Clinical trials: Bronchiectasis With Acute Exacerbation
COPD Exacerbation, Bronchiectasis With Acute Exacerbation
Multi-omics Studies of Host-microbiome Interaction in Chronic Obstructive Pulmonary Disease and Bronchiectasis
Chronic obstructive pulmonary disease (COPD) and bronchiectasis are common chronic respiratory diseases in China. COPD is characterized by irreversible lung function decline due to airway inflammation, emphysema and alveolar…
- Trial name
- NCT05738044
- Testing
- No intervention
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruijin Hospital
Bronchiectasis With Acute Exacerbation
Prevention of OM-85 on Bronchiectasis Exacerbation
Non-cystic fibrosis bronchiectasis is characterized by irreversible dilatation of the medium-sized bronchi as a result of airway injury due to recurrent or chronic inflammation and infection.
- Trial name
- NCT01968421
- Testing
- OM-85 BV
- Where
- 2 sites in China
- Volunteers
- 196 people
- Sponsor
- Chinese Academy of Medical Sciences
Bronchiectasis With Acute Exacerbation
Bronchoscopic Levofloxacin, Gentamicin, or Sham for Acute Exacerbation of Bronchiectasis
Randomized single-center trial evaluating whether bronchoscopic instillation of levofloxacin or gentamicin improves outcomes compared to a sham bronchoscopic procedure in adult ICU patients with non-cystic fibrosis bronchiectasis…
- Trial name
- NCT06209047
- Testing
- Local instillation of gentamicin and Budesonide, Local instillation of Levofloxacin and Budesonide, Bronchoscopic mechanical secretion suction and lavage
- Where
- Egypt
- Volunteers
- 315 people
- Sponsor
- Assiut University
Bronchiectasis Adult
Airway Clearance and Bronchoalveolar Lavage for Bronchiectasis Patients With Exacerbation
No study have evaluated the efficacy and safety of airway clearance therapy (ACT) and bronchoalveolar lavage (BAL) under bronchoscope for bronchiectasis.
- Trial name
- NCT03643302
- Testing
- Version BF-1T26 electronic bronchoscope
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Bronchiectasis Adult, Bronchiectasis With Acute Exacerbation
Airway Clearance by Fiberoptic Bronchoscopy in Bronchiectasis Followed by Gentamicin and Dexamethason Injection
Fiberoptic Bronchoscopic Removal of Secretions and Antibiotic Injection
- Trial name
- NCT06906354
- Testing
- Airway Clearance by Fiberoptic Bronchoscopy in Bronchiectasis Followed by Gentamicin and Dexamethason Injection
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Bronchiectasis, Bronchiectasis With Acute Exacerbation
Comparing Active Cycle of Breathing Techniques (ACBT) and Aerobika in Treating Bronchiectasis in Korea
Title: Comparison of Effectiveness Between Active Cycle of Breathing Techniques (ACBT) and Oscillating Positive Expiratory Pressure (OPEP, Aerobika) Device Assisted Treatment in Patients With Bronchiectasis in Korea: A Randomized…
- Trial name
- NCT07037303
- Testing
- Active Cycle of Breathing Technique (ACBT) and Oscillatory Positive Expiratory Pressure (OPEP) group, Active Cycle of Breathing Technique (ACBT) group
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chungbuk National University Hospital
Bronchiectasis Adult, Bronchiectasis With Acute Exacerbation
Exploring How Viral Infections Affect People With Chronic Lung Disease
Many people with chronic lung disease have disease flare-ups. It was previously believed that these were mainly caused by bacteria but recent evidence suggests that viruses could be an important trigger.
- Conditions
- Bronchiectasis Adult, Bronchiectasis With Acute Exacerbation, COPD (Chronic Obstructive Pulmonary Disease), Respiratory Infection Virus
- Trial name
- PRIVILEGE (NCT06625944)
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Imperial College London
Bronchiectasis Adult, Bronchiectasis With Acute Exacerbation
A Rhinovirus Challenge Study to Investigate Exacerbations and Immune Responses in Bronchiectasis
The goal of this study is to determine if viral infection with the common cold leads to an exacerbation in participants with bronchiectasis.
- Conditions
- Bronchiectasis Adult, Bronchiectasis With Acute Exacerbation, Bronchiectasis With Chronic Infection With Pseudomonas Aeruginosa, Viral Infection
- Trial name
- BARRIER (NCT06931002)
- Testing
- Rhinovirus A-16 Infection
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Bronchiectasis
Therapy of Bronchoalveolar Lavage and Local Amikacin Injection in Patients With Acute Exacerbation of Bronchiectasis
The therapy of bronchoalveolar lavage and local amikacin injection as one of the treatment of bronchiectasis developed in recent years.this study is aim to evaluate the Clinical Efficacy and Safety of Therapy of Bronchoalveolar…
- Trial name
- NCT02509091
- Testing
- Bronchoalveolar Lavage and Local Amikacin Injection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Bronchiectasis with Acute Exacerbation
Value of Bronchoalveolar Lavage with Acetylcysteine in the Treatment of Bronchiectasis.
Bronchiectasis is a clinical syndrome characterised by chronic cough, profuse sputum and/or intermittent haemoptysis, with or without shortness of breath and respiratory failure of varying severity, and abnormal thickening and…
- Trial name
- NCT06726356
- Testing
- Bronchoalveolar Lavage
- Where
- China
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Bronchiectasis, Lower Respiratory Infection
Safety, Efficacy and PK/PD of POL7080 in Patients With Exacerbation of Non-cystic Fibrosis Bronchiectasis.
To test whether POL7080 is effective in patients with exacerbation of non-cystic fibrosis bronchiectasis caused by Pseudomonas aeruginosa infection.
- Trial name
- NCT02096315
- Testing
- POL7080
- Where
- 4 sites in Spain, United Kingdom
- Volunteers
- 20 people
- Sponsor
- Polyphor Ltd.
Non-Cystic Fibrosis Bronchiectasis
Combined Administration of Nebulized Amikacin in Patients With Acute Exacerbation of Non-Cystic Fibrosis Bronchiectasis
This is a multi-centered, randomized, controlled study to assess the efficacy, indications and adverse reactions of combined administration of nebulized amikacin in patients with acute exacerbation of non-cystic fibrosis…
- Trial name
- NCT02081963
- Testing
- Amikacin, Normal saline
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Qilu Hospital of Shandong University
Bronchiectasis, Non-cystic Fibrosis Bronchiectasis
BASE: Bronchiectasis Severity and Exacerbation Risk Study
Non-cystic fibrosis bronchiectasis (NCFB) is a chronic airway disease characterized by permanent bronchial dilatation, impaired mucus clearance, recurrent infection, airway inflammation, and repeated exacerbations.
- Conditions
- Bronchiectasis, Non-cystic Fibrosis Bronchiectasis, Bronchiectasis With Acute Exacerbation
- Trial name
- BASE (NCT07599839)
- Where
- Egypt
- Volunteers
- 750 people
- Sponsor
- Assiut University
Bronchiectasis Adult, Chronic Obstructive Pulmonary Disease
The Characteristic of Airway Microbiome Profiling of COPD-bronchiectasis Overlap Patients and Its Association With Acute Exacerbation
The overlap between chronic obstructive pulmonary disease (COPD) and bronchiectasis is a neglected area of research, and it is not covered by guidelines for clinical practice.
- Conditions
- Bronchiectasis Adult, Chronic Obstructive Pulmonary Disease, Overlap, Microbiome
- Trial name
- NCT04865861
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Guangzhou Medical University
Bronchiectasis
Study of Bronchiectasis and Associated Cardiovascular Comorbidities
Effect of cardiovascular comorbidities on disease severity and quality of life in Patients with acute exacerbation of non-cystic fibrosis bronchiectasis
- Trial name
- NCT05783869
- Testing
- Echocardiography
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Non-cystic Fibrosis Bronchiectasis, Bronchiectasis Adult
Azithromycin to Modify Bronchiectasis Exacerbation Risk
The Azithromycin to Modify Bronchiectasis Exacerbation Risk (AMBER) trial is a prospective, randomized, double-blind, placebo-controlled, parallel-group clinical trial in adults with clinically and radiologically confirmed…
- Conditions
- Non-cystic Fibrosis Bronchiectasis, Bronchiectasis Adult, Bronchiectasis, Bronchiectasis With Acute Exacerbation
- Trial name
- AMBER (NCT07608328)
- Testing
- Standard Bronchiectasis Care, Azithromycin
- Where
- Egypt
- Volunteers
- 500 people
- Sponsor
- Assiut University
Bronchiectasis, Non-cystic Fibrosis Bronchiectasis
Bronchiectasis Phenotype Identification Model
The Bronchiectasis Phenotype Identification Model (BPIM) is a prospective observational development-validation study within the Assiut University bronchiectasis translational research platform.
- Conditions
- Bronchiectasis, Non-cystic Fibrosis Bronchiectasis, Bronchiectasis With Acute Exacerbation
- Trial name
- BPIM (NCT07599969)
- Where
- Egypt
- Volunteers
- 750 people
- Sponsor
- Assiut University
Bronchiectasis Adult
Optimization of Nutritional State on the Outcome of Patients With Acute Exacerbation of Bronchiectasis
Bronchiectasis is a chronic respiratory condition characterized by the abnormal and permanent dilation of the bronchi, leading to recurrent respiratory infections, chronic cough, and significant morbidity.
- Trial name
- NCT06704607
- Volunteers
- 70 people
- Sponsor
- Assiut University
Bronchiectasis
Efficacy and Safety of Long-term Oral Staphylococcus Albicans Tablets in Patients With Bronchiectasis
The main purpose of this study is to investigate whether long-term oral administration of Staphylococcus albicans tablets can significantly reduce the number of acute exacerbations in patients with bronchiectasis.
- Trial name
- NCT05407792
- Testing
- Staphylococcus and Neisseria Tablets, On-demand treatment
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Qianfoshan Hospital
Bronchiectasis, Bronchiectasis With Acute Exacerbation
A Pilot Study to Evaluate the Use of the Vest® System for Treatment of Bronchiectasis Patients in the Home Setting
This a 70 patient multi-site non blinded randomized control trial evaluating the use of the Vest® System for treatment of Non-Cystic Fibrosis Bronchiectasis (NCFBE) patients in the home setting.
- Trial name
- NCT04017312
- Testing
- High Frequency Chest Wall Oscillation, Oscillating Positive Expiratory Pressure (OPEP)
- Where
- 3 sites in United States
- Volunteers
- 43 people
- Sponsor
- Hill-Rom