Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD GroupADO IMAGENCT07540429
ADOLESCENTS IMAGING USING fMRI: Feasibility Study
A study testing functional magnetic resonance imaging (fMRI) in people with Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD Group and Diagnosis of ADHD Using the KSADS-PL for the ADHD Group, run by Etablissement Public de la Sante Mentale de la Somme at 1 site in France.
Trial summary
Impaired social cognition and cognitive control associated with borderline personality disorder (BPD) remain less explored. Recent Franco-Canadian study, has shown the feasibility of a neuroimaging tests in Quebec adolescents with BPD. Read more about this study
- Who is it for?
- Ages 12 to 17 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD Group, Diagnosis of ADHD Using the KSADS-PL for the ADHD Group, Absence of Pathology on the CBCL and Ab-DIB for the Healthy Control Group
- What is being tested?
- functional magnetic resonance imaging (fMRI)
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 21 participants
- Where
- 1 siteFrance
- Study dates
- 8 Jun 2024to 31 Dec 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 12 to 17 years
- Women only
- Healthy volunteers accepted
- Child
Who may be able to join
- Female adolescents meeting DIB-R criteria for BPD group
- Female adolescents meeting kSADS-PL for ADHD group
- Female adolescents without any psychologic disorders
Who cannot join
- Any medical history with head trauma, chronic neurologic disease, any contraindications for fRMI, claustrophobia or pregnancy.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Jean Marc GUILE, Professor contact
France1 site, 1 recruiting
- Recruiting
EPSM de la Somme
Dury, 80480
MICHAEL MONET, 0322534612, unite.2.recherche@epsm-somme.fr
About this study
Official title: Feasibility Study Using Functional Magnetic Resonance Imaging (fMRI) on Bordeline Personality Disorders in Adolescents
Impaired social cognition and cognitive control associated with borderline personality disorder (BPD) remain less explored. Recent Franco-Canadian study, has shown the feasibility of a neuroimaging tests in Quebec adolescents with BPD. This study aims to increase knowledgements related to neural correlates of BPD and clinical disorders.
- Conditions
- Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD Group, Diagnosis of ADHD Using the KSADS-PL for the ADHD Group, Absence of Pathology on the CBCL and Ab-DIB for the Healthy Control Group, All Participants Were Euthymic at the Time of Task Administration
- Being tested
- functional magnetic resonance imaging (fMRI)
- Keywords
- disturbances in social cognition, cognitive control associated, borderline personality disorder, neuroimaging in adolescent girls, child psychiatry
- Medical subject headings
- Borderline Personality Disorder
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
functional magnetic resonance imaging (fMRI)Diagnostic test
Investigators used fMRI to compare patterns of regional brain activation between three groups of adolescents girls: Six female adolescents meeting criteria for BPD, 6 female adolescents meeting criteria of ADHD and 6 female adolescents without psychiatric disorder were recruited.
| Study group | Role | What they receive |
|---|---|---|
| Healthy adolescent girl volunteers | Other | The participants will follow the same study plan Receives: Diagnostic Test: functional magnetic resonance imaging (fMRI) |
| Adolescent girls with borderline personality disorder | Other | The participants will follow the same study plan Receives: Diagnostic Test: functional magnetic resonance imaging (fMRI) |
| Adolescent girls with Attention Deficit Hyperactivity Disorder | Other | The participants will follow the same study plan Receives: Diagnostic Test: functional magnetic resonance imaging (fMRI) |
What is being measured
The primary outcome is the main question the study is designed to answer.
MRI-Acquired Activation Mapping
Establishment of activation maps by statistical analysis of local signal variations to locate functional regions essential to motor skills and language.
Measured: 2 years
Secondary outcomes (1)
Feasibility of this study
Pilot feasibility study with a small sample size
Measured: 2 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Apr 2026
- Study start8 Jun 2024
- Primary completion8 Jun 2027 (estimated)
- Study completion31 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD GroupStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 21 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Etablissement Public de la Sante Mentale de la Somme
- Sponsor type
- Research network
- Collaborators
- Centre Hospitalier Universitaire, Amiens
- Responsible party
- Sponsor
- Investigators
- Jean Marc GUILE, Professor, Principal investigator, EPSM de la Somme
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07540429
- Sponsor's protocol ID
- 2022-A00741-42
- Acronym
- ADO IMAGE
- Status last verified
- Mar 2026
- First submitted
- 18 Feb 2026
- Last updated
- 20 Apr 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Guile JM, Boissel L, Alaux-Cantin S, de La Riviere SG. Borderline personality disorder in adolescents: prevalence, diagnosis, and treatment strategies. Adolesc Health Med Ther. 2018 Nov 23;9:199-210. doi: 10.2147/AHMT.S156565. eCollection 2018.
PubMed 30538595
Study at a glance
From the registry record, last updated by the sponsor on 20 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Feasibility Study Using Functional Magnetic Resonance Imaging (fMRI) on Bordeline Personality Disorders in Adolescents
- ClinicalTrials.gov ID
- NCT07540429
- Acronym / sponsor ID
- ADO IMAGE / 2022-A00741-42
- Conditions
- Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD Group, Diagnosis of ADHD Using the KSADS-PL for the ADHD Group, Absence of Pathology on the CBCL and Ab-DIB for the Healthy Control Group, All Participants Were Euthymic at the Time of Task Administration
- Keywords
- disturbances in social cognition, cognitive control associated, borderline personality disorder, neuroimaging in adolescent girls, child psychiatry
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 21 participants (estimated)
- Lead sponsor
- Etablissement Public de la Sante Mentale de la SommeResearch network
- Collaborators
- Centre Hospitalier Universitaire, Amiens
- Study start
- 8 Jun 2024 (actual)
- Primary completion
- 8 Jun 2027 (estimated)
- Study completion
- 31 Dec 2027 (estimated)
- First posted
- 20 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Impaired social cognition and cognitive control associated with borderline personality disorder (BPD) remain less explored. Recent Franco-Canadian study, has shown the feasibility of a neuroimaging tests in Quebec adolescents with BPD. This study aims to increase knowledgements related to neural correlates of BPD and clinical disorders.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Healthy adolescent girl volunteers | Other | Diagnostic Test: functional magnetic resonance imaging (fMRI)The participants will follow the same study plan |
| Adolescent girls with borderline personality disorder | Other | Diagnostic Test: functional magnetic resonance imaging (fMRI)The participants will follow the same study plan |
| Adolescent girls with Attention Deficit Hyperactivity Disorder | Other | Diagnostic Test: functional magnetic resonance imaging (fMRI)The participants will follow the same study plan |
Who may qualify
- Ages
- 12 to 17 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Child
Key inclusion criteria (3 listed)
- Female adolescents meeting DIB-R criteria for BPD group
- Female adolescents meeting kSADS-PL for ADHD group
- Female adolescents without any psychologic disorders
Key exclusion criteria (1 listed)
- Any medical history with head trauma, chronic neurologic disease, any contraindications for fRMI, claustrophobia or pregnancy.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| functional magnetic resonance imaging (fMRI)Investigators used fMRI to compare patterns of regional brain activation between three groups of adolescents girls: Six female adolescents meeting criteria for BPD, 6 female adolescents meeting criteria of ADHD and 6 female adolescents without psychiatric disorder were recruited. | Diagnostic test | Adolescent girls with Attention Deficit Hyperactivity Disorder, Adolescent girls with borderline personality disorder, Healthy adolescent girl volunteers |
Primary outcome
MRI-Acquired Activation Mapping
Time frame: 2 years
Establishment of activation maps by statistical analysis of local signal variations to locate functional regions essential to motor skills and language.
1 secondary outcome
Feasibility of this study
Time frame: 2 years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Apr 2026.
- Background: PubMed 30538595Guile JM, Boissel L, Alaux-Cantin S, de La Riviere SG. Borderline personality disorder in adolescents: prevalence, diagnosis, and treatment strategies. Adolesc Health Med Ther. 2018 Nov 23;9:199-210. doi: 10.2147/AHMT.S156565. eCollection 2018.
- Individual participant dataSharing planned: Undecided
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Jean Marc GUILE, Professor contact
Jean Marc GUILE, Professor principal investigator
EPSM de la Somme
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing functional magnetic resonance imaging (fMRI) in people with Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD Group and Diagnosis of ADHD Using the KSADS-PL for the ADHD Group, run by Etablissement Public de la Sante Mentale de la Somme at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 20 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact MICHAEL MONET, PhD (0322534612, unite.2.recherche@epsm-somme.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
MRI-Acquired Activation Mapping (time frame: 2 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07540429, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Apr 2026.