Clinical trials: Bronchiectasis
Bronchiectasis
Acute Effects of a Flutter Device and Chest Wall Compression on Respiratory System Impedance in Bronchiectasis Patients
Bronchiectasis is characterized pathologically by the abnormal and permanent dilation of bronchi caused mainly by the perpetuation of inflammation and impaired clearance of secretions.
- Trial name
- NCT02509637
- Testing
- Flutter, Chest Compression, Control
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Non-CF Bronchiectasis, Nontuberculosis Mycobacteria (NTM)
Bronchiectasis and NTM Research Registry
The Bronchiectasis Research Registry is a consolidated database of non-cystic fibrosis (non-CF) Bronchiectasis and Nontuberculosis Mycobacteria (NTM) patients from multiple clinical institutions.
- Trial name
- NCT01822834
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- COPD Foundation
Bronchiectasis, Idiopathic Bronchiectasis
Target Validation and Discovery in Idiopathic Bronchiectasis
Bronchiectasis is a long-term lung condition where the airways become abnormally enlarged, leading to a build-up of mucus and inflammation that makes the lungs more susceptible to recurrent infection.
- Trial name
- NCT03750734
- Testing
- Bronchoscopy, Blood test
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Papworth Hospital NHS Foundation Trust
Asthma, Chronic Obstructive Pulmonary Disease
Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease
This is a single centre exploratory study that aims to apply hyperpolarized xenon-129 (129Xe) magnetic resonance imaging (MRI) methods and measurements in individual patients with and without lung disease to better understand…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease, Bronchiectasis, Emphysema
- Trial name
- NCT03455686
- Testing
- Hyperpolarized 129Xe MRI
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Asthma, COPD
Acoustic Waveform Respiratory Evaluation
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.
- Conditions
- Asthma, COPD, Cystic Fibrosis, Ciliary Motility Disorders
- Trial name
- AWARE (NCT06512064)
- Testing
- AWARE
- Where
- 2 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Indiana University
Bronchiectasis
Different Phenotypes of Bronchiectasis
Bronchiectasis is defined as abnormal chronic dilatation of one or more bronchi. Patients have a structural abnormality of the bronchial wall that predisposes them to bacterial infection likely due to impaired mucus clearance.
- Trial name
- NCT03262064
- Testing
- Pulmonary function tests,Bronchiectasis severity index score
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Halitosis
Treatment of Halitosis With Photodynamic Therapy in Older Patients
Halitosis is the term used to define an unpleasant odor emanating from the mouth. Some lung diseases, such as bronchiectasis, are among the extra-oral causes of this condition.
- Trial name
- NCT03591484
- Testing
- Photodynamic therapy, Treatment with tongue scraper, Periodontal treatment
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Bronchiectasis
Pulmonary Rehabilitation in Non-Cystic Fibrosis Bronchiectasis
The purpose of this study is to assess the effect of pulmonary rehabilitation on the transport of secretions, inflammation and respiratory resistance, and its repercussions on the quality of life in patients with bronchiectasis.
- Trial name
- NCT02823587
- Testing
- Pulmonary Rehabilitation, Control
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Bronchiectasis Adult
Bronchodilators on the Exercise Capacity of Bronchiectasis Patients
The bronchodilators (BD) have been widely used in bronchiectasis (BCE) therapeutic and have been shown to be effective in improving exercise capacity in patients with chronic obstructive pulmonary disease and asthma.
- Trial name
- NCT05183841
- Testing
- Bronchodilator (Ipratropium and Fenoterol)
- Where
- 3 sites in Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Bronchiectasis
Exhaled Breath Condensate Assessment in Stable Non-Cystic Fibrotic Bronchiectasis
The measurement of markers in the expired breath condensate has proven to be a useful method for assessing and monitoring airway inflammation.
- Trial name
- NCT03643263
- Where
- China
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Bronchiectasis
Comparison of Sit-to-stand Test With Six-minute Walk Test in Bronchiectasis and Healthy Children
Children with bronchiectasis and age-matched healthy controls will be evaluated with sit-to-stand test and six-minute walk test and utilization of STST in determining functional capacity will be investigated.
- Trial name
- NCT04153448
- Testing
- Measurement of functional capacity
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Cystic Fibrosis, Bronchiectasis
Effect of HFCWO Vests on Spirometry Measurements
The impact of high-frequency chest wall oscillation therapy on spirometry values (Forced Expiratory Volume, Forced Vital Capacity, Peak Expiratory Flow, Forced Expiratory Flow and Tidal Volume is investigated during use of…
- Trial name
- NCT03628456
- Testing
- International Biophysics AffloVest, Hill-Rom Monarch
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- International Biophysics Corporation
Non-cystic Fibrosis Bronchiectasis
A Clinical Study of RSS0343 in Healthy Subjects
This is a phase I study to evaluate the safety, tolerability and pharmacokinetics of RSS0343 following multiple oral doses in healthy subjects, as well as its effects on the QT/QTc interval.
- Trial name
- NCT07289464
- Testing
- RSS0343 Tablets
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Reistone Biopharma Company Limited
Bronchiectasis
Assessment of an Exhaled Breath Test to Detect Bronchiectasis
To investigate whether the breath test is able to detect bronchiectasis using breathomics. This study was conducted with a prospective specimen collection, evaluator-blinded, case-controlled clinical study designed to evaluate…
- Trial name
- NCT05293314
- Testing
- An exhaled breath test
- Where
- China
- Volunteers
- 544 people, healthy volunteers welcome
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Pediatric Patients With Bronchiectasis
Determination of Physical Fitness Level in Bronchiectasis
The aim of this study is to assess the physical fitness level of children with bronchiectasis. To determine your physical fitness level, we will conduct some game-like tests.
- Trial name
- NCT07121218
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Melis Usul
Healthy Children, Bronchiectasis Adult
The Utility of Lung Clearance Index in Ethnic Groups and in Disease
Introduction: Non-CF, non-PCD bronchiectasis in children is a chronic, suppurative lung disease diagnosed by high resolution computed tomography (HRCT) imaging of the lungs.
- Conditions
- Healthy Children, Bronchiectasis Adult, Lung Clearance Index
- Trial name
- LUCI-ED (NCT05989360)
- Testing
- Lung Clearance Index
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Normal Values of Nasal Nitric Oxide in Healthy Adults
Determination of Normal Values of Nasal Nitric Oxide in Adults
Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterized by impaired airway mucociliary clearance leading to recurrent respiratory infections, bronchiectasis and eventually respiratory insufficiency.
- Trial name
- NCT02133547
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Healthy Participants, Non-cystic Fibrosis Bronchiectasis
A Phase 1a/1b Study to Investigate the Safety, Tolerability, Microbiological Response, and Pharmacokinetics of Inhaled Rev-56 in Adult Healthy Volunteers and Adult Non-cystic Fibrosis Bronchiectasis (NCFB) Patients With Chronic P. Aeruginosa
This is a Phase 1a/1b study to test the safety, tolerability, microbiological response, and pharmacokinetics of inhaled Rev-56 compared to placebo in adult healthy participants and non-cystic fibrosis bronchiectasis (NCFB)…
- Trial name
- NCT07709494
- Testing
- Rev-56 for Inhalation
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Revagenix, Inc.
COPD, Asthma (Diagnosis)
A Study to Evaluate the Diagnostic Performance of Portable Oscillometry Across Chronic Respiratory Diseases
This is a prospective, multicenter, observational cohort study enrolling approximately 4,000 subjects across about 50 centers, including patients with COPD (confirmed and suspected), asthma (confirmed and suspected)…
- Conditions
- COPD, Asthma (Diagnosis), Chronic Respiratory Diseases, Bronchiectasis
- Trial name
- NCT07631507
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Primary Ciliary Dyskinesia, Kartagener Syndrome
Physical Fitness, Exercise Capacity and Activities of Daily Living in Primary Ciliary Dyskinesia: a Retrospective Study
Decreased pulmonary function, peripheral muscle strength, and exercise capacity were reported in primary ciliary dyskinesia (PCD) in recent studies.
- Conditions
- Primary Ciliary Dyskinesia, Kartagener Syndrome, Immotile Cilia Syndrome
- Trial name
- NCT05040607
- Testing
- Data Collection
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hacettepe University