Clinical trials: Blepharitis
Dry Eye Syndromes, Dry Eye
Corneal Epithelial Stem Cells and Dry Eye Disease
To study of a novel, therapeutic Human Cells, Tissues, and Cellular and Tissue-Based Product (HCT/P) in the treatment of severe dry eye disease that is failing conventional treatments.
- Conditions
- Dry Eye Syndromes, Dry Eye, Ocular Inflammation, Ocular Surface Disease
- Trial name
- NCT03302273
- Testing
- Corneal Epithelial Stem Cell Transplant
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Sloan W. Rush, MD
Blepharitis
Treatment of Blepharitis Induced by Demodex Folliculorum Through Eyelid Cleansing With Wipes Containing Topical Chlorhexidine
This study employed an experimental, prospective, longitudinal, before-and-after design to evaluate the efficacy of topical chlorhexidine wipes in treating blepharitis.
- Trial name
- TBIDFTECWCTC (NCT07451678)
- Testing
- Eyelid Cleansing with Wipes Containing Topical Chlorhexidine
- Where
- Mexico
- Volunteers
- 39 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Chronic Blepharitis
Demodex Blepharitis Treatment Study
This is a randomized clinical trial to determine the safety and efficacy of terpinen-4-ol (T4O), the most active ingredient of tea tree oil (TTO), in eradicating ocular demodicosis (reducing ocular demodex counts and achieving…
- Trial name
- DBTS (NCT01647217)
- Testing
- Terpinen-4-ol
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- BioTissue Holdings, Inc
Demodex Blepharitis
Efficacy and Tolerability of Blephademodex Wipes
Primary Objective To evaluate efficacy of Blephademodex eyelid hygiene wipe treatment with a subsequent maintenance period with Blephaclean lid cleansing wipes in Demodex blepharitis, as assessed by the change in ocular symptoms…
- Trial name
- NCT04780165
- Testing
- Blephademodex
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Laboratoires Thea
Blepharitis
Evaluation of SUMMIT BRUSH in Treatment of Blepharitis
Dry Eye Disease (DED) is a multifactorial disease that affects ~15-30 million people in the USA alone. It creates an enormous societal and economic burden, decreases productivity in the workplace, and affects the quality of lives…
- Trial name
- NCT04603222
- Testing
- SUMMIT BRUSH, Ocusoft Lid Scrub Original Foaming Eyelid Cleanser
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Blepharitis
Safety and Efficacy of KPI-121 in Subjects With Inflammatory Meibomian Gland Disease
The primary purpose of this study is to determine the efficacy and safety of KPI-121 ophthalmic suspension compared to vehicle (placebo) in subjects with signs and symptoms of inflammatory meibomian gland disease.
- Trial name
- Maui (NCT02218489)
- Testing
- KPI-121, Vehicle
- Where
- 8 sites in United States
- Volunteers
- 206 people
- Sponsor
- Kala Pharmaceuticals, Inc.
Meibomian Gland Dysfunction, Cataract
Efficacy of LipiFlow in Patients Affected by Meibomian Gland Dysfunction in Reducing Post-cataract Surgery Dry Eye
Dry Eye Disease (DED) is a disease of the ocular surface which may be secondary to a variety of causes, including cataract surgery.
- Conditions
- Meibomian Gland Dysfunction, Cataract, Surgery--Complications, Dry Eye
- Trial name
- LIPICAT (NCT05062564)
- Testing
- LipiFlow Thermal pulsation system, Eyelid warm compresses plus massages
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Blepharitis, Meibomianitis
Treatment of Patients With Blepharitis and Facial Rosacea
To determine the safety and efficacy of sub-antimicrobial dose COL-101 in the treatment of patients who have both blepharitis and facial rosacea
- Conditions
- Blepharitis, Meibomianitis, Dry Eye
- Trial name
- NCT00560703
- Testing
- COL-101 (doxycycline, USP) capsules
- Where
- 8 sites in United States
- Volunteers
- 70 people
- Sponsor
- Galderma R&D
Posterior Blepharitis
Oral Azithromycin Versus Doxycycline in Posterior Blepharitis
One hundred patients with the diagnosis of posterior blepharitis based on history taking and proper physical examinations by two experienced ophthalmologists will include in the study.
- Trial name
- NCT01783860
- Testing
- Azithromycin, Doxycycline
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Tehran University of Medical Sciences
Posterior Blepharitis
Topical IL-1-Ra for Treatment of Posterior Blepharitis
The purpose of this study is to determine the effectiveness and safety of Topical Interleukin-1-Receptor Antagonist in treatment of signs and symptoms of posterior blepharitis.
- Trial name
- NCT00681109
- Testing
- 2.5% IL-1Ra, 5% IL-1Ra
- Volunteers
- 75 people
- Sponsor
- Reza Dana, MD
Artifical Intelligence, Cataract
Development of a Mobile Terminal-Based Intelligent Detection System for Multiple Anterior Segment Diseases of the Eye
This is a multi-center, cross-sectional study evaluating a smartphone-based artificial intelligence (AI) system for anterior segment eye disease screening.
- Conditions
- Artifical Intelligence, Cataract, Pterygium, Keratopathy
- Trial name
- LENS (NCT07634913)
- Testing
- Smartphone-based on-device artificial intelligence system for anterior segment eye disease screening
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Sebaceous Gland Diseases, Blepharitis
Efficacy of iLid Cleanser (Avenova) Versus Vehicle on Ocular Skin Flora
This study is designed to evaluate the effect of Novabay iLid Cleanser, as compared to its Vehicle, on the ocular skin flora. In the pre-randomization phase, subjects will receive a single application of open-label NovaBay iLid…
- Trial name
- NCT02455895
- Testing
- iLid Cleanser
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- NovaBay Pharmaceuticals, Inc.
Blepharitis
Sterile Plant-Based Gauze for Eyelid Hygiene in Anterior Blepharitis
The goal of this clinical trial is to learn whether a sterile gauze containing natural plant extracts can lower the number of bacteria on the eyelid margin in people with bilateral anterior blepharitis.
- Trial name
- BLEPH-GAUZE (NCT07759180)
- Testing
- Plant-Based Sterile Eyelid Gauze, Sterile Cotton Gauze Moistened with Saline Solution
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona
Blepharitis
Trial to Evaluate the Efficacy and Safety of TP-03, LIBRA Study
The Phase III main study is a randomized, controlled, multicenter, double blind, trial to evaluate the efficacy and safety of TP-03 (lotilaner ophthalmic solution, 0.25%), for the treatment of Demodex blepharitis in Chinese…
- Trial name
- NCT05629390
- Testing
- Lotilaner, Vehicle Control
- Where
- 21 sites in China
- Volunteers
- 163 people
- Sponsor
- LianBio LLC
Conjunctivitis, Keratitis
Loteprednol and Tobramycin Versus Tobramycin and Dexamethasone, in the Treatment of Blepharokeratoconjunctivitis
This study is to evaluate the safety and efficacy of loteprednol etabonate [LE] and tobramycin ophthalmic suspension versus tobramycin and dexamethasone ophthalmic suspension in the treatment of ocular inflammation associated…
- Conditions
- Conjunctivitis, Keratitis, Blepharitis
- Trial name
- NCT01028027
- Testing
- Loteprednol and tobramycin, Tobramycin and dexamethasone
- Where
- Singapore
- Volunteers
- 357 people
- Sponsor
- Bausch & Lomb Incorporated
Seborrheic Blepharitis
TTO Swabs Versus Baby Shampoo in Patients With Seborrehic Blepharitis
The aim of the study was to compare the efficacy of lid swabs containing tea tree oil (TTO) and chamomile oil and baby shampoo (BS) in the treatment of seborrheic blepharitis.
- Trial name
- NCT04678531
- Testing
- Swabs containing tea tree oil and chamomile oil
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people
- Sponsor
- Istanbul University - Cerrahpasa
Blepharitis
Study of the Safety and Efficacy of Moxidectin Tablets for the Reduction of Demodex Eyelash Infestation
A Single-Center, Investigator-Masked, Randomized, Placebo-Controlled, Investigator Initiated Study of the Safety and Efficacy of Moxidectin Tablets for the Reduction of Demodex Eyelash Infestation
- Trial name
- NCT06795165
- Testing
- Moxidectin 2 MG Oral Tablet
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Eye Research Foundation, Inc.
Posterior Blepharitis, Meibomian Gland Dysfunction
Evaluation of AXR-270 for the Treatment of Posterior Blepharitis Associated With Meibomian Gland Dysfunction
This study will evaluate the safety, tolerability and efficacy of AXR-270 Cream in treating posterior blepharitis associated with Meibomian Gland Disease (MGD)
- Trial name
- NCT04469998
- Testing
- AXR-270 Low Dose, AXR-270 High Dose, AXR-270 Vehicle
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- AxeroVision, Inc.
Anterior Blepharitis
Clinical Lid Eradication of Antifungal-Responsive FUNGUS Study
The goal of this clinical trial is to learn if Natacyn works to reduce or eliminate laboratory-confirmed fungal organisms in subjects with fungal-positive blepharitis identified in a previous study. asthma in adults.
- Trial name
- CLEAR (NCT07856680)
- Testing
- NATACYN®
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Brent Kramer
Blepharitis, Meibomian Gland Dysfunction
Antimicrobial and Clinical Efficacy of Cliradex® as Compared With I-Lid'n Lash® Hygiene in Treating Blepharitis
Previous studies have shown the clinical and antimicrobial efficacy of eyelid hygiene with tea tree oil (TTO) in resolving chronic blepharitis.
- Trial name
- NCT03422146
- Testing
- Tea Tree Oil (TTO), I-Lid'n Lash® Hygiene
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute