Clinical trials: Bone Marrow Aspirate Concentrate
Critical Limb Ischemia
Bone Marrow Aspirate Concentrate (BMAC) for Treatment of Critical Limb Ischemia (CLI)
Critical Limb Ischemia prevents the legs and feet from receiving oxygen and nutrients needed for proper function. This severe lack of blood flow can lead to painful legs while walking or at rest and can result in foot sores…
- Trial name
- NCT01245335
- Testing
- BMAC injection
- Where
- 34 sites in United States
- Volunteers
- 97 people
- Sponsor
- Harvest Technologies
Knee Osteoarthritis
Treatment for Knee Osteoarthritis With Injections of BMC at the Bone-cartilage Interface. Pilot Study
This pilot study will evaluate the clinica! and radiological results of a treatment for knee osteoarthritis with injections of autologous concentrated bone marrow aspirate at the bone-cartilage interface via percutaneous.
- Trial name
- IOC-target (NCT03110666)
- Testing
- Injection of autologous concentrated bone marrow aspirate
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- Istituto Ortopedico Rizzoli
Unilateral Alveolar Cleft of Maxilla
Bone Marrow Aspirate Concentrate With Bovine Bone Graft for Unilateral Alveolar Cleft Reconstruction
This randomized clinical trial evaluated whether adding autologous bone marrow aspirate concentrate (BMAC) to a bovine-derived bone graft improves healing and bone regeneration in patients undergoing reconstruction of a…
- Trial name
- NCT07786259
- Testing
- BMAC-Enriched Bovine Bone Grafting, Bovine Bone Grafting
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Tanta University
Ankle Osteoarthritis
Evaluation of the Single Injection of BMAC vs HA in the Treatment of the Ankle Osteoarthritis
The aim of the study is to compare the efficacy of the infiltrative therapy of BMAC vs HA up to 24 months in the treatment of the ankle osteoarthritis.
- Trial name
- NCT04883892
- Testing
- BMAC, HA
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Istituto Ortopedico Rizzoli
Heart Failure
Retrograde Application of Bone Marrow Aspirate Concentrate
The aim of our prospective randomised study is to assess the efficacy of the retrograde application of non-selected bone marrow autologous cells concentrate (BMAC) in patients with heart failure with reduced ejection fraction of…
- Trial name
- Retro (NCT03372954)
- Testing
- BMAC
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital Ostrava
Mandible Cyst
Bone Marrow Aspirate Concentrate in Treating Mandibular Cystic Defects
Mandibular cystic defect healing is a complex process. Various methods have been developed to shorten the bone regeneration time and improve its quality.
- Trial name
- NCT05748756
- Testing
- Enucleation and filling by Bone marrow aspirate, Conventional enucleation only
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Hams Hamed Abdelrahman
Knee Osteoarthritis, Musculoskeletal Diseases
Bone Marrow Aspirate Concentrate (BMAC) Treatment for Knee Osteoarthritis
The purpose of the ACCELERATE3 trial is to assess the efficacy of a single intra-articular (IA) injection of autologous BMAC, in one or both knees, compared to a single IA injection of Standard of Care (SOC) in patients with mild…
- Trial name
- ACCELERATE3 (NCT06216028)
- Testing
- Autologous Bone Marrow Aspirate Concentrate
- Where
- Canada
- Volunteers
- 374 people
- Sponsor
- CELL Technologies Inc.
Diabetic Foot Ulcer, Wound Healing
Systemic Biochemical Signature and Functional Quality Index of Calcaneal Bone Marrow Aspirate in Adults Undergoing Foot or Ankle Surgery
This observational prospective cohort study will evaluate whether routine blood tests are associated with the functional quality of calcaneal bone marrow aspirate mesenchymal stem cells in adults undergoing clinically indicated…
- Conditions
- Diabetic Foot Ulcer, Wound Healing, Foot Ulcer Due to Type 2 Diabetes Mellitus, Diabetes Mellitus Type 2
- Trial name
- IQF-BMA (NCT07802106)
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Sao Francisco
Congestive Heart Failure
Retrograde Delivery of BMAC (Bone Marrow Aspirate Concentrate) for Congestive Heart Failure
The primary objective of this feasibility study is to provide clinical data to demonstrate the safety and activity of a concentrate of nucleated cells from bone marrow aspirate (BMAC) produced with the Harvest Bone Marrow…
- Trial name
- NCT01299324
- Testing
- BMAC infusion
- Where
- 3 sites in Germany, India and 1 more
- Volunteers
- 30 people
- Sponsor
- Harvest Technologies
Ischemia
Study of Autologous Bone Marrow Concentrate for the Treatment of Critical Limb Ischemia (CLI)
Injections of concentrated bone marrow mononuclear cells into ischemic tissues will result in vasculogenesis
- Trial name
- NCT00498069
- Testing
- Harvest Smartprep2 BMAC System, SmartPReP2 BMAC System
- Where
- 6 sites in United States
- Volunteers
- 48 people
- Sponsor
- Harvest Technologies
Lumbar Degenerative Disc Disease
Prospective Study of Thoracolumbar Spinal Fusion Graft
This study is a single-center, prospective randomized clinical study intended to compare and evaluate the efficacy of subjects who are treated with bone marrow aspirate concentrate (BMAC) and allograft to iliac crest bone grafts…
- Trial name
- BMAC (NCT02297256)
- Testing
- BMAC & Allograft, Iliac Crest Bone Graft
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- NYU Langone Health
Knee Osteoarthritis
Bone Marrow Versus Adipose Tissue as a Cell Source for Infiltrative Treatment of Knee Osteoarthritis
The MAST-GR study is a randomized controlled interventional trial with parallel treatment arms and 1:1 allocation The primary objective of the study is to compare the safety and efficacy of a single intra-articular infiltration…
- Trial name
- NCT06040957
- Testing
- Bone marrow aspirate concentrate injection, intra-articular injection of Minimally manipulated adipose tissue
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteochondral Lesion of Talus
Microfracture vs. Microfracture and BMAC for Osteochondral Lesions of the Talus
Osteochondral lesions of the talus are thought to be due in large part to traumatic events or repetitive microtrauma that causes damage to both the articular cartilage and the subchondral bone.
- Trial name
- NCT03856021
- Testing
- Microfracture with Bone Marrow Aspirate Concentrate, Microfracture
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Rothman Institute Orthopaedics
Anterior Cruciate Ligament Tear
Bone Marrow Aspirate Concentrate for Anterior Cruciate Ligament Tear Treatment.
A single armed multicenter study enrolling 20 patients using autologous bone marrow aspirate concentrate (which is done under local or general anesthesia to aspirate around 1-2 cc/kg body weight then concentration which is done…
- Trial name
- NCT06353503
- Testing
- autologous bone marrow aspirate concentrate
- Where
- Iraq
- Volunteers
- 20 people
- Sponsor
- abdulmajeed hammadi
Osteo Arthritis Knee
Conventional Platelet-Rich Plasma Versus Concentrated Bone Marrow Stem Cell Injections for Osteoarthritis of the Knee
Previous clinical trials have demonstrated the human body's own healing and regenerative cells can relieve the pain of arthritis.
- Trial name
- NCT03271229
- Testing
- Concentrated Bone Marrow Aspirate (BMAC), Platelet-Rich Plasma (PRP)
- Where
- United States
- Sponsor
- Mayo Clinic
Osteonecrosis of the Femoral Head, Avascular Necrosis of the Femoral Head
Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis
Osteonecrosis of the femoral head (ONFH) is a debilitating musculoskeletal disease that is characterized by localized death of bone cells and associated cellular elements within the subchondral bone.
- Trial name
- BATON (NCT06123481)
- Testing
- Core Decompression, Core Decompression Procedure with Autologous Bone Marrow Aspirate Concentrate
- Where
- 10 sites in United States
- Volunteers
- 192 people
- Sponsor
- Johns Hopkins University
Knee Osteoarthritis
Long-term Evaluation of Outcomes of Patients Undergoing Autologous Bone Marrow Concentrate Infiltration vs. Hyaluronic Acid
This is a prospective observational study for long-term clinical evaluation (minimum 4-year follow-up) in patients treated within the research protocol "OA-bi-blind" (Double-blind randomized trial on the treatment of bilateral…
- Trial name
- NCT06164899
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Ortopedico Rizzoli
Spinal Fusion
BMAC & Allograft vs BMP-2
The aim of this investigation is to compare the use of bone marrow aspirate concentrate (BMAC) and allograft versus recombinant human bone morphogenetic protein-2 (BMP) versus the gold standard fusion in subjects undergoing…
- Trial name
- NCT02924571
- Testing
- Bone Marrow Aspirate Concentrate (BMAC) + Allograft, Recombinant Human Bone Morphogenetic Protein-2 (BMP), Autograft
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- NYU Langone Health
Angina
Safety Study of Transmyocardial Revascularization (TMR) With Bone Marrow Aspirate (BMAC) for Angina Reduction
The purpose of this study is to determine the safety of injecting autologous bone marrow concentrate with laser transmyocardial revascularization (TMR) for treatment of angina which cannot be treated by direct coronary…
- Trial name
- PHOENIX (NCT01285297)
- Testing
- Bone Marrow Aspirate Concentrate
- Where
- 2 sites in Russia, Spain
- Volunteers
- 7 people
- Sponsor
- Cardiogenesis Corporation, a wholly-owned subsidiary of CryoLife, Inc.