Clinical trials: Bipolar I Disorder, open to volunteers
Bipolar Disorder
mHealth Estimate-based Algorithms Signaling Upcoming Recurrence of Episodes in Bipolar Disorders
Veterans with bipolar disorders (BD) experience recurrent and seemingly unpredictable periods of severe impairments in psychosocial functioning, such as participation in social roles and activities.
- Trial name
- MEASURE-BD (NCT06204705)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder (MDD), Schizophenia Disorder
Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders
This is a prospective observational study to identify sociodemographic factors that predict mental health outcomes in the European population and provide evidence linking common, modifiable sociodemographic risk factors for…
- Conditions
- Major Depressive Disorder (MDD), Schizophenia Disorder, Bipolar 1 Disorder, Alzheimer Disease
- Trial name
- Synapsing-SD (NCT07239843)
- Where
- Spain
- Volunteers
- 1,310 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Bipolar Disorder (BD), Bipolar Disorder NOS
Child Bipolar Network Ketogenic Diet Approach to Bipolar Disorder in Adolescents
The present study is an open trial of ketogenic diets for adolescents and young adults (ages 12-21 yrs) in the depressive or mixed phases of bipolar disorder (BD).
- Conditions
- Bipolar Disorder (BD), Bipolar Disorder NOS, Bipolar Disorder I or II, Bipolar Spectrum Disorder
- Trial name
- CBN Keto (NCT06920940)
- Testing
- Ketogenic Therapy
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Psychiatric Disorders, Depression - Major Depressive Disorder
Implementing Action-Based Cognitive Remediation for Transdiagnostic Cognitive Difficulties in a Tertiary Mental Health Hospital
Psychiatric conditions are each defined by different set of symptoms, however, they often share common characteristics such as impairments in cognitive and social functioning.
- Conditions
- Psychiatric Disorders, Depression - Major Depressive Disorder, Schizophrenia and Other Psychotic Disorders, Anxiety and Mood Disorders
- Trial name
- NCT07506070
- Testing
- Action-Based Cognitive Remediation
- Volunteers
- 160 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Bipolar Disorder I or II, Healthy (Controls)
Decoding Emotional Dynamics in Bipolar Disorder
The goal of this neuroimaging study is to investigate how emotional states fluctuate in people with bipolar disorder (BD) compared to healthy controls, and to understand the neural mechanisms driving mood instability.
- Trial name
- NCT07221864
- Testing
- Think and Regulate Affective State Task
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Bipolar Disorder, Bipolar Disorder Type 1
Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder
The goal of this clinical trial is to test how specific components of diet affect brain function and behavior for individuals with bipolar.
- Trial name
- NCT06373016
- Testing
- Glucose, Ketones
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Bipolar, Bipolar Disorder (BD)
Transcranial Photobiomodulation for Bipolar Depression
This study the effectiveness and safety of light therapy device targeted at the brain using a wearable device, the Vielight RX Gamma as a treatment for bipolar depression.
- Conditions
- Bipolar, Bipolar Disorder (BD), Bipolar Disorder Depression
- Trial name
- NCT07510646
- Testing
- Vielight Neuro Rx Gamma
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Vielight Inc.
Bipolar Disorder, Major Depressive Disorder
Functional Magnetic Resonance Imaging Study of Inhibitory Control in Bipolar Disorder and Major Depressive Disorder
Bipolar disorder and unipolar depressive disorder are two chronic mood disorders associated with a significant social impact, even during euthymic phases.
- Trial name
- COLIBRI (NCT07503275)
- Testing
- Analysis of inhibitory control
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Bipolar Disorder
Assessing the Impact of Cannabidiol for Anxiety and Depression in Bipolar Disorder
Preliminary data have suggested that cannabidiol (CBD) may have a number of clinical benefits, including anti-anxiety and antidepressant properties.
- Trial name
- NCT05457465
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mclean Hospital
Psychosis
Immune Mechanisms of Antipsychotic Treatment Response
The aim of this study is to investigate the role of the immune system in psychotic symptoms and their response to treatment. The investigators will collect blood and cerebrospinal fluid samples from participants with psychosis…
- Trial name
- IMAT (NCT06687694)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King's College London
Bipolar II Disorder
Lithium Versus Lamotrigine in Bipolar Disorder, Type II
The investigators want in a 6-month randomized controlled trial (RCT) to compare effects of lithium versus lamotrigine on mood stabilization and other critical patient outcomes in patients with BDII.
- Trial name
- LiLa-Bipolar (NCT06184581)
- Testing
- Lithium Carbonate, Lamotrigine
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Schizophrenia, Autism Spectrum Disorder
Cerebellar Stimulation and Cognitive Control
The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.
- Conditions
- Schizophrenia, Autism Spectrum Disorder, Bipolar Disorder, Depression
- Trial name
- NCT03217110
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Krystal Parker, PhD
Bipolar Disorder, Bipolar Depression
Empagliflozin Adjunctive Therapy in Bipolar Depression
Bipolar disorder is a long-term mental health condition that causes mood changes, with depressive episodes being the most frequent and disabling.
- Conditions
- Bipolar Disorder, Bipolar Depression, Insulin Resistance
- Trial name
- EMPA-BD (NCT07472920)
- Testing
- Empagliflozin (EMPA)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Mental Disorders, Healthy Control
Psychiatric Multi-omics and Neuroimaging Project
This study focuses on the structure and function of the brain and gene expression in peripheral blood of patients with schizophrenia, to explore the interaction and influence between the three.
- Trial name
- PMNP (NCT06580860)
- Testing
- Antipsychotic drugs, antidepressants, mood stabilizers, and sleep aids
- Where
- China
- Volunteers
- 1,899 people, healthy volunteers welcome
- Sponsor
- mingjun Zhong
Bipolar Disorder and Major Depressive Disorder
Social Cognition, Memory, and Executive Functions in Bipolar Disorder and Major Depressive Disorder
Bipolar disorder (BD) are common psychiatric disorders often misdiagnosed, leading to delayed treatment. Even during stable phases, individuals with bipolar disorder experience residual cognitive impairments that affect their…
- Trial name
- COMET (NCT06740331)
- Testing
- Analysis of social cognition, memory functioning, and executive functioning processes
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Schizophrenia, Bipolar Disorder
Time and Virtual Reality in Schizophrenia and Bipolar Disorder
Patients with bipolar disorders report an acceleration or slowing of time flow, and patients with schizophrenic spectrum disorders a time fragmentation. These disorders would be linked to disorders of the sense of self.
- Trial name
- VirtualTimes (NCT04432116)
- Testing
- virtual reality 1, virtual reality 2
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Bipolar I Disorder, Bipolar II Disorder
Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder
The goal of this clinical trial is to identify the specific characteristics (phenotypes) that may be useful to help select the right medication for weight loss, and to study the effect of individualized guided medication in…
- Conditions
- Bipolar I Disorder, Bipolar II Disorder, Schizo Affective Disorder, Obesity
- Trial name
- OBOE-Mayo (NCT07213466)
- Testing
- Group Therapy Program, semaglutide, Phentermine-Topiramate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Schizophrenia Spectrum and Other Psychotic Disorders, Schizophrenia
Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services
The Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS) study aims to understand the early stages of psychotic disorders like Schizophrenia, Schizoaffective Disorder, and Bipolar I Disorder.
- Conditions
- Schizophrenia Spectrum and Other Psychotic Disorders, Schizophrenia, Delusional Disorder, Bipolar 1 Disorder
- Trial name
- BICEPS (NCT06740383)
- Where
- 6 sites in United States
- Volunteers
- 320 people
- Sponsor
- Beth Israel Deaconess Medical Center
Major Depressive Episode (MDE), Major Depressive Disorder (MDD)
LHC-CIDI-5 in Hong Kong
The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12…
- Conditions
- Major Depressive Episode (MDE), Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD), Suicidal Ideation
- Trial name
- NCT06804525
- Testing
- CIDI-5, LHC-CIDI-5
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- The University of Hong Kong
Schizophrenia, Bipolar Disorder
Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications
Previous and our studies have shown that cognitive impairments are core symptoms of three major psychiatric disorders-schizophrenia, bipolar disorder, and major depressive disorder, and are associated with underlying brain…
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder (MDD)
- Trial name
- NCT07444463
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Central South University