Clinical trials: Bile Leak
Obstructive Jaundice, Pancreatic Head Cancer
Impact of Intraoperative PTCD Catheter Retention Versus Removal on Postoperative Short-term Outcomes After Pancreaticoduodenectomy in Obstructive Jaundice
Pancreaticoduodenectomy (PD) is a complex surgical procedure commonly performed for tumors of the pancreatic head and periampullary region.
- Conditions
- Obstructive Jaundice, Pancreatic Head Cancer, Periampullary Neoplasms, Biliary Tract Neoplasms
- Trial name
- NCT07532759
- Testing
- PTCD Catheter Removal, PTCD Catheter Retention
- Volunteers
- 100 people
- Sponsor
- Xu'an Wang
Bile Leakage
Diagnostic Role of the "White Test" With Lipidic Solution in the Early Intraoperative Identification of Open Bile Ducts for the Prevention of Bile Leakage After Liver Resection (BiLe -Trial)
Bile leakage (BL) is the most frequent complication after liver resection. This study is to investigate the role of intraoperative administration of SMOFlipid 20% (fat emulsion which allows intraoperative identification of open…
- Trial name
- BiLe (NCT04523701)
- Testing
- "white" test" (= the administration of SMOFlipid retrograde through the cystic duct)
- Where
- 5 sites in Switzerland
- Volunteers
- 210 people
- Sponsor
- Giulia Manzini
Liver Cancer, Liver Failure
Quantitative MRI and Outcomes of Liver Resection
The present observational study aims to assess the benefit of this quantitative multiparametric magnetic resonance imaging (MRI) in clinical practice, to quantify future liver remnant performance, and to accurately predict the…
- Conditions
- Liver Cancer, Liver Failure, Bile Leak, Liver Metastases
- Trial name
- NCT06181318
- Testing
- Multiparametric MRI scan of the liver
- Volunteers
- 33 people
- Sponsor
- University Hospital Heidelberg
Bile Leakage
The Role of Transpapillary Stenting in the Treatment of Bile Leakage After Liver Transection.
Bile leakage after liver transection is treated by external drainage. The question addressed is whether downstream control by transpapillary stent insertion into distal bile duct can enhance healing.
- Trial name
- NCT01960712
- Testing
- Transpapillary plastic stent (7-10 Fr)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska University Hospital
Common Bile Duct Gall Stones, Infection
Fibrin Sealant for Cholangiotomy Closure Study
Bile leak reduction from the common bile duct, as a result of glue appliance after cholangiotomy.
- Conditions
- Common Bile Duct Gall Stones, Infection, Bile Leak
- Trial name
- NCT02545153
- Testing
- Tisseel, Baxter (Aprotinin and Fibrinogen), Control
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Lasarettet i Enköping
Biliary Anastomosis Complication
Organoids for Bile Leaks
Background: Bile leakage remains a major complication after hepatobiliary surgery and liver transplantation. While most cases are managed through standard radiologic or endoscopic interventions, a subset of patients fails to…
- Trial name
- ASCORB (NCT07214649)
- Testing
- Organoid-guided treatment
- Volunteers
- 25 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Bile Leak
The Need for Repeat ERCP After Endoscopic Treatment of Postsurgical Biliary Leaks
Post-surgical biliary leaks are relatively common after surgeries associated with hepatobiliary health. Left untreated, biliary leaks can lead to significant morbidity.
- Trial name
- NCT05141942
- Testing
- Endoscopic Retrograde Cholangiopancreatography (ERCP)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Calgary
Liver Transplantation, Liver Transplant; Complications
EBD RCT Trial in Living Donor Liver Transplantation
This study was designed to demonstrate incidence of biliary complication rates after living donor liver transplantation according to the implantation of external biliary drainage throug duct-to-duct anastomosis site.
- Conditions
- Liver Transplantation, Liver Transplant; Complications, Bile Stricture, Bile Leakage From Biliary Anastomosis
- Trial name
- NCT04622540
- Testing
- External biliary drainage
- Where
- South Korea
- Volunteers
- 124 people
- Sponsor
- Seoul National University Hospital
Liver Cancer, Hemorrhage Liver
Standard of Care Versus Hemopatch® During Liver Resection
This multicentre prospective and randomized study aims to compare the sealant effect after surgical liver resection of a new collagen - polyethylene glycol hemostatic / sealant patch (Hemopatch) vs standard of care.
- Conditions
- Liver Cancer, Hemorrhage Liver, Bile Leak, Surgery
- Trial name
- IBERLIVER (NCT03166683)
- Testing
- Hemopatch, Standard of care
- Volunteers
- 284 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Postoperative Bile Leak, Focal Liver Lesions
Prevention of Bile Leakage After Liver Resection in Children
Bile leakage is a clinically important complication after liver resection in children and may require prolonged drainage, additional radiological or endoscopic procedures, or repeat surgery.
- Trial name
- NCT07867522
- Testing
- prophylactic extrahepatic biliary drainage during liver resection
- Where
- Russia
- Volunteers
- 12 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Bile Leak, Hepatic Resection
Bile Leak After Liver Surgery
The definition of biliary fistula is heterogeneous and the more accepted is that proposed by the ISGLS. We devised a precise definition of post-resectional biliary fistula and a well-established policy both for its disclosure and…
- Conditions
- Bile Leak, Hepatic Resection, Liver Resection, Hepatectomy
- Trial name
- NCT02056028
- Testing
- Hepatic resection
- Where
- Italy
- Volunteers
- 475 people
- Sponsor
- University of Milan
Bile Leak, Anastomotic Leak Biliary
Factors Influencing Occurrence of Bile Leaks in Surgery
The objective of our study is to identify the factors influencing the occurrence of a biliary leak after performing surgery leading to the creation of a biliary anastomosis to any segment of the digestive tract.
- Conditions
- Bile Leak, Anastomotic Leak Biliary, Biliary Tract Fistula
- Trial name
- NCT04665427
- Testing
- bilioenteric anastomosis i
- Where
- Algeria
- Volunteers
- 108 people
- Sponsor
- University of Oran 1
Surgery--Complications
Bile Leakage Test in Emergency Hydatid Liver Cyst Surgery Case Report
In liver cyst hydatid surgery, presence of cysto-biliary communication (CBC) is important for the prevention of postoperative morbidity. If cysto-biliary connections are not obvious, diagnosis is not easy.
- Trial name
- NCT04705961
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Dr. Ersin Arslan Education and Training Hospital
Biliary Stricture, Bile Duct Stenosi
Biliary Complications in Live Donor Liver Transplantation
The study was designed as a prospective cohort study. The effects of hot and cold ischemic times during live donor liver transplantation on postoperative 1-3 and 6 month follow up biliary complications will be investigated.
- Conditions
- Biliary Stricture, Bile Duct Stenosi, Bile Leak, Bile Duct Injury
- Trial name
- NCT03673033
- Testing
- liver transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Inonu University
Liver Transplant; Complications, Bile Duct; Stricture, Postoperative
The Effect of the Type of Conduit-duct Anastomosis Technique on the Postoperative Course in Patients Undergoing Liver Transplantation
The main objective of the trial is to compare the effect of two end-to-end duct-to-duct anastomosis surgical techniques using the continuous suture method versus interrupted method (control group) on reducing the risk of bile…
- Conditions
- Liver Transplant; Complications, Bile Duct; Stricture, Postoperative, Bile Leak, Quality of Life
- Trial name
- NCT06533592
- Testing
- Continous suture technique, Interrupted suture technique
- Where
- Poland
- Volunteers
- 284 people
- Sponsor
- Medical University of Warsaw
Bile Leak
Plastic vs. Fully Covered Self Expanding Stents (FCSEMS) for Treatment of Anastomotic Bile Leaks
Standard endoscopic management for anastomotic bile leaks following OLT has been endoscopic retrograde cholangiopancreatography (ERCP) with placement of a temporary plastic biliary endoprosthesis (stent) across the site of…
- Trial name
- NCT03333382
- Testing
- Plastic biliary stent, FCSEMS
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Vanderbilt University Medical Center
Liver; Cyst, Hydatid, Granulosus (Etiology)
Radical Versus Conservative Surgery in Liver Cystic Echinococcosis: a Prospective Cohort Study in a High-volume Western Centre
The goal of this observational study is to compare the results in terms of morbidity and disease-free survival between groups of patients with liver cystic echinococcosis (LCE) managed with radical surgery (RS) or conservative…
- Trial name
- NCT06570876
- Testing
- Surgery
- Where
- Spain
- Volunteers
- 192 people
- Sponsor
- Hospital Universitari de Bellvitge
Ampullary Cancer, Duodenal Cancer
Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders
Our institution performs therapeutic ERCP (Endoscopic retrograde cholangiopancreatography ), Endoscopic Ultrasound (EUS) and Interventional Endoscopy in around 1000 patients a year.
- Conditions
- Ampullary Cancer, Duodenal Cancer, Bile Duct Cancer, Bile Duct Disorders
- Trial name
- NCT01438385
- Testing
- Interventional Endoscopy
- Where
- United States
- Volunteers
- 12,000 people
- Sponsor
- Weill Medical College of Cornell University
Laparoscopic Hepatectomy
Feasibility and Impact of ICG and 4K Overlay in Laparoscopic Hepatic Surgery on Real-time Tumor Detection
Achievement of tumor-free resection margin with the largest possible remnant liver parenchyma is the major challenge in hepatic surgery.
- Trial name
- LiverLight (NCT04946591)
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Klinikum Saarbrücken, Klinik für Allgemein-, Viszeral- und Thoraxchirurgie, Chirurgische Onkologie
Postoperative Fistula, Complications of Surgical and Medical Care: General Terms
External Drainage Versus Internal Drainage of Pancreatic Duct With a Stent After Pancreaticoduodenectomy (EDIDPD)
Postoperative pancreatic fistula (POPF) and other surgical complications are common after pancreatoduodenectomy (PD) and POPF is a major complication.
- Trial name
- EDIDPD (NCT01634971)
- Testing
- Internal Drainage of Pancreatic Duct after pancreatomy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital