Clinical trials: Breast Lesions
Breast Neoplasms
Comparison of Stationary Breast Tomosynthesis and 2-D Digital Mammography in Patients With Known Breast Lesions
The goal of the study is to compare the radiologist confidence level in evaluating patients with known breast lesions using a carbon nanotube x-ray based stationary breast tomosynthesis imaging device.
- Trial name
- NCT01773850
- Testing
- Stationary Carbon Nanotube X-ray Digital Breast Tomosynthesis Scanner
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Clinical Effectiveness of CEM in Diagnosis of Additional Findings at Preoperative Breast Magnetic Resonance Imaging
In order to explain the value of adding CESM into the clinical pathway, and also to obtain the relevant clinical data to support future update of clinical guideline, we plan to evaluate the detection rate of CESM for additional…
- Trial name
- COMBO-I (NCT06475066)
- Testing
- contrast-enhanced spectral mammography
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Breast Neoplasms
ShearWave™ Elastography of Breast Lesions in Chinese Patients
We aim to determine if adding ShearWave Elastography to a standard ultrasound breast exam can improve the characterization (classification) of breast lesions.
- Trial name
- BE3 (NCT02226081)
- Where
- 22 sites in China
- Volunteers
- 2,273 people
- Sponsor
- SuperSonic Imagine
Breast Cancer, Ductal Carcinoma
Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer
The goal of this research study is to evaluate the efficacy and safety of low-dose exemestane versus low-dose tamoxifen in post-menopausal women at high risk for breast cancer.
- Conditions
- Breast Cancer, Ductal Carcinoma, Estrogen-receptor-positive Breast Cancer, Atypical Lobular Hyperplasia
- Trial name
- BabyTEARS (NCT07499999)
- Testing
- Exemestane, Tamoxifen
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Dana-Farber Cancer Institute
Metastatic Breast Cancer
Molecular Imaging of Fulvestrant Effects on Availability of ER Binding Sites
The dose of fulvestrant to optimally downregulate estrogen receptors (ER) is currently subject of debate. Effects of fulvestrant on the ERs may be evaluable by molecular imaging using positron emission tomography with the…
- Trial name
- NCT01377324
- Testing
- Diagnostic intervention: Positron Emission Tomography with 16-alpha-[18-fluoro]-17betaestradiol
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- University Medical Center Groningen
Breast Disease
Multimodal Ultrasound Diagnosis Characteristics of Bi-rads Class 4 Breast Lesions
Objective: To explore the potential association between the multimodal ultrasound characteristics and pathological classification of BI-RADS category 4 breast lesions, so as to clarify the diagnostic characteristics of multimodal…
- Trial name
- NCT06025461
- Testing
- no intervention
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Ma Zhe
Breast LN
Comparative Evaluation of Diffusion Weighted MRI And Ultrasonography In The Detection of Breast Lesions
This study aims to conduct a comparative evaluation of Diffusion Weighted MRI (DW-MRI) and Ultrasonography (US) in detecting breast lesions.
- Trial name
- NCT06744101
- Testing
- Evaluate the effectiveness of Diffusion Weighted MRI (DWI) in detecting breast lesions., Compare Sensitivity and Specificity of DWI and USG
- Where
- Pakistan
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Superior University
Breast Neoplasms
Magnetic Occult Lesion Localization and Imaging (MOLLI)
The proposed trial is a non-randomized, single-arm study examining the technical feasibility and safety of magnetic occult lesion localization and imaging (MOLLI) for Breast Conserving Surgery (BCS), in patients with non-palpable…
- Trial name
- MOLLI (NCT03660137)
- Testing
- MOLLI Localization
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre
Breast Fibroadenoma, Atypical Ductal Hyperplasia
Comparing Vacuum-Assisted Percutaneous Excision to Open Surgical Excision for Borderline or High-Risk Breast Lesions
This randomized controlled trial compares vacuum-assisted percutaneous excision to open standard surgical excision in women who have high-risk or borderline, non-malignant breast lesions with respect to efficacy, safety, cosmesis…
- Conditions
- Breast Fibroadenoma, Atypical Ductal Hyperplasia, Atypical Lobular Hyperplasia, Lobular Carcinoma in Situ
- Trial name
- VAPEX (NCT03868475)
- Testing
- Vacuum-assisted percutaneous excision, Open surgical excision
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Non-palpable Breast Lesions
Evaluation of RFID Localization System for Marking and Retrieving Breast Lesions
The goal of this investigation is to obtain clinical data to show the Health Beacons Radiofrequency Identification (RFID) Localization System is safe and performs as intended as a localization device for marking and retrieving a…
- Trial name
- NCT01574664
- Testing
- RFID Tag (Health Beacon)
- Where
- 3 sites in United States
- Sponsor
- Health Beacons
Breast Carcinoma, Breast Carcinoma Metastatic in Lymph Node
Magseed and Magtrace Localization for Breast Cancer
The aim of this study is to compare the efficacy of the Sentimag localization system and its tracer Magtrace, superparamagnetic iron oxide nanoparticles, as a tracer in sentinel node biopsy in breast cancer with Tc99 in a…
- Trial name
- NCT05161507
- Testing
- Magseed, Magtrace, Axillary lymph node metastasis - needle biopsy
- Where
- Czechia
- Volunteers
- 70 people
- Sponsor
- University Hospital Ostrava
Breast Disease, Phyllodes Breast Tumor
Cryotherapy in Breast B3 Lesions
To determine the feasibility of cryotherapy for B3 fibroepithelial lesions
- Trial name
- NCT04571307
- Testing
- cryotherapy
- Where
- Singapore
- Volunteers
- 12 people
- Sponsor
- KK Women's and Children's Hospital
Breast Neoplasm Female
Breast Localization: RFID Tags vs Wire Localization
The RFID trial focuses on breast localization in patients with non-palpable breast cancers. It aims to demonstrate the improvement in patient comfort when using the Radio Frequency Identification (RFID) tag and LOCalizer™ device…
- Trial name
- RFID (NCT04750889)
- Testing
- RFID tags, Wire localization
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Jean Perrin
HER2-positive Breast Cancer
Basket Study for Oligo-metastatic Breast Cancer
The study will include patients with HER2-positive breast cancer and 1- 3 distant metastatic lesions, all amenable for curative intervention. Patients will be stratified by prior therapy and ER expression.
- Trial name
- ANISE (NCT05982678)
- Testing
- Trastuzumab deruxtecan
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer
Added Value of Preoperative Contrast Enhanced Mammography in Staging of Malignant Breast Lesions
Patients diagnosed with breast cancer after routine assessment with digital mammography and ultrasound and scheduled for primary surgery are included in the trial.
- Trial name
- PROCEM (NCT04437602)
- Testing
- Contrast Enhanced Mammography (CEM)
- Where
- 3 sites in Sweden
- Volunteers
- 441 people
- Sponsor
- Region Halland
Benign Breast Neoplasm, Ductal Breast Carcinoma In Situ
Study of Docosahexaenoic Acid (DHA) in Triple Negative Breast Cancer Survivors
This randomized phase II trial studies how well docosahexaenoic acid works in preventing recurrence in breast cancer survivors. Docosahexaenoic acid supplement may prevent recurrence in breast cancer survivors.
- Conditions
- Benign Breast Neoplasm, Ductal Breast Carcinoma In Situ, Invasive Breast Carcinoma, Lobular Breast Carcinoma In Situ
- Trial name
- NCT01849250
- Testing
- Docosahexaenoic Acid
- Where
- 4 sites in United States
- Volunteers
- 65 people
- Sponsor
- National Cancer Institute (NCI)
Breast Diseases, Breast Cancer
Effectiveness and Safety of Preoperative Magnetic Detection of Non-palpable Breast Lesions
Breast cancer is the most common cancer in women and also has the highest death rate. In 2018, 58,500 new cases were diagnosed in metropolitan France. It affects, in 8 out of 10 cases, women aged 50 and over.
- Trial name
- MAGREES (NCT05327218)
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Breast Cancer Female, Diagnoses Disease
Ultrasound-based Diagnostic Model for Differentiating Malignant Breast Lesion From Benign Lesion
This study proposed to construct an ultrasound-based diagnostic model for Differentiating Malignant Breast Lesion From Benign Lesion.
- Trial name
- NCT03080623
- Where
- 4 sites in China
- Volunteers
- 1,981 people
- Sponsor
- Peking University
Breast Diseases
Diagnostic Performance of Shear Wave Dispersive Imaging in Breast Lesions: Comparison With Shear Wave Elastography
Human soft tissue such as breast tissue has viscoelasticity property. However, most ultrasound has only been measured for elasticity and viscosity has been neglected.
- Trial name
- NCT06191926
- Testing
- ultrasound
- Where
- South Korea
- Volunteers
- 594 people
- Sponsor
- Korea University Ansan Hospital
DCIS, Breast Cancer
Delayed Sentinel Lymph Node Biopsy in Ductal Cancer in Situ
The trial aims to investigate the use of superparamagnetic iron oxide (SPIO) nanoparticles as a tracer for delayed sentinel lymph node dissection (d-SLND) in patients where upfront axillary surgery (SLND) is oncologically deemed…
- Conditions
- DCIS, Breast Cancer, Breast Neoplasms, Sentinel Lymph Node
- Trial name
- SENTINOT_2 (NCT04722692)
- Testing
- Delayed SLND, Late SLND
- Where
- 9 sites in United States, Hong Kong and 1 more
- Volunteers
- 500 people
- Sponsor
- Uppsala University