Clinical trials: Brain Function
Alzheimer's Disease, Healthy
The Effect of Acetylcholine on Memory and Attention
This study will examine whether enhancing the chemical acetylcholine in the brain can improve memory and attention. It will identify changes in brain function that occur during these cognitive tasks.
- Trial name
- NCT00001977
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Cognitive Function Abnormal, Atrial Fibrillation (AF)
Low-frequency Electrical Stimulation for Cognitive Enhancement in Atrial Fibrillation
Cognitive function in patients with atrial fibrillation (AF) is often impaired due to the complex influence of various factors (cerebral hypoperfusion, neurodegeneration, microemboli, hypertension, chronic inflammation).
- Trial name
- LESCAF (NCT07063381)
- Testing
- tVNS
- Where
- 2 sites in Russia
- Volunteers
- 60 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Alzheimer's Disease
Transcranial Photobiomodulation (tPBM) in Alzheimer's Disease Study
The purpose of this study is to see if a special light treatment, called photobiomodulation, can help people with memory problems such as Mild Cognitive Impairment or Mild Dementia due to Alzheimer's disease.
- Trial name
- NCT07224607
- Testing
- Photobiomodulation
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Cedars-Sinai Medical Center
Parkinson's Disease
The Effect of a Motor-cognitive Rehabilitation on Attention in Parkinsonian Patients
In this study the Investigators explore two questions: if the attentive reaction times differs in parkinsonian patients from health controls and if an intensive, focused and aerobic rehabilitation program (Multidisciplinary…
- Trial name
- NCT02727257
- Testing
- MIRT
- Where
- Italy
- Volunteers
- 103 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Ischemic Stroke
Clopidogrel Response in Acute Ischemic Stroke
The aim of this study was to determine the prevalence rate and risk factors for chemical laboratory clopidogrel low-response (CLR) in the acute phase after an ischemic stroke.
- Trial name
- Bo-CRISP (NCT01846572)
- Volunteers
- 159 people
- Sponsor
- Ruhr University of Bochum
Ischemic Stroke
The Influence of EMG-triggered Robotic Movement on Function and Mobility of Stroke Patients
Rehabilitation of lower limbs after a stroke supported by robots aims to return to independence and minimize disability caused by the incident, but the results have been mixed.
- Trial name
- NCT04497545
- Testing
- Luna EMG, lower limb rotor
- Where
- Poland
- Volunteers
- 71 people
- Sponsor
- EGZOTech
Epilepsy
Evaluation of the Risk of Cognitive Deficit After Surgery of Epilepsy by Dynamic Spectral Imaging (ISD) of the Cognitive Functions in Patients Explored in StereoElectroEncephaloGraphy (SEEG)
Epilepsy affects between 0.5 and 0.7% of the European population. Despite the availability of numerous drug treatments, one third of patients still have seizures, which are associated with significant cognitive and social…
- Trial name
- ISD SEEG (NCT03094312)
- Testing
- Dynamic Spectral Imaging (ISD)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Image Quality and Contouring Accuracy of the Tumor in Radiotherapy
Single-center, Prospective Study on the Identification and Delineation of Brain and Lung Tumors and At-Risk Organs, and Functional Testing of Surrounding Tissues Based on Dual-Energy CT
This study explored the feasibility of dual-energy CT in head and lung tumors. Dual-energy CT can achieve quantitative CT imaging based on traditional imaging by dual-energy spectral imaging, and enhance the clarity of head and…
- Trial name
- NCT06301100
- Testing
- Dual energy CT after routine simulation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Stroke Treatment, Stroke
Effect of Transcutaneous Auricular Vagus Nerve Stimulation Combined With Upper Extremity Robot-Assisted Training on Upper Extremity Motor Functions in Stroke Patients
The effects of stroke on the upper extremity are a common and significant cause of long-term disability, with 65% of patients reporting an inability to participate in daily activities with the affected upper extremity after 6…
- Trial name
- NCT07257107
- Testing
- Robotics Assisted Education + taVNS
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University - Cerrahpasa
Stroke, Healthy Health Care Professionals
Usability and Acceptability Study of a Functional Electro-stimulator Controlled by Electromyographic Signal (FitFES)
Functional recovery of the upper limb after a cerebral stroke is one of the major critical issues in rehabilitation. The advent of innovative technologies can be helpful to rehabilitators and intervene where there is no other…
- Trial name
- NCT06763874
- Testing
- EMG-based FES device
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Neuropathic Pain
Patterns of Cerebral Activation to Innocuous and Noxious Heat Stimulations in Neuropathic Pain
Patients with neuropathic pain exhibit hyperalgesia and allodynia. Although both peripheral and central determinants are recognized for the pathophysiological basis of neuropathic pain following peripheral injury, the modulating…
- Trial name
- NCT00713024
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Generalized Anxiety Disorder
Drug Treatment Validation of Functional Magnetic Resonance Imaging in Generalized Anxiety Disorder
The purpose of this study is to find out how an anti-anxiety drug or placebo affects the activity of your brain when you are at rest and when you are viewing emotional material, such as, emotional faces and pictures.
- Trial name
- GAD (NCT00662259)
- Testing
- Alprazolam (Xanax)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Diego
Diplegic Cerebral Palsy
Effect of Sensory Integration in Diplegic Cerebral Palsy
The purpose of this study is to compare the effects of sensory integration therapy (SIT) applied in addition to neurodevelopmental treatment (NDT) on Motor Function, Balance, and Trunk Control in diplegia cerebral palsy
- Trial name
- NCT06462859
- Testing
- Sensory Integration Therapy Group, Neurodevelopmental Treatment Group
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Halic University
Cerebral Palsy
Reciprocal Electrical Stimulation Versus Kinesio Taping
This study will be conducted to: 1. evaluate the effect of kinesio taping on hand functions in hemiplegic cerebral palsy children 2.
- Trial name
- NCT05799703
- Testing
- electrical stimulation device, kinesio taping
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Basma Elsaid Mahmoud Bakr
Sarcopenia
Effects of Shanyu Pill in Older Adults With Sarcopenia
Sarcopenia is an age-related condition characterized by progressive loss of muscle mass, muscle strength, and physical function. It may also be associated with impaired cognitive function.
- Trial name
- NCT05919368
- Testing
- Shanyu pill
- Where
- 3 sites in China
- Volunteers
- 192 people
- Sponsor
- Fujian University of Traditional Chinese Medicine
Cerebral Palsy
Improvement in Gross Motor Function and Muscle Tone in Children With Cerebral Palsy Related to Neonatal Icterus
The purpose of this study is to evaluate the safety and effectiveness of stem cells for cerebral palsy related to neonatal icterus
- Trial name
- NCT03123562
- Testing
- Stem cell transplantation
- Where
- Vietnam
- Volunteers
- 25 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Hematoma Absorption and Neurological Function Recovery
Clinical Study on the Treatment of Hypertensive Intracerebral Hemorrhage With Panax Notoginseng Saponin
The purpose of this study is to determine whether panax notoginseng saponins are effective in the treatment of Hypertensive Intracerebral Hemorrhage Patients.
- Trial name
- CSTHIHPNS (NCT02999048)
- Testing
- Panax Notoginseng Saponins
- Volunteers
- 90 people
- Sponsor
- The First People's Hospital of Jingzhou
Parkinson Disease
Multiple Practice Contexts to Reduce Context-dependent Learning in PD
Context-dependent learning (CDL) is a phenomenon that an individual demonstrates superior motor performance in the environmental context in which a task was originally learned and practiced, while the performance may decrease if…
- Trial name
- NCT03368443
- Testing
- treadmill training and overground gait training
- Where
- Taiwan
- Volunteers
- 58 people
- Sponsor
- National Taiwan University Hospital
Cervical Dystonia
Deep Brain Stimulation to Treat Cervical Dystonia
This study will evaluate the effectiveness of deep brain stimulation (DBS) for treating primary dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or abnormal postures.
- Trial name
- NCT00132340
- Testing
- Electrodes
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, Balance
Non-motor Symptoms, Balance, Muscle Strength, and Functional Mobility in Patients With Parkinson's Disease
The purposes of this study is to examine balance, muscle strength, and mobility in relation with non-motor symptoms (NMSs) in patients with Parkinsosn's Disease (PD).
- Conditions
- Parkinson Disease, Balance, Muscle Strength, Mobility
- Trial name
- NCT04420910
- Testing
- Non-Motor Symptoms, Balance, Lower Limb Strength
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University