Clinical trials: Bupivacaine
Caesarian Section, Postoperative Pain
Ketamine Versus Neostigmine in Ultrasound-Guided Transversus Abdominis Plane Block in Caesarean Section
The current study investigates the efficacy and safety of ketamine and neostigmine as adjuvants in transversus abdominis plane blocks for Cesarean sections.
- Trial name
- NCT06871033
- Testing
- TAP block with neostigmine, TAP block with Ketamine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Tympanomastoid Surgery, Cochlear Implant
Great Auricular Nerve Block for Children Undergoing Tympanomastoid Surgery
The investigators goal is to determine the efficacy and duration of analgesia with the addition of Clonidine, an alpha-2 agonist, to local anesthetic blockade using bupivacaine, of the great auricular nerve in children undergoing…
- Conditions
- Tympanomastoid Surgery, Cochlear Implant, Mastoidectomy, Cholesteatoma
- Trial name
- NCT01638052
- Testing
- 0.25% Bupivacaine + Clonidine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Transurethral Resection of Prostate
Effect of Two Different Doses of Intrathecal Dexmedetomidine as Adjuvant in Elderly Patients Undergoing HoLEP
Transurethral resection of the prostate (TURP) is the most common Surgical intervention for elderly patients with benign prostatic hyperplasia.
- Trial name
- NCT05351489
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Anesthesia, Spinal, Arthroplasty, Replacement, Knee
Mepivacaine vs. Bupivacaine Spinal Anesthetic in Total Knee Arthroplasty
The purpose of this study is to determine if a shorter-acting spinal anesthetic called mepivacaine has advantages over a longer-acting medication called bupivacaine.
- Conditions
- Anesthesia, Spinal, Arthroplasty, Replacement, Knee, Pain Management, Early Ambulation
- Trial name
- NCT02980926
- Testing
- Mepivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Post Operative Pain, Acute
Bupivacaine Alone vs Bupivacaine With Tramadol in Local Anesthesia Procedures
This study looked at two different medicines used during local anesthesia to control pain after surgery. Investigators compared bupivacaine alone with bupivacaine mixed with tramadol.
- Trial name
- NCT07469826
- Testing
- Tramadol, Bupivacaine
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Post Operative Pain, Acute, Arthroscopic Shoulder Surgery
Comparison Between Dexametidomedine\Bupivacaine and Plain Bupivacaine in Superior Trunk Block for Arthroscopic Shoulder Surgeries
Comparison between dexametidomedine\bupivacaine and plain bupivacaine in superior trunk block for arthroscopic shoulder surgeries
- Trial name
- NCT07046325
- Testing
- dexametedomidine, Bupivacain
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Postoperative Pain Relief
Dexmedetomidine vs Ketamine as Adjuvants to Bupivacaine in Transversus Abdominus Plane Block in Inguinal Hernioplasty
This clinical trial aims to compare the effect of adding dexmedetomidine versus ketamine to bupivacaine in transversus abdominis plane block in patients undergoing unilateral inguinal hernioplasty.
- Trial name
- DEX\KET in TAP (NCT07194694)
- Testing
- Dexmedetomidine & Bupivacaine., ketamine and bupivacaine injection, Bupivacaine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Pain, Postoperative
Bupivacaine Hydrochloride for Pain Control in Cutaneous Surgery
The purpose of this study is to determine if the addition of bupivacaine HCl injections will improve pain control after skin surgery. This is a randomized clinical trial.
- Trial name
- NCT04260854
- Testing
- Bupivacaine Hydrochloride, Saline
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Stillborn Caesarean Section
Epidural Volume Extension and Intrathecal Use of Local Anesthetics in Cesarean Sections
Intrathecal (i.t.) administration of isobaric bupivacaine, ropivacaine and levobupivacaine with addition of fentanyl for c-section either combined or not with administration of 10 ml of N/S 0,9% epidurally, in order to extent…
- Trial name
- NCT01558713
- Testing
- Bupivacaine- Fentanyl - Normal Saline, Ropivacaine-Fentanyl-Normal Saline, Levobupivacaine- Fentanyl- Normal Saline
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Patras
Postherpetic Neuralgia
Single-dose to Evaluate the Pharmacokinetics of GTX-101 and Subcutaneous Injectable Bupivacaine in Healthy Subjects
This is a single-center, randomized, single-dose, active-controlled study in healthy male and female subjects. The study will enroll subjects to evaluate the PK of 3 dose strengths (50 mg, 100 mg and 200 mg) of GTX-101 compared…
- Trial name
- NCT05517486
- Testing
- GTX-101, Bupivacaine HCl subcutaneous injection
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Grace Therapeutics Inc.
Postoperative Nausea and Vomiting
Dexamethasone for the Prevention of Post-operative Nausea and Vomiting in Patients Undergoing Cesarean Sections
Patients who present for scheduled (non-emergent) cesarean section will be given either intravenous dexamethasone or placebo prior to receiving a duramorph containing spinal anesthetic.
- Trial name
- NCT01734161
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Hemorrhoid, Peri Anal Fistula
Discharge Conditions of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl
In this prospective randomized study the investigators aimed to investigate difference of the duration of spinal anesthesia, discharge times and efficacy between low dose heavy Prilocaine-Fentanyl and heavy Bupivacaine-Fentanyl…
- Trial name
- NCT01880775
- Testing
- Prilocaine, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Teaching and Research Hospital
Anesthesia, Spinal, Elderly
Influence Of Low Dose Intrathecal Naloxone On Bupivacaine - Fentanyl Spinal Anaesthesia For Lower Limb Orthopedic Surgery In Elderly Patients
Fentanyl is a safer alternative than morphine in the management of postoperative pain in elderly. However, pruritus, nausea and vomiting are unwanted side effects of intrathecal fentanyl administration, that can decrease patient…
- Trial name
- NCT04673812
- Testing
- Bupivacaine-fentanyl
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Kasr El Aini Hospital
Shoulder Pain, Supraspinatus Tendinitis
MINIMUM EFFECTIVE VOLUME OF BUPIVACAİNE FOR ANTERIOR SUPRASCAPULAR NERVE BLOCK
Various local anesthetic volumes are used in the literature for anterior suprascapular nerve block (ASSB). There are different studies between 15 ml and 5 ml.
- Conditions
- Shoulder Pain, Supraspinatus Tendinitis, Bankart Lesions
- Trial name
- NCT05241977
- Testing
- anterior supra scapular nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- V.K.V. American Hospital, Istanbul
Pain, Postoperative, Opioid Use
Intra-operative Uterosacral Ligament Bupivacaine Injection During Minimally Invasive Hysterectomy
This is proof of concept, phase I randomized controlled trial studying a short acting non-opioid anesthetic, bupivacaine to improve post-operative pain in gynecologic surgery patients.
- Trial name
- NCT04157075
- Testing
- Bupivacaine
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Postoperative Pain, Hernia
A Safety and Efficacy Study of SABER®-Bupivacaine for Pain Following Hernia Repair
This is a research study testing SABER-Bupivacaine (an experimental pain-relieving medication). SABER-Bupivacaine is designed to continuously deliver bupivacaine, a common local anesthetic, for a few days in order to treat local…
- Conditions
- Postoperative Pain, Hernia, Surgery
- Trial name
- NCT00974350
- Testing
- SABER-Bupivacaine
- Where
- 5 sites in Australia, New Zealand
- Volunteers
- 124 people
- Sponsor
- Durect
Post-operative Pain
Dexmedetomidine Added to Bupivacaine for ESP Block in Children Undergoing Lower Abdominal Surgeries
This study aims to evaluate the effect of adding dexmedetomidine to bupivacaine in erector spinae plane (ESP) blocks on the duration of postoperative analgesia in pediatric patients undergoing lower abdominal surgery.
- Trial name
- NCT07023991
- Testing
- Bupivacaine, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pain, Postoperative, Opioid Use
Liposomal Bupivacaine After Cesarean Delivery
The aim of this study is to determine if local wound infiltration with liposomal bupivacaine at the time of cesarean delivery can decrease opioid use and provide adequate post-operative pain control.
- Trial name
- NCT03907813
- Testing
- Exparel, Saline infiltration
- Where
- United States
- Sponsor
- Wright State University
Post-operative Pain, Total Shoulder Arthroplasty
LIBERATE - LIposomal Bupivacaine vERsus Adjuncts in Total shouldErs
This will be a single-center, prospective, randomized controlled cross-sectional study comparing interscalene brachial plexus block with liposomal bupivacaine versus bupivacaine with epinephrine and PF dexamethasone in patients…
- Conditions
- Post-operative Pain, Total Shoulder Arthroplasty, Osteoarthritis of the Shoulder, Pain Management
- Trial name
- NCT03887650
- Testing
- Liposomal Bupivicaine 1.3%, Bupivacaine 0.5%
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Hartford Hospital
Postoperative Analgesia
Erector Spinae Block Using a Dexmedetomidine Versus Magnesium Sulfate as an Adjuvant to Bupivacaine
This prospective parallel group randomized study will be conducted over 52 adult participants between 20 and 60 years ASA (American Association of Anesthesiologists) I and II undergoing lumbar spine surgery.
- Trial name
- NCT05694897
- Testing
- Erector spinae block using bupivacaine 0.25% and magnesium sulfate, Erector spinae block using bupivacaine and dememdetomidine
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Ain Shams University
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