Clinical trials: Blood Stream Infection
Microbial Colonization
Rifaximin for Infection Prophylaxis in Hematopoietic Stem Cell Transplantation
Primary purpose of the study is to see if rifaximin can improve the balance of bacteria within the gut, which has been shown to improve transplant outcomes.
- Trial name
- NCT03529825
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Emory University
Enterococcus Faecalis Infection, Blood Stream Infection
Antimicrobial Combination Therapy for Treatment of Enterococcus Faecalis Bacteremia
Prospective, multicenter, national, observational pharmacological study on the evaluation of efficacy of appropriate monotherapy vs combination treatment for non-complicated Enterococcus faecalis (EF) bloodstream infection (BSI)…
- Conditions
- Enterococcus Faecalis Infection, Blood Stream Infection, Gut Microbiomes
- Trial name
- MicroEFfAECT (NCT06833593)
- Where
- 4 sites in Italy
- Volunteers
- 510 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Device Related Infection, Vascular Access Complication
The IVCare Adaptive Platform Trial
The IVCare trial is a multicentre adaptive platform study evaluating interventions to prevent infections and other complications associated with central venous access devices (CVADs) in patients with newly inserted or existing…
- Conditions
- Device Related Infection, Vascular Access Complication, Device Related Sepsis, Catheter Infection
- Trial name
- NCT07587593
- Testing
- Connectors/Caps Domain - Standard of Care, Curos™, ClearGuard™ HD
- Volunteers
- 2,500 people
- Sponsor
- The University of Queensland
Cancer
Dental Study in Cancer Patients With Central Venous Catheters
Patients who are preparing to receive chemotherapy are asked to have their teeth cleaned before starting treatment as standard of care.
- Trial name
- NCT00798330
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Rajesh Lalla
Congenital Disorders
Chlorhexidine Swabs Effectiveness in Reducing Blood Stream Infections
Children's Healthcare of Atlanta (Children's) is collaborating with Child Health Corporation of America (CHCA) in the nationwide effort to reduce catheter related blood stream infections (BSIs).
- Trial name
- NCT00485992
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- Children's Healthcare of Atlanta
Ventilator Acquired Pneumonia, Central Line Associated Blood Stream Infections (CLABSI)
Evidence-Based Nursing to Reduce Adverse Events Regarding Ventilator Associated Pneumonia, Pressure Injuries and Central Line Bloodstream Infection in Intensive Care Unit in Bangladesh
Quality of care is crucial for preventing adverse events such as infection in the intensive care units (ICUs). The most common ICU-acquired infections include pneumonia such as Ventilator Associated Pneumonia (VAP), Pressure…
- Conditions
- Ventilator Acquired Pneumonia, Central Line Associated Blood Stream Infections (CLABSI), Pressure Ulcer (PU), Medical Device Related Pressure Ulcer (MDRPU)
- Trial name
- EBP in Nursing (NCT07299799)
- Testing
- Education with EBP, This is a pre- and post- quasi-experimental study.
- Where
- 2 sites in Bangladesh, Japan
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
Candidemia
SIHAM Candidemia Network:An Observational Study
Title: A multicenter observational study of candidemia cases among ICU patients in India Objective: Primary objective: Determine epidemiological and also clinical parameters of candidemia cases among ICU patients in India.
- Trial name
- NCT01281345
- Where
- India
- Volunteers
- 1,400 people
- Sponsor
- Society of Indian Human & Animal Mycologist
Bloodstream Infections
RCT Cefiderocol vs BAT for Treatment of Gram Negative BSI
The purpose of this study is to determine whether a new antibiotic, Cefiderocol which works against a wide variety of gram negative bacteria, is equally effective as the antibiotics that are currently used as current standard of…
- Trial name
- GAMECHANGER (NCT03869437)
- Testing
- Cefiderocol, Best Available Therapy
- Where
- 19 sites in Australia, Malaysia and 4 more
- Volunteers
- 513 people
- Sponsor
- The University of Queensland
Bacteremia, Sepsis
Epidemiology and Determinants of Outcomes of Hospital Acquired Blood Stream Infections in the Intensive Care in Turkey
In this observational study, it is aimed to investigate the mortality and morbidity rates of hospital-acquired blood stream infections that are treated in intensive care units (ICU).
- Conditions
- Bacteremia, Sepsis, Hospital Acquired Condition
- Trial name
- NCT04304456
- Testing
- Treatment
- Volunteers
- 810 people
- Sponsor
- SCARE (Study group for carbapenem resistance)
Blood Stream Infection, Blood Stream Infections
Evaluation of Diagnostic Accuracy and Clinical Performance of the UllCORE Bloodstream Infection (BSI) Test
This study is designed to evaluate the clinical performance of the UllCORE Bloodstream Infection (BSI) Test, an investigational molecular diagnostic test intended to detect microorganisms and selected antimicrobial resistance…
- Conditions
- Blood Stream Infection, Blood Stream Infections, Sepsis, Fungemia
- Trial name
- B-RAPID (NCT07859852)
- Testing
- UllCORE BSI Test
- Where
- 20 sites in United States, France and 3 more
- Volunteers
- 1,500 people
- Sponsor
- Deepull Diagnostics S.L.
Chronic Myeloproliferative Disorders, Infection
Antimicrobial Solution or Saline Solution in Maintaining Catheter Patency and Preventing Catheter-Related Blood Infections in Patients With Malignancies
RATIONALE: Antimicrobial solution comprising trimethoprim-sulfamethoxazole, edetate calcium disodium, and ethanol may help prevent blockages and infections from forming in patients with central venous access catheters or…
- Conditions
- Chronic Myeloproliferative Disorders, Infection, Leukemia, Lymphoma
- Trial name
- NCT01101412
- Testing
- Edetate Calcium Disodium, Ethanol, Trimethoprim-sulfamethoxazole
- Sponsor
- M.D. Anderson Cancer Center
Catheterization, Infection
Trial on the Efficacy of Tegaderm Chlorhexidine Gluconate (CHG) in Reducing Catheter Related Bloodstream Infections
TegaCHG is a multicentric randomized study aimed at evaluating the possibility that the use of TegaDerm CHG dressing may reduce the incidence of catheter related blood stream infections (CRBSI).
- Trial name
- TegaCHG (NCT01142934)
- Testing
- Transparent adhesive dressing with an integrated gel pad containing 2% w/w chlorhexidine gluconate (CHG) (TegaDerm CHG)
- Where
- 8 sites in Italy
- Volunteers
- 1,200 people
- Sponsor
- Catholic University of the Sacred Heart
Bacterial Infections
Quinolone Resistance in Bloodstream Isolates of Escherichia Coli
This proposed study aims to document the risk factors for quinolone resistance in bloodstream isolates of E. coli. Additionally, the adequacy of empiric antibiotic therapy for E. coli bloodstream infections will be assessed.
- Trial name
- NCT00449735
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Pittsburgh
Haematological Malignancy, Febrile Neutropenia
Effect of the BioFire FilmArray (BCID2) for the Rapid Detection of Bloodstream Infection in Haematologic Patients With Febrile Neutropenia
The goal of this observational study is to assess if the molecular diagnostic tool BioFire FilmArray BCID2 is more useful for the microbiological diagnosis of bloodstream infections in hematological patients with febrile…
- Conditions
- Haematological Malignancy, Febrile Neutropenia, Blood Stream Infection
- Trial name
- ONFIRE (NCT06787326)
- Where
- Spain
- Volunteers
- 228 people
- Sponsor
- Hospital Universitari de Bellvitge
Beta Lactam Resistant Bacterial Infection, Enterobacteriaceae Infections
PipEracillin/Tazobactam Versus mERoPENem for Treatment of AmpC Producing Blood Stream Infections
Data regarding optimal treatment for extended-spectrum beta-lactamase (ESBL) producing Enterobacterales bloodstream infection are lacking.
- Conditions
- Beta Lactam Resistant Bacterial Infection, Enterobacteriaceae Infections, Bacteremia
- Trial name
- SPICE-M (NCT05355350)
- Testing
- Piperacillin / Tazobactam Injection, Meropenem
- Where
- 4 sites in Israel
- Sponsor
- Rambam Health Care Campus
Salmonella Septicemia, Salmonella Infections
IDIS Project Work Package 2: Establishing a Biobank at ITM and Collaborating Centres
The IDIS study aims to develop a new rapid diagnostic test for invasive salmonellosis using samples (blood, urine) collected from patients with fever and healthy controls at the Institute of Tropical Medicine (ITM) and…
- Conditions
- Salmonella Septicemia, Salmonella Infections, Fever, Blood Stream Infections
- Trial name
- IDIS (NCT02689193)
- Testing
- Blood sampling
- Where
- 3 sites in Belgium, Cambodia and 1 more
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Blood Stream Infections, Endocarditis
Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin
1. Drug resistance of G+ cocci is a severe healthcare problem. According to the Ministry of Health National Antimicrobial Resistant Investigation Net (mohnarin) surveillance report, the isolation rate of MRSA is some 60% in…
- Conditions
- Blood Stream Infections, Endocarditis, MRSA
- Trial name
- NCT02443064
- Testing
- Vancomycin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhejiang University
Bacteremia, Sepsis
Impact of Rapid Pathogen Identification From Blood Cultures (RABbIT)
Septic shock carries high mortality, which may be exacerbated by inappropriate initial therapy. Inappropriate therapy may result from unanticipated antimicrobial resistance.
- Conditions
- Bacteremia, Sepsis, Fungemia, Blood Stream Infection
- Trial name
- RABbIT (NCT02743585)
- Testing
- Filmarray Blood Culture ID (BCID) panel, Rosco Diagnostica ESBL/carbapenemase screen kit
- Where
- Singapore
- Volunteers
- 832 people
- Sponsor
- Tan Tock Seng Hospital
Vascular Access Complication, Device Related Infection
Chlorhexidine Caps for CLABSI Prevention in Hemodialysis: a Pilot Randomized Controlled Trial
The goal of this clinical trial is to compare a chlorhexidine antimicrobial barrier cap in patients requiring hemodialysis treatment to the standard hemodialysis caps currently used within the Metro North Kidney Health Service.
- Conditions
- Vascular Access Complication, Device Related Infection, Device Related Sepsis, Catheter Infection
- Trial name
- ECHO-HD (NCT07019610)
- Testing
- ClearGuard HD, B Braun Combi-stopper
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- The University of Queensland
Acute Lymphoblastic Leukemia, Bloodstream Infection
The Role of NK Cells to Detect Blood Infection in ALL.
1. Assess possibility of prediction of blood stream infections in ALL patients by profiling of NK cells using flow cytometry. 2. Assess the role of NK cells in development of drug resistance post chemotherapy.
- Trial name
- NCT06160115
- Testing
- Flow cytometry
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Assiut University