Clinical trials: Barrett Esophagus, active
Barrett's Esophagus With Dysplasia
Ursodeoxycholic Acid in Barrett's Endotherapy
Barrett's esophagus (BE) is a condition in which the normal lining of the esophagus is replaced by abnormal tissue that can increase the risk of esophageal cancer.
- Trial name
- NCT07756710
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Columbia University
Esophageal Lesion, Barrett Esophagus
Endoscopic Submucosal Dissection (ESD)
This registry is to evaluate the procedural and clinical outcomes in patients undergoing endoscopic submucosal dissection. All patients will receive standard of medical care and no experimental interventions will be performed.
- Conditions
- Esophageal Lesion, Barrett Esophagus, Gastrointestinal Lesions
- Trial name
- ESD (NCT05468008)
- Testing
- Endoscopic Submucosal Dissection
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- AdventHealth
Barrett Esophagus, Barretts Esophagus With Dysplasia
Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance
The purpose of this research study is to learn about the best approach to sample patients with known or suspected Barrett's esophagus (BE) by comparing the standard Seattle biopsy protocol to sampling using wide area…
- Conditions
- Barrett Esophagus, Barretts Esophagus With Dysplasia, Esophageal Adenocarcinoma
- Trial name
- SWAT-BE (NCT05530343)
- Testing
- Seattle protocol, WATS3D brushings
- Where
- 14 sites in United States
- Volunteers
- 2,298 people
- Sponsor
- University of Colorado, Denver
Barrett Esophagus, Barrett's Esophagus Without Dysplasia
Evaluation of Tethered Capsule Endomicroscopy as a Screening Tool for Barrett's Esophagus in the Primary Care Setting
The investigators will conduct a large study in the primary care clinic to determine the feasibility of using tethered capsule endomicroscopy as a screening method for Barrett's esophagus (BE) in the primary care practice…
- Conditions
- Barrett Esophagus, Barrett's Esophagus Without Dysplasia, Barretts Esophagus With Dysplasia
- Trial name
- NCT04561791
- Testing
- Tethered Capsule Endomicroscopy
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Barrett's Esophagus
Pilot Study for TCE Imaging of the Esophagus Using an OFDI Capsule With a Compact Imaging System
The goal of this research is to test a distal scanning capsule and a compact redesigned version of the OFDI imaging system in healthy and BE participants to assess ease of use, safety and feasibility in preparation for its use in…
- Trial name
- NCT02947971
- Testing
- Experimental OFDI Imaging
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Barrett Esophagus, Esophageal Adenocarcinoma
Trans-Oral Sampling as an Alternative Surveillance of Barrett's Esophagus Pilot
The study aims to address the increasing incidence of esophageal cancer and Barrett's esophagus (BE) in the Western world by exploring a more efficient surveillance method.
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Diagnosis
- Trial name
- TOSS pilot (NCT07490340)
- Testing
- trans oral sampling: endosign
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Barrett Esophagus
Multi-center Clinical Study to Evaluate the C2 CryoBalloon Focal Ablation System
To evaluate the efficacy and safety of the CryoBalloon Focal Ablation System for the treatment of previously-untreated ("treatment naïve") Barrett's Esophagus (BE)
- Trial name
- ColdPlayIII (NCT02514525)
- Testing
- CryoBalloon Ablation System
- Where
- 11 sites in United States
- Volunteers
- 150 people
- Sponsor
- Pentax Medical
Barrett Esophagus, Esophageal Adenocarcinoma
Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation
This randomized phase II trial studies the safety of and how well aspirin works in preventing Barrett's esophagus from returning after it has been successfully eliminated by radiofrequency ablation.
- Trial name
- NCT02521285
- Testing
- Aspirin, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- 10 sites in United States, Canada
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Barrett's Esophagus, Early Esophageal Adenocarcinoma
The Effect of Ablation Therapy on Barrett's Esophagus
To assess the effect of ablative therapy (Photodynamic Therapy or Radiofrequency ablation ) on Barrett's Esophagus
- Trial name
- ablation IN BE (NCT00587314)
- Testing
- Biopsy
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Mayo Clinic
Barrett Esophagus, Esophageal Adenocarcinoma
A Multicenter Prospective Cohort Study Comparing Random Biopsies Versus Wide-Area Transepithelial Brush-Sampling (WATS) for Surveillance of Barrett's Esophagus, the WATS-EURO2 Study
The investigators aim to study the rate of developing a biopsy-based diagnosis of high-grade dysplasia (HGD) and EAC in BE patients in a prospective cohort of 208 BE patients at high risk of progression (i.e.
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Diagnosis
- Trial name
- WATSEURO2 (NCT05642338)
- Testing
- WATS3D
- Where
- Netherlands
- Volunteers
- 416 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Obese Patients, Tobacco Use
Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux
The veteran population is at increased risk for EAC and its precursor lesion, Barrett's esophagus (BE), due to increased prevalence of disease risk factors compared to the general population.
- Conditions
- Obese Patients, Tobacco Use, Veterans, Family History of Esophageal Cancer
- Trial name
- NCT06746623
- Testing
- Enrolled participants will complete Esocheck/Esoguard and diagnostic upper endoscopy.
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Louis Stokes VA Medical Center
Submucosal Esophageal Adenocarcinoma, Barrett Esophagus
Prospective Endoscopic Follow-up of Patients With Submucosal and High Risk Mucosal Esophageal Adenocarcinoma
Aim of this prospective multicenter study is to evaluate the safety of an endoscopic follow-up strategy in patients treated with endoscopic resection (ER) for submucosal or high-risk mucosal esophageal adenocarcinoma (T1bN0M0 or…
- Conditions
- Submucosal Esophageal Adenocarcinoma, Barrett Esophagus, High-risk Mucosal Esophageal Adenocarcinoma
- Trial name
- PREFER (NCT03222635)
- Testing
- Endoscopic follow-up
- Where
- 20 sites in Australia, Belgium and 4 more
- Volunteers
- 225 people
- Sponsor
- Amsterdam UMC
Barrett's Esophagus
Australian Barrett's Cohort With Dysplasia and Early Cancer Study
The purpose of this study is to collect prospective observational data regarding endoscopic management and outcomes of patients with Barrett's oesophagus (BO) with high grade dysplasia and/or intramucosal carcinoma.
- Trial name
- ABCDE (NCT02198976)
- Where
- Australia
- Volunteers
- 300 people
- Sponsor
- Professor Michael Bourke
Airway Disease, Barrett Esophagus
Biomarkers of Airway Disease, Barrett's and Underdiagnosed Reflux Noninvasively (BADBURN)
A majority of Fire Department of New York (FDNY) World Trade Center (WTC) exposed rescue and recovery workers developed gastroesophageal reflux disease (GERD), a risk factor for Barrett's Esophagus (BE) and subsequent esophageal…
- Conditions
- Airway Disease, Barrett Esophagus, Gastroesophageal Reflux Disease
- Trial name
- NCT05216133
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Barrett Esophagus, Transoral Incisionless Fundoplication
Outcomes After Transoral Incisionless Fundoplication (TIF) Following Successful Endoscopic Ablation for Barrett's Esophagus
Barrett's esophagus (BE) is a precancerous lesion characterized by the replacement of the normal stratified squamous epithelium of the distal esophagus by intestinal metaplasia (IM).
- Trial name
- NCT04457193
- Testing
- TIF
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Barrett Esophagus, Esophageal Adenocarcinoma
Lucid Registry Study
This is a multicenter, prospective, observational study designed to capture a limited set of data consisting of diagnostic test results and clinical management information on subjects who undergo EC/EG to assess for the presence…
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
- Trial name
- Lucid Registry (NCT05965999)
- Testing
- EsoCheck®, EsoGuard®
- Where
- United States
- Volunteers
- 8,000 people
- Sponsor
- Lucid Diagnostics, Inc.
Barrett Esophagus, Barretts Esophagus With Dysplasia
Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples
This clinical trial evaluates the use of cytosponge, a minimally invasive collection device, for the detection of Barrett's esophagus (BE) in patients undergoing endoscopy.
- Conditions
- Barrett Esophagus, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia, Esophageal Adenocarcinoma
- Trial name
- SOS4C (NCT06071845)
- Testing
- Cytosponge Procedure, Endoscopic Assessment
- Where
- 5 sites in United States
- Volunteers
- 450 people
- Sponsor
- Mayo Clinic
Superficial Esophageal Cancer, Oesophageal Adenocarcinoma
Multicenter Prospective Cohort on Esophageal Endoscopic Submucosal Dissection
In France in 2018, there were an estimated 2,074 new cases of esophageal adenocarcinoma and 3,224 cases of squamous cell carcinoma.
- Conditions
- Superficial Esophageal Cancer, Oesophageal Adenocarcinoma, Oesophageal Squamous Cell Carcinoma, Barretts Esophagus With Dysplasia
- Trial name
- FEO (NCT07343869)
- Where
- 7 sites in France
- Volunteers
- 750 people
- Sponsor
- Société Française d'Endoscopie Digestive
Barrett Esophagus, Esophageal Adenocarcinoma
Minimally Invasive Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Cancer, SOS5C Trial
This clinical trial studies how well minimally invasive approaches (an artificial intelligence [AI] powered risk tool, nurse navigation, and a sponge on a string [SOS] test) work in diagnosing patients with Barrett's esophagus…
- Trial name
- NCT07206589
- Testing
- Cancer Screening, Computer-Assisted Intervention, Endoscopic Procedure
- Where
- 3 sites in United States
- Volunteers
- 1,010 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Barrett Esophagus, Esophageal Neoplasm
Novel Biomarkers in the Neoplastic Progression of Barrett's Esophagus
The purpose of this study is to determine if there are any early changes in DNA markers of blood and esophageal tissue in people with gastric reflux, Barrett's esophagus or esophageal cancer that can warn of a progression to…
- Conditions
- Barrett Esophagus, Esophageal Neoplasm, Gastroesophageal Reflux
- Trial name
- BE (NCT00431756)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University