Clinical trials: Bisphosphonate-Associated Osteonecrosis of the Jaw
Bone Diseases, Metastases
Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients With Metastatic Cancer
This study seeks to identify risk factors associated with the development of a jaw condition seen in patients with cancer treated with certain medications.
- Conditions
- Bone Diseases, Metastases, Osteonecrosis, Bisphosphonate-Associated Osteonecrosis of the Jaw
- Trial name
- NCT01325142
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- University of Michigan
Medication-related Osteonecrosis of the Jaw, Bisphosphonate-related Osteonecrosis of the Jaw
Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ)
The overall purpose of this project is to answer the following clinical question: Among Medication-Related Osteonecrosis of the Jaw (MRONJ) patients, do those who are treated with the Pentoxifylline and Tocopherol (PENTO) regimen…
- Conditions
- Medication-related Osteonecrosis of the Jaw, Bisphosphonate-related Osteonecrosis of the Jaw, Avascular Necrosis
- Trial name
- NCT03040778
- Testing
- Pentoxifylline, Tocopherol
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Bisphosphonate-associated ONJ, Osteomyelitis of the Jaw
Bisphosphonate-Associated Jaw Osteonecrosis and PET Imaging
1. Bisphosphonate-associated osteonecrosis of the jaw(ONJ)is detectable by positron emission tomography(PET). 2. Bisphosphonate-associated ONJ can be diagnosed and characteristically differentiated from other bony pathologies of…
- Conditions
- Bisphosphonate-associated ONJ, Osteomyelitis of the Jaw, Osteolytic Lesions of the Jaw, Osteoradionecrosis of the Jaw
- Trial name
- NCT00592982
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Arkansas
Osteonecrosis Due to Drugs, Jaw, Osteonecrosis of the Jaw, Bisphosphonate Related
Medical and Surgical Treatment of MRONJ (Medication-related Osteonecrosis of the Jaw Bones)
MRONJ is an acronym used to describe medication-related osteonecrosis of the jaw bones. It has been reported by the AAOMS that bisphosphonates or denosumab can cause this condition.
- Conditions
- Osteonecrosis Due to Drugs, Jaw, Osteonecrosis of the Jaw, Bisphosphonate Related, Osteonecrosis of the Jaw, Bisphosphonate Induced
- Trial name
- NCT06917846
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Akdeniz University
Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ), Oxygen
Topical Oxygen Therapy for BRONJ
A randomized clinical trial comparing Blue®m oral gel and autologous PRF membrane as adjuncts to surgical debridement in BRONJ/MRONJ patients.
- Conditions
- Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ), Oxygen, Topical Administration, Wound Healing
- Trial name
- OXY-BRONJ Tria (NCT07725107)
- Testing
- Topical Blue®m application, PRF membrane placement
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Mansoura University
Bisphosphonate-Associated Osteonecrosis of the Jaw
Prospective Randomized Study: Assessment of PRF Efficacy in Prevention of Jaw Osteonecrosis After Tooth Extraction
This prospective study will include patients taking or having taken bisphosphonates and needing dental extractions. The aim of this study is to validate the contribution of PRF (Platelet Rich Fibrin) in tooth extraction sites.
- Trial name
- PRF (NCT02198001)
- Testing
- tooth extraction with antibiotics (amoxicillin- clavulanate, clindamycine), atraumatic extraction
- Where
- 3 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Osteoporosis, With or Without Treatment, Bisphosphonate Treatment
Biomarker Identification in Orthopaedic & Oral Maxillofacial Surgery Subjects to Identify Risks of Bisphosphonate Use
Bisphosphonates are drugs that prevent bone loss by blocking the activity of cells that normally resorb bone. The most common examples of these drugs are Boniva and Fosamax.
- Conditions
- Osteoporosis, With or Without Treatment, Bisphosphonate Treatment, Atypical Femur Fracture, Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ)
- Trial name
- NCT01875458
- Where
- United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Osteonecrosis of the Jaw, Bisphosphonate Induced, Osteonecrosis of the Jaw, Bisphosphonate Related
Initial Management of MRONJ Stages I and II, a Clinical Trial With Detection of Salivary Biomarkers
Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication in patients receiving antiresorptive therapies, such as Bisphosphonates and Denosumab.
- Trial name
- NCT04584840
- Testing
- Surgical treatment
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Root Canal Infection, Bisphosphonate-Associated Osteonecrosis
Root Canal Treatment Outcome in Patients Under Bisphosphonate Therapy
The aim of this study was to evaluate the survival rate and healing time of compromised teeth and seriously compromised teeth that were endodontically treated in patients which received bisphosphonate therapy .
- Conditions
- Root Canal Infection, Bisphosphonate-Associated Osteonecrosis, Periapical Abscess, Endodontically Treated Teeth
- Trial name
- NCT04399720
- Testing
- Root canal treatment
- Volunteers
- 111 people
- Sponsor
- University of Bologna
Bisphosphonate-Associated Osteonecrosis of the Jaw, Osteonecrosis of the Jaw
Piezoeletric Surgery vs Conventional Surgery for Treatment of MRONJ
To date, surgical therapy of MRONJ remains the therapy of choice while still in association with a medical approach. Surgical intervention aims to stop the progression of the pathology through the removal of the tissue…
- Conditions
- Bisphosphonate-Associated Osteonecrosis of the Jaw, Osteonecrosis of the Jaw, Osteonecrosis Due to Drug
- Trial name
- PIEZOPZ-1 (NCT06622421)
- Testing
- Piezoelectric surgery, Conventional surgery
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Osteonecrosis of the Jaw, Osteonecrosis Due to Drugs, Jaw
Medication Related Osteonecrosis of the Jaws (MRONJ) in a Cohort of Patients Treated by Antiresorptive Drugs
The objective of this prospective observational study is to investigate the incidence of Medication Related Osteonecrosis of the Jaws (MRONJ) in patients receiving antiresorptive drugs for oncohematologic reasons during a 5-year…
- Conditions
- Osteonecrosis of the Jaw, Osteonecrosis Due to Drugs, Jaw, Osteonecrosis Due to Drug, Bisphosphonate-Associated Osteonecrosis
- Trial name
- NCT06457776
- Testing
- Dental management
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- Catholic University of the Sacred Heart
Oral Mucositis, Osteoradionecrosis
Photobiomodulation in Oral Lesions Resulting From Anti-neoplastic Prevention
Introduction: There are several manifestations in the oral mucosa resulting from antineoplastic treatments by chemo (QT) or radiotherapy (RT).
- Conditions
- Oral Mucositis, Osteoradionecrosis, Osteonecroses, Bisphosphonate, Osteonecrosis Due to Drugs, Jaw
- Trial name
- NCT04717765
- Testing
- Preventive, LLL Phototherapy and topical Vit E, Curative, LLL Phototherapy and topical Vit E, Preventive, LLL Phototherapy and LPRF
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Santiago de Compostela
Bone Fragile, Bisphosphonate-Associated Osteonecrosis
Efficacy and Safety on the Use of Bisphosphonates in Paediatrics
The investigators suppose that the impact of bisphosphonate therapy is beneficial on the bone during the growth period with few adverse events.
- Conditions
- Bone Fragile, Bisphosphonate-Associated Osteonecrosis, Children, Adverse Events
- Trial name
- Bisphosphonate (NCT04012320)
- Testing
- No intervention, observational study
- Where
- France
- Volunteers
- 99 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Medication-related Osteonecrosis of the Jaw, Bisphosphonate-Associated Osteonecrosis of the Jaw
Medication-related Osteonecrosis of the Jaw (MRONJ) Registry
Approximately 500 patients will be included in this patient registry. Data collection includes demographics, clinical data of underlying disease and use of bisphosphonates, denosumab and antiangiogenic drugs , degree and…
- Trial name
- MRONJ (NCT02932501)
- Testing
- Conservative treatment, Surgical treatment, Adjuvant non-surgical treatment
- Where
- 14 sites in United States, Finland and 8 more
- Volunteers
- 518 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Bisphosphonate-related Osteonecrosis of the Jaw
Performance Evaluation of the Micromedic BRONJ Risk Assessment in Vitro Diagnostic Assay
To evaluate the performance of the Micromedic BRONJ Risk Assessment in vitro assay (the "BRONJ Assay") in identifying Multiple Myeloma (MM) and/or other cancer subjects at risk for developing Bisphosphonate-related Osteonecrosis…
- Trial name
- BRONJ (NCT02218554)
- Testing
- BRONJ
- Where
- 2 sites in Israel
- Volunteers
- 150 people
- Sponsor
- Micromedic Technologies Ltd