Clinical trials: Bone Aging
Post Menopausal Osteoporosis
Study of the Impact of Mother-of-pearl Nutritional Supplementation on the Prevention of Post-menopausal Osteoporosis
Post-menopausal osteoporosis and the resulting fractures are an important cause of disability and loss of independence. They also increase the risk of morbidity and mortality.
- Trial name
- NUTRANACRE (NCT05571514)
- Testing
- Mother-of-pearl, Calcium Carbonate
- Where
- 7 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Aging, Obesity
Lifestyle Intervention to Improve Bone Quality
Obese older adults will be randomized to participate in either healthy lifestyle intervention or behavioral diet and exercise intervention for one year.
- Trial name
- LIMB-Q (NCT03329963)
- Testing
- Healthy Lifestyle Intervention, Lifestyle Intervention
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Baylor College of Medicine
Osteoporosis, Osteoporotic Fractures
Multifaceted Intervention Using Telehealth to Reduce the Risk of Falls and Fractures in Older Men
Men sustain over one-third of osteoporosis-related fractures worldwide. The burden of osteoporotic fractures in older men is substantial, and men suffer significantly worse fracture-related outcomes than women.
- Conditions
- Osteoporosis, Osteoporotic Fractures, Osteoporosis, Age-Related, Muscle Loss
- Trial name
- MisterFIt (NCT05927623)
- Testing
- Multifaceted Virtual Fracture Prevention Program, Attention Control
- Where
- 5 sites in Canada
- Volunteers
- 45 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Aging
Effects of Resistance Training Programes At Different Intensities on Musculoskeletal, Metabolic, Lipid, Immunological, Inflammatory, Well-being and Functional Parameters in Older Adults.
The aging of the global population is recognized by the World Health Organization (WHO) as a major issue due to the disabilities and comorbidities related to this process, with women being the gender most affected.
- Trial name
- NCT06618469
- Testing
- Elastic band-based resistance training program at high intensity (HI), Elastic band-based resistance training program at moderate-high intensity (MHI-bands), Elastic band-based resistance training program at moderate intensity (MI)
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- University of Valencia
Menopause, Perimenopausal Disorder
Virtual perI-/Menopause Registry of AusTrALia
13 million (50.7%) Australians are born with ovaries, 14% (~3 million) are currently aged 40-59 yrs, \& all such who live to midlife will experience menopause, defined as >12 months without a period.
- Conditions
- Menopause, Perimenopausal Disorder, Postmenopausal Symptoms, Health Knowledge, Attitudes, Practice
- Trial name
- VITAL (NCT06487130)
- Testing
- N/A Observational Registry
- Where
- Australia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Bespoke Clinical Research
Cockayne Syndrome
Pharmacokinetics and Safety Study of Single and Multiple Oral Doses Prodarsan™ in Patients With Cockayne Syndrome
This study is to compare the exposure of orally administered Prodarsan to the intravenous dosed Osmitrol (10% solution) in Cockayne Syndrome (CS) patients.
- Trial name
- NCT01142154
- Testing
- Prodarsan
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- DNage B.V.
Pulmonary Disease, Chronic Obstructive, Osteoporosis
Chronic Obstructive Pulmonary Disease (COPD) and Osteoporosis
The main objective is to study important factors in the patho-physiology of osteoporosis in patients with COPD. Therefore, the investigators will study biological markers in plasma and urine and correlate them to markers of bone…
- Trial name
- NCT01067248
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Urolithiasis and Aging, Renal Calcul and Metabolic Diseases
Metabolic Assessment of Aging Men With Urinary Lithiasis
Urinary lithiasis is a common disease on young adults, but not so far on aging people. Nowadays, the investigators are seeing a gradative growth on men above sixty years old, mainly in industrialized countries.
- Conditions
- Urolithiasis and Aging, Renal Calcul and Metabolic Diseases, Urolithiasis and Osteoporosis
- Trial name
- NCT01246531
- Where
- Brazil
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Aging, Frailty
Testosterone Effects on Bone and Frailty
The purpose of this study is to assess the effects of testosterone replacement on bone density, muscle strength, physical performance, quality of life and prostate symptoms in men selected for low bone mineral density or fracture…
- Conditions
- Aging, Frailty, Osteoporosis
- Trial name
- NCT00182871
- Testing
- testosterone
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- National Institute on Aging (NIA)
Fracture, Fall
Impact of Drugs on the Risk of Falls in the Fracture Department of the Paris Saint-Joseph Hospital Group
Falls of the elderly are a public health problem that have been neglected for too long. The experience of a fall makes the elderly person vulnerable, even in the absence of traumatic consequences, and can sometimes be a reason…
- Trial name
- NCT04470895
- Testing
- Failure Track patients analysis
- Sponsor
- Fondation Hôpital Saint-Joseph
HIV-1-infection, Marker; Structural
SkIn, Muscle and Bone Aging Determinants in HIV Infected-patients.
this study consists of the study of markers of skin, muscular, neurocognitive and bone aging in HIV infected adults and to compare the frequency of these signs to the general population of same gender and age.
- Trial name
- SIMBAD (NCT04067219)
- Testing
- DXA (dual-energy x-ray absorptiometric) measurement
- Volunteers
- 123 people
- Sponsor
- University Hospital, Bordeaux
Bone Health, Osteoporosis
Mediterranean Diet and Progressive Resistance Training Effects on BMD and Bone Turnover in the Elderly
This randomized controlled trial was designed to investigate the effects of progressive resistance training (PRT) combined with a Mediterranean diet on bone mineral density (BMD) and bone turnover markers (BTMs) in older adults.
- Trial name
- MED-RES-BONE (NCT07584785)
- Testing
- Mediterranean Diet combined with Resistance Training
- Where
- Italy
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Sfax
Primary Osteoporosis
Community Smart Aging Model - Resistance Training
This clinical trial aims to evaluate the effectiveness of a smart community-based resistance training program in older adults aged 60 and older with primary osteoporosis.
- Trial name
- NCT07506538
- Testing
- Smart Community-Based Resistance Training, Routine Health Education
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Lingshu Sun
Hip Fractures, Exercise
Entertainement and Training After a Hip Fracture
Older persons are at riskt for falls and fractures. After hip surgery they are normally treated with physical or occupational therapy.
- Conditions
- Hip Fractures, Exercise, Aging
- Trial name
- ENTERAIN-HF (NCT03515395)
- Testing
- Instruction to a computer game and motivation to use it
- Where
- Switzerland
- Sponsor
- Geriatrische Klinik St. Gallen
Bone Health
An Intervention Study to Investigate the Effect of B-vitamin Supplementation for 2-years on Bone Health
An intervention study to investigate the effect of B-vitamin supplementation for 2-years on bone health. This is a dual centre (UCD and University of Ulster) 2-year randomised, placebo controlled, double blind intervention.
- Trial name
- Opti-Age (NCT03892395)
- Testing
- B-vitamin supplementation on bone health, Control group; Vitamin D, a daily capsule containing 10 µg/day vitamin D
- Where
- Ireland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Patella Fracture, Aging
Patella Fracture : A Randomized Controlled Trial
This is a multi-centre, randomized controlled trial comparing operative and non operative treatment for displaced patella fractures in elderly, low-demand patients.
- Trial name
- NCT03445819
- Testing
- Group A: Surgical Treatment, Group B: Conservative Treatment
- Where
- 3 sites in Canada
- Volunteers
- 84 people
- Sponsor
- Unity Health Toronto
Cognitive Decline, Sarcopenia
Holistic Integration for Healthy Longevity and Aging in Place
Background: Taiwan is experiencing rapid population aging, with a growing prevalence of chronic diseases and functional impairments among older adults.
- Conditions
- Cognitive Decline, Sarcopenia, Depression Disorders, Nutrition Disorder
- Trial name
- HIHOPE (NCT06882434)
- Testing
- Local intervention program, Referral Process, Telehealth Education & Digital Integration
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Vitamin D Deficiency
How Much Vitamin D is Required to be Protective Against Deficiency During the Winter Months?
Vitamin D is essential to bone health. In Canada, it is obtained by sunlight exposure of the skin (between April and October) or by a few foods such as fatty fish, eggs or fortified milk and margarine.
- Trial name
- NCT01437696
- Testing
- Vitamin D
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- McGill University
Aging
Age-related Changes in Ovarian Follicular Wave Dynamics
The investigators hypothesize that age-related changes in the number and growth dynamics of ovarian follicles will be associated with changes in hormone levels and corresponding changes in musculoskeletal health.
- Trial name
- NCT01389141
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Osteoporosis, Aging
Vitamin D Supplementation in Older Women
The purpose of this study is to examine the effects of several doses of vitamin D on hormones related to bone, calcium absorption, bone density and muscle strength.
- Trial name
- VIDOS (NCT00472823)
- Testing
- Vitamin D3, Calcium Citrate (Citracal)
- Where
- United States
- Volunteers
- 273 people
- Sponsor
- Creighton University