Clinical trials: Benzodiazepines
Obstructive Sleep Apnea, Obesity
Impact of Smoking, Benzodiazepine (BZD) Use and Obesity on Severe Obstructive Sleep Apnea (sOSA)
In this study the investigators will analyze the influence of smoking, benzodizepine use, and obesity among patients with severe Obstructive Sleep Apnea (sOSA).
- Conditions
- Obstructive Sleep Apnea, Obesity, Smoking
- Trial name
- NCT02539264
- Testing
- Smoking, Obesity, Benzodiazepine use
- Volunteers
- 920 people
- Sponsor
- Astes
Benzodiazepine Dependence
Electroacupuncture for Tapering Off Long-term Benzodiazepine Use
This study aims to examine the efficacy of electroacupuncture for tapering benzodiazepines in long-term users. All eligible subjects will be randomized in a ratio of 1:1 to (1) Electroacupuncture combined with gradual tapering…
- Trial name
- NCT02475538
- Testing
- Electroacupuncture
- Where
- 3 sites in China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Alcoholism
Impact of a One-month Long Detoxification Diazepam Treatment on Early Alcohol Relapse
Alcohol-dependence is a medical condition that can lead to the occurrence of an alcohol withdrawal syndrome (AWS) in case of alcohol drinking cessation. Diazepam is the reference medication for preventing or treating AWS.
- Trial name
- DIAMA (NCT02242955)
- Testing
- Diazepam
- Where
- 2 sites in France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Lille
Substance Withdrawal Syndrome
The Effect of Valproate on Benzodiazepine Withdrawal Severity
The aim of this study is to determine whether valproate is effective in the treatment of benzodiazepine withdrawal symptoms in subjects receiving maintenance treatment for opiate dependence.
- Trial name
- NCT00570219
- Testing
- valproate
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- University of Helsinki
Adverse Drug Effect of Opioids, Adverse Drug Effect of Benzodiazepines
Reducing Concurrent Opioid-Benzodiazepine Prescriptions
The purpose of this effort is to use informative e-mails to improve the process of prescribing of opioids and benzodiazepines within the National Capital Region/Military Health System (NCR/MHS), with the aim of decreasing…
- Trial name
- NCT03887247
- Testing
- E-mail Alert
- Where
- United States
- Volunteers
- 2,234 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Conscious Sedation Failure During Procedure
Balanced Propofol Sedation Versus Propofol Alone Sedation in Therapeutic Endoscopic Retrograde Cholangiopancreatography (ERCP)
Based on previous results, the investigators considered that sedation quality, complications, and procedure outcomes may not be different, however, propofol alone titration may have a fast recovery time than BPS and…
- Trial name
- ERCP (NCT01321047)
- Testing
- Propofol, BPS
- Volunteers
- 204 people
- Sponsor
- Soon Chun Hyang University
Focal Dystonia
Electrophysiological and Neuroimaging Correlates of the Effect of Zolpidem in Patients With Focal Dystonia
To study electrophysiological and imaging correlations of the clinical effectiveness of zolpidem in task-specific dystonia and to elucidate mechanisms underlying its therapeutic effects, patients with focal dystonia will be…
- Trial name
- NCT04692285
- Testing
- Zolpidem
- Where
- 2 sites in Serbia, Slovenia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Automobile Driving
Driving Simulator Performance After Intake of Zopiclone Sleeping Pills
Zopiclone, a widely used hypnotic drug, is frequently found in blood samples taken from drivers suspected of driving under the influence.
- Trial name
- NCT01257165
- Testing
- Zopiclone, Ethanol
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Healthy Subjects
Exploring the Effects of Diazepam and Lorazepam
Aims : exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using…
- Trial name
- ibid (NCT00696033)
- Testing
- Diazepam, Lorazepam
- Where
- 2 sites in France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Epilepsy
Pharmacodynamics of Nasal and Buccal Midazolam Using EEG
Approximately 3 million individuals suffer from epilepsy in America alone and about 200,000 new cases of epilepsy in America are diagnosed each year (Epilepsy Foundation, 2005).
- Trial name
- nMDZ-EEG (NCT01316445)
- Testing
- nasal Midazolam
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Columbia University
Frailty, Deprescription
Understanding Benzodiazepine and Non-benzodiazepine Sedative Use
Inappropriate medication use among the elderly ranges from 11% to 62% and is a major concern for patient safety. Benzodiazepines account for approximately 20 to 25% of inappropriate medications prescribed to the elderly, thus…
- Conditions
- Frailty, Deprescription, Aged
- Trial name
- NCT02833272
- Testing
- EMPOWER Educational Brochure
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Benzodiazepine Withdrawal
Brief Motivational Intervention (BMI) on the Deprescription of Benzodiazepines and Related Substances in Adult Chronic Drug Users
We hypothesise that a short-term intervention by dispensing pharmacists is feasible and relatively easy to implement, and that it could have an impact on the deprescribing of BZD/Z in adult patients.
- Trial name
- BENZ_HALTE (NCT06446349)
- Testing
- Brief motivational intervention
- Where
- 20 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Grenoble
Aging, Benzodiazepine Sedative Adverse Reaction
Optimizing Electronic Health Record Prompts With Behavioral Economics to Improve Prescribing for Older Adults
Prescribing of potentially unsafe medications for older adults is extremely common; benzodiazepines and sedative hypnotics are, for example, key drug classes frequently implicated in adverse health consequences for vulnerable…
- Conditions
- Aging, Benzodiazepine Sedative Adverse Reaction, Anticholinergic Adverse Reaction, Adverse Drug Event
- Trial name
- NUDGE-EHR (NCT04284553)
- Testing
- Order Entry, Open Encounter, Follow-up booster Alert
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Brigham and Women's Hospital
Substance Use Disorders, Opiate Dependence
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
This study has an experimental design and will examine the difference in pre-test and post-test data on the Self-Forgiveness Dual Process Scale (SFDPS) (Griffin, Worthington, Davis, Hook, \& Maguen, 2018) and the Substance Abuse…
- Conditions
- Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder
- Trial name
- NCT03971097
- Testing
- Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pittsburgh
Alcohol Withdrawal State
Dexmedetomidine Addition to Benzodiazepines for Patients With Alcohol Withdrawal State in the ICU
The objective of this randomized controlled study was to evaluate whether DEX addition to benzodiazepine therapy is effective and safe for AWS patients in the intensive care unit (ICU).
- Trial name
- NCT02496650
- Testing
- Dexmedetomidine
- Volunteers
- 70 people
- Sponsor
- Bogomolets National Medical University
Healthy Volunteers, Amyotrophic Lateral Sclerosis
Evaluation of Microglial Activation in ALS With [18F]PBR06 (Peripheral Benzodiazepine Receptor-06) PET
The overall goal of this protocol is to evaluate microglial activation in the brain using [18F]PBR06 in patients with amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT03876002
- Testing
- [18F]PBR06
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Molecular NeuroImaging
Autism Spectrum Disorder, Catatonia
Management of Catatonic Features in Adolescents With Profound Autism
The goal of this clinical trial is to learn if benzodiazepines and ECT can treat Catatonic features in Adolescents with Autistic spectrum disorder, it will also learn about Safety and efficacy of benzodiazepines and ECT.
- Trial name
- MOCFAPA (NCT07498387)
- Testing
- Intranasal Midazolam (Benzodiazepine Challenge Test), Oral Clonazepam, Electroconvulsive Therapy (ECT)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
HIV Infections
A Pilot Pharmacokinetic Phase I Evaluation of BI-RG-587 in HIV-Infected Children
To generate initial information on the pharmacokinetics (blood levels) and dose proportionality of nevirapine (BI-RG-587) plasma levels in HIV-infected children; to assess the safety and tolerance of single rising oral doses of…
- Trial name
- NCT00000634
- Testing
- Nevirapine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Benzodiazepine Refractory Status Epilepticus
Established Status Epilepticus Treatment Trial
The primary objective is to determine the most effective and/or the least effective treatment of benzodiazepine-refractory status epilepticus (SE) among patients older than 2 years.
- Trial name
- ESETT (NCT01960075)
- Testing
- Fosphenytoin, Levetiracetam, Valproic acid
- Where
- 65 sites in United States
- Volunteers
- 478 people
- Sponsor
- University of Virginia
Generalized Anxiety Disorder
Drug Treatment Validation of Functional Magnetic Resonance Imaging in Generalized Anxiety Disorder
The purpose of this study is to find out how an anti-anxiety drug or placebo affects the activity of your brain when you are at rest and when you are viewing emotional material, such as, emotional faces and pictures.
- Trial name
- GAD (NCT00662259)
- Testing
- Alprazolam (Xanax)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Diego