Clinical trials: Biomarker in Early Diagnosis
Huntington Disease
Time-Restricted Eating in Huntington's Disease: A Clinical Pilot Study
This trial examines whether 12 weeks of time-restricted eating (TRE), otherwise known as intermittent fasting, appears safe and feasible in persons with early-stage Huntington's disease (HD).
- Trial name
- TREHD (NCT06490367)
- Testing
- Time-Restricted Eating Diet
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Oregon Health and Science University
Invasive Fungal Infections
Using of Biomarkers and Blood Culture in Early Detection of Systemic Infections
This work aims to: 1. Validate the performance of CRP, and PCT in early differentiating IFI from bacterial bloodstream infections. 2. Compare the results of CRP and PCT with the results of β-D- glucan. 3.
- Trial name
- NCT05737537
- Testing
- procalcitonin ,CRP and 1, 3- β -D- glucan in early diagnosis of invasive infections
- Volunteers
- 90 people
- Sponsor
- Assiut University
Genomics, Thyroid Cancer
Integrating Tumor Genomics and Urinary Exosomal Proteomics to Establish a Multi-Layer Biomarker Framework for Early Risk Stratification and Post-Treatment Surveillance in Fresh Thyroid Cancer Patients
Thyroid cancer is the most common endocrine malignancy, and although differentiated thyroid cancer (DTC) generally confers favorable outcomes, 10-20% of patients still face substantial postoperative risks, including local…
- Conditions
- Genomics, Thyroid Cancer, NGS
- Trial name
- NCT07532356
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Hypertension, Heart Failure
Finding Early Predictors of Myocardial Dysfunction
The study objective is to clarify the grounds of heart exertional dyspnoea stenocardia in patients with well-controlled stage I or II hypertension according to European Society of Hypertension, without changes in epicardial…
- Trial name
- NCT02026154
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Alcohol Use Disorder
Brain Functional Connectivity in Alcohol Use Disorder
Due to the relapsing nature of alcoholism, excessive alcohol consumption represents a significant cost to US society ($249 billion in 20101). About 64% of those entering treatment will relapse within one year.
- Trial name
- NCT02877849
- Testing
- MRI: Brain Imaging data collection
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Facioscapulohumeral Muscular Dystrophy, Facioscapulohumeral Muscular Dystrophy 1
Ultrasound Detection of Early Facial Muscle Changes in FSHD: Thickness and Echo Intensity Findings
Facioscapulohumeral muscular dystrophy (FSHD) is characterized by early and significant involvement of facial muscles; however, objective imaging data focusing on facial muscles are limited.
- Conditions
- Facioscapulohumeral Muscular Dystrophy, Facioscapulohumeral Muscular Dystrophy 1, Neuromuscular Disease
- Trial name
- FACIAL-FSHD (NCT07331025)
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Koç University
Breast Cancer
S9313B Study of Tumor Tissue Samples From Women With Early-Stage Breast Cancer Enrolled on Clinical Trial SWOG-9313
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00949013
- Testing
- immunohistochemistry staining method, laboratory biomarker analysis
- Volunteers
- 1,600 people
- Sponsor
- SWOG Cancer Research Network
Psychotic Disorders
Hormonal and Inflammatory Biomarkers and Response to Cognitive Remediation in Recent-onset Psychosis
This study aims to explore whether hormones or inflammatory markers are associated with cognitive changes following cognitive remediation therapy (CRT) in people with a recent-onset psychotic disorder.
- Trial name
- NCT04418570
- Testing
- cognitive remediation, attendance to an Early Intervention Service for Psychosis
- Volunteers
- 28 people
- Sponsor
- Corporacion Parc Tauli
Lungcancer
SHOX2_PTGER4 DNA Methlyation in Lung Cancer
Data on SHOX2 and PTGER4 DNA Methylation suggest possible use as a biomarker for early lung cancer diagnosis. In this study a control group consisting of COPD patients with a CT-scan of the chest no older than 6 weeks and a…
- Trial name
- Epi1 (NCT04321499)
- Testing
- lung cancer
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- University Hospital, Essen
Sepsis
Sepsis Multiomic Analysis & Risk sTratification in China
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, and delayed diagnosis remains a major driver of mortality, while traditional biomarkers (PCT, CRP, lactate) have limited early…
- Trial name
- China SMART-1 (NCT07599644)
- Where
- China
- Volunteers
- 1,400 people
- Sponsor
- Yuebei People's Hospital
Triple Negative Breast Cancer
NeoAdj. Therapy Comparing Sacituzumab Govitecan (SG) vs. SG+Pembrolizumab in Low-risk, Triple-neg. EBC (ADAPT-TN-III)
TNBC is known for poor prognosis, aggressive patterns of disease, and significant molecular heterogeneity. (Neo)adjuvant chemotherapy (NACT) is standard of care in all node-positive and in node-negative patients with a tumour…
- Trial name
- ADAPT-TN-III (NCT06081244)
- Testing
- Sacituzumab govitecan, Pembrolizumab
- Where
- 43 sites in Germany
- Volunteers
- 348 people
- Sponsor
- Women's Cancer Study Group GmbH
Lung Cancer (Diagnosis)
Blood Based Risk Evaluation With AI for Targeted Primary Health Care in Early Lung Cancer Detection
The study is a prospective, non-randomized feasibility study evaluating blood sample and machine learning-based risk stratification for lung cancer in patients with COPD (chronic obstructive pulmonary disease).
- Trial name
- BREATHE (NCT07552584)
- Testing
- Risk stratification
- Where
- 2 sites in Denmark
- Volunteers
- 1,000 people
- Sponsor
- Vejle Hospital
Ulcerative Colitis (UC), Fecal Calprotetin
DYNAMIC-UC: Early qFIT and Calprotectin Change Predicting Relapse in Biologic-Naive Ulcerative Colitis
This multicenter prospective cohort study aims to evaluate whether a >50% decrease or normalization of both quantitative fecal immunochemical test (qFIT) and fecal calprotectin (FC) levels at 2 weeks after starting conventional…
- Conditions
- Ulcerative Colitis (UC), Fecal Calprotetin, FIT, Biomarker
- Trial name
- DYNAMIC-UC (NCT07111273)
- Testing
- FC and FIT TEST at WEEK0 2 4
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
Metastatic Colorectal Cancer
PERMAD: Personalized Marker-driven Early Switch to Aflibercept in Patients With Metastatic Colorectal Cancer
The primary objective of the two phase PERMAD trial is the evaluation of the impact of a personalized marker-driven treatment approach with early detection of progression and modification of treatment on cytokines and angiogenic…
- Trial name
- PERMAD (NCT02331927)
- Testing
- Aflibercept
- Where
- 3 sites in Germany
- Volunteers
- 150 people
- Sponsor
- University of Ulm
Stroke, Post-Stroke Cognitive Impairment
Immune-Inflammatory Biomarkers in Predicting Early Cognitive Impairment in Adults With Acute Basal Ganglionic Stroke
Post-stroke cognitive impairment (PSCI) is a common and disabling complication that affects memory, thinking, and daily functioning after a stroke.
- Conditions
- Stroke, Post-Stroke Cognitive Impairment, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT07837466
- Volunteers
- 100 people
- Sponsor
- Assiut University
Early-Stage Breast Cancer, Neoadjuvant Therapy
COGNITION: Genomics-Guided Precision Oncology in Early High-Risk Breast Cancer
The COGNITION diagnostic platform elucidates the biomarker profile of neoadjuvant chemotherapy-resistant residual bulk tumors in high risk early breast cancer patients.
- Trial name
- COGNITION (NCT05906407)
- Testing
- Genomic Profiling / Sequencing
- Where
- 12 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- German Cancer Research Center
Colorectal Cancer
Personalized Medicine in Early Stage Colorectal Cancer: Organ Preservation and Immune Benefit
The overall aim of this study is to determine whether the Immunoscore associated with histopathological features of endoscopically resected stage T1 colorectal tumors is predictive of locoregional lymph node invasion, in order to…
- Trial name
- COLOSAVE (NCT06251726)
- Testing
- Immunoscore Colon Test
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Invasive Breast Cancer, Ductal Carcinoma in Situ
Preoperative Testing of the Anti-Progesterone Mifepristone in Early Stage Breast Cancer
The primary objective of this study is to identify the group of women with early stage breast cancer most likely to benefit from treatment with the selective progesterone receptor modulator (SPRM) mifepristone.
- Trial name
- NCT01138553
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, San Diego
Cardiovascular Diseases
Biomarkers in Dermal Interstitial Fluid for Early Diagnosis and Follow-up of Cardiovascular Diseases
Sampling of dISF and blood plasma for qualitative measurements.
- Trial name
- BIO-ISF-CVD (NCT06632353)
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Ascilion AB
Colorectal Cancer (CRC), Microbiome
CARE-CRC: Microbiome Insights and Correlations for Risk and Outcomes in Colorectal Cancer
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths globally, with increasing incidence rates. While predominantly affecting older adults, CRC cases among individuals under 50 (early-onset CRC, or EoCRC)…
- Conditions
- Colorectal Cancer (CRC), Microbiome, Early Onset Colorectal Cancer
- Trial name
- CARE-CRC (NCT06734156)
- Testing
- No intervention: observational study
- Where
- 2 sites in Portugal
- Volunteers
- 400 people
- Sponsor
- Gulbenkian Institute for Molecular Medicine