Clinical trials: Benzodiazepine Withdrawal (Disorder)
COVID-19, ARDS
Assessment of Analgesics and Sedatives in Mechanically Ventilated Patients With COVID-19
The analgesic and sedation requirements in critically ill patients with COVID-19 have yet to be described. There are various factors that are likely affecting the agents being utilized for analgesia and sedation in these patients…
- Conditions
- COVID-19, ARDS, Withdrawal Syndrome, Iatrogenic Disease
- Trial name
- NCT05336656
- Where
- United States
- Volunteers
- 353 people
- Sponsor
- Wilkes University
Substance Withdrawal Syndrome
The Effect of Valproate on Benzodiazepine Withdrawal Severity
The aim of this study is to determine whether valproate is effective in the treatment of benzodiazepine withdrawal symptoms in subjects receiving maintenance treatment for opiate dependence.
- Trial name
- NCT00570219
- Testing
- valproate
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- University of Helsinki
Benzodiazepine Withdrawal
Brief Motivational Intervention (BMI) on the Deprescription of Benzodiazepines and Related Substances in Adult Chronic Drug Users
We hypothesise that a short-term intervention by dispensing pharmacists is feasible and relatively easy to implement, and that it could have an impact on the deprescribing of BZD/Z in adult patients.
- Trial name
- BENZ_HALTE (NCT06446349)
- Testing
- Brief motivational intervention
- Where
- 20 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Grenoble
Substance Use Disorders, Opiate Dependence
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
This study has an experimental design and will examine the difference in pre-test and post-test data on the Self-Forgiveness Dual Process Scale (SFDPS) (Griffin, Worthington, Davis, Hook, \& Maguen, 2018) and the Substance Abuse…
- Conditions
- Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder
- Trial name
- NCT03971097
- Testing
- Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pittsburgh
Opiate Dependence, Drug Dependence
Treatment of Polydrug-Using Opiate Dependents During Withdrawal
Managed detoxification is a first and necessary step prior to treatment and rehabilitation. Detoxification can be a major obstacle for some patients, and the availability of managed and safe withdrawal is a prerequisite for…
- Conditions
- Opiate Dependence, Drug Dependence, Substance Withdrawal Syndrome
- Trial name
- NCT00367874
- Testing
- Buprenorphine, Valproate
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Sorlandet Hospital HF
Substance-Related Disorders
Abuse Liability of Pregabalin and Its Effects on Benzodiazepine Withdrawal Symptoms
The purpose of this study is to determine if a single dose of pregabalin 300mg in patients receiving medications for sedative-hypnotic withdrawal symptoms will produce meaningful differences in measures of "drug liking" and "drug…
- Trial name
- NCT02423018
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Centre for Addiction and Mental Health
Elderly, Drug Therapy Syndrome
Stopping Benzodiazepines and Related Molecules Among Elderly Living in Residential Institutions
Intervention randomized controlled open study with 2 parallel arms . The objective of this study is to evaluate the feasibility of stopping the benzodiazepines treatment in elderly living in nursing homes.
- Conditions
- Elderly, Drug Therapy Syndrome, Substance-Related Disorders, Substance Withdrawal Syndrome
- Trial name
- BenzoFree (NCT02715440)
- Testing
- Immediate intervention
- Volunteers
- 116 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Withdrawal Syndrome, Iatrogenic Disease
AduLt iatrogEnic withdRawal sTudy in the ICU (ALERT-ICU)
Withdrawal from opioids and sedatives administered for medical purposes (i.e. iatrogenic withdrawal) often goes unrecognized in the critically ill, but its prevalence is high.
- Trial name
- NCT04422808
- Where
- United States
- Volunteers
- 2,437 people
- Sponsor
- Wilkes University
Alcohol Dependence, Alcohol Withdrawal Syndrome
Assessment of Valproate on Ethanol Withdrawal
Alcohol use disorder, or heavy drinking, is commonly seen in patients who present to trauma centers. These patients are at risk for Alcohol Withdrawal Syndrome (AWS), which is collection of symptoms that can range from anxiety…
- Conditions
- Alcohol Dependence, Alcohol Withdrawal Syndrome, Trauma, Heavy Drinking
- Trial name
- PAVE (NCT03235531)
- Testing
- Valproate, Lorazepam
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- CAMC Health System
Insomnia
Self Help Program for Hypnotics Withdrawal in Insomniac Patients
Persistent insomnia has a high prevalence in French general population affecting between 15.8 % and 19 % of adults. In France, the disease is mainly managed by general practitioners (GP) who usually proposed intermediate…
- Trial name
- PROPERSOM (NCT02720458)
- Testing
- Standardized gradual hypnotic taper, Short-term simple self-help program
- Where
- 6 sites in France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Bordeaux
Drug Dependence
How to Ease the Withdrawal of Tranquilizers Among Older Consumers?
Benzodiazepines (BZD) are widely used to treat anxiety, insomnia, and depression. These drugs can have very serious side effects if they are taken over a long period of time.
- Trial name
- NCT02281175
- Testing
- Psychosocial intervention, a weekly physician intervention
- Where
- Canada
- Volunteers
- 114 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Psychiatric Disorder, Benzodiazepine Withdrawal
Influence of Olfaction Essential Oils on the Consumption of Benzodiazepine Receptor Agonists & Z-Drugs (BZRAs) Prescribed as " if Needed " in Psychiatric Outpatients (HECBA-PSY).
The goal of this interventional study is to test the use of olfactory Essential Oils through a nasal stick as one of the non-medicinal strategies to propose to the patient to reduce the consumption of medication in a population…
- Trial name
- HECBA-PSY (NCT05583240)
- Testing
- Essences and Essential Oils
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Etablissement Public de Santé Barthélemy Durand
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Alcohol Withdrawal, Alcohol Withdrawal Delirium
Phenobarbital vs Ativan for Alcohol Withdrawal in the Intensive Care Unit
Our aim is to compare outcomes of patients with benzodiazepine-refractory alcohol withdrawal syndrome who are treated with either a phenobarbital-based or a lorazepam based protocol.
- Trial name
- PARTI (NCT04156464)
- Testing
- Phenobarbital, Lorazepam
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- OSF Healthcare System
Impulsivity, Active Suicidal Ideation
Impulsivity and Thought Process Disorder in Patients With Active Suicidal Ideation and Depression
This study is dedicated to achieving a better understanding of how the brain processes information. Specifically, the investigators are studying cognitive function, thought process, and impulsivity in people with and without…
- Conditions
- Impulsivity, Active Suicidal Ideation, Depression
- Trial name
- NCT01770600
- Testing
- Riperidone
- Where
- United States
- Sponsor
- University of Alabama at Birmingham
Chronic Insomnia, Hypnotic Dependence
Telepsychology for Benzodiazepines Withdrawal in Adults Suffering From Hypnotic-dependent Insomnia
Long-term use of benzodiazepines is a long-standing problem, but the optimal withdrawal modalities are not known. The main objective of this study is to compare the effectiveness of a psychological support versus a…
- Trial name
- NCT04751851
- Testing
- Medium duration withdrawal programme with ACT, Long duration withdrawal programme with ACT, Medium duration withdrawal programme without ACT
- Where
- Switzerland
- Volunteers
- 128 people
- Sponsor
- Association Nationale de Promotion des Connaissances sur le Sommeil
Respiratory Failure
Sedation Management in Pediatric Patients Supported on Mechanical Ventilation
The purpose of this two-year project is to pilot test an intervention to change sedation management in pediatric patients supported on mechanical ventilation for acute respiratory failure in the pediatric intensive care unit…
- Trial name
- NCT00142766
- Testing
- Nurse Implemented Goal-Directed Comfort Algorithm
- Where
- 3 sites in United States
- Volunteers
- 245 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Benzodiazepine Withdrawal (Disorder)
Passiflora Extract for Benzodiazepine Withdrawal
The aim of this clinical trials is compare the percentage of patient who achieve a reduction equal to or greater than 50% in the dose of benzodiazepines at 10 weeks of treatment.
- Trial name
- SEDISTRESS (NCT03780595)
- Testing
- Passiflora incarnata, Control
- Where
- 8 sites in Spain
- Volunteers
- 108 people
- Sponsor
- Nutricion Medica S.L.