Clinical trials: CTC
Lung Cancer, Bone Metastases
CTC in Lung Caner Patients With Bone Metastases
1. Evaluate the feasibility of single cell sequencing technology based on three-dimensional bionic capture network; 2. To build a risk prediction model of bone related events based on single cell sequencing; 3.
- Conditions
- Lung Cancer, Bone Metastases, Single Cell Sequencing Technology
- Trial name
- NCT04568291
- Testing
- model treatment, routine treatment
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai 6th People's Hospital
Lung Adenocarcinoma, Stage I, Diagnoses Diseases
Application of Detecting Circulating Tumor Cells in the Accurate Treatment of Early Stage Lung Adenocarcinoma
In 2015-2016, 224,390 cases were newly diagnosed with lung cancer in USA. Of all the cases, 83% are non-small cell lung cancer (NSCLC).
- Conditions
- Lung Adenocarcinoma, Stage I, Diagnoses Diseases, Circulating Tumor Cells, Treatment
- Trial name
- CTCs detection (NCT02951897)
- Testing
- lobectomy, segmentecomy, chemotherapy（pemetrexed+CISPLATIN）
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Third Military Medical University
Estrogen Receptor Negative, Estrogen Receptor Positive
Pembrolizumab and Carboplatin in Treating Patients With Circulating Tumor Cells Positive Metastatic Breast Cancer
The purpose of the study is to evaluate the impact on progression-free survival (PFS) with the combination carboplatin - pembrolizumab in patients with CTC (circulating tumor cells) positive, HER2 negative metastatic breast…
- Conditions
- Estrogen Receptor Negative, Estrogen Receptor Positive, HER2/Neu Negative, Progesterone Receptor Negative
- Trial name
- NCT03213041
- Testing
- Carboplatin, Laboratory Biomarker Analysis, Pembrolizumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Northwestern University
Rectal Cancer Patients
The Effect of Multimodal Treatment of Rectal Cancer on Circulating Tumor Cells: A Prospective, Observational Study
The prospective study will focus on patients undergoing multimodal treatment for rectal cancer. The main objective of the study will be to monitor changes in circulating tumor cells (CTCs) in the peripheral blood of patients…
- Trial name
- NCT07112937
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Colorectal Cancer, Liver Metastases
Postoperation Maintenance Therapy for Resectable Liver Metastases of Colorectal Cancer Guided by ctDNA
The goal of this clinical trial is to compare in resectable liver metastases colorectal cancer patients.The main question it aims to answer is to investigate whether the progression-free survival (PFS) of resectable colorectal…
- Conditions
- Colorectal Cancer, Liver Metastases, Circulating Tumor Cell, Cancer, Therapy-Related
- Trial name
- NCT05797077
- Testing
- Colorectal resection surgery., FOLFOX chemotherapy regimen, Capecitabine
- Where
- China
- Volunteers
- 346 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Gastric Cancer
Clinical Significance of Circulating Tumor Cells (CTCs) in Blood of Patients With Advanced/Metastatic Gastric Cancer
To identify the correlation of CTCs with clinical prognosis in advanced/metastatic gastric cancer. Confirm the presence of CTCs are sensitive for monitoring response to chemotherapy.
- Trial name
- NCT01625702
- Testing
- CellSearch® CTC kit
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Peking University
Solitary Pulmonary Nodule
Evaluate the Auxiliary Diagnostic Value of Circulating Tumor Cells in Benign and Malignant Lung Nodules
By testing the CTC number of new solitary pulmonary nodule patient, evaluating the correlation of CTC number and benign and malignant lung nodules auxiliary diagnosis, the correlation of CTC number and the size of lung nodules of…
- Trial name
- NCT02653859
- Volunteers
- 50 people
- Sponsor
- GenoSaber
Lung Cancer, Lung Neoplasms
A Study to Isolate and Test Circulating Tumor Cells Using the ClearCell® FX EP+ System
The purpose of this study is to isolate and measure circulating tumor cells in the blood stream to advance detection of cancer and treatment monitoring.
- Conditions
- Lung Cancer, Lung Neoplasms, Cancer of Lung, Cancer of the Lung
- Trial name
- NCT02370303
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Mayo Clinic
Serious Emotional Disturbance
Family Health and Development Project
The Family Health and Development Project (FHDP) is a randomized controlled trial to evaluate the effectiveness of the Intensive In-home Child and Adolescent Psychiatric Service (IICAPS) intervention, targeting emotionally…
- Trial name
- FHDP (NCT01567969)
- Testing
- Intensive In-home Child and Adolescent Psychiatric Service, Home-based Child Treatment Coordination
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Yale University
Colorectal Cancer, Circulating Tumor Cell
Prognosis Predicting of CRC Patients Based on Morphology and Molecular Biomaker of CTC
Detecting circulating tumor cells from I-IV stage colorectal cancer patients pre-and post-operatively. Analyzing the morphology and biomarkers of CTCs and builting prognosis predicting model based on the morphology and biomarkers…
- Trial name
- NCT04912882
- Testing
- Circulating tumor cell
- Volunteers
- 1,000 people
- Sponsor
- Fudan University
Colorectal Cancer
Influence of the Surgical Technique Used for Colectomies on the Concentration of Circulating Tumor DNA and the Presence of Circulating Tumor Cells: Comparison of the "no Touch" Technic With Either First Clamping of the Mesenteric Vessels or First Mobilization of the Tumor Followed by Clamping.
Colectomy is the most commonly used therapeutic approach for the treatment of non-metastatic colorectal cancer. This approach is generally very effective however the rate of recurrence and the appearance of metachronous…
- Trial name
- ADNCHIR (NCT03809403)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epithelial-Mesenchymal Transition, Circulating Tumor Cells
Aspirin on CTCs of Advanced Breast and Colorectal Cancer
The purpose of this study is to determine whether Aspirin could affect the number and subtype of circulating tumor cells of metastatic breast cancer and colorectal cancer.
- Trial name
- ACABC (NCT02602938)
- Testing
- Aspirin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhejiang Provincial People's Hospital
Non Small Cell Lung Cancer
Detecting EGFR T790M Mutations From Circulating Tumor Cells
The purpose of this research study is to determine if the EGFR mutation can be detected in CTCs. CTCs are cancer cells that are shed from solid tumors and float freely in the bloodstream.
- Trial name
- NCT01734915
- Testing
- Circulating tumor cell chip
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast
Efficacy Study of Herceptin to Treat HER2-negative CTC Breast Cancer
This is a randomized phase II trial for patients with HER2 negative primary Breast Cancer (BC) who after completing (neo) adjuvant chemotherapy and surgery have detectable circulating tumour cells (CTC) in peripheral blood.
- Conditions
- Breast Cancer, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast, Circulating Tumor Cells
- Trial name
- TREAT-CTC (NCT01548677)
- Testing
- trastuzumab
- Where
- 80 sites in Belgium, France and 2 more
- Volunteers
- 1,317 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Prostate Cancer
Circulating Tumor Cells in Prostate Cancer Patients
The purpose of this study is to determine if a non-invasive cancer treatment, high-dose stereotactic body radiotherapy (SBRT), is associated with changes in circulating tumor cells counts in patients with low- and…
- Trial name
- NCT01414712
- Testing
- Blood Drawing
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Texas Southwestern Medical Center
Breast Cancer, Breast Neoplasms
Genomic Markers for Measuring Breast Cancer Response to Neoadjuvant Chemotherapy
The primary aim of the study is to identify genomic markers (circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), transcriptomic markers) as biomarkers of response to neoadjuvant chemotherapy (NAC) among patients with…
- Conditions
- Breast Cancer, Breast Neoplasms, Cancer, Breast
- Trial name
- NCT03709134
- Testing
- Genomic Markers (CTC/ctDNA)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Sunnybrook Health Sciences Centre
Melanoma
Study of Circulating Tumor Cells Before and After Treatment in Patients With Metastatic Melanoma
Circulating tumor cells (CTC) are the subject of increasing interest in clinical oncology as a prognostic factor and predictor of therapeutic response.
- Trial name
- NCT01573494
- Testing
- Sampling of blood
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
microRNA, Circulating Tumor Cells
The Difference of microRNA and Circulating Tumor Cells in Blood Among Cancer Patients With Immunotherapy
Among the currently important biomarkers, circulating tumor cells and microRNA (miRNA) have received significant attention. The latter, also translated as micro-ribonucleic acid, is a widely present ribonucleic acid (RNA)…
- Conditions
- microRNA, Circulating Tumor Cells, Immunotherapy
- Trial name
- NCT07260370
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Chang Gung Memorial Hospital
Circulating Tumor Cells (CTCs)
Detection of Circulating Tumor Cells in Peripheral Blood From Healthy Volunteers and Patients With Cancer
To address the challenges of isolating and analyzing rare cells, this study aims to validate technical diagnostic instrumentation, tests, protocols and analysis to correlate the number of circulating tumor cells present in whole…
- Trial name
- NCT02904161
- Where
- Taiwan
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- MiCareo Taiwan Co., Ltd.
Circulating Tumor Cell, Hepatocellular Carcinoma
Effects of TIVA Versus Inhalational Anaesthesia on Circulating Tumour Cells in Hepatocellular Carcinoma Patients
More than 80% of patients with cancer will be exposed to anaesthesia at some point in their treatment. There is increasing evidence that perioperative events, including the type of anaesthesia drugs utilised, have an impact on…
- Trial name
- NCT04601961
- Testing
- Propofol, Sevoflurane
- Where
- China
- Volunteers
- 220 people
- Sponsor
- The University of Hong Kong