Clinical trials: COVID-19 Donors
COVID-19
Convalescent Plasma as Treatment for Hospitalized Subjects With COVID-19 Infection
This is a single arm phase IIa study of convalescent plasma for the treatment of individuals hospitalized with COVID-19 infection.
- Trial name
- NCT04343755
- Testing
- Convalescent Plasma
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Hackensack Meridian Health
Solid Tumor, Adult, Healthy Donors
A Biospecimen Collection Study of Leukapheresis-Derived Circulating Tumor Cells, Immune Cells, and Progenitor Cells.
Primary Objective: This is a study to investigate the feasibility of harvesting, expanding, and selecting T lymphocytes from cancer patients and healthy volunteers.
- Conditions
- Solid Tumor, Adult, Healthy Donors, COVID-19 Donors
- Trial name
- NCT00571389
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- BioCytics, Inc.
COVID19, Coronavirus Infection
Convalescent Plasma Collection and Treatment in Pediatrics and Adults
This is a prospective study, using plasma to help fight off infections of those suffering from COVID-19 in accordance with collection guidelines for plasma and FDA IND requirements.
- Conditions
- COVID19, Coronavirus Infection, Coronavirus, Virus Diseases
- Trial name
- NCT04376034
- Testing
- Convalescent Plasma
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- West Virginia University
Accelerated Phase CML, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia
SARS-CoV-2 Donor-Recipient Immunity Transfer
This study investigates whether donors with previous exposure to COVID-19 can pass their immunity by hematopoietic (blood) stem cell transplant (HCT) donation to patients that have not been exposed.
- Conditions
- Accelerated Phase CML, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia
- Trial name
- NCT04666025
- Testing
- Biospecimen Collection, Diagnostic Laboratory Biomarker Analysis, Electronic Health Record Review
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- City of Hope Medical Center
COVID-19 Respiratory Infection
COVID-19 Seroprevalence in Pregnant Women and Blood Donors
The study aims to measure the SARS-CoV-2 seroprevalence (ie. the proportion of people with antibodies against the virus) in pregnant women and blood donors in an administrative area of France, and to determine whether these…
- Trial name
- CoVERED (NCT04893057)
- Where
- France
- Volunteers
- 797 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
COVID-19, Organ Transplant
Immune Registry for Organ Transplantation From COVID Positive Donors.
The purpose of this study is to collect data generated by standard clinical practice to determine the short term and long term clinical outcomes of recipients of solid organ transplantation from COVID-19 infected donors and…
- Trial name
- NCT05595837
- Testing
- Standard organ transplant
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
COVID-19
Convalescent Plasma as Treatment for Subjects With Early COVID-19 Infection
This is a phase II randomized study of convalescent plasma for the treatment of non-immune individuals with COVID-19 infection at high risk of complications.
- Trial name
- NCT04456413
- Testing
- Convalescent Plasma, Best Supportive Care
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Hackensack Meridian Health
Blood Donation
Recruit Blood Donors Via SMS During Epidemic of COVID-19 （Repeat Trial）
The fight against the spread of the 2019-nCoV epidemic has achieved some success in China, but the epidemic is far from over. A key factor making the epidemic under control in China is the government's call for social distance…
- Trial name
- NCT04410458
- Testing
- blood donation SMS
- Where
- China
- Volunteers
- 506,517 people
- Sponsor
- Guangzhou Blood Center
Ovarian Reserve, SARS-CoV-2 Infection
Effect of Sars-cov-2 on Donor Oocyte Quality and Quantity, a Multicenter Retrospective Study.
Purpose: To determine the impact of SARS-CoV-2 infection and immunization on ovarian response to controlled ovarian stimulation (COS) and embryo development after in vitro fertilization (IVF) Methods: A retrospective multicentric…
- Conditions
- Ovarian Reserve, SARS-CoV-2 Infection, Blastocyst
- Trial name
- NCT05562479
- Testing
- Sars Cov 2 infection, Sars Cov 2 vaccination
- Where
- Colombia
- Volunteers
- 428 people, healthy volunteers welcome
- Sponsor
- Novafem
COVID-19, Hematopoietic Stem Cell Transplantation
The Impact of Donor COVID-19 Infection Status on the Recipient in Allo-HSCT
This study was conducted to observe whether COVID-19 can be transmitted through stem cell transplantation and whether COVID-19-positive donors have an effect on early hematopoietic reconstitution and immune reconstitution in the…
- Trial name
- NCT05675826
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chen Suning
Blood Donation
Recruit Blood Donors Via SMS During Epidemic of COVID-19
The fight against the spread of the 2019-nCoV epidemic has achieved some success in China, but the epidemic is far from over. A key factor making the epidemic under control in China is the government's call for social distance…
- Trial name
- NCT04370886
- Testing
- blood donation SMS
- Where
- China
- Volunteers
- 456,517 people
- Sponsor
- Guangzhou Blood Center
COVID
Use of Convalescent Plasma for COVID-19
The plan is to transfuse COVID-19 infected patients with convalescent plasma and observe whether this will result in a significant improvement in clinical outcome in comparison to historical experience.
- Trial name
- NCT04408040
- Testing
- Convalescent Plasma
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Northside Hospital, Inc.
Long Covid
Validation of Biomarkers for Long COVID in the LIINC Viral Immunopathogenesis and Persistence Repeat Donor Cohort (VIPER)
The purpose of this study is to better understand the biological changes associated with Long COVID and to identify laboratory tests (biomarkers) that may help diagnose the condition and measure how it changes over time.
- Trial name
- VIPER (NCT07770022)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Blood Donation
Recruit Blood Donors Via SMS During Epidemic of COVID-19 #Second Repeat Trial#
The fight against the spread of the 2019-nCoV epidemic has achieved some success in China, but the epidemic is far from over. A key factor making the epidemic under control in China is the government's call for social distance…
- Trial name
- NCT04431180
- Testing
- blood donation SMS
- Where
- China
- Volunteers
- 403,535 people
- Sponsor
- Guangzhou Blood Center
COVID-19
A Study to Evaluate Safety and Efficacy of Convalescent Methylene Blue Treated (MBT) Plasma From Donors Recovered From Coronavirus Disease 2019 (COVID-19)
The purpose of the study is to determine if Convalescent anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Methylene Blue Treated (MBT) plasma plus Standard Medical Treatment (SMT) can reduce all-cause mortality…
- Trial name
- NCT04547127
- Testing
- Convalescent anti-SARS-CoV-2 MBT Plasma, Standard Medical Treatment
- Where
- 12 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Instituto Grifols, S.A.
COVID-19, Virus Diseases
STS Administration on Coronavirus Disease (COVID-19) Patients in Critical Care
The primary purpose is to describe the safety of administration of three doses of STS to critically ill patients with confirmed COVID-19.
- Conditions
- COVID-19, Virus Diseases, Corona Virus Infection
- Trial name
- H4COVID (NCT05277285)
- Testing
- Sodium Thiosulfate 25% Solution for Injection
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Covid19
Convalescent Plasma for COVID-19 Research Donor Study
Convalescent Plasma for COVID-19 Research (CONCOR-Donor) study, is a national, natural history study of plasma donors recovered from COVID-19.
- Trial name
- CONCOR-Donor (NCT04555109)
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- The Hospital for Sick Children
COVID19
Assessment of the Effect of Convalescent Plasma Therapy in Patients With Life-threatening COVID19 Infection
This clinical trial proposal is based on the FDA protocol for emergency use of convalescent plasma for treatment of COVID-19 cases, and on the WHO guidelines for use of convalescent plasma in other infectious diseases.
- Trial name
- CP IN COVID19 (NCT04438694)
- Testing
- Convalescent Plasma, Standard of Care
- Where
- Egypt
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Cairo University
COVID-19, Organ Transplant
Transplantation of Deceased Donors With COVID-19 Into COVID-19 Negative Recipients Utilizing Casirivimab and Imdevimab Antibody Cocktail
This study will look to increase the donor pool for the solid organ transplant population by transplanting patients who died with COVID-19 but not from COVID-19 utilizing casirivimab and imdevimab antibody cocktail to prevent the…
- Trial name
- NCT05157997
- Testing
- Casirivimab and Imdevimab Antibody Cocktail
- Where
- United States
- Sponsor
- Northwell Health
Severe COVID-19
Generation of SARS-CoV-2-specific T Lymphocytes From Recovered Donors and Administration to High-risk COVID-19 Patients
Open-label phase I (single-center)/ phase II (multicenter) with randomization 2:1
- Trial name
- CoV-2-STs (NCT05447013)
- Testing
- Coronavirus-2-specific T cells, standard of care (SOC)
- Where
- 2 sites in Greece
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- George Papanicolaou Hospital