Clinical trials: CABG
Coronary Artery Disease
Using WHOOP Fitness Band to Measure Heart Health Variability Before and After Surgery
The goal of this observational study is to use the WHOOP device to measure heart rate variability (HRV) in patients with coronary artery disease (CAD) before and after they have CABG (coronary artery bypass graft) surgery.
- Trial name
- NCT07097168
- Where
- United States
- Sponsor
- Tufts Medical Center
Postoperative Atrial Fibrillation, Strains
Predictive Value of Right Atrial Strain in Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
The incidence of postoperative atrial fibrillation (POAF) after cardiac surgery is around 30%. POAF increases the risk of developing permanent atrial fibrillation and raises the risk of cardiac decompensation, stroke, acute…
- Trial name
- ODFAPO (NCT06054360)
- Where
- France
- Volunteers
- 334 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Atrial Fibrillation, Atrial Flutter
Response to RSD1235 Compared to Placebo in Subjects With Atrial Arrhythmia After Heart Surgery
The purpose of this study is to demonstrate the safety and efficacy of RSD1235 compared to placebo in the conversion of atrial arrhythmia to sinus rhythm in subjects following valvular and/or coronary artery bypass graft surgery.
- Trial name
- NCT00125320
- Testing
- RSD1235
- Where
- 22 sites in United States, Argentina and 4 more
- Volunteers
- 190 people
- Sponsor
- Astellas Pharma Inc
Coronary Artery Bypass Graft Surgery, Pain
Effect of Using Walking Aid on Mobility
The goal of this clinical trial is to evaluate the effect of using walking aid during out-of-bed mobilization of patients who underwent open coronary artery bypass graft surgery on levels of pain and mobility.
- Conditions
- Coronary Artery Bypass Graft Surgery, Pain, Early Mobilization, Walking, Difficulty
- Trial name
- NCT05830682
- Testing
- using a walking aid
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Trakya University
Coronary Artery Disease
Efficacy of Early Short-term Training on Thrombogenesis in Patients Following Coronary Bypass Surgery
Although the benefit of cardiac rehabilitation following coronary artery bypass graft (CABG) is well-established, it is underused.
- Trial name
- NCT02144480
- Testing
- Intensive training, traditional training
- Where
- Taiwan
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Hemodynamic Instability
Effect of Remimazolam and Propofol on Hemodynamic Stability During Anesthesia Induction in OPCAB Patients
Remimazolam is a novel ultra-short-acting benzodiazepine. Several studies demonstrated that its efficacy as a sedative hypnotics for general anesthesia is non-inferior to propofol.
- Trial name
- NCT05423951
- Testing
- REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO], Propofol, Rocuronium
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Seoul National University Hospital
Coronary Disease
Study of INS50589 Intravenous Infusion in Subjects Undergoing Coronary Artery Bypass Grafting (CABG) Involving Cardiopulmonary Bypass
The purpose of this trial is to identify a dose or doses of INS50589 intravenous infusion that are well-tolerated and which reduce postoperative bleeding and blood product transfusion.
- Trial name
- NCT00316212
- Testing
- INS50589 Intravenous Infusion
- Where
- 27 sites in United States
- Volunteers
- 160 people
- Sponsor
- Merck Sharp & Dohme LLC
This Study is Being Conducted to Collect Echocardiographic Data to Test the Lumify Ultrasound With Hemodynamic Automation Device
Testing Automated Echocardiography
The purpose of this research is to determine if software can accurately predict certain heart parameters from chest wall ultrasound (non-radiation, non-invasive, imaging modality).
- Trial name
- NCT04943965
- Testing
- Ultrasound imaging
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Pennsylvania
Coronary Arteriosclerosis, Atrial Fibrillation
A(f)MAZE-CABG Study
Concomitant AF ablation with HIFU in patients with persistent or long standing persistent AF undergoing CABG will be superior in restoring SR, compared with patients with persistent or long standing persistent AF undergoing CABG…
- Conditions
- Coronary Arteriosclerosis, Atrial Fibrillation, Coronary Artery Bypass Graft Surgery
- Trial name
- AFMAZE-CABG (NCT00735722)
- Testing
- HIFU AF Ablation
- Where
- 10 sites in Canada, Finland and 4 more
- Volunteers
- 188 people
- Sponsor
- Abbott Medical Devices
Diabetes Mellitus, Ischemic Heart Disease
Allopurinol in Diabetes Mellitus and Multivessel Coronary Artery Disease
Atherosclerosis is a progressive disease of the arterial wall, arising from the combination of endothelial dysfunction and inflammation. This link is exacerbated in diabetic patients.
- Conditions
- Diabetes Mellitus, Ischemic Heart Disease, Multi Vessel Coronary Artery Disease
- Trial name
- NCT03700645
- Testing
- Allopurinol
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Coronary Artery Disease, Postoperative Complications
Anesthesia Management of Coronary Artery Bypass Surgery and Inflammatory Biomarkers
The goal of this observational study is to evaluate effect of total intravenous anesthesia or inhalation anesthesia on inflammatory biomarkers in coronary artery bypass surgery and their relationship with early postoperative…
- Conditions
- Coronary Artery Disease, Postoperative Complications, Anesthesia
- Trial name
- NCT06209437
- Where
- Turkey (Türkiye)
- Volunteers
- 228 people
- Sponsor
- Ankara City Hospital Bilkent
Heart Diseases, Coronary Artery Disease
Intraoperative Echocardiography in Low-Risk CABG Surgery
This goal of this study is to better understand when and where intraoperative transesophageal echocardiography (TEE) should (or should not) be used during coronary artery bypass graft (CABG) surgeries.
- Conditions
- Heart Diseases, Coronary Artery Disease, Chest Pain, Stenosis Coronary
- Trial name
- NCT06154265
- Testing
- TEE probe
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Coronary Artery Bypass Graft and/or Aortic Valve Replacement Surgery
Sugammadex and Decreased Time to Extubation
The purpose of this study is to demonstrate faster time to extubation after arrival in the cardiothoracic intensive care unit (ICU) in patients undergoing isolated coronary artery bypass grafting (CABG), AVR and AVR/CABG…
- Trial name
- NCT03196167
- Testing
- Sugammadex
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Yale University
CABG Graft Integrity, CABG
The Relationship Between Blood Flow Readings During Surgery and How Well the Graft Stays Open and How Patients Recover Afterward in Coronary Artery Bypass Graft Surgery
The purpose of this study is to learn more about a tool called Transit-Time Flow Measurement (TTFM). TTFM uses sound waves during surgery to check how well blood is flowing through blood vessels.
- Conditions
- CABG Graft Integrity, CABG, Blood Flow, Transit-time Flow Measurement
- Trial name
- SMARTFLOW (NCT07485738)
- Testing
- Transit-Time Flow Measurement (TTFM)
- Where
- United States
- Volunteers
- 1,242 people
- Sponsor
- Weill Medical College of Cornell University
Coronary Artery Disease
The Use of Aging Biomarkers to Predict Adverse Outcomes After Cardiac Surgery
Cardiac surgery associated acute kidney injury (CSA-AKI) has been recognized as the second most common cause of hospital acquired AKI.
- Trial name
- NCT02496234
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Sapere Bio
LAD (Left Anterior Descending) Coronary Artery Stenosis
Reconstruction of Diffusely Diseased Left Anterior Descending with Left Internal Mammary Artery On-lay Patch or Saphenous Vein Patch Without Endarterectomy by Opening the Whole Wall of the Diseased Segment(s) Has Less Risk and Fewer Complications Compared to Endarterectomy Technique
The objective of this study is to compare different surgical strategies for management of severely diseased LAD artery during CABG i.e. LIMA on-lay patch vs.
- Trial name
- NCT06835114
- Testing
- CABG, LIMA on lay patch, Safenous vein patch
- Volunteers
- 90 people
- Sponsor
- Assiut University
Ischemic Cardiomyopathy
Impella Supported OPCABG
The present study introduces a novel approach to coronary revascularization through the use of a short term minimally-invasive left ventricular assist device (LVAD) to minimize myocardial injury and eliminate low output state…
- Trial name
- NCT04339452
- Testing
- Impella 5.5 with SmartAssist Supported OPCABG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Lucian Archambault Durham III
Atrial Fibrillation, Coronary Artery Bypass Grafting
Reduction of Atrial Fibrillation Study in Patients Undergoing Coronary Artery Bypass Grafting. (RASCABG 1 Study)
The purpose of this study is to determine whether postoperatively oral treatment with high dosis amiodarone for five days after intravenously admitted bolusinfusion will minimize the risk for development of atrial fibrillation…
- Trial name
- NCT00287209
- Testing
- Amiodarone
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- University of Aarhus
Coronary Atherosclerotic Heart Disease
Relationship Between Apelin and New-onset Atrial Fibrillation After Coronary Artery Bypass Grafting
To investigate whether apelin can be used as an indicator to predict postoperative atrial fibrillation in patients with coronary atherosclerotic heart disease, and to provide an objective basis for the clinical selection of a…
- Trial name
- NCT02807532
- Testing
- atrial fibrillation, non-atrial fibrillation
- Volunteers
- 120 people
- Sponsor
- General Hospital of Shenyang Military Region
Coronary Artery Disease
Improving the Results of Heart Bypass Surgery Using New Approaches to Surgery and Medication
Surgery for blocked arteries in the heart (coronary artery bypass grafting) can be accomplished using veins from the leg sewn onto the heart to provide an alternate path for blood flow, i.e. 'bypassing' the blockages.
- Trial name
- SUPERIORSVG (NCT01047449)
- Testing
- No-touch SVG harvest vs conventional SVG harvest technique
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- Sunnybrook Health Sciences Centre