Clinical trials: Behavior, Addictive
Alcohol Use Disorder
A Dose-Escalation Study to Determine the Maximum Tolerated Dose of Arbaclofen Placarbil in Subjects With Alcohol Use Disorder
This study will determine the maximum tolerated dose (MTD) of arbaclofen placarbil (AP) in the treatment of subjects with Alcohol Use Disorder (AUD). For every two subjects receiving AP, one subject will receive placebo.
- Trial name
- NCT02511886
- Testing
- Arbaclofen Placarbil
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Indivior Inc.
Smoking Cessation, Nicotine Addiction
Circuitry-Guided Smoking Cessation in Schizophrenia
In a double-blinded, randomized, parallel controlled design, patients with schizophrenia spectrum disorder will be exposed to active or sham repetitive transcranial magentic stimulation (TMS) which was guided by functional…
- Conditions
- Smoking Cessation, Nicotine Addiction, Schizophrenia
- Trial name
- NCT03281629
- Testing
- Active TMS stimulation
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Maryland, Baltimore
Addiction Opiate
Evaluating the Safety of Acute Baclofen in Methadone-maintained Individuals With Opiate Dependence.
Opiate addiction is a major health challenge. The mainstay of treatment is opiate substitution therapy (OST), typically methadone, but many desire to be opiate-free.
- Trial name
- FORWARDS-1 (NCT05161351)
- Testing
- Baclofen, Vitamin D3
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Imperial College London
PTSD, Addiction
N-acetylcysteine in the Treatment of PTSD and Addiction
Examine the effects of N-acetylcysteine on PTSD symptoms, craving and substance use in veterans with PTSD and comorbid substance use disorders.
- Trial name
- NAC (NCT02499029)
- Testing
- N-acetylcysteine
- Volunteers
- 35 people
- Sponsor
- Medical University of South Carolina
Addiction
Deep Brain Stimulation of Nucleus Accumbens for Opioid Relapse Prevention
Nucleus accumbens plays important roles in the process of opiate addiction and initial of relapse after detoxification.According to the single-centered preliminary open-labeled prospective trial results, the investigators…
- Trial name
- NCT03424616
- Testing
- Suzhou Sceneray® DBS System
- Where
- 5 sites in China
- Volunteers
- 60 people
- Sponsor
- Tang-Du Hospital
Smoking, Cannabis
Imaging the Neurochemistry of Drug Addiction With PET
The investigators' project has two overarching goals. 1) The investigators will use newly developed positron emission tomography (PET) technology to investigate the dopaminergic neurochemistry of drugs of abuse including…
- Trial name
- NCT02817698
- Testing
- cannabis
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Yale University
Exercise Addiction, Diet Habit
Dietary Choice in Active Older Adult Women
The present study aimed to determine the effects of negative-calorie diet supplemented with exercise, on weight loss and lipid profile, and to compare its efficiency with low-calorie diet with exercise among elderly adult women…
- Conditions
- Exercise Addiction, Diet Habit, Obesity, Overweight
- Trial name
- NCT03082781
- Testing
- NCDsport, LCDsport
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- P.L.Shupik National Medical Academy of Post-Graduate Education
Opioid Addiction
Transitions Clinic Network: Post Incarceration Addiction Treatment, Healthcare, and Social Support
TCN PATHS will recruit an anticipated 400 participants who are prescribed MOUD who are released from detention facilities. Each individual will be randomized to either 1) standard primary care (SPC) or 2) a Transitions Clinic…
- Trial name
- TCN-PATHS (NCT04309565)
- Testing
- Transitions Clinic Network Primary Care, Standard Primary Care
- Where
- 5 sites in United States, Puerto Rico
- Volunteers
- 398 people
- Sponsor
- Yale University
Cocaine Addiction
Vigabatrin Ph 1 Cocaine Interaction Study
This is a Phase 1 safety/tolerably study to determine if there are clinically significant interactions between oral vigabatrin (gamma vinyl-gamma-amino butyric acid; VGB) concurrent with intravenous (IV) cocaine infusions.
- Trial name
- NCT00626834
- Testing
- Vigabatrin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Addiction
tDCS Effects on Resisting Smoking: Dose Ranging Study
Behaviors such as tobacco use, unhealthy diet, and sedentary behavior have far-reaching health implications. These modifiable behaviors account for a substantial proportion of deaths from cancer, cardiovascular disease and…
- Trial name
- RDR (NCT02624284)
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Digital Addiction and Screen Time Management Among Teachers
Theory of Planned Behavior-Based Digital Addiction and Screen Time Management Training for Teachers
This thesis focuses on problematic internet use, a widespread issue in contemporary society, and its negative effects on sleep quality and psychological well-being.
- Trial name
- NCT07655947
- Testing
- Digital Addiction and Screen Time Management Training Based on the Theory of Planned Behavior, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Craving, Depression, Anxiety
Non-invasive Brain Stimulation in Patients With Methamphetamine Use Disorder
The study aims to apply the intermittent theta burst transcranial magnetic stimulation (iTBS) treatment and evaluate the effect in improving craving, affective symptoms, and cognitive function for those participants in the…
- Conditions
- Craving, Depression, Anxiety, Amphetamine Addiction
- Trial name
- NCT05535101
- Testing
- Intermittent theta burst transcranial magnetic stimulation (iTBS)
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Marijuana Dependence
Baclofen Effects on Marijuana Dependence
Studies show that certain reminders of drug use such as the sight of someone using marijuana, pictures of blunts, particular moments throughout the day, prompt marijuana users to smoke marijuana.
- Trial name
- NCT02011516
- Testing
- Baclofen, Psychosocial
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Smartphone Addiction, Game Addiction, Video
Exploring the Effects of Smartphone and Game Addiction on Activity, Sleep, Stress, and Pain in Youth
This study aims to examine the relationship between smartphone and digital game addiction and various health indicators, including physical activity level, sleep quality, stress, fatigue, and musculoskeletal pain among young…
- Conditions
- Smartphone Addiction, Game Addiction, Video, Musculoskeletal Pain Disorder, Sleep
- Trial name
- NCT06994104
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Addiction, Psychiatric Disorder
Validating Promoted Spiritual Experience
This pilot study of 16 patients will demonstrate a specific psychologically focused intervention to affect a spiritual aspect of psychological health and will measure (1) its effects on general distress, depression, anxiety and…
- Trial name
- NCT05485181
- Testing
- Spiritual Intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Addiction
Leveraging Technology to Address Unhealthy Drug Use in Primary Care Settings
This study will develop a clinical decision support tool that assists primary care providers in carrying out substance use interventions, and then compare (in Phase 2) two clinical scenarios, screening only (SO) vs.
- Trial name
- NCT02893514
- Testing
- Screening Only (SO) condition, SUSIT Condition
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Addictive Behavior, Alcohol Use Disorder (AUD)
Volitional Dysfunction in Self-control Failures and Addictive Behaviors
The aim of this project is to elucidate whether impairments of cognitive control, performance-monitoring, and value-based decision-making and dysfunctional interactions between underlying brain systems are mediating mechanisms…
- Conditions
- Addictive Behavior, Alcohol Use Disorder (AUD), Tobacco Use Disorder, Self-Control
- Trial name
- NCT04498988
- Testing
- Observational study without interventions
- Where
- Germany
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Smoking Cessation, Smoking Cessation Intervention
Unraveling the Genetic Basis of Nicotine Addiction for Novel Therapeutic Strategies
This case-control study aims to investigate the genetic and molecular bases of nicotine addiction to identify potential therapeutic targets.
- Conditions
- Smoking Cessation, Smoking Cessation Intervention, Nicotine Addiction, Epigenetics
- Trial name
- NicoGen (NCT06471387)
- Testing
- Flexiquit Smoking Cessation Intervention
- Where
- Cyprus
- Volunteers
- 200 people
- Sponsor
- University of Cyprus
Substance-Related Disorders
Addictology Expert Patients' Fields of Intervention
Although there are many publications concerning the benefit of the interventions of the self-help movements and peer health mediators in psychiatry, no studies have described the intervention specific to patients with expertise…
- Trial name
- HAPEX (NCT04458987)
- Testing
- Expert patient in addictology
- Where
- France
- Volunteers
- 69 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Smoking Cessation
Impact of Expired Carbon Monoxide Measurement on Smoking Cessation of Pregnant Women
France is the country of Europe where the prevalence of pregnant women smokers is the highest (35.9% before pregnancy and in the 3rd quarter 21.8% in 2008).
- Trial name
- T-CAFE (NCT03842449)
- Testing
- BabyCO, Biological samples
- Where
- France
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges