Clinical trials: Brown Adipose Tissue
Adipose Tissue, Brown Adipose Tissue
Cold Induced Activation of Brown Adipose Tissue in Winter Swimmers
This study investigates cold-induced brown fat activation in winter swimmers and not-winter swimmers by skin temperature measures assessed with infra red thermography imaging and skin temperatures.
- Conditions
- Adipose Tissue, Brown Adipose Tissue, Brown Fat, Uncoupling Protein 1
- Trial name
- COLDBAT_WS (NCT03095846)
- Testing
- Cooling
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Brown Adipose Tissue (BAT) Physiology, Cold Exposure
Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity
The purpose of the study is to asses brown adipose tissue activity after a cold mild stimulus, preceded by 200mg caffeine or placebo administration.
- Trial name
- ACROBAT (NCT06978777)
- Testing
- Caffeine (200 mg)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects.
Glucagon like peptide (GLP-1) agonists, such as liraglutide, exenatide, and semaglutide, have been increasingly used as a medication to address the current twin epidemics of diabetes and obesity.
- Trial name
- NCT05419726
- Testing
- Semaglutide Injectable Product (not provided by the study)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Physical Activity
Brown Adipose Tissue Activation: Effect of Exercise Training and Irisin
This study investigates the brown adipose tissue (BAT) activation and metabolism using positron emission tomography (PET) imaging before and after exercise training intervention at fasting state under normal room temperature and…
- Trial name
- EXEBAT (NCT03359824)
- Testing
- Exercise
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Brown Fat and Muscle Metabolic, Differential Diagnosis
PET/MRI Study on Changes of Fat and Muscle Metabolism.
False positives for Brown Fat \& Muscle（F\&M） always affect the evaluation of metabolic disease treatment. Recently, using PET/CT，international journals such as Journal of Nuclear Medicine reported that the amount of active brown…
- Trial name
- NCT04334720
- Testing
- Comprehensive treatment of tumor
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Obesity, Metabolic Syndrome
Brown Adipose Tissue as a Mechanistic Determinant of Semaglutide Treatment Response in Obesity (BAT-Sema Study)
This study investigates whether the activity of brown adipose tissue (BAT) - a special type of fat that burns energy as heat - can predict how well individuals with obesity respond to semaglutide (Wegovy), a once-weekly…
- Conditions
- Obesity, Metabolic Syndrome, Brown Adipose Tissue
- Trial name
- BAT-Sema (NCT07621640)
- Testing
- Semaglutide (Wegovy®), ¹⁸FDG-PET/CT with cold stimulation, Liver MRI (PDFF + MRE)
- Where
- 2 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Hallym University
Energy Expenditure, Obesity
BRown Fat Activity Measurement With Infrared imaginG tHermography andThermogenesis - the BRIGHT Study
The whole body calorimeter is sensitive enough to reliably measure cold-induced thermogenesis as a surrogate marker of brown adipose tissue (BAT) activation.
- Conditions
- Energy Expenditure, Obesity, Adipose Tissue, Brown
- Trial name
- BRIGHT (NCT02790255)
- Testing
- Cold air, Cold water
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Atrial Fibrillation (AF)
Finerenone After Catheter Ablation to Reduce Atrial Fibrillation Recurrence
Atrial fibrillation (AF) is a common heart rhythm disorder associated with stroke, heart failure, and increased mortality. Catheter ablation with pulmonary vein isolation (PVI) is an effective rhythm-control strategy, but 20-30%…
- Trial name
- FINE-CA (NCT07799519)
- Testing
- Finerenone
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Pediatric Cancer
Use of Propranolol to Reduce FDG Uptake in Brown Adipose Tissue in Pediatric Cancer Patients PET Scans
This is a single-arm, open-label study to assess the safety and effectiveness of a single dose of oral propranolol in reducing18F-fluorodeoxyglucose (FDG) uptake in brown adipose tissue (BAT) in pediatric oncology patients.
- Trial name
- NCT02165683
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Lars Wagner
Coronary Artery Disease
Epicardial Fat in Coronary Artery Disease
We hypothesize that human epicardial fat plays a thermogenic role to the myocardium. We hypothesize that epicardial fat may express genes of brown fat and thyroid function that are down-regulated by the presence of coronary…
- Trial name
- NCT03693261
- Testing
- Coronary artery bypass grafting (CABG), Valve replacement
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Miami
Non-Alcoholic Fatty Liver Disease, Obesity, Morbid
Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention
The study is aimed To quantify the change of adipose tissues, triglyceride in liver and pancreas and cholesterol after lifestyle intervention or bariatric surgery.
- Conditions
- Non-Alcoholic Fatty Liver Disease, Obesity, Morbid, Brown Fat, Metabolic Disease
- Trial name
- NCT03875625
- Testing
- Bariatric surgery, Dietitian led life style modification intervention, Conventional care (control)
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Obesity
CB1 Receptors in Human Brown Adipose Tissue
This study investigates cannabinoid CB1 receptors in human brown adipose tissue (BAT) and other tissues using positron emission tomography (PET) imaging.
- Trial name
- CANBAT (NCT02941172)
- Testing
- Cold exposure, [18F]FMPEP-d2, [18F]FDG
- Where
- Finland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Obesity
Activation of Cervical and Upper Thoracic Brown Adipose Tissue in Humans Via Beta-adrenergic Stimulation
In this study the investigators aim to quantitate the extent of cervical and upper thoracic brown adipose tissue (BAT) activation in lean and obese humans via positron emission tomography-computed tomography (PET-CT) in response…
- Trial name
- NCT01015794
- Testing
- ephedrine hydrochloride
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Regulation of Energy Expenditure
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1
Brown adipose tissue becomes activated during cold conditions to increase thermogenesis (i.e., energy expenditure). Topical menthol application increases resting energy expenditure but it is unclear whether brown adipose tissue…
- Trial name
- NCT07030725
- Testing
- Menthol Gel, Time control
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Indiana University
Thermogenesis, Brown Adipose Tissue
Stimulation of Diet-Induced Thermogenesis by Cold-Exposure
Human fat tissue is essentially white fat, the main function of which is to store excess energy intake, and to release it when necessary.
- Trial name
- BAT&DIT (NCT01898949)
- Testing
- Cold Exposure
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obese Adolescents, Exercise
Study of the Effect of Capsinoid Supplementation on Brown Adipose Tissue in Obese Adolescents
Among the new strategies being considered for the treatment of obesity and its metabolic complications, the activation of brown adipose tissue (BAT) from white adipose tissue looks promising.
- Conditions
- Obese Adolescents, Exercise, Diet Modification, Dietary Supplement
- Trial name
- ADOBAT (NCT06916208)
- Testing
- capsinoid supplementation
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University of Avignon
Neoplasms, Adipose Tissue
Sitagliptin and Brown Adipose Tissue
The obesity epidemic has resulted in an exponential increase in obesity-related disorders including type 2 diabetes, dyslipidemia and cardiovascular disease.
- Trial name
- Sita01 (NCT02294084)
- Testing
- Sitagliptin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ingrid Jazet
Resting Energy Expenditure, Thermogenesis
Mirabegron and Physiological Function in Cold Environments
Many Navy diving operations are performed in cold water. Despite technical advances to improve thermal protection for cold water diving, these applications are cumbersome and do not provide complete thermal protection as thermal…
- Conditions
- Resting Energy Expenditure, Thermogenesis, Brown Adipose Tissue
- Trial name
- NCT04766021
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Obesity (Disorder)
JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity
The Joule MARS study is a single center, randomized, open label clinical trial aiming to explore the metabolic adaptations that occur in response to weight management in adolescents with obesity.
- Trial name
- JOULE-MARS (NCT06852391)
- Testing
- Semaglutide Pen Injector, Behavioural Lifestyle Program (BLP)
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- McMaster University
Obese
Monounsaturated Fatty Acids and Brown/Beige Adipose Tissue in Humans
Considering the high prevalence of obesity its comorbidities in Brazil and in the world, different therapeutic measures have been suggested.
- Trial name
- NCT03024359
- Testing
- Extra virgin olive oil
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil