small Cell Lung Cancer, Cachexia
Ruxolitinib for Cancer Cachexia
To assess toxicity with use of Ruxolitinib in NSCLC cachexia patients; to associate levels of JAK/STAT signaling in blood, adipose, and muscle pre- and post-ruxolitinib treatment with changes in cachexia and anorexia.
- Trial name
- NCT04906746
- Testing
- Identify any dose-limiting toxicity (DLT) when ruxolitinib is administered to NSCLC cachexia patients.
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tu Dan
Pancreatic Cancer, Microbiota
Microbiota and Pancreatic Cancer Cachexia
This monocentric study aims at evaluating the effects of fecal microbiota transplantation from newly diagnosed cachectic and non-cachectic pancreatic cancer patients, and healthy volunteers on several cachexia-related parameters…
- Conditions
- Pancreatic Cancer, Microbiota, Cachexia
- Trial name
- EXTRA (NCT05606523)
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Genton Graf Laurence
Malnutrition; Cachexia
Influence of Protein Intake on Muscle Mass and Health-related Quality of Life During and After Radiotherapy
The influence of radiotherapy on the protein intake and muscle mass of patients has not been extensively investigated to date. It is also unclear whether the localization of the tumor disease and thus the radiation field have…
- Trial name
- pROtein (NCT06480266)
- Where
- Germany
- Volunteers
- 175 people
- Sponsor
- Charite University, Berlin, Germany
Non-Small Cell Lung Cancer, Cachexia
Enteral Nutrition With L-Carnitine for Cachexia in Non-Small Cell Lung Cancer
This is a multicenter, double-blind randomized controlled clinical study designed to evaluate the efficacy and safety of oral nutritional supplements (ONS) containing levocarnitine for cachexia in lung cancer patients scheduled…
- Trial name
- NCT07035444
- Testing
- L-Carnitine 4g, Enteral Nutrition
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Obesity, Child Obesity
Family COMIDA (Consumo de Opciones Más Ideales De Alimentos) (Eating More Ideal Food Options)
The purpose of this study is to determine the most effective family-centered intervention (FCI) for weight loss and obesity prevention in Hispanic families.
- Conditions
- Obesity, Child Obesity, Weight Loss
- Trial name
- NCT07144800
- Testing
- Parent Weekly Individual Telephone Support, Child Education, Parent Initial Counseling
- Where
- United States
- Volunteers
- 1,319 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center