Clinical trials: Brain MRI
Behavioral Flexibility, Healthy Volunteers
Flexibility, Alcohol Misuse, and Excitation
The goal of this study is to learn whether a single non-invasive brain stimulation alpha-transcranial alternating current stimulation (alpha-tACS) session changes measures of excitability in the prefrontal cortex.
- Conditions
- Behavioral Flexibility, Healthy Volunteers, High Risk Alcohol Use
- Trial name
- FLAME (NCT06634771)
- Testing
- 10 Hz transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Multiple Sclerosis
Phase IV Study, Betaseron Versus Copaxone for Relapsing Remitting or CIS Forms of MS Using Triple Dose Gad 3 T MRI
This is the first comparison of efficacy of Betaseron and Copaxone for treatment of relapsing forms of MS.
- Trial name
- BECOME (NCT00176592)
- Testing
- Betaseron, Copaxone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Parkinson Disease
Convection Enhanced Delivery of CSF in DBS for Parkinson's
This study will evaluate safety foremost but also the distribution and initial effectiveness of infusion-enhanced, MRI-guided DBS for patients with medication-refractory, Parkinson's disease
- Trial name
- NCT03540134
- Testing
- Intracerebral Infusion of Autologous Cerebral Spinal Fluid
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Jeff Elias, MD
HIV Associated Neurocognitive Disorder
Study of Paroxetine and Fluconazole for the Treatment of HIV Associated Neurocognitive Disorder
The purpose of this study is to see if paroxetine and fluconazole are safe and effective as a treatment for problems with memory, concentration, thinking, and judgment in people who are infected with HIV.
- Trial name
- ParaFlu (NCT01354314)
- Testing
- Fluconazole, Paroxetine, Paroxetine and Fluconazole
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Johns Hopkins University
Contrast Enhancement in Magnetic Resonance Imaging, Central Nervous System Pathology
A Study to Compare How Well Gadoquatrane Works and Its Safety With an Already Available Contrast Agent for MRI in People With Known or Suspected Brain or Spinal Cord-related Problems
Researchers are looking for a better way to help people with known or suspected brain or spinal cord-related problems scheduled for a "contrast-enhanced" Magnetic Resonance Imaging (MRI).
- Trial name
- Quanti CNS (NCT05915702)
- Testing
- Gadoquatrane (BAY1747846), Gadobutrol, Gadoterate meglumine
- Where
- 78 sites in United States, Argentina and 13 more
- Volunteers
- 321 people
- Sponsor
- Bayer
Metastatic Malignant Neoplasm in the Brain, Primary Brain Neoplasm
Ferumoxytol- and Gadolinium-Labeled MRI in Measuring Tumors Before or After Treatment in Patients With Primary or Metastatic Brain Tumors
This phase II trial studies how well magnetic resonance imaging (MRI) using contrast imaging agent ferumoxytol works in comparison to standard imaging agent gadolinium in measuring tumors in patients undergoing treatment for…
- Trial name
- NCT00659126
- Testing
- 3 Tesla Magnetic Resonance Imaging, Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- OHSU Knight Cancer Institute
Spinal Cord Injuries
Investigation of Brain Functional MRI as an Early Biomarker of Recovery in Individuals With Spinal Cord Injury
Early detection of response to therapeutic intervention is vital, as it will enable early termination of intervention in non-responding patients, prevent unnecessary financial burden, and allow for early changes to the…
- Trial name
- NCT03854214
- Testing
- Functional Electric Stimulation cycling, Passive cycling
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Cough
Functional Magnetic Resonance Imaging of ATP Cough in Chronic Cough Patients
Persistent cough is a distressing symptom for people with respiratory disorders. Patients also often experience an ongoing urge-to-cough that prompts coughing, and which fails to resolve the sensation.
- Trial name
- NCT03722849
- Testing
- Adenosine Triphosphate, Capsaicin, Functional Brain Imaging
- Where
- Australia
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Stuart Mazzone
Stroke, Hemiparesis
Perinatal Stroke: Understanding Brain Reorganization
The incidence of perinatal stroke is relatively common, as high as 1 in 2,300 births, but little is known about the resulting changes in the brain that eventually manifest as cerebral palsy (CP).
- Trial name
- NCT02743728
- Testing
- Magnetic Resonance Imaging, Transcranial Magnetic Stimulation, General Movement Assessment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
Bipolar Disorder, Bipolar Depression
PET and MRI Brain Imaging of Bipolar Disorder
The primary aims of this study are to: 1. Quantify serotonin transporter (5-HTT) binding potential (BP) in vivo in bipolar disorder patients (BPD) during a major depressive episode (MDE). 2.
- Conditions
- Bipolar Disorder, Bipolar Depression, Unipolar Depression
- Trial name
- NCT01880957
- Testing
- Lithium, Lamotrigine
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Clinical Indication for Brain MRI
Comparative Study of Conventional 1.5 and 3.0T MR Images With Synthetically Reconstructed MR Images
This study is being conducted for regulatory submission of the GE Healthcare MAGnetic resonance Image Compilation (MAGiC), a point-of-care synthetic MR reconstruction software for GE 1.5T and 3.0T MR scanners.
- Trial name
- NCT02596854
- Testing
- Neurological MRI
- Where
- 6 sites in United States
- Volunteers
- 117 people
- Sponsor
- GE Healthcare
Cerebral Amyloid Angiopathy
Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy
Cerebral Amyloid Angiopathy (CAA) is a condition caused by the build-up of a protein called amyloid, predominantly Aβ40, within the walls of brain blood vessels, especially those blood vessels in the occipital lobe of the brain.
- Trial name
- NCT01821118
- Testing
- Ponezumab
- Where
- 13 sites in United States, Canada and 3 more
- Volunteers
- 36 people
- Sponsor
- Pfizer
Obsessive-Compulsive Disorder, Tic Disorders
Effects of Ondansetron in Obsessive-compulsive and Tic Disorders
This project investigates the use of 4 weeks of 24 mg/day ondansetron as compared to placebo on symptoms and brain functioning in patients with obsessive-compulsive disorder (OCD) and tic disorders (TD).
- Conditions
- Obsessive-Compulsive Disorder, Tic Disorders, Tourette Syndrome
- Trial name
- NCT03239210
- Testing
- Ondansetron
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- NYU Langone Health
Central Nervous System Pathology
Study to Find the Appropriate Dose of a New Gadolinium-based Contrast Agent (GBCA) for Adults Undergoing Magnetic Resonance Imaging (MRI) for Known or Highly Suspected Brain and/or Spinal Cord Conditions
Researchers in this study want to find the appropriate dose of drug BAY1747846 for adults undergoing MRI for known or highly suspected brain and/or spinal cord conditions so that the image quality is similar to that of drug…
- Trial name
- NCT04307186
- Testing
- Gadoquatrane (BAY1747846), Gadobutrol (Gadovist/Gadavist)
- Where
- 17 sites in United States, Bulgaria and 2 more
- Volunteers
- 57 people
- Sponsor
- Bayer
Solid Tumors, ER/PR Positive Breast Cancer
MM-398 (Nanoliposomal Irinotecan, Nal-IRI) to Determine Tumor Drug Levels and to Evaluate the Feasibility of Ferumoxytol Magnetic Resonance Imaging to Measure Tumor Associated Macrophages and to Predict Patient Response to Treatment
This is a Phase I study to understand the biodistribution of MM-398 and to determine the feasibility of using Ferumoxytol as a tumor imaging agent.
- Conditions
- Solid Tumors, ER/PR Positive Breast Cancer, Triple Negative Breast Cancer, Metastatic Breast Cancer With Active Brain Metastasis
- Trial name
- NCT01770353
- Testing
- Ferumoxytol, MM-398
- Where
- 7 sites in United States
- Volunteers
- 45 people
- Sponsor
- Ipsen
Brain Tumor, Primary, Brain Tumor, Recurrent
Performance of Elucirem in DSC-MRI Perfusion of Brain Gliomas
This trial aimed to study the performance of Elucirem (gadopiclenol) in Dynamic Susceptibility Contrast Magnetic Resonance Imaging (DSC-MRI) perfusion of brain gliomas.
- Trial name
- GDX-44-016 (NCT06057168)
- Testing
- Elucirem, Dotarem
- Where
- 11 sites in Hungary, Italy and 1 more
- Volunteers
- 138 people
- Sponsor
- Guerbet
Stroke
Novel Brain Signal Feedback Paradigm to Enhance Motor Learning After Stroke
Stroke (795,000/year in the US and 30 million existing stroke survivors in the world) damages brain neural structures that control coordinated upper limb movement.
- Trial name
- NCT02856035
- Testing
- Neural feedback plus FES and motor training
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Diffuse Intrinsic Pontine Glioma
A Phase II Study of Pegylated Interferon Alfa 2b (PEG-Intron(Trademark)) in Children With Diffuse Pontine Gliomas
Diffuse pontine gliomas are tumors on the pons portion of the brainstem. Their peak incidence is in children between 5 and 10 years old. Their location makes surgical resection impossible.
- Trial name
- NCT00036569
- Testing
- adjuvant therapy, pegylated interferon alfa
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- National Cancer Institute (NCI)
Parkinson Disease
N-Acetylcysteine for Neuroprotection in Parkinson's Disease
The overall objective of this developmental/exploratory study is to use noninvasive proton magnetic resonance spectroscopy (1H MRS) to assess (a) whether brain levels of the antioxidant glutathione (GSH) are decreased in vivo, as…
- Trial name
- NAC for PD (NCT01470027)
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Perinatal Hypoxia, Dopamine
Measuring Brain Activity of School Age Children
This observational study will investigate whether differences in birth events and oxygen levels during the newborn period affects the brain activity of children during the middle childhood years.
- Conditions
- Perinatal Hypoxia, Dopamine, Neurobehavioral Manifestations
- Trial name
- NCT03407729
- Testing
- Magnetic Resonance Imaging, Cognitive Performance Testing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University