Clinical trials: Bronchiolitis; Respiratory Syncytial Virus
Bronchiolitis
Studying Innate Immune Responses in Infants With Bronchiolitis
This study aims to establish whether impaired innate immune responses are associated with severity of Respiratory syncytial virus (RSV) infection.
- Trial name
- NCT01159795
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Bronchiolitis; Respiratory Syncytial Virus
Steroid Therapy in Acute Bronchiolitis A New Old Line of Therapy.
The aim of the present study is to evaluate the efficacy of steroid therapy and hospital stay in patients with acute bronchiolitis at assiut university children hospital.
- Trial name
- NCT03436225
- Testing
- Dexamethasone orally., Dexamethasone parenteral., Inhaled nebulized Budesonide.
- Volunteers
- 80 people
- Sponsor
- Assiut University
Bronchiolitis
Peginterferon α-2b Injection for the Treatment of Pediatric RSV Bronchiolitis
This is a multicenter, randomized, positive-controlled, non-inferiority clinical study, planning to enroll 90 children with bronchiolitis caused by respiratory syncytial virus infection, to evaluate the safety and efficacy of…
- Trial name
- NCT06827249
- Testing
- Peginterferon α-2b injection, Recombinant Human Interferon α2b
- Where
- 3 sites in China
- Volunteers
- 90 people
- Sponsor
- Children's Hospital of Soochow University
Bronchiolitis, Respiratory Syncytial Virus
Cough Assist in Bronchiolitis
RSV bronchiolitis in children is still associated with significant morbidity and mortality. RSV infection results in increased mucus production, edema and inflammation at the lower airways and impaired mucociliary clearance.
- Trial name
- NCT01757496
- Testing
- Cough Assist
- Where
- 2 sites in Belgium
- Volunteers
- 1 people
- Sponsor
- University Hospital, Antwerp
Bronchiolitis; Respiratory Syncytial Virus
COVID-19 Impact on RSV Emergency Presentations
Bronchiolitis is a very common winter disease that normally affects children less than one year of age. It is a common reason for parents and carers to bring their child to an Emergency Department (ED) and the frequent need for…
- Trial name
- BronchSTART (NCT04959734)
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- University Hospitals, Leicester
Bronchiolitis
Immature Myeloid Cells in Respiratory Syncytial Virus Bronchioliltis
The investigators hypothesize that Respiratory Syncytial Virus (RSV) infection may influence the population of lung immature myeloid cells and dendritic cells in a way that will impair their ability to invoke an effective immune…
- Trial name
- NCT01684527
- Testing
- Respiratory secretions obtained
- Where
- Israel
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Respiratory Syncytial Virus, Bronchiolitis
Azithromycin to Prevent Wheezing Following Severe RSV Bronchiolitis-II
The main objective of the APW-RSV II clinical trial is to evaluate if the addition of azithromycin to routine bronchiolitis care, among infants hospitalized with RSV bronchiolitis, reduces the occurrence of recurrent wheeze…
- Trial name
- APW-RSV-II (NCT02911935)
- Testing
- Oral azithromycin
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Washington University School of Medicine
RSV Infection, Acute Bronchiolitis
Effect of Heliox on RSV Bronchiolitis
Helium is an inert gas with a density almost one-seventh of that of air. Based on its properties breathing a mixture of helium and oxygen (heliox) will lead to a reduction in resistance through narrowed airways and consequently…
- Trial name
- NCT03171142
- Testing
- Heliox, Air
- Volunteers
- 104 people
- Sponsor
- Wael Seliem
Respiratory Syncytial Virus Bronchiolitis
Comparison of High Flow Oxygenation Therapy and CPAP in Children With Bronchiolitis.
Bronchiolitis in infants and young children often requires respiraty support. In Denmark Continous Positive Airway Pressure ( CPAP) are routinely used in children with moderate-severe bronchiolitis.
- Trial name
- NCT02618213
- Testing
- Optiflow Junior, Continous Positive Airway Pressure
- Where
- 2 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Bronchiolitis, Respiratory Syncytial Virus Infections
Assessment of Airway Obstruction in Infants With Lower Respiratory Infections
The purpose of this study is to evaluate how two different aerosol medications may improve airway function in infants with respiratory illness.
- Trial name
- NCT00435994
- Testing
- Inhaled primatene will be given as a breathing treatment, Nasal Washing
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Indiana University
Bronchiolitis, Bronchiolitis, Viral
Nasal and Bronchial Absorption Sampling in RSV Bronchiolitis
This study will compare the novel methods of NS and BS with the standard technique of nasophayngeal aspiration (NPA) and routine ETT suction.
- Conditions
- Bronchiolitis, Bronchiolitis, Viral, RSV Infection, Respiratory Failure
- Trial name
- RSV-SAM (NCT03062917)
- Testing
- Nasal and Bronchial Sampling
- Where
- United Kingdom
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Bronchiolitis; Respiratory Syncytial Virus
RSV Seasonality in Martinique in Children Aged 2 Years or Less
The epidemiological characteristics of RSV bronchiolitis differ between tropical and temperate zones. This study seeks to understand which climatic factors could influence the specific seasonality of these bronchiolitis in…
- Trial name
- VRS-12 (NCT04415229)
- Where
- Martinique
- Volunteers
- 1,237 people
- Sponsor
- University Hospital Center of Martinique
Bronchiolitis, Infection
Exhaled Nitric Oxide Levels in Infants and Young Children Infected With RSV or Other Viral Infections
The fraction of exhaled nitric oxide (FeNO) in expired air is a reliable measure of airway inflammation and has been used as a marker in asthma and other respiratory illnesses such as primary ciliary dyskinesia, bronchopulmonary…
- Conditions
- Bronchiolitis, Infection, Nitric Oxide
- Trial name
- NCT01098227
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus (RSV)
Infection With Respiratory Syncytial Virus in Infants
IRIS (Infection with RespIratory Syncytial Virus) is an observational, multi-center study enrolling infants with severe RSV infection and healthy controls.
- Conditions
- Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus (RSV), Respiratory Syncytial Virus-bronchiolitis
- Trial name
- IRIS (NCT04925310)
- Where
- 2 sites in Germany
- Volunteers
- 350 people
- Sponsor
- Hannover Medical School
Respiratory Syncytial Virus Infections, Severe Acute Respiratory Infection
Effectiveness of Immunization in Preventing Severe Acute Respiratory Infection RSV in Children Under 6 Months in Bogotá
This study aims to evaluate the real-world effectiveness of two preventive immunization strategies against Respiratory Syncytial Virus (RSV)-associated severe acute respiratory infection in infants less than six months of age in…
- Conditions
- Respiratory Syncytial Virus Infections, Severe Acute Respiratory Infection, Bronchiolitis, Viral, Viral Respiratory Tract Infection
- Trial name
- NCT07279298
- Testing
- RSVpreF vaccine (Abrysvo) and Nirsevimab (Beyfortus) or unexposed
- Where
- Colombia
- Volunteers
- 1,097 people
- Sponsor
- Bogotá District Health Secretariat
Rhinovirus, RSV Infection in Children Less Than 5 Years of Age
Impact of the Covid-19 on RSV Epidemic in the Metropolis of Lyon
The magnitude of seasonal RSV epidemics brings each year new logistical challenges for the hospitalization of young infants with bronchiolitis that overwhelm hospital capacities and lead to specific winter plans with…
- Trial name
- IPCoVRS-2 (NCT05348655)
- Testing
- epidemiology
- Where
- 2 sites in France
- Volunteers
- 600 people
- Sponsor
- Hospices Civils de Lyon
Acute Bronchiolitis Due to Respiratory Syncytial Virus, Bronchiolitis Acute
Mucociliary Clearance Techniques for Acute Bronchiolitis
To assess the efficacy of mucociliary clearance techniques in non-hospitalised infants with a first episode of mild to moderate acute bronchiolitis.
- Conditions
- Acute Bronchiolitis Due to Respiratory Syncytial Virus, Bronchiolitis Acute, Bronchiolitis Acute Viral
- Trial name
- CLEARBRONCH (NCT06689631)
- Testing
- Respiratory Physiotherapy
- Volunteers
- 70 people
- Sponsor
- Universidad de León
Respiratory Syncytial Virus Bronchiolitis
Respiratory Syncytial Virus (RSV) Follow-Up Study (MK-0476-374)
This is a prospective, multicenter, observational study in participants who completed the 24-week, placebo-controlled MK-0476 Protocol 272 (NCT00076973) study of montelukast in the treatment of respiratory symptoms subsequent to…
- Trial name
- NCT01140048
- Volunteers
- 343 people
- Sponsor
- Organon and Co
RSV Bronchiolitis
Azithromycin to Prevent Wheezing Following Severe Respiratory Syncytial Virus (RSV) Bronchiolitis
This trial is a proof-of-concept pilot study aim to investigate the biologic and clinical effects of early azithromycin treatment in children hospitalized with Respiratory Syncytial Virus (RSV) bronchiolitis.
- Trial name
- APW-RSV (NCT01486758)
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Bronchiolitis, Acute Bronchiolitis
Risk Factors and Severity of Bronchiolitis in Hospitalized Children at Assiut University Hospital
The purpose of this observational study is to identify the risk factors that make bronchiolitis more severe in infants and toddlers.
- Conditions
- Bronchiolitis, Acute Bronchiolitis, Respiratory Syncytial Virus Infection
- Trial name
- NCT07505420
- Volunteers
- 65 people
- Sponsor
- Assiut University