Clinical trials: Breathlessness
COPD Exacerbation, Respiratory Failure
Predictability of Echographic Excursion of the Diaphragm for Intubation in COPD- Patients With Acute Respiratory Failure in ED
The investigators seek to evaluate if the ultra-sound measure of the diaphragm expansion is predictive of admission into an ICU and/or intubation for patients with COPD.
- Trial name
- PREEDICT-ED (NCT04591509)
- Where
- 3 sites in France
- Volunteers
- 390 people
- Sponsor
- European Georges Pompidou Hospital
Malignancy
Does Transcranial Magnetic Stimulation of the Cingulate Cortex Modulate the Perception of Dyspnoea?
The treatment we are studying is Transcranial Magnetic Stimulation (TMS). In TMS, an electromagnetic pulse is passed into the brain through a coil placed on the head.
- Trial name
- TMS (NCT00830921)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Oxford
Chronic Obstructive Pulmonary Disease
Arm Training in Patients With Chronic Obstructive Pulmonary Disease
Patients with chronic lung disease often report shortness of breath when they use their arms for simple activities of daily living such as dressing, lifting, shaving, bathing and brushing their hair and teeth.
- Trial name
- NCT00657293
- Testing
- Arm training program
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- West Park Healthcare Centre
ARDS
MultiStem Administration for COVID-19 Induced ARDS (MACoVIA)
Multicenter investigation featuring an open-label lead-in followed by a double blinded, randomized, placebo-controlled Phase 2/3 part to evaluate the safety and efficacy of MultiStem therapy in subjects with moderate to severe…
- Trial name
- MACoVIA (NCT04367077)
- Testing
- MultiStem
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- Healios K.K.
Acute Decompensated Heart Failure
Low Level Tragus Stimulation in Acute Decompensated Heart Failure
Acute Decompensated Heart Failure (ADHF) is a major cause of morbidity and mortality. It is associated with increased systemic inflammation.
- Trial name
- TREAT-HF (NCT02898181)
- Testing
- Neuromodulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Meconium Aspiration Syndrome
Efficacy of Nebulised Inhalational Steroids in Neonates With Meconium Aspiration Syndrome
Meconium aspiration syndrome (MAS) is a major cause of respiratory distress in term and post-term neonates and is associated with significant neonatal morbidity.
- Trial name
- NCT07763119
- Testing
- Budesonide, Normal Saline
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Teaching Hospital
Dyspnea, Malignant Neoplasm
High-Flow Oxygen in Reducing Shortness of Breath Caused by Exercise in Patients With Cancer
This randomized phase II trial studies how well high-flow oxygen works in reducing difficulty breathing during exercise (exertional dyspnea) in patients with cancer.
- Trial name
- NCT02357134
- Testing
- Oxygen Therapy, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- M.D. Anderson Cancer Center
Long COVID, Long Covid19
Stellate Ganglion Block to Treat Long COVID 19 Case Series
An assessment of the effectiveness of Stellate Ganglion Block in alleviating symptoms of Long COVID-19.
- Conditions
- Long COVID, Long Covid19, Post-COVID-19 Syndrome, Post Acute COVID-19 Syndrome
- Trial name
- NCT05812209
- Testing
- Stellate Ganglion Block
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Metamorphosis LTD
Dyspnea, Pregnancy Related
Effectiveness of Volume Spirometry and Deep Breathing Exercise for Dyspnea During Third Trimester of Pregnancy
During pregnancy women undergoes anatomical, mechanical and physiological changes to meet the demand of growing fetus. Dyspnea is a common complaint in pregnancy related to change in respiratory centre threshold and sensitivity.
- Trial name
- NCT04994028
- Testing
- Conventional treatment, conventional treatment with volume Spirometry and deep breathing
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Riphah International University
Dyspnea, Acute Respiratory Failure
Value of Diaphragmatic Motion Measurement at Ultrasonography to Predict Poor Prognosis in Emergency Department Patients With Acute Respiratory Failure
Acute respiratory failure is one of the most common diagnosis in patients admitted in the Emergency Department. Acute respiratory failure is associated with morbidity and mortality.
- Trial name
- PREDIRE (NCT04119505)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Montpellier
Shortness of Breath
Effect of Senobi Versus Buteyko Technique on Functional Performance of Chronic Obstructive Pulmonary Disease Patient.
Effect of Senobi breathing exercise versus Buteyko breathing technique on functional performance among chronic obstructive pulmonary patient.
- Trial name
- NCT06196957
- Testing
- pursed lip breathing
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
COPD
Effect of Sleep Deprivation on Breathlessness and Exercise Capacity in COPD
This is a randomized controlled cross-over trial designed to measure the effect of one night's sleep deprivation on exercise endurance, ventilation and breathlessness in outpatients with COPD.
- Trial name
- NCT04997200
- Testing
- One night's sleeplessness
- Where
- 2 sites in Sweden
- Volunteers
- 20 people
- Sponsor
- Skane University Hospital
Amyotrophic Lateral Sclerosis, Dyspnea
The Reliability and Validity of Turkish Version of ''The Dyspnea-ALS-Scale (DALS-15)"
The Dyspnea-ALS-Scale (DALS-15) is a uni-dimensional scale to measure dyspnea in patients with Amyotrophic Lateral Sclerosis. It can be easily and rapidly applied.
- Trial name
- NCT04305639
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Istanbul Medeniyet University
Pediatric Acute Respiratory Distress Syndrome
Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT)
The goal of this clinical trial is to perform a PEEP titration protocol and use EIT to identify the optimal PEEP at which lung overdistention and collapse are most effectively balanced.
- Trial name
- NCT06684119
- Testing
- Electrical Impedance Tomography positive end-expiratory pressure titration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Los Angeles
Pulmonary Disease, Chronic Obstructive (COPD)
Additional Effects of Box Breathing Technique With Short Term Pulmonary Rehabilitation on Dyspnea and Functional Capacity in Patients With Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease is progressive and irreversible respiratory condition characterized by persistent airflow limitation leading to dyspnea and reduced functional capacity.
- Trial name
- NCT07518472
- Testing
- Short term Pulmonary Rehabilitation, Box breathing with short term pulmonary rehabilitation
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Foundation University Islamabad
Asthma
Effects of Aerobic Training With and Without Sniff Maneuver
This study was planned to assess effects of Aerobic training with and without Sniff maneuver on Dyspnea, Functional capacity and Quality of life among Asthma Patients.
- Trial name
- NCT07064057
- Testing
- Aerobic exercise combined with the sniff maneuver technique, Aerobic exercise
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Bronchiectasis Adult, Yoga
Effects of an Online Yoga Program on Exercise Capacity and Quality of Life in Bronchiectasis Patients
Bronchiectasis is a chronic lung disease characterized by persistent cough, sputum production, shortness of breath, and recurrent infections, which can reduce physical capacity and quality of life.
- Trial name
- YOGA-BR (NCT07540936)
- Testing
- Yoga Program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Istanbul Medipol University Hospital
Pulmonary Disease, Chronic Obstructive
Shortness Of Breath Questionnaire Validation Study
This study will last for approximately 8 weeks and will involve 4 visits. The study is being carried out to validate a shortness of breath questionnaire
- Trial name
- NCT00411372
- Testing
- fluticasone propionate/salmeterol 250/50mcg combination, salmeterol 50mcg
- Sponsor
- GlaxoSmithKline
Cystic Fibrosis Patients
Effects of Breathing Exercises Combined With Endurance and Strength Training in Patients With Cystic Fibrosis.
Cystic fibrosis (CF) is a multi-system inherited disease. It's a common autosomal recessive illness. It mostly affects the lungs, liver, and pancreatic exocrine glands, as well as the intestines.
- Trial name
- NCT05655637
- Testing
- Exercise
- Where
- Pakistan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Hypertrophic Cardiomyopathy
Effect of Eleclazine (GS-6615) on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy
The primary objective of this study was to evaluate the effect of eleclazine (GS-6615) on exercise capacity as measured by Peak oxygen uptake (VO2) achieved during cardiopulmonary exercise testing (CPET), in participants with…
- Trial name
- LIBERTY-HCM (NCT02291237)
- Testing
- Eleclazine
- Where
- 46 sites in United States, Australia and 6 more
- Volunteers
- 172 people
- Sponsor
- Gilead Sciences