Clinical trials: Benchmark
Ovarian Cancer
Benchmarking Intra-tumor Heterogeneity In Ovarian Cancer: Linking In-vivo Imaging Phenotypes With Histology And Genomics
The purpose of this research study is to learn if differences seen in scans before surgery match differences seen when looking at tumor samples with pathology and genetic tests.
- Trial name
- NCT02144311
- Testing
- PET/CT Scan, MRI
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Healthy Subjects
Normative Metrics of High-Resolution Anorectal Manometry With the Use of Solid-State Catheter in a Healthy Russian Cohort
High resolution anorectal manometry (HRAM) normative values are still need to be studied in different populations and with the use of different (solid-state and water-perfused) systems.
- Trial name
- NCT03918213
- Testing
- High-Resolution anorectal manometry with the use of solid-state catheter
- Where
- 2 sites in Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Russian Academy of Medical Sciences
Gall Stone, Gallbladder Inflammation
Benchmarks in Elective Laparoscopic Cholecystectomy
The aim of this observational cohort study is to define peri- and postoperative reference values for elective laparoscopic cholecystectomy, using the achievable benchmarks of care methodology (ABC™).
- Conditions
- Gall Stone, Gallbladder Inflammation, Gall Bladder Pain, Gallstone
- Trial name
- NCT06692517
- Testing
- Laparoscopic cholecystectomy
- Volunteers
- 60,000 people
- Sponsor
- Region Östergötland
Quercetin, Lipid Metabolism
Effects of Quercetin on Metabolic Health
Quercetin is a natural flavonoid compound widely found in vegetables, fruits, and nuts. It has a long history of use as a dietary supplement.
- Conditions
- Quercetin, Lipid Metabolism, Aging
- Trial name
- NCT05297032
- Testing
- Quercetin Phytosome
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Thorne HealthTech, Inc
Developmental Dysplasia of the Hip
Reliability of Ultrasound Metrics Used in Hip Dysplasia Diagnostics - a Prospective Study
Several measurements are used to evaluate hip dysplasia in hip ultrasound of children. Despite having being used since the 1980s, reliability studies have failed to find acceptable reliaiblity values for the gold standard…
- Trial name
- NCT06233487
- Testing
- Repeat hip ultrasound measurements
- Where
- Denmark
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Severe Traumatic Brain Injury
Benchmark Evidence Led by Latin America: Trial of Intracranial Pressure - Pediatrics
Narrative: Worldwide, traumatic brain injury (TBI) is a leading cause of death and disability among children and adolescents. The Investigators aim to test whether pediatric TBI treatment guided by invasive intracranial pressure…
- Trial name
- BELA TRIPP (NCT05566431)
- Testing
- ICP, CREVICE
- Where
- 11 sites in United States, Colombia and 4 more
- Volunteers
- 428 people
- Sponsor
- University of Washington
Mild Traumatic Brain Injury, Post-Concussive Symptoms
Consistency of Automated Neuropsychological Assessment Metrics (ANAM) Performance in Those With Deployment Acquired Mild Traumatic Brain Injury (TBI)
The purpose of this project is to explore the degree to which performance consistency on neuropsychological measures varies in a sample of Operation Iraqi Freedom (OIF)/Operation Enduring Freedom (OEF) Veterans with a history of…
- Trial name
- ANAM (NCT01334528)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
Pituitary Adenoma, Pituitary Tumor
Setting Benchmarks for Transsphenoidal Resection of Pituitary Adenomas
To conduct a retrospective multicenter cohort study to define benchmark values for best achievable outcomes following transsphenoidal resection of pituitary adenomas.
- Conditions
- Pituitary Adenoma, Pituitary Tumor, Pituitary Diseases
- Trial name
- NCT04951557
- Testing
- Transsphenoidal resection
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Dysphagia
Standardizing Swallow Pressure Measurements
This study aims to directly compare and contrast swallowing pressure and impedance measurements obtained from two high-resolution manometry (HRM) systems: the Laborie LMT Pharyngeal System and the Medtronic ManoScan ESO HRM…
- Trial name
- NCT07475091
- Testing
- Laborie LMT Pharyngeal System (3.7 mm catheter), Medtronic ManoScan ESO HRM System (4.2 mm catheter)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Prediabetes
Returning to Normoglycemia With Targeted Use of Real-time CGM Data and Nutrition-focused Lifestyle Changes
The purpose of the ReTURN study is to understand how glycemia, specifically percent of time above 140 mg/dL (TA140), changes over time in people who are randomized to receive either continuous glucose monitoring (CGM)-guided care…
- Trial name
- RETURN (NCT07832474)
- Testing
- CGM-guided care
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- HealthPartners Institute
Renal Cell Carcinoma
Quantitative Imaging Metrics From CECT in Measuring Disease Response or Progression in Patients With Kidney Cancer
This pilot research trial studies quantitative imaging metrics derived from contrast enhanced computed tomography (CECT) in enhancing assessment of disease status in patients with kidney cancer.
- Trial name
- NCT02370290
- Testing
- Medical Chart Review, Informational Intervention
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Southern California
Pulmonary Disease, Chronic Obstructive
Digihaler in Chronic Obstructive Pulmonary Disease (COPD)
This is a multi-center 3-month study to determine the variation in ProAir Digihaler metrics [peak inspiratory flow (PIF), inhalation volume, number of inhalation events] amongst COPD patients in the ambulatory setting.
- Trial name
- NCT05241288
- Testing
- Albuterol eMDPI DS
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- University of North Carolina, Chapel Hill
Operational Metrics of the Emergency Department
Prospective Evaluation of Computerized Physician Order Entry in the Emergency Department
This study will evaluate various performance metrics of emergency department operations after the implementation of computerized physician order entry in an academic emergency department.
- Trial name
- CPOE (NCT01444768)
- Testing
- Computerized Physician Order Entry
- Where
- United States
- Sponsor
- Beth Israel Deaconess Medical Center
Performance Assessment, Motion Metrics
Do Motion Metrics Lead to Improved Skill Acquisition on Simulators?
Emphasizing the growing popularity of motion metrics are the majority of available virtual reality simulators and some newer hybrid models that offer motion tracking for performance assessment.
- Trial name
- NCT01052168
- Testing
- skills training
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Heart Failure
RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure
BRITISH is a UK multicentre trial of patients who have been diagnosed with heart failure due to Non-Ischemic Cardiomyopathy (NICM, or heart failure that is not caused by blocked heart arteries.
- Trial name
- BRITISH (NCT05568069)
- Testing
- Implantable Cardioverter-Defibrillator (ICD) or Cardiac Resynchronisation Therapy Defibrillator (CRTD)
- Where
- 47 sites in United Kingdom
- Volunteers
- 2,504 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Aortic Stenosis
PRessure-based Evaluation of Disease Improvement in the Course of TAVI
The goal of this prospective observational study is to learn if advanced heart pressure wave analysis (using methods called WIA and REPA) can help predict the success of the procedure and long-term recovery in adults (aged 60-90)…
- Trial name
- PREDIC-TAVI (NCT07509554)
- Testing
- Transcatheter aortic valve replacement (TAVR / TAVI)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Cerebral Palsy (CP)
Wearable Eye Tracking During Bimanual Tasks in Children With Cerebral Palsy
This observational pilot study will include 40 children and adolescents aged 6 to 12 years: 20 with cerebral palsy and 20 with typical development.
- Trial name
- NCT07806994
- Testing
- Wearable Eye-Tracking Assessment During Structured Bimanual Tasks
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Cannabis Use, Alcohol Use, Unspecified
Distinguishing Alcohol Intoxication, Cannabis Intoxication and Co-intoxication Using Electroencephalography (EEG)
This is a randomized, parallel-group study designed to explore the differences between cannabis intoxication, alcohol intoxication and co-intoxication involving both alcohol and cannabis, utilizing electroencephalography (EEG) as…
- Trial name
- NCT06259916
- Testing
- Alcohol, Cannabis
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Arthroplasty, Replacement, Knee
Knee Connect: Measuring Range of Motion and Gait Metrics After Total Knee Arthroplasty
The main goals of total knee replacement (TKR) surgery are to relieve pain and to allow patients to remain active. Sunnybrook is working with Kineris Inc.to advance a wearable device, the Knee Connect, aimed at tracking the…
- Trial name
- NCT03651739
- Testing
- Knee Connect
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Sunnybrook Health Sciences Centre
Multiple Sclerosis
The Gut Microbiome in Adult Multiple Sclerosis
This study aims to assess the following research questions: 1. Map and benchmark the gut microbiome of patients with RRMS, and PPMS versus matched healthy controls 2.
- Trial name
- MICROMS5Y (NCT04929145)
- Where
- 2 sites in Belgium
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- National MS Center Melsbroek