Clinical trials: Brain Injury, Chronic
Cerebral Palsy (CP)
Effects of Barefoot vs. Shod Whole Body Vibration Training in Children With Cerebral Palsy
Cerebral palsy (CP) refers to a group of lifelong conditions that affect the development of movement and coordination that lead to activity limitations due to damage to the developing fetal or neonatal brain tissue.
- Trial name
- NCT06596525
- Testing
- Conventional physical therapy, Barefoot Whole Body Vibration Training (WBVTb), Shod Whole Body Vibration Training (WBVTs)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Trakya University
Cerebral Palsy, Hip Surgery Corrective
Tranexamic Acid to Reduce Blood Loss After Varus Derotation Osteotomy
TABLO (Tranexamic Acid to reduce Blood Loss after varus derotation Osteotomy) is a clinical trial of postoperative tranexamic acid vs placebo in non-ambulatory children with cerebral palsy (CP) undergoing reconstructive hip…
- Conditions
- Cerebral Palsy, Hip Surgery Corrective, Tranexamic Acid Use, Blood Loss, Surgical
- Trial name
- TABLO (NCT07672158)
- Testing
- Tranexamic Acid (IV)
- Where
- Australia
- Volunteers
- 52 people
- Sponsor
- Murdoch Childrens Research Institute
Cervical Spinal Cord Plasticity
Cervical Spinal Cord Associative Plasticity
Associative plasticity has been used to promote functional recovery from conditions affecting movement. Prior work from the Carmel laboratory has shown that paired associative stimulation protocols timed to converge in the…
- Trial name
- NCT07539025
- Testing
- SCAP, MagPro X100, Digitimer DS8R
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cerebral Palsy
Functional Strength Training and Virtual Reality in Children With CP
Virtual reality (VR) has shown to be effective to improve arm function in children with cerebral palsy (CP). Recently, functional strength training (FST) starts to show to improve arm function in patients with stroke but has not…
- Trial name
- NCT04147468
- Testing
- Virtual Reality, Functional Strength Training
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Georgia State University
Cerebral Palsy
Effect of Whole Body Vibration With Weighted Vest on Motor Function in Children With Spastic Diplegia
Whole body vibration has been widely used in rehabilitation of individuals with disabilities as well as children with cerebral palsy.
- Trial name
- NCT05606926
- Testing
- physical therapy program, whole body vibration (without extra weight vest), whole body vibration (with weight vest)
- Volunteers
- 30 people
- Sponsor
- Cairo University
Cerebral Palsy
Effect of Botulinum Toxin on Muscles of Children With Cerebral Palsy
Cerebral palsy (CP) is a group of non-progressive motor dysfunction but often changing, secondary to injury or brain abnormalities that occur in early stages of development.
- Trial name
- TOXIMUS_CP (NCT02853240)
- Testing
- Muscle biopsy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Cerebral Palsy
Effects of Swiss Ball vs Frenkle Exercises on Static and Dynamic Balance in Ataxic CP
Several studies have highlighted the significant impact of cerebral palsy, a prevailing neurological and musculoskeletal developmental disorder among childhood disabilities worldwide.
- Trial name
- NCT06673797
- Testing
- Effects of Swiss Ball exercises, EFFECTS OF FRENKEL EXERCISES ON STATIC AND DYNAMIC BALANCE IN ATAXIC CHILDREN WITH CEREBRAL PALSY
- Where
- Pakistan
- Volunteers
- 18 people
- Sponsor
- Riphah International University
Cerebral Palsy
The Effect of Selective Dorsal Rhizotomy on a Multidimensional Outcome Set in Children With Spastic Cerebral Palsy: a Retrospective Study
Cerebral palsy or CP is the single largest cause of childhood physical disability, with a prevalence of 2-3 per 1000 livebirths.
- Trial name
- NCT06340425
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cerebral Palsy (CP)
Comparative Effects of Frenkel's and Core Stability Exercises in Children With Cerebral Palsy
The aim of this study is to determine and compare the effects of Frenkel's and core stability exercises on the motor function, postural stability and core muscle strength in children with cerebral palsy.
- Trial name
- NCT06696989
- Testing
- Frenkel's exercises, Core stability exercises
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Infant, Newborn, Infant, Low Birth Weight
Inflammatory Cytokines Associated With Perinatal Brain Injury
This observational study assessed whether measurements of certain pro-inflammatory and anti-inflammatory cytokines in the blood (either singly or in combination) at birth and/or up to day of life 21 can predict cerebral palsy at…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Cytokines (NCT01035697)
- Where
- 18 sites in United States
- Volunteers
- 1,067 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Traumatic Brain Injury
A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy
This study aims to determine the safety of HB-adMSC infusion and treatment effects of HB-adMSC infusion on brain structure, neurocognitive/functional outcomes, and neuroinflammation after subacute and chronic neurological injury…
- Trial name
- NCT04063215
- Testing
- HB-adMSCs
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Hope Biosciences LLC
Cerebral Palsy
Diet and Activity in Cerebral Palsy
This study aims to fill a gap in the literature, identify relevant clinical measures, and provide insight into the independent modifiable risk factors of obesity in the CP population with the long-term goal of improving…
- Trial name
- NCT02175108
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Shirley Ryan AbilityLab
Traumatic Brain Injury
Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury
Acute intermittent hypoxia (AIH) involves 1-2min of breathing low oxygen air to stimulate neuroplasticity. Animal and human studies show that AIH improves motor function after neural injury, particularly when paired with…
- Trial name
- NCT06520358
- Testing
- Acute Intermittent Hypoxia (AIH), Task specific Airway Protection Training
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Cerebral Palsy
Improvement on GMFCS Level of Patients With Cerebral Palsy Treated by Repeated Botulinum Toxin-A
The aim of this retrospective, monocenter, observational study is to evaluate the changes in GMFCS levels of children with cerebral palsy (CP) who received repeated Botulinum Toxin-A (BoNT-A) injections in the lower limb(s) with…
- Trial name
- NCT03344952
- Testing
- Botulinum toxin type A, Physical therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 503 people
- Sponsor
- Kocaeli University
Cerebral Palsy, Pain, Chronic
Cognitive Behavioral Therapy for Chronic Pain in Adults With Cerebral Palsy
The purpose of this study is to understand if cognitive behavioral therapy can feasibly be provided to groups of adults with cerebral palsy and chronic pain via virtual group therapy sessions.
- Trial name
- NCT06269926
- Testing
- Cognitive Behavioral Therapy for Chronic Pain
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Chronic Subdural Hematoma
High Concentration Oxygen Therapy for Pneumocephalus in Chronic Subdural Haematoma: A Prospective Observational Study
Normobaric oxygen therapy was shown to be effective in reducing post craniotomy pneumocephalus. Theoretical assessment of normobaric oxygen therapy in treating pneumocephalus has shown that a higher level of oxygen concentration…
- Trial name
- NCT05143216
- Testing
- Low concentration oxygen group: Room air (0-2Litre Oxygen via Nasal Canula), High concentration oxygen group: Room air (12-15Litre Oxygen via Non-rebreather Mask)
- Where
- Hong Kong
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Dr. David Yuen Chung CHAN
Cerebral Palsy, Spastic
The Effectiveness of Repetitive Transcranial Magnetic Stimulation for Spastic Diplegia Cerebral Palsy
Cerebral palsy describes a group of permanent disorders of the development of movement and posture, causing activity limitation that are attributed to non-progressive disturbances that occurred in the developing fetal or infant…
- Trial name
- NCT05198921
- Testing
- repetitive Transcranial Magnetic Stimulation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universitat de Lleida
Home-based Programs, EzyGain
EMMVIES : Walking Training at Home in VIrtual Reality for Children With Chronic Illnesses Impacting Physical Health
Over the past 30 years, the prevalence of congenital or acquired chronic diseases in children has risen, affecting between 10 and 30% of them, or at least 100,000 children in France.
- Conditions
- Home-based Programs, EzyGain, AMY Treadmill, Cerebral Palsy
- Trial name
- EMMVIES (NCT07021638)
- Testing
- EMMVIES program
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Angers
Cerebral Palsy
Functional and Neuroplastic Effects of HABIT-ILE in Children With Bilateral Cerebral Palsy
This randomized controlled trial will compare the effects of neuroplastic and functional changes of Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) when presented in two periods (2HG; n=24) versus a…
- Trial name
- FuN HABIT-ILE (NCT06428032)
- Testing
- Hand-Arm Bimanual Intensive Therapy Including Lower Extremities
- Where
- Chile
- Volunteers
- 48 people
- Sponsor
- Universidad Nacional Andres Bello
Cerebral Palsy (CP)
Upper Extremity Strengthening Interventions in Children With UCP
This study aims to compare the effects of two different upper extremity strengthening exercise approaches-bilateral strengthening exercises based on Proprioceptive Neuromuscular Facilitation (PNF) patterns and plyometric…
- Trial name
- PNF vs PLY-UCP (NCT07116798)
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people
- Sponsor
- Biruni University
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