Clinical trials: Behçet Disease
Behcet Disease
Phase III Study in Refractory Behcet's Disease
The purpose of this pivotal trial is to evaluate subcutaneous (SQ) AIN457 as an adjunctive therapy to reduce the rate of exacerbations of posterior uveitis or panuveitis secondary to Behçet's disease during the 24 weeks of study…
- Trial name
- SHIELD (NCT00995709)
- Testing
- AIN457
- Where
- 49 sites in United States, Egypt and 15 more
- Volunteers
- 118 people
- Sponsor
- Novartis Pharmaceuticals
Behçet Disease
A Study to Evaluate the Efficacy and Safety of Hemay005 in the Treatment of Behçet Disease
This is a phase 2, multi-center, randomized, placebo-controlled, double-blind, parallel-group study with an equal randomization among the Hemay005 high dose, lower dose and placebo treatment groups.
- Trial name
- NCT04609397
- Testing
- Hemay005
- Where
- 31 sites in China
- Volunteers
- 89 people
- Sponsor
- Tianjin Hemay Pharmaceutical Co., Ltd
Behçet Disease
Apremilast Pediatric Study in Children With Active Oral Ulcers Associated With Behçet's Disease
The aim of this study is to estimate the efficacy of apremilast compared to placebo in the treatment of oral ulcers in pediatric participants from 2 to < 18 years of age with oral ulcers associated with Behçet's disease (BD)…
- Trial name
- BEAN (NCT04528082)
- Testing
- Apremilast
- Where
- 27 sites in France, Greece and 6 more
- Volunteers
- 60 people
- Sponsor
- Amgen
Behcet Syndrome
A Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in the Treatment of Behçet Disease
The purpose of this study is to assess whether Apremilast is safe and effective in the treatment of patients with Behcet Disease.
- Trial name
- NCT00866359
- Testing
- Apremilast (CC-10004)
- Where
- 7 sites in United States, Turkey (Türkiye)
- Volunteers
- 111 people
- Sponsor
- Amgen
Behçet
Neurofilament Light Chain as a Potential Marker in Behcet's Disease
To determine the role of neurofilament light chain in Behçet's disease with or without neurological affection and its relation to neurological manifestation (either peripheral or central ).
- Trial name
- NCT06060275
- Testing
- serum sample and nerve conduction study and cerebrospinal fluid study
- Volunteers
- 60 people
- Sponsor
- Assiut University
Uveitis, Diabetic Retinopathy
Biomarkers of Common Eye Diseases
To identify biomarkers of common eye diseases based on single-cell sequencing technologies using PBMC samples. These diseases include uveitis, diabetic retinopathy, age-related macular degeneration and polypoid choroidal…
- Conditions
- Uveitis, Diabetic Retinopathy, Age-related Macular Degeneration, Polypoidal Choroidal Vasculopathy
- Trial name
- NCT04101604
- Testing
- Collection of blood samples
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Behçet
Role of Femoral Vein Wall Thickness and Inflammatory Markers in Patients With Behcet Disease
Evaluation of femoral vein wall thickness and inflammatory indices in patients with Behcet disease and assessment of their relation to the disease activity and related some clinical manifestations
- Trial name
- NCT06721234
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
SARS-CoV Infection, Systemic Disease
Serologic Profile of SARS CoV2 in COVID-19 Patients With Systemic Diseases
An observational study aiming to assess the serological profile of SARS-Cov2 patients with systemic diseases such as systemic lupus erythematosus, Sjogren syndrome, sarcoidosis, inflammatory myopathies, Behçet's disease…
- Conditions
- SARS-CoV Infection, Systemic Disease, Systemic Lupus Erythematosus, Sjogren's Syndrome
- Trial name
- NCT04530461
- Testing
- Serological test
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- faida agili
Behçet Disease, Inflammation
How Sirtuin Levels Change During Behçet Disease
Our primary aim in our study is to evaluate the relationship between the activity, which will be evaluated by clinical and standard phase reactants, and the IL-6 and TNF-α levels, which will be measured in serum, in Behçet\'s…
- Conditions
- Behçet Disease, Inflammation, Vasculitis
- Trial name
- NCT06266247
- Testing
- Take blood samples
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
Behçet Disease, Uveitis
Interferon α2a Versus Cyclosporine for Refractory Behçet's Disease Uveitis
Brief summary: This study compares the long-term efficacy and safety of interferon (IFN) α2a and cyclosporine (cyclosporin A, CsA) following suppression of acute attack by high-dose oral glucocorticosteroid in patients with…
- Trial name
- NCT03209219
- Testing
- Interferon Alfa-2A, Cyclosporine Pill
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Peking Union Medical College Hospital
Behçet Disease
Efficacy and Safety of Ustekinumab, a Human Monoclonal Anti-IL-12/IL-23 Antibody, in Patients With Behçet Disease
The purpose of this study is to evaluate the proof of concept of efficacy of ustekinumab in subjects with Behçet disease, including patients with oral ulcers (STELABEC-1) and patients with active posterior uveitis or panuveitis…
- Trial name
- STELABEC (NCT02648581)
- Testing
- Subcutaneous Ustekinumab
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Behçet Disease
Thrombophilia and Thrombosis in Behçet's Disease
Behçet's disease (BD) is a systemic vasculitis of unknown cause, affecting mainly young adults. Vasculopathy has been reported in 16.8-51.5% of cases.
- Trial name
- NCT06451575
- Testing
- Blood collection
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Pericarditis, Tako-TSUBO Cardiomyopathy
Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular Research
INFLAME-BANK is a French multicenter prospective observational ancillary study of the international EACVI-INFLAME project. It aims to establish a biobank and perform immunophenotyping and proteomic analyses in patients with…
- Conditions
- Pericarditis, Tako-TSUBO Cardiomyopathy, Myocarditis, Inflammatory Cardiomyopathies
- Trial name
- INFLAME-BANK (NCT07737470)
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Behçet
Assessment of Endocan Serum Levels in Patients With Behcet Disease
The aim of our study was to assess serum endocan levels in patients with Behcet disease and to correlate it with various disease clinical and laboratory parameters of disease activity as well as carotid intima media thickness.
- Trial name
- NCT03853135
- Testing
- measurement of serum endocan
- Where
- Egypt
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Benha University
Behcet Disease, COVID
Familial Mediterranean Fever and Behçet: Analysis Before and After Covid19 Pandemic
Behcet' disease (BD) is a chronic inflammatory disease which is characterized by oral and genital ulcers, uveitis and skin lesions.
- Conditions
- Behcet Disease, COVID, FMF
- Trial name
- NCT04403438
- Testing
- ıt will be compared pain, sleep, fatigue, physical activity level and quality of life and questioning exercise habits before and after the covid-19 outbreak in patients with Behçet and FMF.
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul University
Behçet's Syndrome
Withdrawal of Colchicine in Behçet Syndrome
Behçet's syndrome is a multisystem variable vessel vasculitis. Clinical features include mucocutaneous manifestions such as oral ulcers, genital ulcers, papulopustular lesions and nodular lesions, musculoskeletal manifestations…
- Trial name
- NCT06146192
- Testing
- Colchicine
- Volunteers
- 130 people
- Sponsor
- Istanbul University - Cerrahpasa
Behçet Disease Affecting Oral Mucosa
Topical Pentoxifylline Gel on Behcet's Disease Oral Ulcers
Although Behçet's Disease (BD) has no FDA-approved therapies, numerous clinical reports suggest that oral ulcers of BD may resolve when treated with systemic ingested pentoxifylline (PTX).
- Trial name
- NCT03888846
- Testing
- Pentoxifylline, Colchicine
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Ipekyolu Ilac Ltd. Sti
Behcet's Disease, Vasculitis
Induction Therapy With Anti-TNFα vs Cyclophosphamide in Severe Behçet Disease
Behçet's disease (BD) is a systemic vasculitis of arterial and venous vessels of any size, involving young patients (from 15 to 45 years). BD significantly increases morbidity and mortality.
- Trial name
- ITAC (NCT03371095)
- Testing
- Infliximab, Cyclophosphamide
- Where
- 27 sites in France
- Volunteers
- 53 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Behçet Disease
Plasma Soluble Urokinase Plasminogen Activator Receptor and Behçet's Disease .
The purpose of the study is to determine whether plasma levels of the soluble urokinase plasminogen activator(suPAR) can serve as a blood-based biomarker for diagnosis of Behçet's disease and its correlation with disease activity.
- Trial name
- NCT04105439
- Volunteers
- 90 people
- Sponsor
- Assiut University
Behçet Disease
IMPACT_BD (IMProving AdherenCe to Treatment in Behçet's Disease)
Behçet's disease (BD) is an autoimmune, rare, and severe multisystemic inflammatory disease characterized by recurrent oral aphthous ulcers, genital ulcers, skin lesions, and both anterior and posterior uveitis; articular…
- Trial name
- IMPACT_BD (NCT05128357)
- Testing
- the study is observational, no intervention foreseen
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana