Clinical trials: Body Weight, active
Overweight and Obesity
An Open Label 100 Person Study Evaluating a Natural Supplement for Weight Loss and Fat Loss.
The goal of this clinical trial is to learn if motus, a natural supplement can support healthy weight loss and fat loss in a real world setting without caloric restrictions or exercise requirements.
- Trial name
- NCT07152470
- Testing
- Diet and Exercise Tracking
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Prostasis, LLC, dba Tonum Health
Adolescent Overweight, Adolescent Obesity
Improving Sleep, Decision-Making, and Eating in Adolescents With Obesity
This study is being performed to understand the effects of a lifestyle modification and sleep intervention on weight loss outcomes in adolescence.
- Conditions
- Adolescent Overweight, Adolescent Obesity, Sleep, Eating Behaviors
- Trial name
- STAR (NCT06745570)
- Testing
- Lifestyle Modification and Sleep Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Nemours Children's Clinic
Prediabetes, Brain Insulin Sensitivity
Long-term Effects of Avocado Consumption on Health in Pre-diabetic Individuals
Primary aim of the study is to assess the effect of 12-week daily avocado consumption on cerebral blood flow and markers of cardio- and vascular health in both, the periphery and the brain, in pre-diabetic individuals with…
- Conditions
- Prediabetes, Brain Insulin Sensitivity, Cerebral Blood Flow, Satiety and Food Intake
- Trial name
- NCT07752225
- Testing
- Avocados
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Maastricht University Medical Center
Obesity, Menopause
Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal Women
In postmenopausal women, obesity increases the risk of physical function decline, premature aging, and vascular dysfunction. Semaglutide and tirzepatide are potent obesity medications.
- Trial name
- NCT07057310
- Testing
- semaglutide or tirzepatide, Lifestyle modification intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Bariatric Surgery, Bone Health
Bone Health After Bariatric Surgery in Patients With Type 2 Diabetes
Background: Bone fragility is a complication of type 2 diabetes. Diabetes treatments may ameliorate or deteriorate bone fragility in this population.
- Conditions
- Bariatric Surgery, Bone Health, Obesity, Morbid, Diabetes Mellitus, Type 2
- Trial name
- BODI (NCT03455868)
- Testing
- Bariatric surgery
- Where
- 3 sites in Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Ventral Hernia
Bariatric SUrgery With Mesh REpair of Ventral Hernia: a Randomized Controlled Trial
The primary objective of the study is to demonstrate that hernia recurrence (VH) repair with non absorbable mesh concomitant to Bariatric Surgery (BS) decreases the risk of VH, with or without surgical repair, during the first…
- Trial name
- BeSURE (NCT05488288)
- Testing
- Mesh repair, Suture repair
- Where
- France
- Volunteers
- 354 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity/Overweight
This is a Multi-centre, Multi-drug, Platform Study in Chinese Participants Living With Obesity / Overweight
This study is to assess the safety and tolerability, PK characterisation, efficacy, and immunogenicity of the study intervention, and it allows assessment of the monotherapy or combination therapy of AZD6234 and AZD9550 in…
- Trial name
- NCT07017179
- Testing
- AZD6234, AZD9550, Plocebo
- Where
- 3 sites in China
- Volunteers
- 16 people
- Sponsor
- AstraZeneca
Obesity
Weight Loss Study: Genetics and Response to Naltrexone/Bupropion
The goal of this clinical trial is to understand if genetic variations are associated with the amount of weight loss with diet and while taking an FDA-approved medication for weight loss.
- Trial name
- NCT05919797
- Testing
- Naltrexone-Bupropion Combination
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Columbia University
Depression - Major Depressive Disorder, Generalized Anxiety Disorder (GAD)
Microbiota Modulation for Psychiatry Patients
The investigators aim to confirm pilot study findings (REB 119638) on the effects of delayed release apple cider vinegar (drACV).
- Conditions
- Depression - Major Depressive Disorder, Generalized Anxiety Disorder (GAD), Anxiety
- Trial name
- ACV-MTPIES-002 (NCT07899424)
- Testing
- Dietary Supplement: Acetate (Apple Cider Vinegar)
- Volunteers
- 62 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Obesity, Morbid, Bariatric Surgery Candidate
Cognitive Impairment, Obesity, and the Effects of Bariatric Surgery
Study is designed to screen psychological cognitive baseline and retention/improvement after weight loss surgery.
- Trial name
- NCT05215886
- Testing
- Surgery
- Where
- United States
- Volunteers
- 9,500 people
- Sponsor
- University of California, Davis
Overweight or Obesity, Chronic Low-back Pain
Lifestyle Intervention in Overweight/Obese Chronic Low Back Pain (CLBP) Patients: an International Multi-center RCT
Chronic low back pain (CLBP) is the most expensive cause of workrelated disability: it causes the highest number of years lived with disability.
- Trial name
- BO2WL (NCT05811624)
- Testing
- Physiotherapy intervention, including behavioral weight reduction program combined with pain neuroscience education and cognition-targeted exercise therapy., Physiotherapy intervention, including pain neuroscience education and cognition-targeted exercise therapy alone.
- Where
- 2 sites in Belgium, Switzerland
- Volunteers
- 252 people
- Sponsor
- Vrije Universiteit Brussel
Obesity & Overweight
Investigating the Effects of 24 Hour LEAP2 Infusion in Individuals With Overweight and Obesity
This study investigates whether temporarily blocking the ghrelin receptor affects appetite and food intake in people with overweight or obesity.
- Trial name
- H24LEAP2 (NCT07897383)
- Testing
- Liver-expressed antimicrobial peptide 2
- Volunteers
- 18 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Arthroplasty, Overweight and Obesity
Healthy Living After Knee Replacement
The purpose of this study is to examine if a weight loss program designed for adults after knee replacement improves weight loss, physical activity, pain, and function, as well as if the program is cost effective, as compared to…
- Trial name
- NCT05190666
- Testing
- PACE Weight Loss program, Chronic Disease Self-Management
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Obesity
Probiotic for Weight Management in Overweight and Obese Adults
To evaluate the impact of pasteurized Akkermansia muciniphila Akk11 capsules versus placebo on body composition (including body weight, BMI, body fat percentage, waist-to-hip ratio, wrist circumference, visceral fat area, and…
- Trial name
- NCT07507929
- Testing
- Probiotic
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Obesity, Asthma
Intragastric Balloon in Obese Patients With Uncontrolled Asthma
The aim of this project is to study the effect of an intragastric balloon (IGB) on asthma control in obese patients. Obese patients with uncontrolled asthma will be recruited and randomly assigned to two intervention arms : an…
- Trial name
- BOA (NCT05364957)
- Testing
- Intragastric balloon device, Dietary, Exercise intervention
- Where
- France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Toulouse
Drug Discontinuation, Substance Use Disorders
Clinical and Neurobehavioral Changes With Weight Loss Drug Discontinuation and Reinitiation
The goal of this clinical study with research procedures is to learn how stopping and restarting tirzepatide (a medication that helps regulate blood sugar and appetite) affects brain activity, behavior, and health in adults ages…
- Conditions
- Drug Discontinuation, Substance Use Disorders, Eating Behavior Changes, Tirzepatide
- Trial name
- CLIN-GLP1 (NCT07387796)
- Testing
- Discontinuation and Reinitiation of Tirzepatide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas at Dallas
Cesarean Section, Surgical Wound Infection
Timing of Cesarean Wound Dressing Removal on Wound Healing in Women With BMI ≥ 30 kg/m²
Cesarean delivery is one of the most common surgical procedures in obstetric care. Women with obesity (body mass index [BMI] of 30 kg/m² or higher) are at increased risk for postoperative wound complications, including surgical…
- Conditions
- Cesarean Section, Surgical Wound Infection, Wound Healing, Obesity
- Trial name
- NCT07846930
- Volunteers
- 726 people
- Sponsor
- Assiut University
Craniopharyngioma
A Comparative Study Evaluating the Impact of Intensive Dietary Care on Weight Change and Biological Parameters in Patients Who Underwent Surgery for Craniopharyngioma During the First Postoperative Year
Craniopharyngiomas are rare benign tumors that develop in the hypothalamic-pituitary region. Their prevalence is estimated at approximately 1 in 50,000 people in France.
- Trial name
- CRANIODIET (NCT07835165)
- Testing
- Intensive dietary care
- Volunteers
- 75 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Diabetes Mellitus, Type 2
Maridebart Cafraglutide Versus Semaglutide in Participants With Type 2 Diabetes
The main objective of this trial is to evaluate whether maridebart cafraglutide is non-inferior to semaglutide in improving glycemic control in participants with type 2 diabetes (T2D) who are receiving metformin treatment, with…
- Trial name
- MARITIME-T2D-3 (NCT07866066)
- Testing
- Maridebart cafraglutide, Semaglutide
- Where
- 8 sites in United States, Canada
- Volunteers
- 1,300 people
- Sponsor
- Amgen
Obesity, Childhood, Diabetes Mellitus, Type 2
The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort
The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort study is a unique and comprehensive longitudinal study of 630 Caucasian children and their parents that was designed to investigate the natural history and…
- Conditions
- Obesity, Childhood, Diabetes Mellitus, Type 2, Cardiovascular Risk Factor, Pediatric ALL
- Trial name
- QUALITY (NCT03356262)
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
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