Clinical trials: Beta Lactam Adverse Reaction
Drug Allergy
In Search of the Correct Diagnosis of Beta-lactam Allergy: From the Validation of a Risk Stratification Tool to Accurate Endotyping
Testing a clinical decision tool (BL-Predictor)
- Trial name
- Allergy (NCT07011212)
- Testing
- BL-Predicter
- Volunteers
- 332 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Beta Lactam Adverse Reaction
B-lactam Databank Algorithm
Background: Antibiotic allergy constitutes a major health problem with serious medical and financial consequences when under- but also overdiagnosed. About one and a half million Belgians report having an allergy to penicillin.
- Trial name
- NCT06243380
- Where
- Belgium
- Volunteers
- 921 people
- Sponsor
- University Hospital, Antwerp
Drug Allergy, Cephalosporin Allergy
Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing
Cephalosporin antibiotics are commonly used but can result in allergic reactions and anaphylaxis. There is no clear diagnostic approach for cephalosporin-allergic patients, and guidance for the use of other antibiotics in…
- Conditions
- Drug Allergy, Cephalosporin Allergy, Drug Hypersensitivity, Antibiotic Allergy
- Trial name
- DACAT (NCT06406114)
- Testing
- Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing
- Where
- 6 sites in United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Allergic Reaction, Beta Lactam Adverse Reaction
Investigation of Cross-allergies Between Cefazolin and Amoxicillin With Skin Tests and Provocation Test
Antibiotic prophylaxis in the operating room reduces the frequency of occurrence of surgical site infections (SSI) by preventing bacterial proliferation. The main antibiotic used in all surgery is CEFAZOLINE.
- Trial name
- CEFAZOPE (NCT05605795)
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Drug Hypersensitivity
Negative Predictive Value of Drug Provocation Tests to Beta-lactams
Patients with a complete drug allergy work-up to betalactam antibiotics were contacted (by mail) and asked to answer a questionnaire regarding the tolerance upon readministration of a negatively tested beta-lactam.
- Trial name
- NPVDPT (NCT02844712)
- Testing
- Evaluation of reexposure to a negatively tested betalactam
- Where
- France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Montpellier
Beta Lactam Adverse Reaction
Optimization of Perioperative Antibiotic Prophylaxis in Patients Allergic to Beta-lactams in the Orthopedic Surgery and Trauma Departments
When surgery is required, a consultation with an anesthesiologist is mandatory. This preoperative consultation allows for the selection of the appropriate antibiotic prophylaxis tailored to the patient and the type of procedure.
- Trial name
- ORTHO-PEN (NCT07342647)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Hypersensitivity, Beta Lactam Adverse Reaction
Protocol of Reintroduction of Beta-lactams in Children at Low Risk of Anaphylaxis.
The purpose of this study is to establish the rationale for the practice of performing an oral reintroduction test without previous skin tests in children at low risk of IgE-mediated reaction or drug-induced toxidermia, and to…
- Trial name
- TRO-b-lact (NCT03553251)
- Where
- France
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Drug Hypersensitivity
Optimal Doses for Drug Provocation Tests to Beta-lactams
Drug provocation tests (DPT) are widely in case of suspicion of drug hypersensitivity (and in the absence of contraindications), but there are no standardized protocols and most groups use hypothesis (clinically-driven)…
- Trial name
- NewBL (NCT02839551)
- Testing
- simplified drug provocation test
- Where
- France
- Volunteers
- 1,252 people
- Sponsor
- University Hospital, Montpellier
Penicillin Allergy, Aminopenicillin Allergy
The Diagnosis of Beta-lactam Hypersensitivity in Thailand
The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity will be determined by using commercially available standard skin test reagents and the diagnostic agents available in Thailand.
- Conditions
- Penicillin Allergy, Aminopenicillin Allergy, Beta Lactam Adverse Reaction
- Trial name
- NCT01667055
- Where
- Thailand
- Volunteers
- 500 people
- Sponsor
- Chulalongkorn University
Penicillin Allergy
Safety and Efficacy of an Oral Penicillin Challenge in Low Risk Hospitalized Patients
Penicillin allergy is the most common drug allergy reported by patients. Approximately 10% of the population and 20% of inpatients carry a label of penicillin allergy.
- Trial name
- NCT04408508
- Testing
- Amoxicillin 250 MG
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Pharmacokinetics, Beta Lactam Adverse Reaction
Beta-lactam Pharmacokinetics in Secondary Care
Currently in the UK, TDM is routinely performed for aminoglycosides and glycopeptide antimicrobial agents, given fears over the narrow therapeutic window of these agents and the serious adverse events associated with toxicity.
- Conditions
- Pharmacokinetics, Beta Lactam Adverse Reaction, Penicillin Allergy
- Trial name
- NCT03033394
- Testing
- Beta-lactam antibiotic
- Where
- United Kingdom
- Volunteers
- 65 people
- Sponsor
- Imperial College London
Antibiotic Allergy
Support Tool for Antibiotic Allergy deLabeling
Antibiotic allergy labels (AAL) are reported in 7% of inpatient's charts, especially for beta-lactams (86% of AAL, i.e., prevalence of 6%).
- Trial name
- STAAL (NCT06771440)
- Testing
- EPR search
- Where
- Belgium
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven