Clinical trials: Brain Abscess
Brain Abscess
Circulating Cell-Free DNA for Brain Abscess Diagnosis: A Pilot Study
Brain abscess is a severe intracranial infection associated with significant morbidity and mortality. Standard management combines neurosurgical intervention, when feasible, with prolonged intravenous antibiotic therapy.
- Trial name
- METABCES-PoC (NCT07479225)
- Testing
- Plasma Microbial Cell-Free DNA Metagenomic Sequencing
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Brain Abscess, Cerebral Abscess
Partial Oral Antibiotic Treatment for Bacterial Brain Abscess
The investigators aim to determine if oral antibiotics are clinically acceptable as treatment of brain abscess. Following 2 weeks of standard intravenous antibiotic therapy, half of patients will continue with this treatment for…
- Trial name
- ORAL (NCT04140903)
- Testing
- Early transition to oral antibiotics, Standard treatment of intravenous antibiotics
- Where
- 4 sites in Denmark
- Volunteers
- 400 people
- Sponsor
- Henrik Nielsen
Central Nervous System Infections, Bacterial Meningitis
Central Nervous System Infections in Denmark
The Danish Study Group of Infections of the Brain is a collaboration between all departments of infectious diseases in Denmark. The investigators aim to monitor epidemiological trends in central nervous system (CNS) infections by…
- Conditions
- Central Nervous System Infections, Bacterial Meningitis, Viral Meningitis, Aseptic Meningitis
- Trial name
- DASGIB (NCT03418441)
- Testing
- Community-acquired CNS infections
- Where
- 8 sites in Denmark
- Volunteers
- 1,900 people
- Sponsor
- Aalborg University Hospital
Lateral Sinus Thrombosis, Mastoiditis
Otogenic CSVT Retrospective Case Series and Associated Thrombophilia
The aim of this study is to report the clinical presentation, Microbiological, laboratory and imaging evaluation, prothrombotic factors analysis, medical and surgical management and outcomes in children with Otogenic Cerebral…
- Conditions
- Lateral Sinus Thrombosis, Mastoiditis, Otitis Media
- Trial name
- CSVT PCR (NCT03864055)
- Where
- Israel
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Toxoplasmosis, Cerebral
Dexamethasone for Cerebral Toxoplasmosis
Toxoplasma gondii infects over one third of the global human population. Cerebral toxoplasmosis is the most common opportunistic infection in HIV patients resulting in up to 50% of mortality with proper treatment and 80% without…
- Trial name
- De-Tox (NCT04341155)
- Testing
- Dexamethasone
- Where
- Indonesia
- Volunteers
- 138 people
- Sponsor
- Universitas Padjadjaran
Cerebral Toxoplasmosis
Study of a Cohort of Non-HIV Immunocompromised Patients With Toxoplasmosis at the Strasbourg University Hospital
Toxoplasmosis in HIV-positive individuals is well-studied and has a codified management protocol, which is not the case for other immunodeficiencies, except for recent recommendations in the context of hematopoietic stem cell…
- Trial name
- TOXO (NCT07299500)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Toxoplasmosis, Cerebral, HIV Infections
Toxoplasmic Encephalitis in Patients With AIDS. Treatment and Prevention of Relapse
To compare pyrimethamine and intravenous (IV) clindamycin vs. pyrimethamine and sulfonamides in the treatment of AIDS patients with central nervous system (CNS) Toxoplasma gondii.
- Trial name
- NCT00002064
- Testing
- Pyrimethamine, Clindamycin
- Where
- United States
- Sponsor
- Palo Alto Medical Foundation
Brain Abscess, Fatigue
Cognitive Function and Fatigue After Brain Abscess
Brain abscess is a focal bacterial or fungal infection of the brain. Treatment is neurosurgical drainage of pus followed by long-term antibiotic treatment.
- Conditions
- Brain Abscess, Fatigue, Cognitive Dysfunction
- Trial name
- NCT04938362
- Testing
- FDG-PET, EEG
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University of Oslo
Toxoplasmosis, Cerebral, HIV Infections
A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive Patients
To determine the manner in which pyrimethamine is metabolized and excreted in patients currently receiving zidovudine (AZT). An important goal of this measurement is to establish the optimal dose of pyrimethamine necessary to…
- Trial name
- NCT00000973
- Testing
- Pyrimethamine, Leucovorin calcium, Zidovudine
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Intracranial Hemorrhage, Ventriculitis
Clearance of Intracranial Blood Products by Continuous Irrigation With the IRRAflow System
The study is a multi-center prospective cohort, controlled, phase 4 post-market registry evaluating the efficacy and radiographic outcomes associated with the use of the IRRAflow® Active Fluid Exchange System compared to standard…
- Conditions
- Intracranial Hemorrhage, Ventriculitis, Intracranial Abscess
- Trial name
- CRYSTAL (NCT06649097)
- Testing
- IRRAflow® CNS (Active Fluid Exchange) System
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Christopher P Kellner
Meningitis, Encephalitis
BIGlobal Intervention Study: Improving Diagnosis and Management of Suspected Brain Infections Globally
Background: Patients with suspected brain infections pose major challenges to low and middle income countries, including their disproportionately high burden, diverse causes with inadequate surveillance, requirement for invasive…
- Conditions
- Meningitis, Encephalitis, Abscess Brain
- Trial name
- NCT04190303
- Testing
- Pragmatic, multi-component package
- Where
- 4 sites in Brazil, India and 1 more
- Volunteers
- 2,233 people
- Sponsor
- University of Liverpool
Toxoplasmosis, Cerebral, HIV Infections
A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii Infection
To evaluate pyrimethamine as a prophylactic agent against toxoplasmic encephalitis in individuals who are coinfected with HIV and latent Toxoplasma gondii.
- Trial name
- NCT00000666
- Testing
- Pyrimethamine
- Where
- 16 sites in United States
- Volunteers
- 600 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Toxoplasmosis, Cerebral, HIV Infections
A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS
To collect information on the effectiveness and toxicity of clindamycin plus pyrimethamine and leucovorin calcium for the treatment of acute toxoplasmic encephalitis in adult patients with AIDS.
- Trial name
- NCT00000674
- Testing
- Pyrimethamine, Leucovorin calcium, Clindamycin
- Where
- 13 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Brain Injury
The NEUROlogically-impaired Extubation Timing Trial (NEURO-ETT)
This trial in brain-injured patients will test which of the following will lead to better patient outcomes: (1) an airway management pathway consisting of daily assessments and removal of the breathing tube as soon as patients…
- Trial name
- NCT04291235
- Testing
- Airway Management Pathway, Usual Care
- Where
- 14 sites in Canada
- Volunteers
- 332 people
- Sponsor
- Sunnybrook Health Sciences Centre
Toxoplasmosis, Cerebral, HIV Infections
A Pilot Study of 566C80 for the Salvage Treatment of Toxoplasmic Encephalitis in Patients Infected With the Human Immunodeficiency Virus (HIV) Who Have Failed or Are Intolerant of Pyrimethamine-Sulfadiazine
To evaluate the safety and tolerance of atovaquone (566C80) in AIDS patients with central nervous system (CNS) toxoplasmosis. To evaluate the efficacy of 566C80 in the acute treatment and suppression of CNS toxoplasmosis in AIDS…
- Trial name
- NCT00001994
- Testing
- Atovaquone
- Where
- 22 sites in United States, Canada
- Sponsor
- Glaxo Wellcome
Acute Brain Injury
The NEUROlogically-impaired Extubation Timing Trial
This randomized controlled trial will enrol patients with acute severe brain injury who pass a spontaneous breathing trial but have decreased level of consciousness. It will directly compare (1) prompt extubation vs.
- Trial name
- NEURO-ETT (NCT02920580)
- Testing
- Extubation, Usual Care
- Where
- 13 sites in Canada
- Volunteers
- 27 people
- Sponsor
- Sunnybrook Health Sciences Centre
Brain Abscess
MICROBIOLOGY OF CEREBRAL ABSCESSES
Establish the repertoire of bacteria and Archaea responsible for brain abscesses. Correlate the microbial repertoire to epidemiological, clinical and radiological data; to define the different nosological entities falling within…
- Trial name
- NCT04018742
- Testing
- Surgical puncture
- Volunteers
- 20 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Toxoplasmosis, Cerebral, HIV Infections
Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis
To evaluate the efficacy, safety, and tolerance of atovaquone with either pyrimethamine or sulfadiazine in AIDS patients with toxoplasmic encephalitis.
- Trial name
- NCT00000794
- Testing
- Sulfadiazine, Clarithromycin, Atovaquone
- Where
- 16 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Toxoplasmosis, Cerebral, HIV Infections
A Study of Azithromycin Plus Pyrimethamine in the Treatment of a Brain Infection in Patients With AIDS
To evaluate the effectiveness and toxicity of oral azithromycin and pyrimethamine as acute therapy for toxoplasmic encephalitis in AIDS patients.
- Trial name
- NCT00000966
- Testing
- Azithromycin, Pyrimethamine, Leucovorin calcium
- Where
- 11 sites in United States
- Volunteers
- 45 people
- Sponsor
- Pfizer
Bacterial Infections, Bone Diseases, Infectious
Fosfomycin I.v. for Treatment of Severely Infected Patients
The purpose of this European, multicentric, prospective, non-interventional study is to document and evaluate the efficacy and safety of the treatment of severely infected patients with intravenously administered fosfomycin…
- Conditions
- Bacterial Infections, Bone Diseases, Infectious, Osteomyelitis, Central Nervous System Bacterial Infections
- Trial name
- FORTRESS (NCT02979951)
- Where
- 50 sites in Austria, Germany and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Infectopharm Arzneimittel GmbH