Clinical trials: Borderline Personality Disorder (BPD)
Borderline Personality Disorder (BPD)
Cortical Plasticity of the Tactile Mirror System in Borderline Personality Disorder
People with borderline personality disorder (BPD) show alterations in the empathic abilities, which may involve the functioning of the mirror neuron system in the somatosensory domain.
- Trial name
- SG2019-EXP2 (NCT06702215)
- Testing
- Cross-modal paired associative stimulation (cm-PAS) protocol
- Where
- Italy
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Borderline Personality Disorder (BPD)
Social Integration During Psychiatric Inpatient Therapy as Predictor of Treatment Response
The present longitudinal study aims at (i) identifying neurobiological mechanisms associated with successful social integration during the treatment of inpatients with Borderline Personality Disorder (BPD) and (ii) improving…
- Trial name
- SANITY (NCT04770038)
- Testing
- Dialectical Behavior Therapy (DBT)
- Where
- Germany
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Oldenburg
Borderline Personality Disorder
DBT Techniques by E-mail for Patients With BPD
Purpose: The aim of the current study was to evaluate the efficacy of online Dialectical Behavioural Therapy (e-DBT) in the treatment of individuals with symptoms of borderline personality disorder (BPD).
- Trial name
- NCT04493580
- Testing
- iDBT, In-Person DBT
- Where
- Canada
- Volunteers
- 107 people
- Sponsor
- Dr. Nazanin Alavi
Borderline Personality Disorder
Seroquel Extended Release (XR) for the Management of Borderline Personality Disorder (BPD)
The Primary objective of this study is to evaluate Seroquel XR in the treatment of borderline personality disorder (BPD). As in many initial randomized control trials, the study will be of relatively short duration - 8 weeks - to…
- Trial name
- NCT00880919
- Testing
- quetiapine extended-release
- Where
- 3 sites in United States
- Volunteers
- 95 people
- Sponsor
- University of Minnesota
Borderline Personality Disorder (BPD)
Epigenetic Changes in Psychotherapy of Adolescents With Borderline Personality Pathology
The link between epigenetic changes as an effect of psychotherapy has been investigated recently. Genes investigated in these studies were brain-derived neurotrophic factor (BDNF), NR3C1, FKBP51, MAOA and GLUT1.
- Trial name
- NCT04095546
- Testing
- routine psychotherapy for Borderline Personality Disorder (BPD)
- Sponsor
- University Hospital, Basel, Switzerland
Borderline Personality Disorder (BPD)
The Role of Gender in Borderline Personality Disorder
This study is a mixed-methods, single-arm cross-sectional study comprising 1) a qualitative, exploratory, critical-constructivist content analysis examining the significance of gender in relationship experiences and…
- Trial name
- BPD-G (NCT07639957)
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University Hospital Heidelberg
Borderline Personality Disorder, Borderline Personality Disorder (BPD)
Effectiveness of Autobiographical Rewriting Workshops on the Socio-Professional Functioning of Patients With Borderline Personality Disorder Undergoing Third-Wave Cognitive and Behavioral Therapy: A Randomized Controlled Trial
This study evaluates the effectiveness of autobiographical rewriting workshops combined with third-wave Cognitive Behavioral Therapy (CBT) in improving social and professional functioning in individuals with Borderline…
- Trial name
- ICS (NCT07199166)
- Testing
- Autobiographical Rewriting Workshops, Non-specific writing workshops
- Volunteers
- 140 people
- Sponsor
- University Hospital, Montpellier
Borderline Personality Disorder (BPD), Antisocial Personality Disorder (ASPD)
Mentalization Based Treatment - Introductory (MBT-I) Group for Male Prisoners With Borderline and/or Antisocial Personality Disorder
Established evidence base with MBT for treatment of Borderline Personality Disorder (BPD) and/or Antisocial Personality Disorder (ASPD).
- Trial name
- NCT04033835
- Testing
- Mentalization Based Treatment-Introductory, Treatment as usual
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- NHS Greater Glasgow and Clyde
Borderline Personality Disorder
Stress & Social Cognition in BPD (part 2)
The investigators will examine how a combination of pharmacological mineralocorticoid receptor (MR) stimulation and psychosocial stress will influence prosocial behavior in patients with Borderline Personality Disorder (BPD)…
- Trial name
- SOKO-2 (NCT05310253)
- Testing
- Fludrocortisone, Trier Social Stress Test (TSST)
- Where
- Germany
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Borderline Personality Disorder
DBT for Chronically Self-harming Individuals With BPD: Evaluating the Clinical & Cost Effectiveness of a 6 mo. Treatment
Standard one-year dialectical behaviour therapy (DBT), which has four components, is an effective treatment for people with borderline personality disorder.
- Trial name
- FASTER-DBT (NCT02387736)
- Testing
- Dialectical Behaviour Therapy-6 months, Dialectical Behaviour Therapy-12 months
- Where
- 2 sites in Canada
- Volunteers
- 240 people
- Sponsor
- Centre for Addiction and Mental Health
Borderline Personality Disorder
DBT and Escitalopram in Borderline Personality Disorder
Subjects will receive six months of DBT, consisting of one 90-minute group and one 60-minute individual session per week as well as telephone availability of the individual therapist.
- Trial name
- NCT00255554
- Testing
- Dialectical Behavioral Therapy, Escitalopram
- Where
- United States
- Sponsor
- Bronx VA Medical Center
Autism Spectrum Disorder, Borderline Personality Disorder BPD
Perimenstrual Symptoms and Emotional Dysregulation in Autism
Emotional dysregulation (ED) is defined by difficulties in modulating the experience and expression of emotions, which are characterized by particularly marked reactivity, intensity, and duration.
- Conditions
- Autism Spectrum Disorder, Borderline Personality Disorder BPD, a Premenstrual Dysphoric Disorder (PMDD)
- Trial name
- MEDEA (NCT06871345)
- Testing
- Semi-structured interviews SCID, Self-report questionnaires, Momentary Ecological Assessment (EMA)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Personality Disorder, Borderline, Personality Trait
Bridging Affect Consciousness, Mentalization and Trauma- Exploring an Integrative Treatment Approach for Personality Disorder (PD).
Study background: Specialized Group Outpatient Clinic within specialist mental health services, tailoring two year group treatment programmes for severe Avoidant PD (AvPD) and Borderline PD (BPD) with Affect Consciousness (AC)…
- Conditions
- Personality Disorder, Borderline, Personality Trait, Personality Disorder, Personality Type
- Trial name
- NCT06983002
- Testing
- Experimental group: AC-group therapy intervention., Control group 1: Body Awareness Group., Control group 2: Art Psychotherapy group.
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Helse Stavanger HF
Impulse Control Disorders, Borderline Personality Disorder
fMRI in Impulsivity
This study aims to use resting-state and task based functional Magnetic Resonance Imaging (fMRI) as a tool to evaluate trait characteristics of impulsivity in subjects with borderline personality disorder.
- Trial name
- NCT02755181
- Testing
- Experimental
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Borderline Personality Disorder
Evaluating an Internet-Based Self-Management Intervention for Borderline
The trial aims to evaluate the effectiveness of a novel internet intervention (Priovi), which was designed to introduce relevant schema therapy techniques to Persons with Borderline Personality Disorder (BPD).
- Trial name
- REVISIT (NCT03418142)
- Testing
- Priovi, CAU
- Where
- Germany
- Volunteers
- 206 people
- Sponsor
- Gaia AG
Borderline Personality Disorder
Psychoeducation of Borderline Patients
Recent research suggests that BPD is a common, serious but treatable disorder with a better than previously recognized prognosis.
- Trial name
- NCT01719731
- Testing
- Education, Non-Education
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mclean Hospital
Posttraumatic Stress Disorder (PTSD), Borderline Personality Disorder (BPD)
Effectiveness of PTSD-treatment Compared to Integrated PTSD-PD-treatment in Adult Patients With Comorbid PTSD and BPD
The goal of PROSPER-B is to study effectiveness of EMDR compared to integrated DBT-EMDR in treatment-seeking, adult patients with comorbid PTSD and Borderline Personality Disorder (BPD).
- Trial name
- PROSPER-B (NCT03833453)
- Testing
- EMDR, DBT
- Where
- Netherlands
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Arkin
Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD Group, Diagnosis of ADHD Using the KSADS-PL for the ADHD Group
ADOLESCENTS IMAGING USING fMRI: Feasibility Study
Impaired social cognition and cognitive control associated with borderline personality disorder (BPD) remain less explored. Recent Franco-Canadian study, has shown the feasibility of a neuroimaging tests in Quebec adolescents…
- Conditions
- Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD Group, Diagnosis of ADHD Using the KSADS-PL for the ADHD Group, Absence of Pathology on the CBCL and Ab-DIB for the Healthy Control Group, All Participants Were Euthymic at the Time of Task Administration
- Trial name
- ADO IMAGE (NCT07540429)
- Testing
- functional magnetic resonance imaging (fMRI)
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Etablissement Public de la Sante Mentale de la Somme
Self-Harm, Deliberate, Suicidal Behavior
Intensive Dialectical Behavior Therapy for Self-Harm and Suicidal Behavior in Youth: A Pilot Study
The prevalence of self-harm and suicidal behavior among adolescents has increased dramatically over the past two decades-a fourfold rise that represents both a severe personal burden and a substantial public health challenge.
- Conditions
- Self-Harm, Deliberate, Suicidal Behavior, Borderline Personality Disorder (BPD)
- Trial name
- NCT07450105
- Testing
- Intensive Dialectical Behavior Therapy
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Haukeland University Hospital
Borderline Personality Disorder
Study to Test the Efficacy and Safety of Vafidemstat in Adult Borderline Personality Disorder Population
PORTICO is a Phase IIb study to evaluate the efficacy and safety of vafidemstat in an adult borderline personality disorder (BPD) population.
- Trial name
- NCT04932291
- Testing
- vafidemstat
- Where
- 21 sites in United States, Bulgaria and 3 more
- Volunteers
- 211 people
- Sponsor
- Oryzon Genomics S.A.