Clinical trials: Biliary Stricture
Bile Duct Neoplasms, Jaundice, Obstructive
A Single-center, Prospective Cohort Study on the Differentiation of Benign and Malignant Bile Duct Stenosis Based on Bile and Peripheral Blood cfDNA Methylation Profiles
The goal of this observational study is to detect the methylation characteristics of cfDNA in the bile and plasma of patients with bile duct stricture.
- Conditions
- Bile Duct Neoplasms, Jaundice, Obstructive, Bile Duct Diseases
- Trial name
- NCT06115655
- Testing
- cfDNA methylation detection
- Where
- China
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Pancreatic Cancer, Cholangiocarcinoma
MicroRNAs as Bile-based Biomarkers in Pancreaticobiliary Cancers
pancreatic or biliary-tract cancer can be a serious diagnosis, as many patients present too late for surgery. Cancer cells have been found to release small messenger molecules called that regulate cancer genes called microRNAs…
- Conditions
- Pancreatic Cancer, Cholangiocarcinoma, Ampullary Cancer, Biliary Stricture
- Trial name
- MIRABILE (NCT06258824)
- Testing
- Small RNA Sequencing and Validation of candidate miRNAs
- Where
- United Kingdom
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Bile Duct Obstruction, Extrahepatic, Cancer of the Pancreas
Self-expandable Metal Stents Versus Multiple Plastic Stents for Palliation of Biliary Obstruction
A randomised clinical trial to compare the clinical efficacy of multiple plastic stents to fully covered self expanding metal stents in the palliation of distal malignant biliary obstruction in patients with irresectable tumours.
- Conditions
- Bile Duct Obstruction, Extrahepatic, Cancer of the Pancreas, Cancer of the Bile Duct, Biliary Stricture
- Trial name
- NCT03821025
- Testing
- Biliary stent
- Where
- South Africa
- Volunteers
- 150 people
- Sponsor
- University of Cape Town
Biliary Stricture
Prospective Evaluation of Winged Biliary Stent Patency in Patients With Benign Biliary Obstruction
Evaluation of ERCP with placement of a winged plastic biliary stent without a lumen for management of benign biliary strictures.
- Trial name
- NCT03115411
- Testing
- Winged biliary stent (ViaDuct™)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Stanford University
Choledocholithiasis, Cholangiocarcinoma
Prospective Study of the Risk of Bacteremia in Directed Cholangioscopic Examination of the CBD
When a doctor performs Endoscopic retrograde cholangiopancreatography "ERCP" (Endoscopy to examine the bile duct) a flexible tube is inserted into the mouth and into the stomach.
- Conditions
- Choledocholithiasis, Cholangiocarcinoma, Benign Stricture of Common Bile Duct
- Trial name
- NCT01673269
- Testing
- Blood culture ( aerobic and anaerobic)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Biliary Stricture, Bile Duct Cancer
Evaluation of diagnostiC Capacity of eccDNAs as Biomarkers in Indetermined biLiary Stricture(ECCBILE)
Biliary stricture is mainly malignant in the adults and caused by several types of fatal malignancies such as pancreatic cancer, cholangiocarcinoma, and metastatic tumor, which have poor prognosis that the overall survival of…
- Conditions
- Biliary Stricture, Bile Duct Cancer, Pancreas Cancer
- Trial name
- ECCBILE (NCT06277531)
- Where
- 2 sites in China
- Volunteers
- 99 people
- Sponsor
- Peking University Third Hospital
Secondary Cholangitis, Bile Duct Strictures of Unknown Origin
Biliary Candidiasis - Optimization of Diagnostics and Therapy
Biliary obstruction and cholangitis are common problems in gastroenterology and need specific therapeutic interventions. Besides a variety of potential causes, infections of the biliary tract with Candida and other fungal species…
- Trial name
- NCT01109550
- Testing
- ERCP
- Where
- Germany
- Volunteers
- 123 people
- Sponsor
- University Hospital Muenster
Malignant Hilar Stricture, Bilateral Stent Insertion
Two Bilateral Metal Stenting in Hilar Malignancy
The overall median survival of nonresectable malignant hilar obstruction in most series has been less than 6 months. Most patients with malignant hilar obstruction present with advanced disease, making allative endoscopic…
- Trial name
- NCT01141088
- Testing
- Bilateral stent-in-stent insertion, Bilateral side-by-side insertion
- Where
- 2 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Soon Chun Hyang University
Biliary Strictures Caused by Malignant Neoplasms
Study of the WallFlex™ Biliary Partially-covered Stent for the Palliative Treatment of Malignant Bile Duct Obstruction
This is a a prospective study of the WallFlex™ Biliary Partially-covered Stent designed to collect data to support regulatory clearance by the FDA in the United States and to determine the functionality of the WallFlex™ Biliary…
- Trial name
- NCT00713427
- Testing
- WallFlex™ Biliary Partially-Covered Stent
- Where
- 6 sites in Belgium, France and 4 more
- Volunteers
- 70 people
- Sponsor
- Boston Scientific Corporation
Chronic Pancreatitis
The PASTEC Study: Endoscopic Stenting Versus Surgery for the Treatment of Bile Duct Stricture in Chronic Pancreatitis
Biliary obstruction complicates the course of chronic pancreatitis in 3%-23% of patients and in these cases, endoscopy and surgery are the treatment modalities of choice.
- Trial name
- PASTEC (NCT02366988)
- Testing
- Endoscopic Biliary Stenting, Surgical treatment Bilio-enteric anastomosis
- Where
- 7 sites in France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Lille
Cholangiocarcinoma, Biliary Stricture
EYEMAX® Versus SPYGLASS™ DS for Biliary Stricture Diagnosis
Cholangiocarcinoma remains difficult to diagnose because of the limited sensitivity of currently available endobiliary sampling techniques.
- Trial name
- EYE/SPY (NCT07620080)
- Testing
- EYEMAX® cholangioscopy system, SPYGLASS™ DS system
- Volunteers
- 120 people
- Sponsor
- David KARSENTI
Liver Transplant; Complications, HLA Antigens
The Relationship Between HLA Tissue Compatibility and Biliary Complications in Patients With Liver Transplantation
Liver transplantation has become the accepted treatment option for advanced liver failure in recent years. In addition to the increase in the number of centers performing transplant and the decrease in complication rates…
- Trial name
- NCT04885582
- Testing
- HLA antigen results
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Inonu University
Liver Transplant Disorder, Ischemic Cholangiopathy
Endoscopic Management of Non-anastomotic Biliary Strictures Following Liver Transplantation.
The study will evaluate the results of endoscopic treatment of NON-anastomotic biliary strictures following liver transplantation
- Conditions
- Liver Transplant Disorder, Ischemic Cholangiopathy, Non-anastomotic Biliary Stricture, Biliary Stricture
- Trial name
- STEBINANSIED (NCT05761483)
- Testing
- ERCP
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Malignant Biliary Stenosis
Cholangioscopy or Conventional Techniques for Indeterminate Biliary Stenosis
Biliary stenosis not associated with a mass is difficult to diagnose with certainty. The diagnosis is usually based on a first-line cytological study of biliary brushing, which allows a diagnosis in 30 to 50% of cases.
- Trial name
- NCT04840537
- Testing
- endoscopic retrograde cholangiopancreatography with cholangioscopy in the first procedure of ERCP
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Frederic PRAT, MD, PhD
Benign Biliary Strictures, Chronic Pancreatitis
Self-expandable, Fully Covered Metal Stents in Biliary Strictures Due to Chronic Pancreatitis
The purpose of the study was to analyze the resolution rate of benign biliary strictures due to chronic pancreatitis after temporary insertion of unflared-ends and flared-ends fully covered self-expandable metal stents.
- Trial name
- NCT01457092
- Testing
- FC Nitinol SEMS (Niti-S, TaeWoong Medical Co., Korea)
- Volunteers
- 17 people
- Sponsor
- Catholic University of the Sacred Heart
Bile Duct Disease
Newly Designed Fully Covered Metal Stent for the Benign Biliary Stricture
The purpose of this study is to determine the feasibility, easy removability, safety, and migration rate of flared end fully covered self-expanding metal stent (FCSEMS) and anchoring FCSEMS for benign biliary stricture.
- Trial name
- NCT00945516
- Testing
- Bona stent® (Flared end FCSEMS), Hanarostent® (Anchoring FCSEMS)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Asan Medical Center
Patients With Biliary Stricture Treated During ERCP With Available MRCP and Abdominal CT Scan
Preclinical Development of a 3D Bili-MRI Reconstruction Tool and an Artificial Intelligence Algorithm to Assist Endoscopists in Performing Endoscopic Retrograde Cholangiopancreatography (ERCP)
ERCP is a complex interventional endoscopic procedure based on 2D visualization of the biliary tract. 3D modeling and AI are promising solutions to improve navigation and safety during ERCP.
- Trial name
- MAAGIE (NCT07401485)
- Testing
- retrospective study based on data already collected during routine care (no intervention)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bile Duct Neoplasms
Covered or Uncovered Bile Duct Stents
The study is investigator initiated. Tumors that gives the narrowing of the bile ducts prevents bile from flowing from the liver to the intestine resulting in jaundice and the risk of bacterial growth in bile with severe…
- Trial name
- NCT01232101
- Testing
- covered or uncovered stents
- Where
- Sweden
- Volunteers
- 71 people
- Sponsor
- Göteborg University
Biliary Strictures Post Liver Transplantation
Trial Comparing Kaffes Stent With Plastic Prosthesis in the Treatment of Anastomotic Biliary Strictures Post Orthotopic Liver Transplantation
Biliary anastomotic strictures (post liver transplantation) occur in 15-20 % of the cases. Biliary stenting using plastic prosthesis during a period of 1 year is the treatment of choice.
- Trial name
- NCT01339078
- Testing
- Plastic stenting, Kaffes stenting
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- University Hospital, Ghent
Endoscopic Retrograde Cholangiopancreatography, Klatskin Tumor
Application of Endoscopic Scissors Cutting ENBD Tube in the Treatment of Malignant Hilar Biliary Strictures
The purpose of this study is to evaluate application value of the endoscopic cutting technique in the treatment of malignant hilar biliary strictures.
- Trial name
- ENBD (NCT03353181)
- Testing
- Endoscopic scissors, Biliary stent
- Where
- China
- Sponsor
- Changhai Hospital