Clinical trials: COVID-19 Lower Respiratory Infection
Postacute Sequelae of Sars-CoV-2, Post-Acute COVID-19 Syndrome
Transcutaneous Electrical Nerve Stimulation (TENS) in Patients With Postacute Sequelae of Sars-CoV-2
The purpose of the pilot study is to examine acceptability and proof of concept effectiveness of a wireless TENS technology to address PASC associated FM.
- Conditions
- Postacute Sequelae of Sars-CoV-2, Post-Acute COVID-19 Syndrome, Widespread Chronic Pain, Fatigue Syndrome, Chronic
- Trial name
- NCT05200858
- Testing
- TENS - high-dose, TENS - low-dose
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
COVID-19 Pneumonia, COVID-19
Cardiac Magnetic Resonance Tissue Characterization in COVID-19 Survivors
The purpose of this study is to test if visualizing the heart with cardiac MRI/echo will be important in the understanding cardiac function and prediction of cardiopulmonary symptoms, physical effort tolerance, and outcomes in…
- Conditions
- COVID-19 Pneumonia, COVID-19, COVID-19 Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05164744
- Testing
- Cardiac MRI, Echocardiogram, 6-minute walk test
- Where
- 3 sites in United States
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
COVID-19, Upper Respiratory Infection
A Noninvasive Multimodal Biosensing Device for Screening and Monitoring Response to Treatment of Infectious Respiratory Diseases
Background: The COVID-19 outbreak has strained the health care system. New tools are needed for diagnostic testing and monitoring of people who have the virus.
- Conditions
- COVID-19, Upper Respiratory Infection, Lower Respiratory Infection
- Trial name
- NCT05035420
- Testing
- Fitbit, Douglas Bag, Periflux 6000 EPOS
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
COVID-19 Lower Respiratory Infection, Microbial Colonization
Oral Probiotics and Secondary Bacterial Pneumonia in Severe COVID-19
Background and aims: Patients with severe Coronavirus Disease 2019 (COVID-19) are prone to secondary bacterial pneumonia. The use of probiotics against oral pathogens might prevent lung colonization and progression to bacterial…
- Conditions
- COVID-19 Lower Respiratory Infection, Microbial Colonization, Severe COVID-19, Secondary Bacterial Pneumonia
- Trial name
- NCT05175833
- Testing
- Oral probiotics
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Universidade de Passo Fundo
COVID-19 Lower Respiratory Infection, SARS-CoV2 Infection
Osteopathic Manipulative Therapy Effects on Prolonged Post-COVID Olfactory Dysfunction
The goal of this project is to determine the efficacy of a treatment method that increase a participants sense of smell after suffering from COVID-19 related decline in smell.
- Trial name
- NCT05112887
- Testing
- Osteopathic Manipulative Therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ohio University
Acute Limb Ischemia
Evaluation of Acute Lower Limb Ischemia
The primary objective of this study is to evaluate the effect of different treatment modalities on clinical outcome of patients suffering from acute lower limb ischemia (ALI).
- Trial name
- PROMOTE-ALI (NCT05138679)
- Testing
- Revascularization, Primary major amputation, Best medical treatment
- Where
- 37 sites in Austria, Croatia and 8 more
- Volunteers
- 700 people
- Sponsor
- Medical University Innsbruck
Covid19, Hypoxia
Higher vs. Lower Doses of Dexamethasone for COVID-19 and Severe Hypoxia
We aim to assess the benefits and harms of higher (12 mg) vs lower doses (6 mg) of dexamethasone on patient-centered outcomes in patients with COVID-19 and severe hypoxia.
- Trial name
- COVIDSTEROID2 (NCT04509973)
- Testing
- Dexamethasone
- Where
- 53 sites in Denmark, India and 2 more
- Volunteers
- 1,000 people
- Sponsor
- Scandinavian Critical Care Trials Group
Covid19, COVID-19 Pneumonia
A Retrospective Study of COVID-19 Treatments
Surveys administered to subjects who have recovered from COVID-19 to assess how effective their treatment was.
- Conditions
- Covid19, COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Acute Bronchitis
- Trial name
- NCT04949230
- Testing
- No Intervention Used
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- ProgenaBiome
COVID-19
DAS181 for STOP COVID-19
It is a multicenter, randomized, placebo-controlled, double-blind study. The study population is defined as subjects diagnosed with lower respiratory tract COVID-19 who require supplemental oxygen ≥2 LPM at the time of…
- Trial name
- NCT04354389
- Testing
- DAS181
- Where
- 2 sites in Italy
- Sponsor
- Ansun Biopharma, Inc.
Severe COVID-19
COVID-19 and VA-LRTI: Second Versus First Wave of the Pandemic
Multicenter observational retrospective cohort study aiming at comparing the incidence of ventilator-associated lower respiratory tract infections between COVID-19 patients from the first and the second wave of the pandemic.
- Trial name
- CoVAPid2 (NCT05256511)
- Where
- France
- Sponsor
- University Hospital, Lille
COVID-19 Lower Respiratory Infection
Phase I/II Study of COVID-19 DNA Vaccine (AG0302-COVID19 High-dose)
This study will assess the safety and immunogenicity of AG0302-COVID19 in healthy volunteers.
- Trial name
- NCT04993586
- Testing
- AG0302-COVID19 for Intramuscular Injection, AG0302-COVID19 for Intradermal Injection
- Where
- 6 sites in Japan
- Volunteers
- 422 people, healthy volunteers welcome
- Sponsor
- AnGes, Inc.
STEMI, Covid19
Evaluation of the Effect of Long-term Lipid-lowering Therapy in STEMI Patients With Coronavirus Infection COVID-19
It is planned to include 200 patients hospitalized with primary myocardial infarction with and without ST segment elevation (STEMI or NSTEMI) in combination with COVID-19 within the first 15 days from the disease onset.
- Conditions
- STEMI, Covid19, NSTEMI
- Trial name
- CONTRAST-3 (NCT04900155)
- Testing
- Atorvastatin 80mg, Atorvastatin-Ezetimibe
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Penza State University
Lower Respiratory Tract Infection, Parainfluenza
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19.
- Conditions
- Lower Respiratory Tract Infection, Parainfluenza, Immunocompromised, COVID-19
- Trial name
- NCT03808922
- Testing
- DAS181, DAS181 COVID-19, DAS181 OL
- Where
- 28 sites in United States, Australia and 3 more
- Volunteers
- 274 people
- Sponsor
- Ansun Biopharma, Inc.
Influenza Infection, SAD-RV Infection and COVID-19
DAS181 for Patients With Severe Hospitalized Flu and SAD-RVs (COVID-19)
This is a Phase IIb study consisting of two cohorts to evaluate efficacy, safety and pharmacokinetics of DAS181 in IFV infection. An approximate total of 280 subjects will be enrolled into this study.
- Trial name
- STOP-Flu (NCT04298060)
- Testing
- DAS181
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Ansun Biopharma, Inc.
Presence of COVID-19 Compatible CT Abnormalities
CT Abnormalities Evocative of Lung Infection Are Associated With Lower 18F-FDG Uptake in Confirmed COVID-19 Patients
CT signs that are evocative of lung COVID-19 infections have been extensively described, whereas 18F-FDG-PET signs have not. Our current study aimed to identify specific COVID-19 18F-FDG-PET signs in patients that were (i)…
- Trial name
- NCT04512118
- Testing
- PET-CT of 18F-FDG
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Central Hospital, Nancy, France
Sepsis, Pneumonia
Comparative Effectiveness of Readmission Reduction Interventions for Individuals With Sepsis or Pneumonia
An adaptive platform trial to compare effectiveness of different care models to prevent readmissions for patients hospitalized with sepsis or lower respiratory tract infection.
- Conditions
- Sepsis, Pneumonia, Lower Resp Tract Infection, Covid19
- Trial name
- ACCOMPLISH (NCT04829188)
- Testing
- Structured Telephone Support (STS), Low-intensity Remote Patient Monitoring (RPM-Low), High-intensity Remote Patient Monitoring (RPM-High)
- Where
- United States
- Volunteers
- 1,296 people
- Sponsor
- University of Pittsburgh
Covid19, COVID-19 Pneumonia
NAC for Attenuation of COVID-19 Symptomatology
The objective of this study is to determine whether oral NAC is effective at attenuating COVID-19 disease symptom severity and duration of symptoms.
- Conditions
- Covid19, COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Lower Respiratory Infection
- Trial name
- NACinCOVID2 (NCT05074121)
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Covid19, COVID-19 Pneumonia
Efficacy and Safety of Antimicrobial Stewardship Intervention in Hospitalized COVID-19 Patients (COVASP)
COVID-19 is respiratory disease caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2), a novel coronavirus which has spread rapidly across the world with over 149.9 million laboratory confirmed cases and over 3.1…
- Conditions
- Covid19, COVID-19 Pneumonia, COVID-19 Lower Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- COVASP (NCT04896866)
- Testing
- Antimicrobial stewardship prospective audit and feedback
- Where
- 3 sites in Canada
- Volunteers
- 833 people
- Sponsor
- University of Alberta
COVID-19
A First-In-Human Phase 1b Study of AmnioPul-02 in COVID-19 / Other LRTI
This is a first-in-human (FIH), Phase 1b, open-label, dose-escalation, safety trial consisting of 3 dose levels. Subjects will always be treated in cohorts of size 3, with from 3 up to 6 cohorts i.e. 9-18 subjects.
- Trial name
- NCT05348772
- Testing
- AmnioPul-02
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Amniotics AB
Acute Hypoxemic Respiratory Failure
Efficacy of DEXamethasone in Patients With Acute Hypoxemic REspiratory Failure Caused by INfEctions
Background: There are no proven therapies specific for pulmonary dysfunction in patients with acute hypoxemic respiratory failure (AHRF) caused by infections (including Covid-19).
- Trial name
- DEXA-REFINE (NCT04545242)
- Testing
- Dexamethasone
- Where
- 40 sites in Spain
- Volunteers
- 980 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín