Clinical trials: COPD
Chronic Obstructive Pulmonary Disease (COPD)
A Clinical Study to Investigate if a Single Dose of an Approved Drug Product (Glycopyrrolate Inhalation Solution) Reduces Trapped Air in the Lungs of Participants With Chronic Obstructive Pulmonary Disease.
A clinical study to investigate if a single dose of an approved drug product (glycopyrrolate Inhalation Solution) reduces trapped air in the lungs of participants with chronic obstructive pulmonary disease.
- Trial name
- NCT04155047
- Testing
- Glyocopyrrolate Inhalation Solution administered by Magnair
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Sunovion Respiratory Development Inc.
Emphysema
Evaluation of the Spiration® Valve System for Emphysema to Improve Lung Function
EMPROVE is a multicenter, prospective, randomized, controlled study designed to evaluate the safety and long-term effectiveness of the Spiration Valve System in patients with emphysema.
- Trial name
- EMPROVE (NCT01812447)
- Testing
- Spiration Valve System, Medical Management
- Where
- 34 sites in United States, Canada
- Volunteers
- 172 people
- Sponsor
- Olympus Corporation of the Americas
Chronic Obstructive Pulmonary Disease
Treatment of Chronic Obstructive Pulmonary Disease by Infusion of Allogenic Mesenchymal Stem Cells
This phase II study is a randomized, placebo-controlled, double-blind study to evaluate the safety and efficacy of UMC119-06-05 compared to placebo in treating subjects with moderate to severe COPD.
- Trial name
- NCT06491043
- Testing
- UMC119-06-05
- Where
- 2 sites in Taiwan
- Volunteers
- 90 people
- Sponsor
- Meribank Biotech Co., Ltd.
Chronic Obstructive Pulmonary Disease
COPD Rehabilitation in Primary and Secondary Health Care
Pulmonary rehabilitation of COPD patients are implemented in a non-randomized manner in two settings: primary and secondary health care. The effect on quality of life and hospitalizations will be evaluated
- Trial name
- NCT00320333
- Testing
- pulmonary rehabilitation programme
- Where
- 2 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Chronic Obstructive Pulmonary Disease
Efficacy of "On Line" Telematic Spirometry
The investigators aim to demonstrate that spirometry performed "on line" with a technician in a remote place from the patient has the same efficacy as the one performed personally.
- Trial name
- NCT00844116
- Testing
- spirometry
- Where
- Spain
- Volunteers
- 226 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Pulmonary Disease, Chronic Obstructive
Neutrophil Imaging in Healthy Subjects Following Lipopolysaccharide or Saline Challenge and in Subjects With Chronic Obstructive Pulmonary Disease
This is an exploratory study to further develop an imaging platform for the assessment of whole lung neutrophil retention. The primary objective of the study is to quantify and compare neutrophil retention in the lungs of…
- Trial name
- NCT02551614
- Testing
- Lipopolysaccharide challenge, Saline challenge, Labelled neutrophils and Imaging assessment
- Where
- 2 sites in United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obstructive Pulmonary Function, Restrictive Pulmonary Function
Study to Compare the Pharmacokinetics and Pharmacodynamics of ASA Powder for Oral Inhalation With Non-enteric-coated Chewable Aspirin in Adult Subjects With Obstructive or Restrictive Pulmonary Function
The goal of this clinical trial is to compare the pharmacokinetics (PK) pharmacodynamics (PD), safety and tolerability of acetylsalicylic acid powder for oral inhalation (I-ASA) with non-enteric-coated chewable aspirin (C-ASA) in…
- Trial name
- NCT05625347
- Testing
- single dose (100 mg) of ASA, single dose (162 mg) of non-enteric-coated chewable aspirin tablets
- Where
- 4 sites in United States
- Volunteers
- 4 people
- Sponsor
- Vectura, Inc.
Chronic Obstructive Lung Disease
Comparison of the Two and Six- Minute Walk Tests in Evaluating Oxygen Desaturation in Patients With Severe COPD
All measurements are performed on two consecutive days at the beginning of a pulmonary rehabilitation program in a randomized cross-over study design.
- Trial name
- NCT02462343
- Testing
- walk tests
- Volunteers
- 26 people
- Sponsor
- Schön Klinik Berchtesgadener Land
COPD Exacerbation Acute
Comparing the Effects of Manual Hyperinflation and Diaphragmatic Proprioceptive Neuromuscular Facilitation on Pulmonary Functions in Patients on Mechanical Ventilation
the goal of this clinical trial is to compare between to important physiotherapy modalities applied on mechanically ventilated COPD patients the the main question the study aim to answer is which one of the two modalities has the…
- Trial name
- NCT06221033
- Testing
- manual hyperinflation, Diaphragmatic proprioceptive neuromuscular facilitation technique, traditional physiotherapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- omar hasham mohamed
COPD
Effects of Endoscopic Lung Volume Reduction on Diaphragm Function and Conformation
Chronic obstructive lung disease (COPD) is a common disease that is frequently complicated by hyperinflation. The resulting increase in lung volume impairs the diaphragmatic function because of a shortening of the diaphragmatic…
- Trial name
- NCT05799352
- Testing
- Endoscopic lung volume reduction
- Where
- Belgium
- Volunteers
- 35 people
- Sponsor
- Erasme University Hospital
COPD
Qui Gong Programme vs Short Form Sun Style Tai Chi in COPD Patients
This was a Randomized control Trial. Purposive sampling was done to obtained Sample (n=78) which were randomly allocated to Group A (n=39) and Group B (n=39).
- Trial name
- NCT04357678
- Testing
- Qi Gong Programme, Short Form Sun Style Tai Chi
- Where
- Pakistan
- Volunteers
- 78 people
- Sponsor
- Riphah International University
COPD
Counseling During Pulmonary Rehabilitation
The purpose of this study is to investigate if a physical activity counseling program during pulmonary rehabilitation increases the physical activity level in daily life in patients with Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT02455206
- Testing
- physical activity counseling, Usual care
- Where
- Switzerland
- Volunteers
- 43 people
- Sponsor
- Zurich University of Applied Sciences
Chronic Obstructive Pulmonary Disease
Efficacy and Safety of Tulobuterol Patch Combined With Tiotropium Bromide for Relieving Dyspnea Symptom of Chronic Obstructive Pulmonary Disease
Phrase: IV Indication: dyspnea symptom of chronic obstructive pulmonary disease (COPD) Objective: to evaluate efficacy and safety of tulobuterol patch combined with Tiotropium bromide for relieving dyspnea symptom of COPD Design…
- Trial name
- NCT01465906
- Testing
- tulobuterol, Tiotropium Bromide
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai Zhongshan Hospital
Chronic Obstructive Pulmonary Disease, Dyspnea
Abdominal Binding in Chronic Obstructive Pulmonary Disease
Conventional approaches to relieve dyspnea (respiratory discomfort) in chronic obstructive pulmonary disease (COPD) have focused on improving respiratory motor drive (e.g., hyperoxia) and/or dynamic respiratory mechanics (e.g.…
- Trial name
- NCT01852006
- Testing
- Abdominal Binder
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University
Chronic Obstructive Pulmonary Disease (COPD)
Bronchioscopic Lung Volume Reduction (BLVR)
For patients with emphysema, lung volume reduction by insertion of endobronchial valves could be an expedient approach to improve the diaphragm function and the strength of breathing muscles.
- Trial name
- BLVR (NCT02415478)
- Testing
- endoscopic lung volume reduction by valves
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- RWTH Aachen University
Chronic Obstructive Pulmonary Disease
Comparing Treatment Efficacy With HD/MD Flu Plus Sal in Chronic Obstructive Pulmonary Disease (COPD) Patients
Chronic obstructive pulmonary disease is characterized as inflammatory airway with not fully reversible airflow limitation.Combination treatment with inhaled corticosteroid (ICS) and long-acting β2 agonists (LABA)attains an…
- Trial name
- NCT01131806
- Testing
- fluticasone/ salmeterol 125/25 mcg/puff, fluticasone/ salmeterol 250/25 mcg/puff
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Chronic Obstructive Pulmonary Disease, Bronchiolitis
Noninvasive Positive Pressure Ventilation Using Helium:Oxygen Versus Air:Oxygen in Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease Patients Exposed to Sulfur Mustard
to assess the effectiveness of helium:oxygen mixture adjunct with non-invasive ventilation in sulfur mustard exposed patients with acute decompensation
- Trial name
- NCT00515606
- Testing
- helium:oxygen
- Sponsor
- Baqiyatallah Medical Sciences University
Chronic Obstructive Pulmonary Disease (COPD)
Description of the Ability to Learn How to Handle Inhaler Devices in COPD
Chronic Obstructive Pulmonary Disease (COPD) is the fourth leading cause of death in the world and further increase in its prevalence and mortality has been predicted.
- Trial name
- INTUITIVE (NCT02813200)
- Testing
- Seretide® Diskus® 500/550 μg, Ultibro® Breezhaler® 110/50 μg, Spiriva® Respimat® 2,5 μg
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Bordeaux
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety of LAS 34273 in Patients With Moderate to Severe Stable Chronic Obstructive Pulmonary Disease(COPD)
To evaluate the efficacy and safety of LAS 34273 compared to placebo in patients with moderate to severe COPD during one year of treatment.
- Trial name
- NCT00358436
- Testing
- Aclidinium bromide
- Where
- 120 sites in United States, Argentina and 5 more
- Volunteers
- 804 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive, Bronchospasm
Prophylactic Efficacy of Relenza Against Influenza A and B
In response to the European regulatory authorities, GSK is conducting a post-marketing observational study to assess the efficacy of Relenza when used as prophylaxis against influenza. SPECIFIC AIMS 1.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Bronchospasm, Influenza, Human, Asthma
- Trial name
- NCT01156701
- Testing
- Receiving a prescription of Relenza for prophylaxis, No prophylaxis with Relenza
- Volunteers
- 171,705 people
- Sponsor
- GlaxoSmithKline