Clinical trials: Bladder Cancer Requiring Cystectomy
Bladder Cancer Requiring Cystectomy, Ileal Conduit
A Feasibility Randomized Trial Evaluating Early vs Late Stent Removal Following Radical Cystectomy and Ileal Conduit Formation for Bladder Cancer
Bladder cancer is the 4th most common cancer in men and 5th most common type of cancer in Canada. Urothelial cancer accounts for approximately 90% of malignancies.
- Conditions
- Bladder Cancer Requiring Cystectomy, Ileal Conduit, Urinary Diversion
- Trial name
- STENT-OPT (NCT06595446)
- Testing
- Early Stent removal, Late Stent removal
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Western University, Canada
Cystectomy, Bladder Cancer Requiring Cystectomy
Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis
The aim of this trial is to test whether postoperative antibiotics targeted towards bacteria in the urine can reduce the risk of infection after surgical removal of the bladder (cystectomy) compared to a standardised antibiotic…
- Conditions
- Cystectomy, Bladder Cancer Requiring Cystectomy, Postoperative Infections, Antibiotic Prophylaxis
- Trial name
- REINFORCE (NCT06709196)
- Testing
- Pivmecillinam, Amoxicillin clavulanic acid, Amoxicillin
- Where
- 5 sites in Denmark
- Volunteers
- 248 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Bladder (Urothelial, Transitional Cell) Cancer, Bladder Cancer Requiring Cystectomy
Treatment Expedition With MRI Processing and Optimization for Muscle Invasive Bladder Cancer
The TEMPO-MIBC trial is a phase III, single-center, two-arm, randomized, controlled trial. Its primary objective is to evaluate the efficacy of a simplified diagnostic and treatment pathway for muscle-invasive bladder cancer…
- Conditions
- Bladder (Urothelial, Transitional Cell) Cancer, Bladder Cancer Requiring Cystectomy, Bladder Carcinoma, Bladder Neoplasm
- Trial name
- TEMPO-MIBC (NCT07067749)
- Testing
- multiparametric magnetic resonance imaging (mpMRI) of the bladder, Transurethral resection of bladder tumour (TURBt), Circulating tumour DNA levels assessment
- Where
- Italy
- Volunteers
- 92 people
- Sponsor
- University of Rome Tor Vergata
Bladder Cancer Requiring Cystectomy
Open Vs Robotic-Assisted Radical Cystectomy: A Randomized Trial
This is a multi-institutional, randomized trial evaluating oncologic, perioperative, and functional outcomes following two standard care procedures for radical cystectomy.
- Trial name
- NCT01157676
- Testing
- Open radical cystectomy, Robotic assisted radical cystectomy, DaVinci robot
- Where
- 16 sites in United States
- Volunteers
- 350 people
- Sponsor
- University of Miami
Recurrent Bladder Urothelial Carcinoma, Recurrent Renal Pelvis Urothelial Carcinoma
Erlotinib Hydrochloride in Treating Participants With Muscle Invasive or Recurrent Urothelial Cancer
This phase II trial studies how well erlotinib hydrochloride works in Treating participants with muscle invasive urothelial cancer or urothelial cancer that has come back.
- Conditions
- Recurrent Bladder Urothelial Carcinoma, Recurrent Renal Pelvis Urothelial Carcinoma, Recurrent Ureter Urothelial Carcinoma, Recurrent Urethral Urothelial Carcinoma
- Trial name
- NCT00749892
- Testing
- Erlotinib Hydrochloride
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- M.D. Anderson Cancer Center
Bladder Cancer Requiring Cystectomy, Ureteral Stents
STENT X: a Randomized Trial to Assess Stent-free Radical Cystectomy
Radical Cystectomy (RC) remains the gold standard for localized muscle-invasive bladder cancer (MIBC); however, use of ureteral stents at time of surgery remains controversial without level 1 evidence to comment on risks or…
- Trial name
- NCT07655284
- Testing
- ureteral stents, no ureteral stent
- Where
- 2 sites in United States, Brazil
- Sponsor
- Brigham and Women's Hospital
Bladder Cancer
Incontinent Urinary Diversion Using an Autologous Neo-Urinary Conduit
The purpose of this study is to see if the Neo-Urinary Conduit(NUC), which is made in the laboratory from a combination of a patient's own cells and other materials can be used to form a conduit to safety allow urine flow from…
- Trial name
- NCT01087697
- Testing
- Neo-Urinary Conduit
- Where
- 6 sites in United States
- Volunteers
- 8 people
- Sponsor
- Tengion
Bladder Cancer Requiring Cystectomy, Erectile Dysfunction Following Radical Prostatectomy
Pilot Study of a New Nerve Grafting Method During Bladder Cancer Surgery to Help Preserve Erections.
This pilot study will evaluate the safety and 1-year erectile function recovery in 10 patients undergoing a novel Nerve Restoring Radical Cystectomy (NR-RC), which includes a genitofemoral nerve graft.
- Trial name
- NR-RC (NCT07140588)
- Testing
- Patients undergoing radical cystectomy will receive a novel NR-RC procedure using a genitofemoral nerve graft to enhance erectile function recovery.
- Volunteers
- 10 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital