Clinical trials: Brain Trauma
Brain Injuries, Intracranial Hypertension
Development and Evaluation of the ICP Waveform Tracing Capabilities and Safety of HS-1000 Device
Invasive intracranial pressure (ICP) monitoring, using modalities such as parenchymal pressure transducer or external ventricular drain (EVD), provides an ICP waveform that encapsulates valuable diagnostic and monitoring clinical…
- Trial name
- NCT02772471
- Testing
- HS-1000
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- HeadSense Medical
AI (Artificial Intelligence), Mammary Cancer
Experiment on the Use of Innovative Computer Vision Technologies for Analysis of Medical Images in the Moscow Healthcare System
It is planned to integrate various services based on computer vision technologies for analysis of the certain type of x-ray study into Moscow Unified Radiological Information Service (hereinafter referred to as URIS).
- Conditions
- AI (Artificial Intelligence), Mammary Cancer, Lung Cancer, X-Rays; Lesion
- Trial name
- NCT04489992
- Where
- Russia
- Volunteers
- 133,000 people, healthy volunteers welcome
- Sponsor
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Bronchopulmonary Dysplasia, Encephalomalacia
Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants
The purpose of this study is to determine whether treatment of very preterm infants at high-risk for lung and brain injury with low dose hydrocortisone results in improved pulmonary and neurologic outcomes.
- Conditions
- Bronchopulmonary Dysplasia, Encephalomalacia, Premature Birth
- Trial name
- NCT00167544
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Nationwide Children's Hospital
Concussion, Mild, Convergence Insufficiency
Spectacles Lens in Concussed Kids
We will be looking at 3 treatment arms in the form of different type of glasses to see if one is superior to helping kids have sustained a concussion and are symptomatic.
- Conditions
- Concussion, Mild, Convergence Insufficiency, Accommodation; Insufficiency
- Trial name
- SLICK (NCT03123822)
- Testing
- Glasses
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Concussion Post Syndrome
The Effect of Binasal Occlusion on Balance Following a Concussion
This study evaluates the effect of binasal occlusion (BNO) glasses on balance and eye movement in adults with dizziness after a concussion.
- Trial name
- NCT03355339
- Testing
- Binasal occlusion, No binasal occlusion
- Volunteers
- 40 people
- Sponsor
- University of Ottawa
Brain Injuries
Behavioral Trial Studying Programmed Training to Improve Advocacy Skills for Individuals With Traumatic Brain Injury
The Midwest Advocacy Project (MAP) is a community-based multiple-site randomized practical behavioral trial of advocacy skill training for individuals with traumatic brain injury (TBI), their families, and significant others.
- Trial name
- MAP (NCT01002677)
- Testing
- Advocacy training curriculum, Self-directed
- Where
- 3 sites in United States
- Volunteers
- 234 people
- Sponsor
- Mayo Clinic
TBI (Traumatic Brain Injury)
Evaluation of Military Service and Family Members for Post Concussive and Posttraumatic Stress Symptoms
This protocol is designed to facilitate the recruitment, screening and registry of Military Service Members (SMs) and individuals eligible for care in the Department of Defense (DoD) healthcare system.
- Trial name
- MRP (NCT03191357)
- Testing
- n/a observational
- Where
- United States
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Concussion, Mild, Concussion; Eye
EYE-SYNC Concussion Classification Study
The purpose of this study is to determine the sensitivity and specificity of an aid in assessment of concussion based on eye-tracking, in comparison to a clinical reference standard appropriate for sport-related concussion…
- Conditions
- Concussion, Mild, Concussion; Eye, Concussion, Brain, Concussion, Severe
- Trial name
- NCT04381767
- Testing
- EYE-SYNC
- Where
- United States
- Volunteers
- 1,303 people
- Sponsor
- Sync-Think, Inc.
Mild Traumatic Brain Injury, Concussion, Post Concussive Syndrome, Chronic
Effect of Mental Imagery in Patients With Persistent Post-concussion Symptoms
Background: Mild Traumatic Brain Injury (mTBI) often results in persistent emotional, cognitive, and somatic symptoms-such as headaches and dizziness.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Post Concussive Syndrome, Chronic, Post Traumatic Headache
- Trial name
- NCT07166536
- Testing
- Provocation Test for Symptoms Using Mental Imagery
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Reuth Rehabilitation Hospital
Post-traumatic Stress Disorder
Brain Markers of Treatment Response in Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to examine if treatment of post-traumatic stress disorder in combat veterans with paroxetine changes brain responses as measured by functional magnetic resonance imaging and if brain responses can…
- Trial name
- NCT00700999
- Testing
- Paroxetine
- Where
- 3 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Brain Injury
Genotype Influence on Recovery After Traumatic Brain Injury
Genetic differences in response to brain injury may reasonably be expected to play a role in the initial consequences of traumatic brain injury and in the rate of recovery from such injury.
- Trial name
- NCT00018499
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Traumatic Brain Injury
A Health & Wellness Intervention for Individuals With Traumatic Brain Injury (TBI)
The primary goal of the proposed study is to evaluate the efficacy of a replicable community-based group intervention, designed to address both general wellness and specific TBI health-related issues.
- Trial name
- NCT01334398
- Testing
- Health & Wellness
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- VA Eastern Colorado Health Care System
Chronic Subdural Hematomas
PHIL™ Middle Meningeal Artery Embolization for First-Line Treatment of Chronic Subdural Hematoma IDE Trial
This is a prospective, randomized, controlled, open-label, blinded endpoint (PROBE) clinical investigation in which patients with non-emergent chronic subdural hematoma (cSDH) requiring treatment will be randomized (1:1) to…
- Trial name
- PHILFIRST (NCT07576998)
- Testing
- PHIL™ (Precipitating Hydrophobic Injectable Liquid), Surgical evacuation
- Volunteers
- 475 people
- Sponsor
- Microvention-Terumo, Inc.
Spinal Cord Injuries
Investigation of Brain Functional MRI as an Early Biomarker of Recovery in Individuals With Spinal Cord Injury
Early detection of response to therapeutic intervention is vital, as it will enable early termination of intervention in non-responding patients, prevent unnecessary financial burden, and allow for early changes to the…
- Trial name
- NCT03854214
- Testing
- Functional Electric Stimulation cycling, Passive cycling
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Brain Injuries, Traumatic, Confusional State
Multisensory Stimulation and Enriched Environments During Post-traumatic Amnesia
The objective of this Phase II trial is to evaluate the feasibility of this study protocol to progress to a large-scale Phase III RCT in the future.
- Conditions
- Brain Injuries, Traumatic, Confusional State, Sensory Motor System Disorder, Alteration of Cognitive Function
- Trial name
- NCT02792985
- Testing
- Multisensory stimulation protocol, Control protocol
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Institut Guttmann
Perinatal Hypoxia
Serum Erythropoietin Level in Perinatal Asphyxia
This study is to evaluate brain and kidney injuries in full-term neonates with perinatal asphyxia by detecting specific biomarker in blood (Erythropoietin).
- Trial name
- NCT05018364
- Testing
- Serum erythropoietin level
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
TBI (Traumatic Brain Injury)
Clinical Significance of circMETTL9 Gene in Traumatic Brain Injury
Objective: The relevance of circMETTL9 to the degree of injury, disturbance of consciousness, cognitive function and prognosis in patients with moderate to severe traumatic brain injury (TBI) remains unknown.
- Trial name
- NCT05484921
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nantong University
Upper Extremity Spasticity, Stroke
Efficacy of Functional Electrical Stimulation (FES) in Persons Receiving Botulinum Neurotoxin for Upper Extremity Spasticity
FES is a form of treatment with a device to aid movement in people who have had damage to their brain or spinal cord. Small electrical impulses are used to excite/stimulate the nerves that supply paralyzed muscles.
- Conditions
- Upper Extremity Spasticity, Stroke, Acquired Brain Injury
- Trial name
- Botox + FES (NCT00462449)
- Testing
- Functional Electrical Stimulation (FES) through the Ness H200
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pittsburgh
Photophobia, Traumatic Brain Injury
Objectively Diagnose and Monitor Treatment of Light Sensitivity
The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and…
- Conditions
- Photophobia, Traumatic Brain Injury, Migraine
- Trial name
- NCT03694626
- Testing
- Pupillography, Ocular Coherence Tomography (OCT), Wrist-watch sensor device
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Congenital Heart Defects, Hypoplastic Left Heart Syndrome
Cerebral Perfusion During Neonatal Cardiac Surgery
Neonates with a congenital heart defect are often in need of early cardiac surgery. In complex congenital heart defects, cardiopulmonary bypass is usually employed, with or without deep hypothermic circulatory arrest (DHCA).
- Conditions
- Congenital Heart Defects, Hypoplastic Left Heart Syndrome, Aortic Coarctation
- Trial name
- NCT01032876
- Testing
- Deep Hypothermic Circulatory Arrest, Antegrade Cerebral Perfusion
- Where
- Netherlands
- Volunteers
- 37 people
- Sponsor
- UMC Utrecht
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