Clinical trials: Bone Substitutes
Periodontology, Oral Surgery
Case Series of New Alloplastic Bone Graft Material
A case series to compare the handling and effectiveness of two different treatment approaches using a new alloplastic bone graft material in ridge preservation compared to allograft existing historical data.
- Trial name
- NCT02221557
- Testing
- easy-graft (beta-Tricalcium Phosphate)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Sunstar Americas
Alveolar Ridge Augmentation
Comparison of the Use of Natural and Synthetic Bone Substitutes in Dental Implants
The goal of this clinical trial is to compare the effectiveness of a natural and synthetic bone substitute in preserving the alveolar ridge (bone) of a single- rooted tooth after an extraction.
- Trial name
- BSNS (NCT05938114)
- Testing
- Bonalive, Bio-Oss®
- Where
- 6 sites in United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Central Lancashire
Bone Substitutes
Pre-market Study to Evaluate Safety and Performance of GreenBone Implant
Multi-center, prospective, open-label, single-arm, first-in-human clinical investigation. The patient enrollment will be as follow: initial 5 patients enrolled at PI site.
- Trial name
- GreenBric (NCT03836404)
- Testing
- Iliac crest reconstruction surgery
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- GreenBone Ortho S.p.A.
Bone Regeneration, Bone And Bones
Effects of Autogenous Dentin Graft on Socket Preservation
Various graft materials are used to reconstruct bone defects in the jaws due to tooth loss, trauma, advanced periodontal diseases, pathological lesions and congenital disorders.
- Conditions
- Bone Regeneration, Bone And Bones, Bone Substitutes
- Trial name
- NCT04131894
- Testing
- autogenous dentin graft, platelet rich fibrin (PRF)
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Bone Augmentation
Evaluation of the Safety and Performance of the Neobone®: A Prospective Observational Study in Dental Area
This study aims to collect real-world clinical data to gather information on the performance and safety of the Neobone® when used according to its intended purpose and current clinical applications.
- Trial name
- NeoDent01 (NCT07179497)
- Where
- Portugal
- Volunteers
- 66 people
- Sponsor
- Bioceramed
Bone Defects, Orthopaedic Surgery (30 Minutes or Longer)
Evaluation of the Safety and Performance of the Neocement®
This study aims to collect real-world clinical data to gather information on the performance and safety of the Neocement® when used according to its intended purpose and current clinical applications.
- Trial name
- Neocement01 (NCT06973226)
- Where
- Portugal
- Volunteers
- 80 people
- Sponsor
- Bioceramed
Alveolar Ridge Enlargement
Alveolar Ridge Preservation Using Different Bone Substitutes
The primary objective of this study was to compare the efficacy of using allograft, autogenous tooth graft, and beta-tricalcium phosphate for alveolar ridge preservation (ARP) by examining the alveolar ridge height and width at…
- Trial name
- NCT05812872
- Testing
- Toothgraft, Allograft, Alloplast
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Bone Augmentation, Bone Loss, Alveolar
Evaluation of a Novel Horizontal Ridge Augmentation Technique in Dentistry
This case series aimed to assess the efficacy of a novel horizontal ridge augmentation modality using histomorphometry and Raman spectroscopy.
- Trial name
- NCT05612737
- Testing
- Horizontal bone augmentation
- Where
- Hungary
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Alveolar Bone Resorption, Sequela
Bone Material Comparison in Maxillary Sinus Augmentation
Hard and soft tissue deficiencies of an alveolar ridge arise as sequelae of tooth extraction when socket preservation is not applied.
- Conditions
- Alveolar Bone Resorption, Sequela, Tooth Extrusion
- Trial name
- NCT04433117
- Testing
- Shefabone, Bio-Oss
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mohanad Al-Sabbagh
Osteoarthritis of the Knee
Autograft Versus Calcium Phosphate Macroporous Bioceramics as Bone Substitute for Tibial Valgus Osteotomy
The aim of the study is to compare radiological behavior of blocks of macroporous phosphocalcium as bone substitute in comparison with iliac crest autograft in tibial valgus osteotomy.
- Trial name
- NCT00200603
- Testing
- calcium phosphate macroporous bioceramics
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Nantes University Hospital
Residual Bone Height, Marginal Bone Loss
Influence of Residual Bone Height on Marginal Bone Loss Around Implants Following Lateral Sinus Floor Augmentation With Deproteinized Bovine Bone Mineral
Data collection will be done on all patients who underwent a lateral maxillary sinus floor augmentation in the Faculty of Dental Medicine, both in the Periodontology Department and in the Oral Surgery Department.
- Conditions
- Residual Bone Height, Marginal Bone Loss, Implant Type, Smoking
- Trial name
- NCT07550491
- Testing
- sinus lift using DBBM
- Where
- Lebanon
- Volunteers
- 142 people
- Sponsor
- Saint-Joseph University
Hopeless Tooth
Performance of Next-X in Alveolar Ridge Preservation
The goal of this case series study is to evaluate the clinical and histological outcomes of a protocol for managing hopeless teeth, focusing on alveolar preservation and subsequent dental implant placement.
- Trial name
- NCT06698276
- Testing
- Alveolar Ridge Reconstruction
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Sinus Floor Augmentation
PLGA-coated Biphasic Calcium Phosphate in Sinus Lift
The study aims to investigate the radiological and histomorphometric results of the use of PLGA-coated biphasic calcium phosphate granules in sinus floor elevation, to analyze the underlying molecular processes by…
- Trial name
- NCT03474627
- Testing
- Non-coated HA/TCP particles, PLGA-coated HA/TCP particles
- Where
- 2 sites in Spain
- Volunteers
- 36 people
- Sponsor
- Universidad de Granada
Fusion of Spine, Lumbar Region
Evaluation of Fusion After ALIF With an Osteoinductive Material or With Homologus Bone
The aim of this study was to determine whether instrumented anterior lumbar interbody Fusion with a new nanocrystalline hydroxyapatite embedded in a silica gel matrix (NH-SiO2) was associated with superior radiological and…
- Trial name
- NCT03331159
- Testing
- NanoBone, Homologous Bone
- Volunteers
- 20 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Degenerative Disc Disease
Actifuse ABX Versus INFUSE in Posterolateral Instrumented Lumbar Fusion (PLIF) With Interbody Fusion
The primary objective of this clinical trial is to evaluate the success rates of Actifuse ABX and INFUSE in achieving bone fusion. The secondary objective of this clinical trial is to assess clinical outcome measurements.
- Trial name
- APPRAISET1 (NCT01013389)
- Testing
- Actifuse ABX, INFUSE, plus master granules (MGG)
- Where
- 2 sites in Australia, Netherlands
- Volunteers
- 20 people
- Sponsor
- Baxter Healthcare Corporation
Alveolar Ridge Augmentation, Bone Substitutes
Alveolar Ridge Preservation (ARP) Study Using Alloplastic Biomaterial and a Resorbable Synthetic Membrane. A Digital Workflow (CBCT/Scanner) Evaluates Hard and Soft Tissue Volumetric Changes at 4 Months, Validating Support for the Gingival Phenotype and Buccal Bone Plate.
The dimensional collapse of the alveolar ridge following tooth extraction represents a critical challenge for implant rehabilitation.
- Conditions
- Alveolar Ridge Augmentation, Bone Substitutes, Guided Tissue Regeneration, Periodontal, Cone-Beam Computed Tomography
- Trial name
- NCT07879495
- Testing
- Alveolar Ridge Preservation using a synthetic alloplastic bone substitute and a resorbable polymer membrane, Minimally invasive flapless tooth extraction followed by unassisted spontaneous healing
- Volunteers
- 28 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Implant Site Reaction
Sinus Augmentation With Allograft-Bone Substitute in Severe Maxillary Atrophy
This study was conducted in two phases. In Phase 1, lateral window sinus floor augmentation was performed using a mixture of hydroxyapatite (30%) and β-tricalcium phosphate (70%) combined with autologous platelet-rich fibrin…
- Trial name
- NCT07186166
- Testing
- 30% HA+70% β-TCP (Osteon II, Dentium, Korea)
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Can Tho University of Medicine and Pharmacy
Cervical Disc Disorder With Radiculopathy, Spinal Stenosis
Comparative Study of Gene-Activated Bone Substitute "Histograft" for Lumbar and Cervical Spinal Fusion
The goal of this clinical trial is to evaluate the safety and efficacy of the combination product "Histograft", a bone substitute based on octacalcium phosphate (OCP) and plasmid DNA encoding VEGFA gene, in spinal fusion…
- Conditions
- Cervical Disc Disorder With Radiculopathy, Spinal Stenosis, Lumbar and Other Intervertebral Disc Disorders With Radiculopathy, Biomechanical Lesion, Unspecified
- Trial name
- NCT06365307
- Testing
- Osteoplastic material based on octacalcium phosphate and biologically active nucleic acids for bone tissue regeneration Nucleostim-VEGF ("Histograft"), Synthetic osteoplastic material based on β-TCP or bone autograft
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- Histograft Co., Ltd.
Peri-Implantitis
Peri-implantitis Surgical Regenerative Therapy Using Bovine Bone Substitute With Hyaluronic Acid
The study aimed to assess 6- and 12-months evaluation of clinical, microbiological, and radiography outcomes after performing peri-implantitis regenerative surgical therapy with the bovine bone substitute with or without…
- Trial name
- NCT05171582
- Testing
- Surgery 1 (Test group), Surgery 2 (Control group)
- Where
- Serbia
- Volunteers
- 25 people
- Sponsor
- Botiss Medical AG
Anterior Cruciate Ligament Injury
Synthetic Bone Graft Substitute vs. Autologous Spongiosa in Revision Anterior Cruciate Ligament Reconstruction
The overall objective is the histological and radiological assessment of bony consolidation of the tibial/femoral tunnel using either bone graft substitute (Actifuse) or autologous spongiosa in patients undergoing revision…
- Trial name
- NCT02845141
- Testing
- Actifuse, bone graft
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Berufsgenossenschaftliche Unfallklinik Ludwigshafen