Clinical trials: CNS Disorder, Intracranial
Carotid Artery Stenosis, Acute Ischemic Stroke
Acute Stroke of CArotid Artery Bifurcation Origin Treated With Use oF the MicronEt-covered CGUARD (SAFEGUARD-STROKE)
Prospective, single-center, clinical registry of patients with acute stroke of carotid artery bifurcation origin undergoing endovascular treatment using the Micronet-covered CGUARD Stent to seal the culprit lesion under proximal…
- Trial name
- NCT05195658
- Testing
- Thrombectomy and Stenting under neuroprotection
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- John Paul II Hospital, Krakow
Brain Injuries
Brain Injury Therapy of Exercise and Enriched Environment
The purpose of this study is to determine whether exercise or exercise with enrichment is beneficial in individuals who previously had a head injury.
- Trial name
- BITEEE (NCT03256643)
- Testing
- Exercise, Delayed Exercise, Exercise and enrichment
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Wayne State University
Surgeries Undergoing General Anesthesia
Impact of Intraoperative Oxygenation Practices on Patient Outcomes
This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80)…
- Trial name
- IntraOp Ox (NCT07224243)
- Testing
- Lower FiO2, Intermediate FiO2, Higher FiO2
- Where
- 4 sites in United States
- Volunteers
- 54,000 people
- Sponsor
- Frederic T Billings IV
Stroke, Gait, Hemiplegic
A Comparison Between the Exoskeleton Hybrid Assistive Limb and Conventional Gait Training Early After Stroke
Overall aim is to evaluate HAL for gait training early after stroke and the effect of HAL on short- and long-term functioning, disability and health compared to conventional gait training as part of an inpatient rehabilitation…
- Conditions
- Stroke, Gait, Hemiplegic, Ambulation Difficulty, Hemiparesis
- Trial name
- HAL-RCT (NCT02410915)
- Testing
- Hybrid Assistive Limb (HAL); gait training, Control Group; Conventional gait training
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Danderyd Hospital
Traumatic Brain Injury
Augmentation of Cognitive Training in Children With TBI With D-Cyloserine
Traumatic Brain Injury (TBI) is the most common cause of death and long-term disability in children. Much of the long-term disability stems from neurocognitive impairments that are not greatly helped by current cognitive training…
- Trial name
- DCS (NCT02312635)
- Testing
- D-Cycloserine, Cogmed Working Memory Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Stroke, Atherosclerosis
ParisK: Validation of Imaging Techniques
The possibility of the identification of the risk of rupture of a carotid plaque will have tremendous impact in clinical decision making.
- Trial name
- ParisK (NCT01208025)
- Testing
- Magnetic Resonance Imaging (MRI), Multidetector Computed Tomography (MDCT), Ultrasonography (US), Transcranial Doppler (TCD)
- Where
- 4 sites in Netherlands
- Volunteers
- 244 people
- Sponsor
- Maastricht University Medical Center
Adult Glioblastoma, High Grade Glioma
A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)
The primary objective will be to demonstrate the manufacturing feasibility and safety, and to determine the maximum tolerated dose (MTD) of RNA-LP vaccines in (Stratum 1) adult patients with newly diagnosed GBM (MGMT low level or…
- Conditions
- Adult Glioblastoma, High Grade Glioma, WHO Grade III or IV Malignant Glioma
- Trial name
- PNOC020 (NCT04573140)
- Testing
- Autologous total tumor mRNA and pp65 full length (fl) lysosomal associated membrane protein (LAMP) mRNA loaded DOTAP liposome vaccine administered intravenously (RNA loaded lipid particles, RNA-LPs)
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Florida
PTSD - Post Traumatic Stress Disorder, TBI-Traumatic Brain Injury
Adaptation of the STAIR-NT for First Responders
This study is a randomized controlled pilot examining the implementation of an adapted intervention, Skills Training in Affective and Interpersonal Regulation-Narrative Therapy (STAIR-NT), among a first responder population with…
- Trial name
- NCT07212140
- Testing
- Adapted STAIR-NT
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Florida State University
Cerebral Visual Impairment, Refractive and Accommodative Disorders
Babies in Glasses; a Feasibility Study.
This is a feasibility study to begin investigating the possibility that early use of near vision glasses will improve vision in infants at risk of Cerebral Visual Impairment (CVI), leading to further improvement in other areas of…
- Conditions
- Cerebral Visual Impairment, Refractive and Accommodative Disorders, Hypoxic-Ischemic Encephalopathy, Premature Birth
- Trial name
- BiG (NCT05048550)
- Testing
- Near vision spectacles
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Lower Urinary Tract Symptoms, Parkinsonism
Effect of Need to Void on Parkinsonian Gait
This study evaluates the effect of the need to void on parkinsonian gait
- Conditions
- Lower Urinary Tract Symptoms, Parkinsonism, Gait Disorders, Neurologic
- Trial name
- NCT03314610
- Testing
- Gait speed
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Pierre and Marie Curie University
Stroke, Acute, Stroke, Ischemic
Effects of Atalante Exoskeleton on Gait Recovery in Non- or Poorly Ambulatory Patients With Hemiparesis in the Acute/Subacute Phase (Month 1 to 4)
The present clinical investigation - EarlyExo, is an interventional, international, multicentric, prospective, single-blinded randomized controlled trial.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke, Subacute, Stroke Hemorrhagic
- Trial name
- EarlyExo (NCT06107010)
- Testing
- Use of the Atalante exoskeleton
- Where
- 5 sites in France, Germany and 1 more
- Volunteers
- 66 people
- Sponsor
- Wandercraft
Cognitive Decline, Cognitive Dysfunction
Brain Vascular and Neurocognitive Health
The overall research objective of this proposal is to determine the acute and chronic impact of transcranial photobiomodulation on indices of cerebral vascular health and neurocognitive function.
- Conditions
- Cognitive Decline, Cognitive Dysfunction, Alzheimer Disease, Vascular Disease, Peripheral
- Trial name
- NCT06497413
- Testing
- Transcranial Photobiomodulation, Transcranial Photobiomodulation helmet (Neuradiant 1070 Plus) with no light administered
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Glycogen Storage Disease Type II
Effect of Motor Development, Motor Function and Electrophysiologic Findings of IOPD Under ERT
To investigate the motor development, motor function and electrodiagnostics presentation in IOPD under ERT.
- Trial name
- NCT02761421
- Testing
- observation study
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Spastic Cerebral Palsy, Spastic Hemiplegic Cerebral Palsy
Halliwick Concept on Motor Functions in Spastic CP
This randomized controlled trial will investigate the effect of hydrotherapy (halliwick concept) on motor functions in children with spastic cerebral palsy (CP). Minimum of 30 Spastic CP children will be recruited for this study.
- Trial name
- NCT05094921
- Testing
- Aquatic Halliwick method, Conventional physical therapy
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- October 6 University
Parkinson's Disease
A Phase 2 Study to Evaluate the Safety and Efficacy of RM-131 in Patients With Parkinson's Disease & Chronic Constipation
The purpose of this study, called MOVE-PD, is to investigate how individuals with Parkinson's disease (PD) and chronic constipation (CC) respond to RM-131 as compared to placebo.
- Trial name
- MOVE-PD (NCT01955616)
- Testing
- RM-131
- Where
- 13 sites in United States
- Volunteers
- 18 people
- Sponsor
- Motus Therapeutics, Inc.
Parkinson's Disease
Brain Fitness in Parkinson's Disease
The purpose of this study is to examine the feasibility and potential effectiveness of a cognitive training program among persons with Parkinson's disease.
- Trial name
- NCT01155349
- Testing
- InSight, No contact-control group
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of South Florida
Stroke
Impact of Training on Gait and Strength in Stroke Survivors
Background: A discrepancy between strength gain and gait changes following various training programs aimed at improving gait function after stroke has been noted.
- Trial name
- NCT01818349
- Testing
- isokinetic lower-limb training, isokinetic upper-limb training
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Université de Montréal
Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome
The Danish Out-of-Hospital Cardiac Arrest Study
After resuscitation from Out-of-Hospital Cardiac Arrest (OHCA) patients experience Post Cardiac Arrest Syndrome due to ischemia and reperfusion injury.
- Trial name
- DANOHCA (NCT05895838)
- Testing
- Dexamethasone, Backrest elevation, Early wakeup call
- Where
- 5 sites in Denmark
- Volunteers
- 1,000 people
- Sponsor
- Christian Hassager
Cluster Headache
A Close Examination of Patient Experiences in Cluster Headache Clinical Research
Historically, participation in clinical studies is highly skewed towards particular demographic groups of people. This research will invite several participants to gather a wide range of information on clinical trial experiences…
- Trial name
- NCT05978258
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Stroke, Ischemic Stroke
Feasibility Study of IV Recombinant Tissue Plasminogen Activator (rtPA) vs. Primary Endovascular Therapy for Acute Ischemic Stroke
This pilot trial will be the first step toward direct comparison of delivery of endovascular reperfusion therapy to intravenous recombinant tissue plasminogen activator (rt-PA) in a time-to-treatment framework shown as most…
- Trial name
- EARLY (NCT01869478)
- Testing
- Intravenous Thrombolysis, Endovascular Arterial Reperfusion
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic