Clinical trials: Brown Adipose Tissue
Polycystic Ovary Syndrome (PCOS)
Brown Adipose Tissue Modulation in Polycystic Ovary Syndrome Using Infrared Thermography
This study will investigate brown adipose tissue-related physiological responses in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07896642
- Testing
- inositol
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Health and Technology University
Fibromyalgia, Pain
Effect of Temperature on Pain and Brown Adipose Activity in Fibromyalgia
The pathophysiology of pain related to fibromyalgia is not understood. This condition is difficult to diagnose and to treat. One clue may be that tender points (areas which hurt typical of fibromyalgia) are most densely located…
- Trial name
- NCT01322425
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cardiometabolic Diseases
Deciphering a Novel and Unique Brown Adipose Tissue Depot in Women
Type of Study: Clinical Trial Goal: The goal of this clinical trial is to investigate specific brown and beige fat cells in the dorsocervical area of young, lean adult women.
- Trial name
- DEBATE (NCT06426082)
- Testing
- Thermoneutral condition, Cold condition, Aerobic exercise condition
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Type 2 Diabetes, Cold Acclimation
Chronic Cold Acclimation Stimulates the Browning of Subcutaneous White Adipose in Patients With Type 2 Diabetes Mellitus
Adipose tissues, which include white adipose tissue (WAT) and brown adipose tissue (BAT), play an essential role in regulating whole-body energy homeostasis.
- Trial name
- NCT02775253
- Testing
- Chronic cold acclimation
- Where
- China
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Xiang Guang-da
Brown Adipose Tissue
Short Term Effect of Glucocorticoids on Brown Adipose Tissue Thermogenesis in Humans
Interventional, Placebo controlled cross-over study to investigate the short-term effects of glucocorticoids (prednisone) on human brown adipose tissue.
- Trial name
- GlucoBAT (NCT03269747)
- Testing
- Prednisone
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Tumour
Effect of Mirabegron on Promoting Brown Adipose Tissue Activation
In previous preclinical studies, our group found that Mirabegron, a clinical drug, could activate brown adipose tissue and inhibit tumor growth in tumour-bearing mice.Investigators look forward to further evaluating the effect of…
- Trial name
- NCT05779514
- Testing
- Mirabegron
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Zhejiang Provincial People's Hospital
Adiposity, Metabolic Complication
Insight Into New Brown Adipose Tissue Activators.
The general purpose of the study was to provide new information about the role of macronutrients intake, metabolomics, proteomics and microRNA on BAT activation.
- Conditions
- Adiposity, Metabolic Complication, Metabolic Disturbance, Healthy
- Trial name
- NCT04787952
- Testing
- cold expossure
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Healthy Lifestyle
BATokines as Biomarkers of Brown Fat in Humans
Brown adipose tissue (BAT) burns excess calories to produce heat in response to environmental cold. Rapidly growing evidence from rodent and human studies suggests that the presence and activation of brown fat are far more…
- Trial name
- NCT05050240
- Testing
- Cooling Vest Procedure, Fasting overnight
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Healthy
Circadian Brown Adipose Tissue Metabolism
Brown adipose tissue is poorly understood fat that can metabolize glucose in order to generate heat. Since activated brown fat has a high metabolic rate, it is of great interest as a potential target to combat obesity.
- Trial name
- NCT02285270
- Testing
- FDG PET/CT
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Brown Adipose Tissue, Human
A Multi-modal Cohort Study of Brown Adipose Tissue Based on Paired Comparisons at Room Temperature and After Cold Exposure
This study is a single-center, prospective clinical study that plans to prospectively recruit volunteers aged 18-40 years, including metabolically healthy individuals and those with diabetes mellitus and hyperlipidemia.
- Trial name
- BAT-PACT (NCT07908719)
- Testing
- cold exposure
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Brown Fat
Efficacy of Pharmacological Stimulation of BAT and WAT in Lean and Obese Young Adults
To determine whether pharmacological stimulation of supraclavicular Brown Adipose Tissue (BAT or "Brown Fat") and subcutaneous White Adipose Tissue (WAT) using an FDA-approved beta3 agonist is as effective in increasing oxidative…
- Trial name
- MiraBAT (NCT02354807)
- Testing
- Mirabegron, Cold exposure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Otto Muzik
Obesity
Circulating Microvesicles Regulating Metabolic Homeostasis in Obesity After Caloric Restriction Programs
The main aim of the present study is to evaluate the effectiveness of two dietary protocols: Daily Caloric Restriction (DCR) and Early Time-Restricted Feeding + DCR (eTRE) on metabolic homeostasis and the influence of circulating…
- Trial name
- TREV (NCT06395246)
- Testing
- Active Comparator: Continuous calorie restriction, eTRE
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Obesity
Secretin Activates Human Brown Fat and Induces Satiation.
15 healthy males will be studied with PET/CT, using FDG to investigate glucose metabolism, and radiowater to investigate perfusion.
- Trial name
- GUTBAT (NCT03290846)
- Testing
- Secretin Human, Saline Solution, Cold exposure
- Where
- Finland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Obesity
The Role of Brown Adipose Tissue in Triglyceride Clearance in People
The recent discovery of functional brown adipose tissue (BAT) in humans has led to a paradigm shift in adipose tissue biology; it is now believed that adipocytes may play a significant role in regulating substrate metabolism.
- Trial name
- BAT-TG (NCT02786251)
- Testing
- Cold exposure, Exposure to thermoneutral conditions
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obesity
Hyperpolarized Xenon-129 Magnetic Resonance Imaging and Spectroscopy of Brown Fat: Healthy Adult Volunteer Pilot Study
The primary goal of this study is to evaluate the feasibility of detecting Brown Adipose Tissue (BAT) in healthy subjects by using hyperpolarized xenon gas MRI.
- Trial name
- NCT02220426
- Testing
- Xenon
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Obesity
Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects.
Glucagon like peptide (GLP-1) agonists, such as liraglutide, exenatide, and semaglutide, have been increasingly used as a medication to address the current twin epidemics of diabetes and obesity.
- Trial name
- NCT05419726
- Testing
- Semaglutide Injectable Product (not provided by the study)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Thermogenesis, Brown Adipose Tissue
Stimulation of Diet-Induced Thermogenesis by Cold-Exposure
Human fat tissue is essentially white fat, the main function of which is to store excess energy intake, and to release it when necessary.
- Trial name
- BAT&DIT (NCT01898949)
- Testing
- Cold Exposure
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obese
Monounsaturated Fatty Acids and Brown/Beige Adipose Tissue in Humans
Considering the high prevalence of obesity its comorbidities in Brazil and in the world, different therapeutic measures have been suggested.
- Trial name
- NCT03024359
- Testing
- Extra virgin olive oil
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Type2 Diabetes
Effects of Fructose/Glucose-rich Diet on Brown Fat in Healthy Subjects (GB7)
Activating brown and beige adipose tissue (herein described as BAT) has been recently recognized as a potential means to increase energy expenditure and lower blood glucose, however, BAT activity appears to be reduced with…
- Trial name
- GB7 (NCT03188835)
- Testing
- Diet, cold exposure, 18FDG
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Obesity, Type 2 Diabetes
Cold Stress Stimulate the Browing of Subcutaneous White Adipose in Healthy Adults
Adipose tissues, which include white adipose tissue (WAT) and brown adipose tissue (BAT), play an essential role in regulating whole-body energy homeostasis.
- Trial name
- NCT02159144
- Testing
- cold stress
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Xiang Guang-da