Clinical trials: Blood Donors
Blood Donors, Apheresis
Collection and Distribution of Blood Components From Healthy Donors for In Vitro Research Use
Background: Many different research projects need a steady supply of human blood. Blood donated by screened, healthy people may be used to test new drugs, for example, or to learn how blood cells work.
- Trial name
- NCT07877259
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Blood Donors, Research Subjects
COLLECT BLOOD/RESEARCH USE
This protocol is designed to provide a mechanism for the Department of Transfusion Medicine, Clinical Center to collect and process blood components from paid, healthy volunteer donors for distribution to NIH intramural…
- Conditions
- Blood Donors, Research Subjects, Apheresis
- Trial name
- NCT00001846
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Iron Deficiency, Latent Iron Deficiency
Reticulocyte Hemoglobin Equivalent (RET-He) in Early Detection of Iron Deficiency Among Blood Donors and Its Potential Impact on Donor Eligibility and Transfusion Safety
Blood donation is essential for healthcare, but repeated whole-blood donation can deplete the body's iron stores. Standard pre-donation screening relies on hemoglobin levels to ensure donor safety; however, a drop in hemoglobin…
- Conditions
- Iron Deficiency, Latent Iron Deficiency, Blood Donors, Iron Deficiency Anemia
- Trial name
- NCT07861607
- Volunteers
- 300 people
- Sponsor
- Assiut University
Increase Repeat Blood Donation Attempts Among First-time Donors
Community-based Communication for Blood Donation in Ghana
A randomized controlled trial to evaluate the effectiveness of the WhatsApp groups or docudrama compared to a control group (usual engagement with blood services) on repeat blood donation attempts among first-time blood donors in…
- Trial name
- C-CAD (NCT05973890)
- Testing
- WhatsApp, docudrama
- Where
- United States
- Volunteers
- 882 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Blood Donation, Blood Platelets
grouP O wholE blooD : storagE leSion impacT And infLammation
"Etablissement Français du Sang" (EFS) prepares labile blood products from blood donations that are separated by type (red blood cells, plasma and platelets).
- Conditions
- Blood Donation, Blood Platelets, Blood Donors, Inflammation
- Trial name
- PEDESTAL EFS (NCT06809010)
- Testing
- Whole blood donation, Apheresis donation
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Etablissement Français du Sang
Healthy Blood Donor
Comparison of the Impact of Different Suspension Mediums on ABO Antibody Titres.
Accurate estimation of ABO antibody titres is vital in Transfusion Medicine due to their involvement in hemolytic transfusion reactions, hemolytic disease of the fetus and newborn, and solid-organ transplant rejection.
- Trial name
- NCT07054372
- Testing
- Titres on conventional test tube method with different diluent
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Patients With Different Manifestations of Lyme Borreliosis, Persons With Nonspecific Symptoms and Positive Borrelia Antibodies in Serum
Anti-phospolipid Antibodies in Lyme Borreliosis
Background Lyme borreliosis, caused by Borrelia burgdorferi sensu lato is transmitted to humans through the bite of an infected Ixodes tick. B.
- Conditions
- Patients With Different Manifestations of Lyme Borreliosis, Persons With Nonspecific Symptoms and Positive Borrelia Antibodies in Serum, Blood Donors
- Trial name
- NCT06929546
- Testing
- Anti-phospholipid antibodies
- Where
- Slovenia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Blood Disease, Blood Donors
Blood Donation--Immune Sequelae and Recruitment
To determine if there were immune sequelae related to the long-term donation of blood or blood products.
- Trial name
- NCT00005341
- Sponsor
- University of New Mexico
Platelet Dysfunction in Blood Donors
Platelet Dysfunction in Blood Donors
Platelets are circulating blood cells. They bind to each other and to the damaged vessel wall to prevent excessive bllod loss. Unlike quantitative platelet defects, there is no automated, simple test to diagnose qualitative…
- Trial name
- DysPlaq (NCT03599219)
- Testing
- sample
- Where
- France
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Etablissement Français du Sang
Blood Donors, Anti-HLA Antibody
Obstetrical History and Anti-HLA Antibodies Level
Chronic histiocytic intervillositis (CHI) is associated with severe and recurrent obstetrical complications. A link between anti-HLA Antibodies (Ab) and CHI has recently been established.
- Trial name
- OBS-HLA (NCT06021925)
- Testing
- Obstetrical history, Anti-HLA Antibody tests
- Where
- France
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Blood Donors
Community-Based Communication Approaches for Blood Donation in Ghana
DESIGN This pilot study utilizes a mixed-methods approach to develop a novel docu- drama communication strategy, design WhatsApp intervention, evaluate the feasibility of a larger pragmatic randomized controlled trial (RCT) of…
- Trial name
- C-CAD (NCT04783077)
- Testing
- WhatsApp, Control, Docudrama
- Where
- Ghana
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Related Donors Donating Peripheral Blood Stem Cells (PBSC) to a Family Member, Acute Myelogenous Leukemia
A Phase II Study Evaluating the Safety and Efficacy of Subcutaneous Plerixafor
This is a Phase II, open-label, two strata, multicenter, prospective study of plerixafor-mobilized HLA-identical sibling allografts in recipients with hematological malignancies.
- Conditions
- Related Donors Donating Peripheral Blood Stem Cells (PBSC) to a Family Member, Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome
- Trial name
- NCT01696461
- Testing
- Plerixafor
- Where
- 12 sites in United States
- Volunteers
- 127 people
- Sponsor
- Center for International Blood and Marrow Transplant Research
Hematopoietic Stem Cell Transplantation, Haplo-identical Donor
Haplo HCT vs Haplo-cord HCT for Patients With AML
Patients who have acute myeloid leukemia and will undergo haplo-identical donor hematopoeitic cell transplantation (haplo HCT) are potential candidates of this trial.
- Conditions
- Hematopoietic Stem Cell Transplantation, Haplo-identical Donor, Cord Blood Unit, Acute Myeloid Leukemia
- Trial name
- NCT03719534
- Testing
- haplo-HCT, haplo-cord HCT
- Where
- 5 sites in China
- Volunteers
- 134 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Transmission, Blood, Recipient/Donor
Clinical Investigation to Evaluate the Haemonetics POLFA Modified Sample Needle Assembly With Vacuum Tube Holder
This study evaluates whether whole blood transferred through the new POLFA needle assembly meets supernatant hemoglobin acceptability standards.
- Trial name
- NCT02476851
- Testing
- POLFA (Needle Assembly), Kawasumi (Needle Assembly)
- Where
- 3 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Haemonetics Corporation
Blood Donors
Evaluation of Whole Blood With CPD Anticoagulant and AS-7/SOLX Additive Solution
This study will evaluate a new blood collection and filtration system that is intended to be used to collect, filter, separate and store red blood cells and, separately, plasma.
- Trial name
- NCT02145507
- Testing
- SOLX (Investigational), AS-3 (Control)
- Where
- 2 sites in United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Haemonetics Corporation
Blood Donors
Blood Donor Competence, Autonomy and Relatedness Enhancement
The purpose of this study is to determine whether enhancing blood donor competence, autonomy, and/or relatedness increases intrinsic motivation to donate and improves donor retention.
- Trial name
- NCT02717338
- Testing
- Competence, Autonomy, Relatedness
- Where
- United States
- Volunteers
- 2,580 people
- Sponsor
- Ohio University
Blood Donors
Addressing Fear and Risk of Vasovagal Reactions Among High School Donors
In this study, high school donors will be asked about their blood donation-related fears prior to their donation. Half of the donors reporting fear will be assigned to a brief coping skills intervention.
- Trial name
- NCT03835299
- Testing
- Fear Intervention
- Where
- United States
- Volunteers
- 4,035 people
- Sponsor
- Ohio University
Blood Donors, Dengue
Dengue Seroprevalence Study in Blood Donors in the French West Indies
Dengue is an infectious disease most prevalent in the world. This disease is endemic in the Caribbean, with an increase in seasonal rains.
- Trial name
- DengSeroprevAn (NCT01104740)
- Testing
- Biological sample collection
- Where
- 2 sites in Guadeloupe, Martinique
- Volunteers
- 817 people, healthy volunteers welcome
- Sponsor
- Etablissement Français du Sang, Martinique
Autologous Blood Transfusion, Physical Performance
Transfusion of Whole Blood to Military Forces in a Combat Situation
During military action there might be situations where civil requirements for blood transfusion are not obtainable. Numerous warfare experiences suggest that administration of whole blood to a patient with uncontrollable…
- Conditions
- Autologous Blood Transfusion, Physical Performance, Donor Safety
- Trial name
- NCT04496700
- Testing
- Whole blood donation and transfusion
- Where
- 2 sites in Norway
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Rh Negative Blood Donor
The Effect of Message Framing on Blood Donation-Study 1
Rh negative blood group is a rare blood group in China, as it only accounts for 0.3-0.4 percent of the Han population. Therefore, low inventory is often found in blood collection and supply agencies in many regions in China.
- Trial name
- NCT03741413
- Testing
- Gain-frame SMS, Loss-frame SMS, Control SMS
- Where
- China
- Volunteers
- 2,074 people
- Sponsor
- Guangzhou Blood Center