Clinical trials: Borderline Personality Disorders
Borderline Personality Disorder
Training of Neural Responding in BPD
Emotion-related brain activation is made visible for patients via neurofeedback with the aim to improve discriminability of emotional arousal and emotion regulation.
- Trial name
- IP5n (NCT02866110)
- Testing
- Neurofeedback, MRI
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Mindfulness, Borderline Personality Disorder
Change in Mindfulness in Borderline Personality Disorder
The current study aims to investigate the effect of dialectical behavioral therapy on mindfulness in patients with Borderline Personality Disorder. A treatment group will be compared to a waitlist control group.
- Trial name
- NCT03297840
- Testing
- Dialectical Behavioural Therapy (DBT)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Katharina Bachmann
Borderline Personality Disorder, Sleep Disturbance
Real-time Experiences With Sleep Training Study
Borderline personality disorder (BPD) is a serious mental illness that often first emerges in adolescence. Effective treatments are typically expensive, lengthy, and intense (e.g., Dialectical Behavior Therapy).
- Trial name
- REST (NCT04507308)
- Testing
- Single-session sleep intervention drawn from principles of the TSC-youth protocol
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- University of Utah
Borderline Personality Disorder
Parenting Skills for Mothers With Borderline Personality Disorder: A Newly Developed Group Training Program
N=15 mothers with Borderline Personality Disorder who had young children (aged 0-6 years) participated in a 12-week training program.
- Trial name
- NCT02935218
- Testing
- Parenting Skills for Mothers with BPD
- Volunteers
- 15 people
- Sponsor
- Freie Universität Berlin
Borderline Personality Disorder
Effects of Motive-Oriented Therapeutic Relationship in the Early-Phase Treatment of Borderline Personality Disorder
The present research aims at examining the effectiveness of a specific set of therapist relational interventions and attitudes, called the Motive-Oriented Therapeutic Relationship (MOTR), based on Plan Analysis (Caspar, 2007) in…
- Trial name
- MOTR (NCT01896024)
- Testing
- Psychiatric Management, Motive-oriented therapeutic relationship/Plan Analysis
- Where
- Switzerland
- Volunteers
- 85 people
- Sponsor
- University of Lausanne Hospitals
Borderline Personality Disorder
Psychoeducational Videos and Digital Assessments for BPD
In this study, 100 adults who were recently diagnosed with borderline personality disorder (BPD) will be randomized to either receive educational videos about BPD or educational videos about other topics.
- Trial name
- NCT05358925
- Testing
- Psychoeducational Videos, Neuropsychological Feedback, Non-BPD-related Educational Videos
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Mclean Hospital
Infusion of Ketamine in Severe Borderline Personality Disorder, Borderline Personality Disorder (BPD)
Ketamine Infusion for Symptomatic Improvement in Severe Borderline Personality Disorder
The main objective of this pilot study is to evaluate at D9 the evolution of BPD symptoms' intensity(scale BSL-23) in severe BPD patients, after two Ketamine infusions (0.5mg/kg at H0 and H24).
- Trial name
- BorderKET (NCT07099534)
- Testing
- IV Ketamine (0.5 mg/kg) Infusion - Two Doses Administered 24 Hours Apart for Severe Borderline Personality Disorder
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Toulouse
Alcohol Use Disorder, Borderline Personality Disorder
Nalmefene in Alcohol Dependence and Borderline Personality Disorder
The objective is to study the effectiveness of Nalmefene in decreasing alcohol intake in subjects with alcohol use disorder and comorbid BPD.
- Trial name
- NCT02752503
- Testing
- Nalmefene
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Borderline Personality Disorder
Effectiveness of a One-day Psychoeducation Program on Internalized Stigmatization for BPD Patients
Education day on borderline personality disorder (BPD), including a transmission of current scientific knowledge on the disease.
- Trial name
- EDUC-BPD (NCT05428462)
- Testing
- Psychoeducation day on borderline personality disorder
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Borderline Personality Disorder
Promoting Recovery Processes in Women With Borderline Personality Disorder Using a Dynamic Cognitive Intervention
The field of psychiatric rehabilitation focuses on creating a personal narrative and developing coping strategies and environmental supports.
- Trial name
- NCT01531634
- Testing
- Dynamic Cognitive Intervention Group
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hillel Yaffe Medical Center
Borderline Personality Disorder (BPD)
Combining Transcranial Magnetic Stimulation With Emotion Regulation Skills Training in Borderline Personality Disorder
Impaired emotion regulation is a core feature of borderline personality disorder (BPD) and a known driver of functional impairment, interpersonal difficulties, self-harm, and suicidality.
- Trial name
- NCT07714005
- Testing
- Transcranial Magnetic Stimulation (TMS), Emotion Regulation Skills Training
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Borderline Personality Disorder
Neural Mechanisms of Dialectical Behavioral Therapy in Patients with Borderline Personality Disorder
This research examines the behavioral and neural mechanisms of dialectical behavior therapy (DBT) effect in patients with borderline personality disorder (BPD).
- Trial name
- NeuroDBT (NCT06882330)
- Testing
- Dialectical behavior therapy
- Where
- Czechia
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Masarykova Univerzita
Emotional Instability, Borderline Personality
Exploring a New Measure of Emotion Regulation
Background: Emotion regulation has been established as an important concept in mental health research across a range of different diagnoses.
- Trial name
- EMER (NCT04779619)
- Testing
- Online self-report questionnaire completion
- Where
- United Kingdom
- Volunteers
- 903 people, healthy volunteers welcome
- Sponsor
- Sussex Partnership NHS Foundation Trust
Stress Disorders, Post-Traumatic, Borderline Personality Disorder
Treating PTSD in Patients With Borderline Personality Disorder
Individuals with borderline personality disorder (BPD) are the quintessential multi-problem patients, often presenting to treatment with numerous dysfunctional behaviors and comorbid diagnoses.
- Conditions
- Stress Disorders, Post-Traumatic, Borderline Personality Disorder, Suicide, Self-Injurious Behavior
- Trial name
- NCT01081314
- Testing
- Dialectical Behavior Therapy, PTSD Protocol
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Washington
Borderline Personality Disorder
Study of Lamotrigine Treatment of Affective Instability in Borderline Personality Disorder
This study investigates the hypothesis that instability in mood in patients with borderline personality disorder will respond the mood stabilizing medication lamotrigine.
- Trial name
- NCT00634062
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Mclean Hospital
Borderline Personality Disorder
Depakote ER in Borderline Personality Disorder
This study examines the effect of Depakote ER versus placebo in a randomized trial of borderline personality disorder. Patients all participate in DBT therapy and those who are not responsive are assigned to either Depakote ER or…
- Trial name
- NCT00222482
- Testing
- Depakote ER
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Borderline Personality Disorder
A Trial of Brexpiprazole in the Treatment of Borderline Personality Disorder
There are currently no pharmacological treatments approved to treat borderline personality disorder (BPD). This trial will be conducted to evaluate the efficacy and safety of brexpiprazole for the treatment of participants…
- Trial name
- NCT04100096
- Testing
- Brexpiprazole
- Where
- 77 sites in United States, Spain and 1 more
- Volunteers
- 332 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Effects of Oxytocin on Borderline Personality Disorder, Borderline Personality Disorder
"The Effects of Oxytocin on Patients With Borderline Personality Disorder"
RCT. Two substudies (clinical and experimental). Main objective of the trial is to examine if oxytocin, compared to placebo shows any additional effect on the therapy achievements (outcome) of patients with borderline personality…
- Trial name
- NCT01243658
- Testing
- Oxytocin
- Where
- Germany
- Volunteers
- 138 people
- Sponsor
- Prof. Dr. Markus Heinrichs
Borderline Personality Disorder
MBT in Groups for Adolescents With BPD or Subthreshold BPD Versus TAU - the M-GAB Randomized Controlled Trial
Background: Although it is now possible to diagnose Borderline Personality Disorder (BPD) in adolescents younger than 18 years according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V), and…
- Trial name
- M-GAB (NCT02068326)
- Testing
- Mentalization Based Treatment, Treatment As Usual
- Where
- Denmark
- Volunteers
- 112 people
- Sponsor
- Psychiatric Research Unit, Region Zealand, Denmark
Borderline Personality Disorder
Short Integrative And Neurocognitive Therapy For Young Adults With Borderline Personality Disorder
Borderline personality disorder (BPD) is a severe, high-suicidal psychiatric disorder associated with impulsive, endangering behaviors.
- Trial name
- SINTYA (NCT05913544)
- Testing
- SINTYA
- Where
- France
- Volunteers
- 74 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes