Clinical trials: Bipolar Depressive Disorder
Bipolar Depression
Repetitive Transcranial Magnetic Stimulation for Treating Resistant Bipolar Depression
The aim of this randomized, single-blind trial is to evaluate the effectiveness and tolerability of high frequency or low frequency repetitive transcranial magnetic stimulation (rTMS) in patients with resistant bipolar…
- Trial name
- NCT01586793
- Testing
- Magstim Rapid2 Stimulator
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Douglas Mental Health University Institute
Postpartum Depression
Quetiapine in the Treatment of Postpartum Depression (PPD) in Bipolar Disorder (BD), Type II
This is a 9-week single-centre, open-label, dose-escalating study evaluating the efficacy and safety of Quetiapine XR given as monotherapy in the treatment of non-lactating, post-partum women diagnosed with Bipolar II Disorder.
- Trial name
- NCT01527448
- Testing
- Quetiapine XR (seroquel)
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- BC Women's Hospital & Health Centre
Unipolar Depression, Bipolar Depression
Voice Changes During ECT
Depressed patients talk differently when they are depressed compared to when they are well. But it is hard to actually measure what the differences are.
- Conditions
- Unipolar Depression, Bipolar Depression, Bipolar Disorder, Manic
- Trial name
- VAPRE (NCT04420793)
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Depression; Bipolar Disorder
Comparing Different Patterns of rTMS in Major Depression
This trial will compare the trajectories of improvement for three different patterns of twice-daily rTMS in major depression: two daily sessions of dorsomedial prefrontal rTMS delivered at 0 min vs. 30 min vs. 60 min intervals.
- Trial name
- NCT02778035
- Testing
- Dorsomedial prefrontal rTMS
- Where
- 2 sites in Canada
- Volunteers
- 180 people
- Sponsor
- University Health Network, Toronto
Bipolar Disorder
Supraphysiological Doses of Levothyroxine as Adjunctive Therapy in Bipolar Depression
There is growing evidence that thyroid axis dysfunction may contribute to the pathophysiology of bipolar illness. Open-label studies have consistently demonstrated that the behavioral expression of bipolar disorder can be…
- Trial name
- NCT01528839
- Testing
- L-Thyroxine
- Where
- 5 sites in United States, Germany
- Volunteers
- 74 people
- Sponsor
- Charite University, Berlin, Germany
Substance Use Disorders, Depression
A Novel Person-Centered Treatment Component for Substance Use Treatment
A person-centered substance use treatment component, the Natural Recovery Program, was developed in a residential substance use treatment setting.
- Conditions
- Substance Use Disorders, Depression, Bipolar Disorder, Psychosis
- Trial name
- NCT02005367
- Testing
- Natural Recovery-Horticulture, Natural Recovery-Art/Music
- Where
- United States
- Volunteers
- 643 people
- Sponsor
- Hampton VA Medical Center
Bipolar Depression, Bipolar I Disorder
SYNCED - SYNChronized Eating in Bipolar Depression Study
Bipolar disorders (BD) are a group of complex disorders that impact mood, behaviour and cognition and are known to cause significant suffering and impairment.
- Conditions
- Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder
- Trial name
- NCT06560957
- Testing
- Time restricted eating, Eating ad libitum with nutritional counselling
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Ottawa
Mood Disorders, Major Depressive Disorder
Unobtrusive Monitoring of Affective Symptoms and Cognition Using Keyboard Dynamics (UnMASCK)
Mood disorders are associated with significant financial and health costs for the United States, partially due to cognitive problems in these patients that can worsen disease course and impair treatment response.
- Conditions
- Mood Disorders, Major Depressive Disorder, Bipolar Disorder I, Bipolar Disorder II
- Trial name
- UnMASCK (NCT04358900)
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Bipolar Disorder, Bipolar Depression
Vitamin D Supplementation for Bipolar Depression
The purpose of this study is to whether vitamin d supplementation in those with low levels may reduce depression symptoms in people experiencing bipolar depression.
- Trial name
- NCT01884844
- Testing
- Vitamin D3, Cholecalciferol
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of Massachusetts, Worcester
Bipolar Disorder, Bipolar Depression
Empagliflozin Adjunctive Therapy in Bipolar Depression
Bipolar disorder is a long-term mental health condition that causes mood changes, with depressive episodes being the most frequent and disabling.
- Conditions
- Bipolar Disorder, Bipolar Depression, Insulin Resistance
- Trial name
- EMPA-BD (NCT07472920)
- Testing
- Empagliflozin (EMPA)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Bipolar Disorder Depression
Candesartan as an Adjunctive Treatment for Bipolar Depression
This study will assess the safety and tolerability of Candesartan when used in patients with Bipolar Disorder, in addition to their medication treatment.
- Trial name
- NCT04430959
- Testing
- Candesartan
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Bipolar Disorder
Controlled Study of the Use of Quetiapine Fumarate in the Treatment of Patients With Bipolar Depression
The purpose of this study is to determine the efficacy of quetiapine compared to placebo in the treatment for a major depressive episode in patients with bipolar disorder after receiving treatment for up to 8 weeks.
- Trial name
- NCT00083954
- Testing
- Quetiapine Fumarate
- Where
- 36 sites in United States
- Volunteers
- 530 people
- Sponsor
- AstraZeneca
Alcohol Dependence, Bipolar Disorder
Open Label Trial of Acamprosate in Bipolar Alcoholics
The purpose of this study is to determine whether acamprosate (Campral) is safe and effective in treating alcohol dependence in individuals with bipolar disorder.
- Trial name
- NCT00330486
- Testing
- Acamprosate
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Medical University of South Carolina
Bipolar Disorder, Schizophrenia
Comparison of Physical Fitness, Physical Activity Level in Patients With Bipolar Disorder and Schizophrenia
According to the World Health Organization; Bipolar disorder ranks in the top 20 causes of disability among all medical conditions and 6th among mental disorders worldwide.
- Trial name
- NCT05936983
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Yeditepe University
Bipolar Disorder
Adjunctive Isradipine for the Treatment of Bipolar Depression
This study investigates the medication isradipine, which is currently approved by the FDA to treat high blood pressure, in the treatment of depression in bipolar disorder.
- Trial name
- Isradipine (NCT01784666)
- Testing
- Isradipine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
Cancer, Severe Major Depression
Bridge: Proactive Psychiatry Consultation and Case Management for Patients With Cancer
The purpose of this research is to understand if it is helpful for patients with mental illness to be connected to a psychiatrist and case manager at the time of cancer diagnosis.
- Conditions
- Cancer, Severe Major Depression, Schizophrenia, Bipolar Disorder
- Trial name
- NCT03360695
- Testing
- Proactive Psychiatry Consultation (PPC), Enhanced Usual Care (EUC)
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder, Major Depressive Disorder
Clinical Validation Study for EDIT-B Test: an Aid for Differential Diagnosis of Bipolar Disorder, Based on RNA Editing Blood Biomarkers
Differentiation between major depressive disorder (MDD) and bipolar disorder (BD) as soon as possible in the patient journey represents a major clinical issue.
- Trial name
- EDIT-B (NCT05603819)
- Testing
- EDIT-B
- Where
- 4 sites in Denmark, France and 1 more
- Volunteers
- 418 people
- Sponsor
- Alcediag
Bipolar Disorder
Pharmacokinetics of Quetiapine Across Pregnancy and Postpartum
The widespread and common use of quetiapine in childbearing and pregnant women demands more data to inform dosing and toxicity in pregnancy.
- Trial name
- Quetiapine (NCT02978534)
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Northwestern University
Bipolar Disorder
A Six-week Flexible Dose Study Evaluating the Efficacy and Safety of Geodon in Patients With Bipolar I Depression.
This is a 6-week trial that evaluates the efficacy and safety of Geodon (ziprasidone) in outpatient subjects ages 18 and older with Bipolar Disorder type I, depressed.
- Trial name
- NCT00282464
- Testing
- Geodon (Ziprasidone)
- Where
- 43 sites in United States
- Volunteers
- 392 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Bipolar Disorder
A Study Evaluating the Efficacy of Administered Maintenance Treatments in Bipolar Disorder I and II.
The primary objective of the study is to evaluate the efficacy of administered maintenance treatments in bipolar disorder I and II, defined as the percentage of patients who experience a relapse episode during the first 9 months…
- Trial name
- NCT01202604
- Where
- 33 sites in Greece
- Volunteers
- 294 people
- Sponsor
- AstraZeneca