Clinical trials: Bipolar Affective Disorder, active
Major Depressive Disorder, Bipolar Disorder
Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
The purpose of this research is to measure brain activity in individuals with mood disorders and memory problems using a simple, safe, and noninvasive method called functional near-infrared spectroscopy (fNIRS).
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Mild Cognitive Impairment
- Trial name
- NCT06897670
- Testing
- Observational assessment using functional near-infrared spectroscopy (fNIRS), a noninvasive, portable brain imaging tool that measures changes in brain blood flow and oxygen levels.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Schizophrenia Disorders, Major Depression
Non-Coding RNAs Gene Expression in Psychiatric Disorders
This study aims to investigate whether specific non-coding RNAs, molecules involved in the regulation of gene expression, are altered in individuals with psychiatric disorders such as schizophrenia, bipolar disorder, major…
- Conditions
- Schizophrenia Disorders, Major Depression, Bipolar Affective Disorders, Obsessive Compulsive Disorder (OCD)
- Trial name
- PsiRNA26 (NCT07649993)
- Testing
- Reverse Transcription Quantitative Polymerase Chain Reaction
- Where
- 5 sites in Italy
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Carmen Concerto
Bipolar Disorder
AMIloride for the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Treated With Lithium
Lithium (Li) is the leading treatment for BD, protecting against both maniac and depressive relapse, and reducing the risk of suicide and mortality.
- Trial name
- AMIND (NCT05044611)
- Testing
- Anhydrous Amiloride Hydrochloride
- Where
- 2 sites in France
- Volunteers
- 148 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Schizophrenia and Related Disorders, Major Depressive Disorder
Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure
Schizophrenia, bipolar and major depressive disorders collectively affect over 10 million people across the EU and are associated with annual healthcare and societal costs in excess of 100 billion Euros.
- Conditions
- Schizophrenia and Related Disorders, Major Depressive Disorder, Bipolar Depression
- Trial name
- INTENSIFY (NCT05603104)
- Testing
- Clozapine, Esketamine Nasal Product, Escitalopram
- Where
- Israel
- Volunteers
- 1,254 people
- Sponsor
- Dr. Inge Winter
Depression, Depression, Bipolar
Dallas 2K: A Natural History Study of Depression
The primary objective of this initiative is to implement a prospective study that will allow us to identify and validate biosignatures of response to treatments for depression and depression outcome (using an integrated array of…
- Trial name
- D2K (NCT02919280)
- Testing
- Observational Study
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Bipolar Disorder
Observation of Clozapine Treatment Safety in Bipolar Disorder.
The purpose of the registry is to record incidence of adverse events during treatment with clozapine in patients suffering from bipolar disorder.
- Trial name
- CloGD (NCT06011460)
- Testing
- Clozapine
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Gdansk
Treatment Resistant Depression, Major Depressive Episode
University of Iowa Interventional Psychiatry Service Patient Registry
The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD).
- Conditions
- Treatment Resistant Depression, Major Depressive Episode, Major Depression, Major Depressive Disorder
- Trial name
- NCT04480918
- Testing
- Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (TMS), Ketamine
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Mark Niciu
Bipolar Disorder (BD)
Real-world Lithium Intake
The aim of the present study is to study compliance with lithium therapy and patterns of lithium intake among a representative group of patients with bipolar disorder in a real-world clinical setting.
- Trial name
- NCT07167563
- Testing
- Lithium (LI) based on clinical indication
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Major Depression, Bipolar Affective Disorder
Treatment Response In ECT Patients
Clarification Regarding Study Type: Observational This study is a prospective, non-interventional observational study. The decision to administer Electroconvulsive Therapy (ECT) and the selection of the anesthetic agent (ketamine…
- Conditions
- Major Depression, Bipolar Affective Disorder, Bipolar Depression Depressed Phase
- Trial name
- NCT07463911
- Testing
- Electroconvulsive Therapy (ECT)
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Nurdan Sağbaş
Bipolar Disorder Type I With Mania
A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)
This is a phase 3, open-label extension study to assess the long-term safety of KarXT for the treatment of mania or mania with mixed features in Bipolar-I disorder (BP-I) The primary objective of the study is to evaluate the…
- Trial name
- NCT06929273
- Testing
- KarXT, Lithium, Valproate
- Where
- 184 sites in United States, Argentina and 18 more
- Volunteers
- 450 people
- Sponsor
- Bristol-Myers Squibb
Depression, Anxiety
Physical Exercise for Treatment of Depression and Anxiety - RCT
In a 12 week randomly controlled open trial 102 participants with symptoms of depression and/or anxiety will be exposed to either aerobic high intensity training (HIT) or relaxation therapy.
- Trial name
- FYPO (NCT04714528)
- Testing
- Physical Exercise, Relaxation Therapy
- Where
- Sweden
- Volunteers
- 87 people
- Sponsor
- Region Örebro County
Bipolar Disorder
Bipolar Disorder Integrative Staging: Incorporating Biomarkers Into Progression Across Stages
Bipolar disorder (BD) is a lifelong, recurrent condition with growing evidence supporting a neuroprogressive course, entailing the need to adopt staging models to guide stage-speci c interventions.
- Trial name
- BOARDING-PASS (NCT07343739)
- Testing
- psychometric clinical assessment, biological acquisition, neuroimaging data
- Where
- Italy
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Depression, Major Depressive Disorder
Non-invasive BCI and Application Verification for Depressed People
Major Depressive Disorder (MDD) is a serious mental illness and public health problem that poses threat to both physical and mental health.
- Conditions
- Depression, Major Depressive Disorder, Bipolar Depression
- Trial name
- NCT06417437
- Testing
- SSRI, rTMS, Neuro-Feedback
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Time Restricted Eating, Diet, Mediterranean
Healthy Lifestyles for Bipolar Disorder
The goal of this clinical trial is to compare the effects of two different healthy lifestyles on outcomes for those with bipolar disorder.
- Trial name
- HL (NCT06188754)
- Testing
- Time restricted eating, Mediterranean diet
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of California, Berkeley
Depression, Alcoholism
Suicidal Behavior in Patients Diagnosed With Bipolar Disorder
The purpose of this study is to learn the environmental and psychological factors that impact suicidality in patients diagnosed with Bipolar Disorder.
- Conditions
- Depression, Alcoholism, Drug Abuse
- Trial name
- NCT02604277
- Testing
- Interpersonal and Social Rhythm Therapy (ISRT), Bipolar-Specific Cognitive Behavioral Therapy (CBT), Mindfulness-Based Stress Reduction (MBSR)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Emory University
Bipolar II Disorder
Lithium Versus Lamotrigine in Bipolar Disorder, Type II
The investigators want in a 6-month randomized controlled trial (RCT) to compare effects of lithium versus lamotrigine on mood stabilization and other critical patient outcomes in patients with BDII.
- Trial name
- LiLa-Bipolar (NCT06184581)
- Testing
- Lithium Carbonate, Lamotrigine
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Bipolar Disorder
NeuroPsyBiT-BD Omics: Genomic & Epigenomic Biobank of Bipolar Disorder
Brief Summary The goal of this observational study is to establish a comprehensive biobank and phenotypic data repository for patients diagnosed with bipolar disorder in Türkiye.
- Trial name
- NeuroPsyBiT-BD (NCT07173842)
- Testing
- Biobanking and Phenotypic Data Collection
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Selçuk State Hospital
Bipolar Disorder, Mood Disorders
Characterizing MyMood Patterns of Use
MyMood is an electronic mood-charting tool available to the general population of Sunnybrook Health Sciences Centre (SHSC). This project aims to characterize duration and frequency of use of MyMood by users characteristics and…
- Conditions
- Bipolar Disorder, Mood Disorders, Depression, Dysthymia
- Trial name
- NCT04664374
- Testing
- MyMood
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Sunnybrook Health Sciences Centre
Bipolar Disorder
Neurofeedback for Bipolar Disorder
Bipolar Disorder (BD) is a severe mood disorder affecting between 1% and 3% of the general population. It is characterized by the succession of depressive and manic episodes, with periods of stabilization during which patients…
- Trial name
- NEUROFEED-BD (NCT05802446)
- Testing
- Real-time fMRI Neurofeedback
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bipolar Depression, Bipolar Disorder (BD)
PROgram To Enhance Cardiovascular Risk Trough an Intervention of Nutrition in Bipolar Disorder
Individuals with Bipolar Disorder (BD) have twice the risk of being affected by metabolic comorbidities and a 1.8-fold increased risk of mortality from cardiovascular diseases when compared to the general population.
- Trial name
- PROTECTION-BD (NCT06488573)
- Testing
- Nutritional intervention
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- University of Sao Paulo