Clinical trials: Bone Resorption
Alveolar Bone Resorption
Application of Sticky Bone and Bio-Oss Collagen in Alveolar Ridge Preservation
In this experiment, after non-traumatic tooth extraction, the blank group underwent natural healing, and the Bio-Oss Collagen underwent alveolar ridge preservation using Bio-Oss Collagen and the Sticky Bone group using Sticky…
- Trial name
- NCT05902689
- Testing
- alveolar ridge preservation with bio-oss collagen, alveolar ridge preservation with sticky bone
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Alveolar Ridge Augmentation, Bone Substitutes
Alveolar Ridge Preservation (ARP) Study Using Alloplastic Biomaterial and a Resorbable Synthetic Membrane. A Digital Workflow (CBCT/Scanner) Evaluates Hard and Soft Tissue Volumetric Changes at 4 Months, Validating Support for the Gingival Phenotype and Buccal Bone Plate.
The dimensional collapse of the alveolar ridge following tooth extraction represents a critical challenge for implant rehabilitation.
- Conditions
- Alveolar Ridge Augmentation, Bone Substitutes, Guided Tissue Regeneration, Periodontal, Cone-Beam Computed Tomography
- Trial name
- NCT07879495
- Testing
- Alveolar Ridge Preservation using a synthetic alloplastic bone substitute and a resorbable polymer membrane, Minimally invasive flapless tooth extraction followed by unassisted spontaneous healing
- Volunteers
- 28 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Dental Implant, Bone Resorption
Randomized Clinical Study Comparing Two Guided Surgery Techniques for Free-end Implant Placement
This is a randomized multicenter clinical study that compares two static guided surgery techniques in free-end partial edentulism.
- Trial name
- NCT06764654
- Testing
- Dental implant placement
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Aula Dental Avanzada
Jaw, Edentulous, Partially, Bone Resorption
Clinical and Radiographic Evaluation of UV-Treated Dental Implants With or Without Melatonin in the Upper Posterior Jaw
The purpose of this study is to evaluate and compare the clinical and radiographic outcomes of using photofunctionalized (UV-treated) dental implants with or without the application of melatonin hormone in the posterior maxilla…
- Conditions
- Jaw, Edentulous, Partially, Bone Resorption, Dental Implant Failure
- Trial name
- UV-MEL-IMPLANT (NCT07853976)
- Testing
- UV-Photofunctionalized Dental Implant, Conventional Dental Implant
- Where
- Egypt
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Jaw, Edentulous, Partially, Dental Implant Failure
Densah Bur Versus Modified Conventional Drilling in Early Loaded Maxillary Implants
This study aims to clinically and radiographically evaluate the efficacy of Densah burs (osseodensification) compared to the modified conventional drilling technique for early-loaded dental implants in the posterior maxilla.
- Conditions
- Jaw, Edentulous, Partially, Dental Implant Failure, Bone Resorption
- Trial name
- NCT07850583
- Testing
- Densah Bur Osseodensification, Modified Conventional Drilling
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Mansoura University
Guided Bone Regeneration, Bone Resorption
The Effect of IPD on Lateral Bone Augmentation
Guided Bone Regeneration (GBR) is a widely used technique during dental implant surgery to help rebuild bone around the implant and improve its long-term appearance and stability.
- Conditions
- Guided Bone Regeneration, Bone Resorption, Diagnostic Imaging
- Trial name
- NCT06999915
- Testing
- Group 1 (Test Group): IP and GBR as an over-contour augmentation beyond IPD, Group 2 (Control Group): IP and GBR as a contour augmentation up to IPD
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Queen Mary University of London
Bone Loss, Osteoclastic, Bone Loss, Alveolar
Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting
This study aims to evaluate bone formation in grafts in terms of its quality (density), quantity (volume) and maturation obtained with the application of a tissue-engineered bone grafting compound containing concentrated…
- Conditions
- Bone Loss, Osteoclastic, Bone Loss, Alveolar, Alveolar Bone Loss, Alveolar Bone Atrophy
- Trial name
- NCT04998058
- Testing
- Maxillary sinus floor elevation grafting with synthetic bone substitute.
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Tooth Loss
Healing Dynamics in Human Extraction Sockets Grafted With Bio-Oss Collagen®
The purpose of this study is to clinically, radiographically and histologically evaluate the healing sequence of post-extraction sockets grafted with Bio-Oss Collagen® at 3, 6 and 9 months following tooth extraction in…
- Trial name
- NCT03659617
- Testing
- xenograft (BioOss Collagen)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Maxillary Deficiency, Bone Resorption
Using Chin Bone Rings for Sinus Lifting and Dental Implants in One Surgery
This study evaluates the Bone Ring Technique, a single stage procedure that combines external sinus floor elevation and dental implant placement using an autogenous bone ring harvested from the chin.
- Trial name
- BRT-SINUS (NCT07619846)
- Testing
- Bone Ring Technique (BRT)
- Where
- Syria
- Volunteers
- 10 people
- Sponsor
- Damascus University
Alveolar Bone Loss, Alveolar Ridge Resorption After Extraction
THBC/CGF for Alveolar Bone Regeneration: A Real-World Study
This study aims to combine real-world research with relevant bone repair materials and techniques to improve alveolar bone resorption in extraction sockets following impacted wisdom tooth removal, while achieving effective bone…
- Conditions
- Alveolar Bone Loss, Alveolar Ridge Resorption After Extraction, Tooth, Impacted
- Trial name
- NCT07779421
- Testing
- Temperature-sensitive hydroxybutyl chitosan-loaded concentrated growth factor, Temperature-sensitive hydroxybutyl chitosan, Autologous Concentrated Growth Factor
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Stomatological Hospital Affiliated with Fujian Medical University
Alveolar Bone Resorption
Reducing the Time Interval for Implant Placement After Extraction Socket Preservation Using BIOTECK Materials and OITECH Implant System
This randomized controlled clinical study aims to compare two healing periods (4 vs 6 months) after extraction socket preservation using equine-derived enzymatically treated biomaterials (BIOTECK® system), prior to implant…
- Trial name
- BIO-OI-TECHEIP (NCT07746869)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Bioteck S.p.A.
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial
Spinal cord injury (SCI) results in lower limb muscle loss, bone loss, and high fat mass that impede the recovery of physical function, increase bone fracture risk, and worsen health and quality of life.
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Injuries, Spinal Cord, Spinal Cord Contusion
- Trial name
- TRT-SCI (NCT07742553)
- Testing
- testosterone cypionate, finasteride
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- VA Office of Research and Development
Bone Substitutes, Alveolar Bone Grafting
Bone Augmentation Techniques in the Mandible Posterior Region
This study will compare three methods to rebuild lost bone in the back part of the lower jaw (posterior mandible) before dental implant placement.
- Trial name
- NCT06661447
- Testing
- Cortical Shell Bone Grafting
- Where
- Ecuador
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Universidad de Especialidades Espiritu Santo
Implant Complication, Bone Resorption
Standard Implants With Bone Regeneration vs Short Implants
A study designed as a randomized controlled trial of parallel group design will be conducted at the Dental clinic of the University of Valencia to compare, considering different parameters, the rehabilitation with dental implants…
- Trial name
- NCT03524885
- Testing
- Short implant placement, Bone regeneration with longer implants
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Horizontal Alveolar Ridge Deficiency
Comparison of Split Box and Split Bone Block Techniques in Horizontal Ridge Augmentation
Horizontal alveolar ridge deficiencies may prevent the placement of dental implants and often require bone augmentation procedures before implant treatment.
- Trial name
- SBBTvsSBT (NCT07656662)
- Testing
- Split Bone Block Technique, Split Box Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Marmara University
Alveolar Bone Resorption
LPRF Block vs. DBBM in Horizontal Bone Reconstruction
split-mouth RCT. 12 patients. horizontal GBR performed. 2 grafts were compared: test was LPRF block, control was 50% autogenous bone and 50% DBBM. 25 months follow-up.
- Trial name
- NCT07584629
- Testing
- guided bone regeneration
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Alveolar Bone Loss, Periodontal Diseases
Evaluation of the Effectiveness of Odontogenic Grafts Obtained From Human Teeth on Bone Formation
Tooth extraction triggers a cascade of biological events mediated by the local inflammatory response following surgical intervention and by the loss of masticatory stimulation to the periodontium.
- Conditions
- Alveolar Bone Loss, Periodontal Diseases, Periodontal Bone Loss, Periodontal Atrophy
- Trial name
- NCT07573761
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Orthopedic Disorder, Calcium Metabolism Disorders
High- Versus Low-calcium Water for Bone Health
The experimental study investigates which metabolic responses of calcium and parathyroid hormone are observable in blood and urine in a cohort of 41 healthy adults following a sequence of different exposures: low-calcium water…
- Conditions
- Orthopedic Disorder, Calcium Metabolism Disorders, Bone Resorption, Water-Electrolyte Imbalance
- Trial name
- NCT05772364
- Testing
- Loading of low-calcium water first, then high-calcium water
- Where
- Italy
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Alveolar Bone Resorption, Socket Preservation
Efficacy Of Eggshell-Derived Nanohydroxyapatite Based Mineralized Plasmatic Matrix Versus Xenogeneic Based Mineralized Plasmatic Matrix in Posterior Mandibular Socket Preservation
After tooth extraction, the alveolar bone, which supports the teeth, undergoes a natural resorption process. This bone loss can be significant, especially in the first few months post-extraction, leading to a reduction in both…
- Conditions
- Alveolar Bone Resorption, Socket Preservation, Wound Healing, Nano-hydroxyapatite
- Trial name
- NCT07404098
- Testing
- Socket preservation using eggshell-derived nanohydroxyapatite-based mineralized plasmatic matrix along with platelet-rich fibrin (PRF)., Socket preservation using deproteinized bovine bone mineral (DBBM) xenograft along with platelet-rich fibrin (PRF).
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University
Alveolar Bone Loss, Socket Shield Technique
Socket Shield Technique With CGF and Xenograft for Immediate Implants
This prospective case series aims to evaluate the clinical and radiographic outcomes of immediate implant placement using the socket shield technique combined with concentrated growth factors (CGF) and xenograft in the esthetic…
- Conditions
- Alveolar Bone Loss, Socket Shield Technique, Bone Resorption, Immediate Dental Implant Placement
- Trial name
- CGF (NCT07520513)
- Testing
- Socket Shield Technique with Immediate Implant Placement and CGF + Xenograft
- Where
- Egypt
- Volunteers
- 7 people
- Sponsor
- Cairo University