Clinical trials: Breast-Conserving Surgery
Breast Cancer Female
Simulating Outcomes From Breast Conserving Surgery Using 3D Surface Imaging
Most women with breast cancer are able to have an operation to remove the cancer while preserving the breast (breast conserving therapy, BCT).
- Trial name
- NCT03250260
- Testing
- 3-dimensional photograph with simulation, Viewing of a 2-dimensional photographic library
- Where
- United Kingdom
- Volunteers
- 117 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Breast Neoplasms, Breast Cancer
Surgical Outcome of BCS Using ICG-F in Breast Cancer Patients After Preoperative Chemotherapy
Neoadjuvant chemotherapy for advanced breast cancer has led to an increased rate of breast-conserving surgery (BCS) in these patients.
- Trial name
- NCT06780735
- Testing
- The margin-positive rate using the localization technique
- Where
- South Korea
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Breast Cancer
PersonaLized neoAdjuvant Strategy ER Positive and HER2 Negative Breast Cancer TO Increase BCS Rate
In ER+ and HER2- breast cancer(BC) patients for whom BCS is not feasible, we investigate the rate of BCS can be increased while decreasing unnecessary chemotherapy thru selective neoadjuvant chemotherapy or neoadjuvant endocrine…
- Trial name
- NCT03900637
- Testing
- Leuprorelin acetate, Letrozole, MammaPrint
- Where
- South Korea
- Volunteers
- 122 people
- Sponsor
- Seoul National University Hospital
Breast Cancer, Breast Surgery
A Retrospective Analysis of Robot-Assisted Versus Endoscopic Breast-Conserving Surgery for Breast Cancer
Robotic surgical systems provide notable advantages including enhanced dexterity, a magnified three-dimensional high-definition view, and high-resolution imaging, thereby improving operative stability and precision.
- Trial name
- NCT07321145
- Testing
- Robotic breast-conserving surgery, Endoscopic breast-conserving surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Breast Cancer
"The Efficacy of 'Radioguided Occult Lesion Localization' (ROLL) Versus 'Wire-guided Localization' (WGL) in Breast Conserving Surgery for Non-palpable Breast Cancer: a Randomized Clinical Trial"
Rationale: Approximately 25% of breast cancers detected are non palpable. Accordingly, a localization technique is required to help the surgeon to find and remove the cancer.
- Trial name
- ROLL (NCT00539474)
- Testing
- Radio guided occult lesion localisation
- Where
- 4 sites in Netherlands
- Volunteers
- 316 people
- Sponsor
- UMC Utrecht
Breast Neoplasm Female, Lymphatic Metastasis
Omitting Biopsy of SEntinel Lymph Node With Radiation After Neoadjuvant Chemotherapy in Breast Cancer (OBSERB) Trial
The OBSERB study is a multi-center, non-blinded, pragmatic, parallel, randomized controlled trial in which patients with cT1-3N1 and ycN0 breast cancer.
- Trial name
- OBSERB (NCT04116125)
- Testing
- Radiotherapy
- Volunteers
- 1,380 people
- Sponsor
- Kyungpook National University Chilgok Hospital
Breast Cancer
High Five (HiFi) Accelerated Partial Breast Irradiation Study
To establish the role of adjuvant multicatheter interstitial high-dose-rate brachytherapy in doubly accelerated and radiobiologically equivalent irradiation scheme of 5 x 5,4 Gy in 3 days of treatment (High Five, HiFi-APBI)…
- Trial name
- HiFi (NCT05142202)
- Testing
- Breast Irradiation after Breast-Conserving Surgery
- Where
- Poland
- Volunteers
- 147 people
- Sponsor
- The Greater Poland Cancer Centre
Patient Reported Outcome, Oncological Safety
Patient Report Outcome and Oncological Safety -Oncoplastic and Conventional BCS Cohort
Breast-conserving surgery (BCS) is the traditional surgical treatment for early-stage breast cancer patients. There are evidences indicating that oncoplastic BCS could improve cosmetic outcomes and/or quality of life, and has…
- Conditions
- Patient Reported Outcome, Oncological Safety, Breast-conserving Surgery, Breast Cancer Female
- Trial name
- NCT05054777
- Testing
- oncoplastic breast-conserving surgery, conventional breast-conserving surgery
- Volunteers
- 5,000 people
- Sponsor
- Shandong Cancer Hospital and Institute
Breast Cancers
Partial Breast Re-irradiation for Breast Cancer
Breast cancer is the most common malignancy in women. Breast-conserving surgery (BCS) with adjuvant whole-breast irradiation (WBI) is currently the standard of care in the oncological treatment of primary breast cancer and offers…
- Trial name
- BREAST (NCT06954623)
- Testing
- Radiation Therapy
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg
Breast Reconstruction
Immediate Breast Reconstruction With Free Greater Omentum
Luminal subtype breast cancer, accounting for 70 to 80% of all breast cancers, has been reported to be associated with good prognosis.
- Trial name
- NCT03370250
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xijing Hospital
Breast Cancer
RAPID: Randomized Trial of Accelerated Partial Breast Irradiation
To determine if Accelerated Partial Breast Irradiation, using 3D CRT, is as effective as Whole Breast Irradiation following breast conserving surgery in women with an new histological diagnosis of ductal carcinoma in situ only or…
- Trial name
- NCT00282035
- Testing
- APBI utilizing 3D-CRT radiation, Whole breast irradiation
- Where
- 33 sites in Australia, Canada and 1 more
- Volunteers
- 2,135 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Breast Cancer
Observation of the Effect of Preoperative Use of Dexmedetomidine Hydrochloride Nasal Spray on Optimizing Awake Sedation During Breast-Conserving Surgery for Breast Cancer and Postoperative Awake Status
This clinical trial aims to evaluate the efficacy and safety of Dexmedetomidine Hydrochloride Nasal Spray for conscious sedation and anxiety relief during breast-conserving surgery.
- Trial name
- NCT07350928
- Testing
- Induction of anesthesia with dexmedetomidine nasal spray prior to surgery
- Where
- China
- Volunteers
- 394 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Early-Stage Breast Cancer
PBI for Low-risk Breast Cancer
This non-inferiority, phase 3 clinical trial evaluates the cosmetic non-inferiority of a one-week regimen (26 Gy/5 Fx) versus a three-week regimen (40 Gy/15 Fx) using intensity-modulated radiation therapy (IMRT) for partial…
- Trial name
- NCT07814365
- Testing
- 3-week PBI, 1-week PBI
- Where
- China
- Sponsor
- Fudan University
Breast Conserving Surgery, Mastectomy With Reconstruction
A Study of the BREAST-Q REACT Tool for People Having Breast Surgery
The researchers are doing this study to find out whether it is practical (feasible) to conduct a larger study looking at the effects of the BREAST-Q Real-time Engagement and Communication Tool (REACT) on people's quality of life…
- Trial name
- NCT06550401
- Testing
- BREAST-Q Physical Well-Being, QuickDASH
- Where
- 6 sites in United States
- Volunteers
- 69 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Comparison of Axillary Sentinel Lymph Node Biopsy Versus no Axillary Surgery
Although there is no doubt that the presence of lymph node metastases worsens prognosis of a patient, unambiguous evidence to support lymph node dissection is still lacking.
- Trial name
- INSEMA (NCT02466737)
- Testing
- no axillary surgery versus SLNB, SLNB versus completion ALND
- Where
- 150 sites in Austria, Germany
- Volunteers
- 5,505 people
- Sponsor
- University of Rostock
Early-Stage Breast Carcinoma
Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation in Early Breast Cancer
Hypofractionation with simultaneous integrated boost has been investigated in a few trials and appears to be safe and feasible. Investigators initiated this multicenter two-armed phase III prospective trial to analyse the…
- Trial name
- HYPOSIB (NCT02474641)
- Testing
- Standard Radiation, Hypofractionation with SIB
- Where
- 88 sites in Germany
- Volunteers
- 2,324 people
- Sponsor
- University Hospital Schleswig-Holstein
Breast Cancer, Breast Lymphedema
Efficacy of Kinesio Taping Versus Compression Therapy on Breast Lymphedema Induced by Radiotherapy After Breast-Conserving Surgery
Breast cancer patients often develop breast lymphedema after breast-conserving surgery and radiotherapy, causing swelling, pain, and heaviness that affect quality of life.
- Trial name
- NCT07767305
- Testing
- Routine Care, Kinesio Taping, Compression Therapy
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Tangshan People's Hospital
Breast Cancer
Does Intra-operative MarginProbe Use Reduce Re-excision Rates?
The new device we are looking at is called the MarginProbe. It is a disposable probe which measures the margins of tissue removed to check they are clear of cancer cells, during breast conservation surgery.
- Trial name
- MarginProbe (NCT02774785)
- Testing
- MarginProbe
- Where
- United Kingdom
- Volunteers
- 127 people
- Sponsor
- Manchester University NHS Foundation Trust
Breast Cancer
APBI Versus EBRT Therapy After Breast Conserving Surgery for Low-risk Breast Cancer
To assess the role of interstitial brachytherapy alone compared to whole breast irradiation in a defined low-risk group of invasive breast cancer or ductal carcinoma in situ concerning local failure (all ipsilateral local…
- Trial name
- NCT00402519
- Testing
- Accelerated partial breast irradiation, External beam whole breast irradiation
- Where
- 11 sites in Austria, Germany and 3 more
- Volunteers
- 1,300 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Breast Cancer
Toxicity Outcomes of Simultaneous Integrated Boost in Adjuvant Breast Radiotherapy Acronym
This prospective study systematically evaluates toxicity outcomes in breast cancer patients treated with adjuvant radiotherapy using the simultaneous integrated boost (SIB) technique after breast-conserving surgery.
- Trial name
- SIB (NCT07407192)
- Testing
- Adjuvant Breast Radiotherapy With Simultaneous Integrated Boost (SIB)
- Where
- Slovenia
- Volunteers
- 93 people
- Sponsor
- Institute of Oncology Ljubljana