Clinical trials: COVID19 ARDS
SARS-CoV-2 (COVID-19) Severe Pneumonia
Study to Evaluate the Safety and Efficacy of ATYR1923 (Efzofitimod) In Participants With Severe Pneumonia Related to COVID-19
To evaluate the safety and preliminary efficacy of efzofitimod, compared to placebo matched to efzofitimod, in hospitalized participants with SARS-CoV-2 (COVID-19) severe pneumonia not requiring mechanical ventilation.
- Trial name
- NCT04412668
- Testing
- Efzofitimod 1 mg/kg, Efzofitimod 3 mg/kg
- Where
- 10 sites in United States, Puerto Rico
- Volunteers
- 36 people
- Sponsor
- aTyr Pharma, Inc.
Covid-19
Evaluation of the Evolution of Pregnancies in the First Trimester Following MAR Management During a COVD-19 Pandemic Period
Because of the physiological changes inherent in pregnancy, pregnant women with lower respiratory tract infections often have more worrisome outcomes compared to non-pregnant individuals, including a higher rate of hospital and…
- Trial name
- AMPCOVID-19 (NCT04415359)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Strasbourg, France
Covid19 Pneumonia
Prevention of COVID-19 Infection to Severe Pneumonia or ARDS
A trial of EC-18 in patients with mild/moderate pneumonia due to COVID-19
- Trial name
- NCT04569227
- Testing
- EC-18
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Enzychem Lifesciences Corporation
COVID-19, COVID-19 Acute Respiratory Distress Syndrome
Study of Cysteamine-pantetheine Disulfide (TTI-0102) in Mild to Moderate COVID-19
This is multi-center, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, pharmacodynamics (PD) and efficacy of TTI-0102 for the treatment of patients with mild to moderate COVID-19.
- Trial name
- NCT05212662
- Testing
- TTI-0102
- Sponsor
- Thiogenesis Therapeutics, Inc.
Pneumonia, Viral, Covid19
Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19
Introduction: SARS-CoV2 infection produces severe pneumonia with pulmonary alveolar collapse. There is no specific treatment to date.
- Conditions
- Pneumonia, Viral, Covid19, ARDS, Oxidative Stress
- Trial name
- ANTIOX-COVID (NCT04570254)
- Testing
- Vitamin C, Vitamin E, Melatonin
- Where
- Mexico
- Volunteers
- 110 people
- Sponsor
- Unidad Temporal COVID-19 en Centro Citibanamex
COVID-19, SARS-CoV Infection
Glycine Supplement for Severe COVID-19
This study will explore whether a daily supplement of glycine, a substance that has antiinflammatory, cytoprotective, and endothelium-protecting effects, can improve mortality, as well as clinical and biochemical parameters, in…
- Conditions
- COVID-19, SARS-CoV Infection, SARS (Severe Acute Respiratory Syndrome), SARS Pneumonia
- Trial name
- NCT04443673
- Testing
- Glycine
- Where
- Mexico
- Volunteers
- 59 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
Respiratory Distress Syndrome, Mechanical Ventilation
Mechanical Ventilation Strategy for Coronavirus Disease 2019 (COVID-19)
This is a prospective, randomized, single-center, open-label controlled trial, designed to compare the efficacy of two ventilation strategies (Low Tidal Volume and positive end-expiratory pressure (PEEP) based on the Acute…
- Conditions
- Respiratory Distress Syndrome, Mechanical Ventilation, SARS (Severe Acute Respiratory Syndrome)
- Trial name
- COVEN (NCT04497454)
- Testing
- EIT-Group, ARDSNet
- Where
- Brazil
- Volunteers
- 128 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Respiratory Distress Syndrome, Coronavirus
Prone Position Improves End-Expiratory Lung Volumes in COVID-19 Acute Respiratory Distress Syndrome
Covid-19 associated Acute Respiratory Distress Syndrome (ARDS) may present with profound hypoxemia not fully explained with pulmonary infiltrates.
- Conditions
- Acute Respiratory Distress Syndrome, Coronavirus, Mechanical Ventilation Complication, Ventilation Perfusion Mismatch
- Trial name
- NCT04818164
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Istanbul University - Cerrahpasa
Ards
Duration of Prone Position in the Severe Acute Respiratory Syndrome Coronavirus 2 (COVID-19).
The OMELETTE study is a randomised, controlled, unicentric, open-label study to prove the noninferiority of reduced prone position (PP) sessions (more tan 16 hours) versus prolonged PP (48 hours).
- Trial name
- OmeLEtte (NCT05012267)
- Testing
- 16-hour PP
- Where
- Spain
- Volunteers
- 61 people
- Sponsor
- Ignacio Saez de la Fuente
COVID-19 Pneumonia, COVID-19 Respiratory Infection
Follow-up of Covid-19 Long Term Sequelae
The protocol, in accordance with the objectives of ORCHESTRA project - Work Package 2, aims at investigating the characteristics and determinants of COVID-19 long-term sequelae.
- Conditions
- COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Acute Bronchitis, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05097677
- Testing
- Not applicable (observational study)
- Where
- 7 sites in Belgium, France and 4 more
- Volunteers
- 7,599 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
COVID-19 Acute Respiratory Distress Syndrome
Macintosh Versus Macgrath for Laryngoscopy in COVID 19 Hypoxemic ICU Patients
In this comparative prospective study, we aim to compare the classic Macintosh laryngoscope and the Mac Grath videolaryncoscope in ICU covid 19 patients recruiting intubation and invasive mechanical ventilation.
- Trial name
- NCT04956913
- Testing
- Mac Grath, Macintosh
- Volunteers
- 80 people
- Sponsor
- Mongi Slim Hospital
Severe Acute Respiratory Syndrome Coronavirus 2, Acute Respiratory Distress Syndrome
Pulmonary Fibrosis During Severe COVID-19 Pneumonia
The COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), an emerging coronavirus, which has already infected 192 million people with a case fatality rate close to 2%.
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2, Acute Respiratory Distress Syndrome, Pulmonary Fibrosis
- Trial name
- FIBRO-COVID (NCT04987528)
- Testing
- Aminoterminal type III peptide of procollagen, Lung computed tomography
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hôpital Européen Marseille
ARDS, COVID-19 Acute Respiratory Distress Syndrome
Comparison of ARDS COVID-19 (WHO) vs ARDS Influenza in the ICU
Since the beginning of the SARS CoV 2 pandemia, the SARS CoV 2 was frequently compared with the seasonal influenza virus. However, few studies compared patients presenting acute respiratory distress syndrome (ARDS) induced by…
- Conditions
- ARDS, COVID-19 Acute Respiratory Distress Syndrome, Influenza
- Trial name
- NCT04941092
- Testing
- no intervention
- Where
- France
- Volunteers
- 157 people
- Sponsor
- Central Hospital, Nancy, France
Sars-CoV2
Endotracheal Tube Obstruction in Covid-19 Patients Requiring Mechanical Ventilation
The COVID-19 pandemic is very present in our region, the Grand-Est region is considered as one of the first COVID-19 epicentres in France.
- Trial name
- TubeObs-Covid (NCT04394429)
- Where
- France
- Volunteers
- 184 people
- Sponsor
- University Hospital, Strasbourg, France
Covid19, Corona Virus Infection
Umbilical Cord Lining Stem Cells (ULSC) in Patients With COVID-19 ARDS
ULSC-CV-01 is a clinical trial that comprises both Phase 1 and Phase 2a, which will be conducted sequentially. This trial will evaluate the safety and potential efficacy of allogeneic Umbilical Cord Lining Stem Cells (ULSC)…
- Conditions
- Covid19, Corona Virus Infection, SARS-CoV Infection, ARDS
- Trial name
- ULSC (NCT04494386)
- Testing
- Umbilical Cord Lining Stem Cells (ULSC)
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Restem, LLC.
COVID-19 Pneumonia, ARDS Due to Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2
Plasma SARS-CoV-2 RNA Levels in Critically Ill COVID-19 Patients
Retrospective, observationnal study. Evaluation of the association between plasmatic SARS-CoV-2 RNA and day 60 mortality in ICU adult COVID-19 patients.
- Trial name
- pRNA-COVID-ICU (NCT05115045)
- Testing
- plasmatic SARS-CoV-2 RNA quantification
- Where
- France
- Volunteers
- 122 people
- Sponsor
- Hopital of Melun
COVID-19, Acute Respiratory Distress Syndrome
Treatment of Lung Injury From COVID-19 Infection With Intravenous Sodium Nitrite
This multicenter, randomized, double-blind, placebo-controlled clinical trial will evaluate the efficacy and safety of intravenous Sodium Nitrite Injection for treatment of patients infected with COVID-19 who develop lung injury…
- Conditions
- COVID-19, Acute Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- NCT04401527
- Testing
- Sodium Nitrite, Normal Saline
- Where
- 2 sites in United States
- Sponsor
- Hope Pharmaceuticals
COVID, Sars-CoV2
Using GM-CSF as a Host Directed Therapeutic Against COVID-19
The coronavirus disease 2019 (COVID-19) has rapidly become a pandemic. COVID-19 poses a mortality risk of 3-7%, rising to 20% in older patients with co-morbidities.
- Conditions
- COVID, Sars-CoV2, ARDS, Human
- Trial name
- NCT04400929
- Testing
- Sargramostim, Normal Saline 0.9%
- Where
- Singapore
- Volunteers
- 2 people
- Sponsor
- Singapore General Hospital
Covid19
Early Cognitive Assessment and Evolutionary Monitoring of Patients With Severe ARDS on COVID-19 Pneumonia Requiring Mechanical Ventilation
The new coronavirus pandemic responsible for the severe acute respiratory syndrome SARS-CoV2 requires, in its severe forms, the use of invasive ventilation in intensive care.
- Trial name
- CognitiVID (NCT04468035)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Respiratory Failure
Repeated Measures Trial of Temporary Automated Manual Ventilation Versus Noninvasive Oxygenation or Conventional Vent
The COVID-19 pandemic has led to a potential shortage of life-saving mechanical ventilators. The purpose of this study is to determine whether a novel simpler to device, the automated bag-valve-mask (BVM) compressor, can be used…
- Trial name
- NCT04369274
- Testing
- Mechanical ventilation with the automated BVM compressor
- Sponsor
- Massachusetts General Hospital