Clinical trials: Bone Level
Diabetes Mellitus, Type 2, Bone Loss
Effect of Vitamins D3 and K2 in uOc and Insulin Serum Levels in Patients With Diabetes Mellitus
Introduction: Patients with DM2 have chronic hyperglycemia derived from a decrease in insulin sensitivity, cause of comorbidities such as bone demineralization, decreasing quality of life and increasing mortality.
- Conditions
- Diabetes Mellitus, Type 2, Bone Loss, Insulin Resistance
- Trial name
- NCT04041492
- Testing
- Supplementation with Vitamin D3 y K2
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- University of Guadalajara
Jaw, Edentulous, Partially
The Role of Immediate Provisional Restorations on Bone Level Implants
The study is designed to evaluate the clinical and radiographic outcomes of Straumann® Bone Level Implant SLActive placed in healed alveolar ridge (at least 8 weeks post extraction) and immediately provisionalised versus the same…
- Trial name
- NCT00906165
- Testing
- Straumann® Bone Level SLActive Implant (4.1mm diameter)
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Institut Straumann AG
Endocrine System Diseases, Vitamin D Deficiency
Serum Sclerostin Level & Treatment of Vitamin D Deficiency
The aim of this study is to determine serum sclerostin levels and change in serum sclerostin levels in patients with Vitamin D deficiency treated with calcium and vitamin D.
- Trial name
- OMSOST (NCT01553344)
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Bagcilar Training and Research Hospital
Dental Implants
Five Year Survival Study Evaluating the Genesis Dental Implant System
The purpose of this research study is to document the use if the Keystone Dental Genesis Dental Implant System in standard clinical use and to provide 5 year survival data.
- Trial name
- Genesis Dental (NCT01573026)
- Where
- 8 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Keystone Dental, Inc.
Childbirth
A Clinical Phase II Study of the Materna Device to Shorten Delivery Time During Childbirth
This feasibility study is a prospective, non-randomized, single arm study to evaluate safety and prevention of maternal pelvic soft-tissue damage using the Materna Medical Device.
- Trial name
- NCT06698185
- Testing
- Materna Prep Device
- Where
- United States
- Sponsor
- Materna Medical
CML, Philadelphia Chromosome Positive (Ph+)
Study of Nilotinib in Ph+ CML-CP Patients With Low Imatinib Trough Plasma Concentrations
This study is to determine the number of European Leukemia Network (ELN)guideline defined treatment failure events from time of study entry in CML-CP patients with low imatinib trough concentrations treated with nilotinib.
- Conditions
- CML, Philadelphia Chromosome Positive (Ph+), Chronic Myelogenous Leukemia Chronic Phase(CML-CP) Patients With Low Imatinib Trough Levels
- Trial name
- MACS1148 (NCT01131325)
- Testing
- nilotinib
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Myeloid Leukemia
Investigating Intracellular and Plasma Imatinib Levels in Chronic Myeloid Leukemia
The purpose of this study is to find out if the level of imatinib in the bloodstream, and the level that leukemia cells will predict how quickly your chronic myeloid leukemia improves with the treatment.
- Trial name
- OCT-1 (NCT00947830)
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- Brian Leber
High Tibial Osteotomy With Allograft Wedge, High Tibial Osteotomy Without Allograft Wedge
Assessing Physical Activity Levels of Patients Following HTO.
High tibial osteotomy (HTO is often indicated in physically active patients. The insertion of a bone graft during surgery has been shown to have good clinical and biomechanical outcomes, however objective data regarding…
- Conditions
- High Tibial Osteotomy With Allograft Wedge, High Tibial Osteotomy Without Allograft Wedge, Pre- and Post-operative Physical Activity Levels
- Trial name
- NCT03526172
- Testing
- High tibial osteotomy, Allograft wedge, Accelerometer
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Winchester
Vitamin D Deficiency, Secondary Hyperparathyroidism
Vitamin D Status in Males in Jerusalem Area and Its Correlation to Parathyroid Hormone (PTH) Level and Bone Mineral Density
Because of its high sun exposure, Israel was traditionally supposed to be protected from vitamin D deficiency, and the country food products hardly contain vitamin D supplements.
- Conditions
- Vitamin D Deficiency, Secondary Hyperparathyroidism, Osteomalacia
- Trial name
- NCT01025128
- Testing
- 25 OH vitamin D
- Where
- Israel
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Clalit Health Services
Periodontal Disease, Postmenopausal Osteoporosis (PMO)
Relationship Between Periodontal Disease and Postmenopausal Osteoporosis
Elevated sclerostin levels in serum and alveolar bone of osteoporotic patients may exert deleterious effects on the periodontium, thereby contributing to the progression and increased severity of periodontal disease.
- Trial name
- NCT07294105
- Testing
- clinical assessment, Radiographic Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Lumbar Spinal Stenosis
Study Comparing Local/ MAC Anesthesia in Lumbar Decompression
Explore efficacy, complications, and other factors associated with anaesthetic choice- To evaluate the efficacy of local + MAC as an alternative anesthetic to general anesthesia and to analyze patients' outcomes and experiences.
- Trial name
- NCT04992572
- Testing
- Propofol Injection, Lidocaine Hydrochloride, Injectable
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Degenerative Disc Disease, Spine Fusion
Post Marketing Study of MagnetOs Putty Compared to Local Autograft in Patients Undergoing Posterolateral Lumbar Fusion
This is a phase IV post-marketing study for MagnetOs Putty. MagnetOs Putty is a synthetic bone graft extender product that is routinely used by surgeons as a treatment for patients with leg pain and/or back pain and undergoing…
- Trial name
- PARTNER (NCT04679896)
- Testing
- MagnetOs Putty
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kuros Biosurgery AG
Hip Fractures
Basic Mobility and Physical Activity During Hospitalization for a Hip Fracture: Functions Needed and Strategies Used
Present study aim to gain an understanding of functions needed and strategies used for patients following hip fracture surgery to be independent in basic mobility activities during acute hospitalization, and establish knowledge…
- Trial name
- HIP-ME-UP (NCT05756517)
- Where
- Denmark
- Volunteers
- 101 people
- Sponsor
- Hvidovre University Hospital
Periimplant Crestal Bone Level Changes
Influence of Platform-switching on Bone Level Alterations: a 3 Year Randomized Clinical Trial (RCT).
The concept of platform-switching has been introduced to implant dentistry based on clinical observations of reduced periimplant crestal bone loss.
- Trial name
- NCT01917305
- Testing
- platform-shifted implant
- Volunteers
- 25 people
- Sponsor
- Søren Jepsen
Bone Loss, Alveolar
Short Dental Implants (5 mm) Versus Long Dental Implants (10 mm)
The purpose of this study is to evaluate the survival rate of 5 mm short implants compared to longer implants (10 mm) placed in sinus-grafted sites.
- Trial name
- NCT04144322
- Testing
- Zimmer T3 Short Ex Hex With Discrete Crystalline Deposition, Zimmer T3 with Discrete Crystalline Deposition Ex Hex Parallel Walled implants
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Degenerative Disc Disease, Lumbar Disc Disease
LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)
The objective of this study is to evaluate the safety and effectiveness of LDGraft (investigational device) compared to 100% human tissue product allograft bone (control) when applied in an ALIF procedure in the treatment of…
- Conditions
- Degenerative Disc Disease, Lumbar Disc Disease, Spine Disease, Lumbar Spine Degeneration
- Trial name
- RESTORE (NCT06462729)
- Testing
- LDGraft, Allograft Bone
- Where
- 4 sites in United States, Australia
- Volunteers
- 40 people
- Sponsor
- Locate Bio Pty Ltd
Leukemia
Biomarkers in Blood Samples From Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors identify and lean more about biomarkers related to cancer.
- Trial name
- NCT01385150
- Testing
- mutation analysis, protein analysis, laboratory biomarker analysis
- Volunteers
- 220 people
- Sponsor
- Eastern Cooperative Oncology Group
Spinal Fusion, Hyperglycemia
Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery
This study is a randomized controlled trial that will evaluate the effect of non-invasive auricular vagal nerve stimulation on inflammatory markers, glycemic control, postoperative pain, and inflammation-related clinical outcomes…
- Conditions
- Spinal Fusion, Hyperglycemia, Postoperative Pain Management, Postoperative Care
- Trial name
- TAPIS (NCT07218133)
- Testing
- Auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Alexander T. Yahanda
Displacement of Other Bone Devices, Implants and Grafts, Mechanical Complication of Other Bone Devices, Implants and Grafts
Influence of Low-level Laser Therapy on Stability and Displacement of Orthodontic Miniscrew Implants
The purpose of this study is to evaluate the effect of Low level laser therapy on stability and displacement of orthodontic miniscrew implants using two different force application protocols.
- Trial name
- NCT02891499
- Testing
- Low-level laser therapy, Mediate force application
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Partial Edentulism
Study of Certain Prevail Implants Used to Treat All Types of Edentulism in the Maxilla and Mandible
This observational, prospective clinical study evaluates the performance of the Certain Prevail implant system to show potential crestal bone and soft tissue preservation following the crestal bone.
- Trial name
- PrevailMulti (NCT00728884)
- Where
- Austria
- Volunteers
- 161 people
- Sponsor
- ZimVie