Clinical trials: Blast Injuries
Traumatic Brain Injury, Cognitive Symptoms
Cognitive Rehabilitation of Blast Traumatic Brain Injury (TBI)
The purpose of this study is to investigate the efficacy of a structured rehabilitation program on cognitive function and quality of life in individuals with blast-induced traumatic brain injury (bTBI).
- Trial name
- CRbTBI (NCT01138020)
- Testing
- Cognitive Intervention, Educational intervention
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- VA Office of Research and Development
Multiple Trauma, Blast Injuries
Factors Affecting Return to Work Among OEF/OIF Veterans With Polytrauma
The goal of this study is to examine things that make it easy or hard for OEF/OIF veterans with polytrauma to live independently or do things "on their own" at home and in the community.
- Conditions
- Multiple Trauma, Blast Injuries, Brain Injuries
- Trial name
- NCT00872690
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- US Department of Veterans Affairs
Dizziness, Brain Injury
Vestibular Consequences of Blast-related Mild Traumatic Brain Injury (TBI)
The purpose of this project is to determine the effects of mild traumatic brain injury and blast exposure on the inner ear balance and central nervous systems.
- Trial name
- NCT01021137
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Blast Injuries
Long-Term Effects of Repetitive, Low-Level Blast Exposure on Special Operations Forces Service Members
This is a pilot study to identify biomarkers that individually, and in combination, demonstrate the greatest sensitivity to repetitive, low-level blast exposure (RLLBE) neurotrauma in Special Operations Forces (SOF) personnel.
- Trial name
- ReBlast (NCT05183087)
- Testing
- 3T Connectome MRI, 7 Tesla MRI, TSPO PET
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Ocular Injury, Blast Injuries
Fireworks Eye Injuries During Festivals in Upper Egypt
The aim of this study is to explore and report the epidemiology and outcome of fireworks ocular injuries in Upper Egypt. Primary outcome : type and severity of injury of fireworks eye trauma during festives.
- Trial name
- NCT06512532
- Testing
- fireworks eye injury
- Where
- Egypt
- Volunteers
- 59 people
- Sponsor
- Assiut University
Wounds, Gunshot, Arm Injuries
Trial of Negative-pressure Wound Therapy Use in Conflict-related Extremity Wounds
There is a treatment method called negative-pressure wound therapy (NPWT) that is well established and used for the treatment of wounds.
- Conditions
- Wounds, Gunshot, Arm Injuries, Leg Injuries, Wound Infection
- Trial name
- VACoCREW (NCT02444598)
- Testing
- Vaccum Assisted Closure device, Conventional wound dressings
- Where
- 2 sites in Iraq, Jordan
- Volunteers
- 116 people
- Sponsor
- Karolinska Institutet
Blast or Combat Exposure, Head Injury Trauma
Pre-post Evaluation of the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans With Repeated Blast Exposure
A Pre-post Study Evaluating the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans with Sequelae of Repeated Blast Exposure.
- Trial name
- NCT04313712
- Testing
- ibogaine with magnesium treatment
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Tinnitus
Caroverin and Inner Ear Diseases
This trial is a randomized, double blind, placebo controlled study on patients suffering from inner ear diseases with tinnitus as a principal symptom.
- Trial name
- NCT01174979
- Testing
- Caroverin
- Where
- Austria
- Volunteers
- 170 people
- Sponsor
- Phafag AG
Concussion, Mild
Novel Protection Against Potential Brain, Hearing and Vision Injury During Blast Wave Exposure
The purpose of the study is to monitor changes in brain structure and function between the pre-training and post-training, in a population of tactical team members wearing the Device and compared to a similar population not…
- Trial name
- BLAST (NCT03017924)
- Testing
- Q collar
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Wounds and Injuries, War-Related Injuries
Retrospective Morbidity and Mortality Study of Conflict-Related Injuries: Erbil, Iraq
A retrospective morbidity and mortality study, using routinely collected data, investigating the epidemiology of patients with conflict-related injuries presenting to a dedicated trauma hospital in Erbil, Iraq, during the…
- Conditions
- Wounds and Injuries, War-Related Injuries, Gunshot Wound, Blast Injuries
- Trial name
- NCT03358758
- Where
- Sweden
- Volunteers
- 1,832 people
- Sponsor
- Karolinska Institutet
Blast Injury
Precision Biomarkers to Detect Brain Injury in Active-Duty United States Special Operations Forces With Repeated Blast Exposure
This is a 4-year, longitudinal study of 100 active-duty Navy SEALs. The goal of the study is to determine whether repeated blast exposure affects SEAL brain health and to develop an initial diagnostic testing protocol that…
- Trial name
- NCT07131475
- Testing
- PBR28 TSPO PET
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Burn Scar Pain, Neuropathic Pain
Ultrasound Predictors of Persistent Burn Scar Pain After Blast and Drone-Related Injuries: A Prospective Cohort Study
Persistent burn scar pain is common after blast and drone-related injuries and may be driven by scar fibrosis, vascular activity, and peripheral nerve involvement within scar tissue.
- Conditions
- Burn Scar Pain, Neuropathic Pain, Combat-Related Burn Injury, Scar-Related Pain
- Trial name
- US-SCAR-PAIN (NCT07438769)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Traumatic Brain Injury
Advanced MRI in Blast-related TBI
Thousands of soldiers, marines, and other military personnel have had injuries to the brain due the wars in Iraq and Afghanistan.
- Trial name
- NCT00785304
- Where
- 2 sites in United States, Germany
- Volunteers
- 100 people
- Sponsor
- Washington University School of Medicine
Corneal Foreign Body Following Blast Injury
Visual Prognosis in Non-Penetrating Corneal Blast Injuries
The purpose of this study is to assess visual quality of patients with non-penetrating, non-metallic, stable corneal foreign bodies.
- Trial name
- NCT00414219
- Testing
- Visual quality of patients with corneal eye injuries
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Traumatic Brain Injury
Early Digital, Analyte and Neurologic Biomarkers of Acute and Chronic Brain Injury and Recovery in CQT Instructors
Repetitive blast exposure has been shown to lead to more severe neurobehavioral impairments versus a single exposure. Blast-induced Traumatic Brain Injury (TBI) can lead to short- and long-term adverse outcomes Even mild brain…
- Trial name
- NCT05917665
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Blast Injuries, Brain Injuries
Central Auditory Processing Deficits Associated With Blast Exposure
The current conflicts in Afghanistan and Iraq have resulted in unprecedented rates of exposure to high-intensity blasts and resulting brain injury.
- Conditions
- Blast Injuries, Brain Injuries, Age Factors
- Trial name
- NCT01567020
- Testing
- Diagnostic
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pressure Ulcer
Evaluating Blast-X® in Combination With Negative Pressure Wound Therapy
A Multi-center, Prospective Clinical Trial Evaluating the Combination of BlastX and Negative Pressure Wound Therapy (VAC).To evaluate the 4-week healing trajectory/wound area reduction with BlastX/VAC as compared with historical…
- Trial name
- BlastVac-001 (NCT04265170)
- Testing
- BlastX with negative pressure therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- SerenaGroup, Inc.
Post-Traumatic Stress Disorder, Blast Injury
Virtual Reality Therapy and Imaging in Combat Veterans With Blast Injury and Posttraumatic Stress Disorder
The main purpose of this study is to determine whether functional magnetic resonance imaging (fMRI), can distinguish between service members with and without traumatic brain injury (TBI), as well as those with posttraumatic…
- Trial name
- ViRTICo-BP (NCT01990547)
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Traumatic Brain Injury, Posttraumatic Stress Disorder
LED Treatment to Improve Cognition and Promote Recovery in TBI
This study investigates the efficacy of a novel neuromodulation treatment, light emitting diodes (LED), on cognition, neuropsychiatric status and quality of life in individuals with traumatic brain injury (TBI).
- Trial name
- LED-TBI (NCT02404402)
- Testing
- LED
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury, Post-Concussive Syndrome
Hyperbaric Oxygen Therapy (HBO2T) for Post-Concussive Symptoms (PSC) After Mild Traumatic Brain Injury (mTBI)
The goal of this research is to serve as a demonstration project to determine the tolerability of individuals with persistent post-concussive symptoms from combat-related mild TBI (traumatic brain injury), identify dose-finding…
- Trial name
- HBOT (NCT01220713)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Virginia Commonwealth University